• Title/Summary/Keyword: Biological studies

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Bioactive Marine Natural Products

  • Son, Byeng-Wha
    • Korean Journal of Pharmacognosy
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    • v.21 no.1
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    • pp.1-48
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    • 1990
  • Marine organisms have proven to be rich sources of interesting organic molecules. A great number of compounds with diverse structural features and interesting biological activities have been isolated. Recent studies on secondary metabolites of marine organisms are discussed with a focus on a variety of biological activities and marine natural product literatures are also reviewed.

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Differences of Narrative Representations by Foster Care, Adopted and Biological Family Children (가정위탁유아, 연장입양유아와 일반유아의 내적표상에서의 차이)

  • Shin, Hye Won;Min, Sung Hye
    • Korean Journal of Child Studies
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    • v.29 no.3
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    • pp.157-174
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    • 2008
  • This study used the person-oriented approach to explore differences in narrative representations of 97 4-, 5- and 6-year old children (30 foster care, 40 biological family, 17 adopted). Using the MacArthur Story Stem Battery (Bretherton et al., 1990), observations were made to obtain children's narrative representations of content themes and performances. Descriptive statistics, ANOV A and hierarchical cluster analyses were performed. The results of this study were that : (1) Biological family children showed more empathy/helping representations. Foster care children and adopted children showed more anxious representations, and foster care children showed more dysregulated aggression. (2) Four clusters of foster care and adopted children and five clusters of family biological children were found.

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Histochemical and Ultrastructural Studies on the Salivary Gland of a Land Snail, Nesiohelix samarangae (동양달팽이 (Nesiohelix samarangae) 타액선의 조직화학적 및 미세구조적 연구)

  • Lee, Yong-Seok;Kang, Bo-Ra;Shin, Hui-Jin;Jeong, Kye-Heon
    • The Korean Journal of Malacology
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    • v.20 no.1
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    • pp.7-16
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    • 2004
  • Histochemical and ultrastructural studies on the salivary gland and salivary duct of a land snail Nesiohelix samarangae were conducted to observe structural characteristics and function. The salivary gland consisted of one type of epithelial cell, one type of supporting cell, and six types of gland cells. Four out of six gland cell types were histochemically identified on these secretions. The one secreted acid mucopolysaccharide and the other three secreted neutral mucopolysaccharide. The salivary duct epithelium had only one type of columnar cell with microvilli on its luminal surface. The basal protoplasmic membranes of the epithelial cells were deeply infolded so many times all along the cell bases.

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Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer's disease

  • Yoo, Seung-Min;Park, Jisu;Kim, Seo-Hyun;Jung, Yong-Keun
    • BMB Reports
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    • v.53 no.1
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    • pp.35-46
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    • 2020
  • Despite enduring diverse insults, mitochondria maintain normal functions through mitochondrial quality control. However, the failure of mitochondrial quality control resulting from excess damage and mechanical defects causes mitochondrial dysfunction, leading to various human diseases. Recent studies have reported that mitochondrial defects are found in Alzheimer's disease (AD) and worsen AD symptoms. In AD pathogenesis, mitochondrial dysfunction-driven generation of reactive oxygen species (ROS) and their contribution to neuronal damage has been widely studied. In contrast, studies on mitochondrial dysfunction-associated inflammatory responses have been relatively scarce. Moreover, ROS produced upon failure of mitochondrial quality control may be linked to the inflammatory response and influence the progression of AD. Thus, this review will focus on inflammatory pathways that are associated with and initiated through defective mitochondria and will summarize recent progress on the role of mitochondria-mediated inflammation in AD. We will also discuss how reducing mitochondrial dysfunction-mediated inflammation could affect AD.