• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.114-117
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• 1996

In this study, remote articulation training system which connects the hearing disabled trainee and the speech therapist via B-ISDN is introduced. The hearing disabled does not have the hearing feedback of his own pronunciation, and the chance of watching his speech organs' movement trajectory will offer him the self-training of articulation. So the system has two purposes of self articulation training and trainer's on-line checking in remote place. We estimate the vocal tract articulatory movements from the speech signal using inverse modelling and display the movement trajectory on the sideview of human face graphically. The trajectories of trainees' articulation is displayed along with the reference trajectories, so the trainee can control his articulating to make the two trajectories overlapped. For on-line communication and ckecking training record, the system has the function of video conferencing and transferring articulatory data.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.298-302
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• 1996

The representative beat with high SNR could be obtained by the signal averaging, correct and fast detection of significant points and waveform boundary could be obtained by adoption of search interval. All experimental results of waveform boundary were compared with CSE database which had the 5 referees results and 11 ECG measurement programs. All results were within tolerance made by referees, especially the end point of T wave were more close to the referee's results than other 11 measurement programs. The diagnosis parameters that might be used in the Minnsota code criteria were extracted from the representative beat. The diagnostic classification were fulfilled using Minnsota code criteria. Through the comparison on the diagnosis results from designed automated ECG analyzer(YECGA) and the results ECG analyzer manufactured by Fukuda denshi(FCG-2201) in Japan, reliance of the performance on designed system(YECGA) could be validated.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.36-40
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• 1996

There are two prevailing techniques, mechanical and optical profilometers, to measure 3-dimensional configurations of the human skin furrows. The methods have some limitations such as, accuracies or resolutions of the acquired 3-dimensional data and consistencies according to the repeated experiments. We devised an optical profilometer that is called stereo image optical profilometer (SOP) based on stereo image processing techniques. A stereo image is a pair of images that obtained from two cameras which have different angles. From the digital stereo images, the clinical informations for skin can be obtained by some signal processing techniques. In this paper, we focused on the 3-dimensional graphical visualizations of the structures and state of the skin furrows by solving the corresponding problem from the left and right pairs of the stereo images.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.243-246
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• 1996

This study was peformed to characterize the physiological signal prior to develop an algorithm which quantifies EEGs evoked by tactile stimulation. The experiment was devised with four experimental conditions, which were control and two levels of pressures in tactile sensation. Twenty subjects were used to obtain EEGs while applying tactile stimulation using two types of textiles, soft towel and sand paper, to the right hand of each subject. EEGs were acquired for 20 seconds, and each trial was repeated five times randomly at the different levels of stimulus intensities. The index, $S_{n}$, was obtained by calculating the ratio of energy distribution in the time-frequency plot for each scored psychological state of the subject. The results showed that dominant aspects of the EEG signals have their maximal frequencies concentrated at a lower ranges for the resting and pleasant state, while the spectral energies were distributed to higher frequency ranges when subjects experience an unpleasant emotion.

• Journal of Biomedical Engineering Research
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• v.32 no.2
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• pp.85-92
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• 2011

Bioluminescence imaging (BLI) is the most sensitive animal imaging technique for molecular imaging research. Generally, highly sensitive CCD is used to detect an optical probe introduced in a living mouse. However, in many cases, the light signal emitted from a probe is too small to detect because it is scattered and attenuated by the tissue prior to being detected. The problem is that scattering and attenuation not only inhibit accurate measurement but also make image quality down. Thus we introduced a new method to reduce noise by using property of CCD and method to improve image quality of bioluminescence image by using two steps Gaussian blurring.

• Journal of Biomedical Engineering Research
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• v.29 no.1
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• pp.25-31
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• 2008

It is well known that temporal information, i.e speech onset, about input speech can be represented to the response nerve signal of auditory nerve better depending on the adaptation effect occurred in the auditory nerve synapse. In addition, the performance of a speech processor of cochlear implant can be improved by the adaptation effect. In this paper, we observed the emphasis characteristic of speech onset in the recently proposed adaptation algorithm, analyzed the characteristic of performance change according to the variation of parameters and compared with transient emphasis spectral maxima (TESM) is the previous typical strategy. When observing false peaks which are generated everywhere except speech onset, in the case of the proposed model, the false peak were generated much less than in the case of the TESM and it is more distinguishable under noise.

• Journal of Biomedical Engineering Research
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• v.29 no.3
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• pp.191-197
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• 2008

This research focused on the development of wireless telemetry system that can monitor heart rates of multiple rehabilitation patients in real time without constraint. The whole system consists of the multiple patient's side devices (PSDs) and one central monitoring system (CMS). The PSD consists of a microphone, amplifier, filter, microcontroller, and RF (Radio Frequency) modem. In addition, the PSD was designed to be wearable and low power consumption. The CMS consists of an RF modem and general PC and it was designed to monitor heart rates from multiple patients simultaneously. The system warns an alarm signal when a patient's heart rate exceeds the pre-set range for each patient. This system can be useful to monitor the heart rate of exercising rehabilitation patients and control the patients condition and the exercising level.

• Journal of Biomedical Engineering Research
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• v.29 no.3
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• pp.239-248
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• 2008

In this study, a new method using a capacitive sensor and an adaptive filter was proposed to deal with artifacts contaminating an oscillation signal in oscilometric blood pressure measurement. The proposed method makes use of a variation of the capacitance between an electrode fixed to a cuff and an external object to detect artifacts caused by the external object bumping into the cuff. The proposed method utilizes the adaptive filter based on linear prediction to remove the detected artifacts. The conventional method using linear interpolation and the proposed method using the adaptive filter were applied to three types of the artifact-contaminated oscillation signals(no overlap, non-consecutive overlap, and consecutive overlap between artifacts and oscillations) to compare them in terms of the artifact reduction performance. The proposed method was more robust than the conventional method in the case of consecutive overlap between artifacts and oscillations. The proposed method could be useful for measuring blood pressure in such a noisy environment that the subject is being transported.

• Radiation Oncology Journal
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• v.36 no.3
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• pp.172-181
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• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.55-63
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• 2005

A novel imaging system for High-resolution Ultrasonic Transmission Tomography (HUTT) and soft tissue differentiation methodology for the HUTT system are presented. The critical innovation of the HUTT system includes the use of sub-millimeter transducer elements for both transmitter and receiver arrays and multi-band analysis of the first-arrival pulse. The first-arrival pulse is detected and extracted from the received signal (i.e., snippet) at each azimuthal and angular location of a mechanical tomographic scanner in transmission mode. Each extracted snippet is processed to yield a multi-spectral vector of attenuation values at multiple frequency bands. These vectors form a 3-D sinogram representing a multi-spectral augmentation of the conventional 2-D sinogram. A filtered backprojection algorithm is used to reconstruct a stack of multi-spectral images for each 2-D tomographic slice that allow tissue characterization. A novel methodology for soft tissue differentiation using spectral target detection is presented. The representative 2-D and 3-D HUTT images formed at various frequency bands demonstrate the high-resolution capability of the system. It is shown that spherical objects with diameter down to 0.3㎜ can be detected. In addition, the results of soft tissue differentiation and characterization demonstrate the feasibility of quantitative soft tissue analysis for possible detection of lesions or cancerous tissue.