• Title/Summary/Keyword: Biology and Life Science

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CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway

  • Kang, Bo-Ram;Kim, Ho;Nam, Sung-Hee;Yun, Eun-Young;Kim, Seong-Ryul;Ahn, Mi-Young;Chang, Jong-Soo;Hwang, Jae-Sam
    • BMB Reports
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    • v.45 no.2
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    • pp.85-90
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    • 2012
  • Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.

Development of the Bibliographic Information Network Prototype for Biology and Life Science (생명과학 문헌정보 네트워크 프로토타입 개발)

  • Ahn, Bu-Young;Song, Chi-Pyoung
    • Journal of Information Management
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    • v.36 no.2
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    • pp.125-151
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    • 2005
  • The eight types of Korean bibliographic information of biology and life science are included in PubMed that serves universal medical bibliographic information. Other domestic bibliographic information are served on its own format at different organizations. To fulfill the CCBB homepage user's request that it is necessary that integration of bibliographic service for quick acquisition of research information, we intends to construct metadata registry and service about bibliographic information of biology and life science. This paper describes the design and implementation of bibliographic information network prototype for biology and life science that can be used to share latest research result, seminar presentation data, research note, and research paper etc as well as to exchange information between researchers through Open Archiving Community.