• Proceedings of the KOSOMBE Conference
• /
• v.1995 no.05
• /
• pp.167-170
• /
• 1995

A quadrature-channel MODEM using amplitude modulation was constructed. To test the MODEM, 6.4 MHz sinusoidal wave 1 KHz triangular wave were modulated, then the modulated signal was fed into the demodulator, to reconstruct the triangular wave.

• Journal of Biomedical Engineering Research
• /
• v.32 no.3
• /
• pp.191-197
• /
• 2011

Lifting chair is a typical assistive product to aid for standing up and sitting down for persons with disability. It is particularly useful for the elderly persons whose muscular system is weakened by degenerative joint disease. This paper describes biomechanical assessments of lifting chair with hip-up function. In experiments we measured 3D motion and electromyographic(EMG) signal on the femoral muscle when subject performs the standing motion on the predetermined seat height. Based on assessment of the standing motion, we select the hip-up angle as 15 degrees to cover the relative femoral angle when EMG peak value is appeared. Using an implemented prototype lifting chair with hip-up function we perform standing experiments with five subjects. The experimental results show that the lifting and hip-up functions are effective to assist for standing up motion with less muscle force.

• Proceedings of the Safety Management and Science Conference
• /
• 2002.05a
• /
• pp.31-36
• /
• 2002

In this paper, we developed a working adaptation evaluation system using finger force measurement which interact between material and biological system. The system consists of a finger force transducer, a signal conditioner, an A/D converter, a computer, and a software system for data processing. The finger force transducer is made by a load cell and a special mechanism. The data processing software controls the A/D converter, data monitoring, and data analysis for group classification. The developed system were tested by 4 different materials in left hand and the finger forte transducer in the other hand's thumb and index finger with 16 persons. As the results of experiments, the developed system could measure the finger force quantitatively and classify the measured values into four groups.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2002.05a
• /
• pp.366-372
• /
• 2002

Tele-medicine and emergency medical system are necessary for moving from an accidental point or far distance to a hospital and emergency treatment or home treatment before a hospital. Emergency treatment is extremely important in the case of death before arriving a hospital and deformed or disabled by medical treatment delay. A necessary element for this medical system is the emergency communication system. This system is on preparing for an ability of furnishing patient status to a corresponding health service by monitoring the patient at an ambulance of the accident place. This is the transportation of basic biological information of a patient to a medical center by wireless communication system and the corresponding hospital or medical center examine the patient by monitoring, then they can send emergency medical order to the patient for emergency treatment. The TRS is most efficient way of emergency medical communication system, which is currently used with popularity. In this paper studied simultaneously a way of detecting and transporting bio-logical signals, and monitoring of transporting data with communication of voice in the accident place or ambulance.

• BMB Reports
• /
• v.47 no.3
• /
• pp.141-148
• /
• 2014

Bone is an active tissue, in which bone formation by osteoblast is followed by bone resorption by osteoclasts, in a repeating cycle. Proteomics approaches may allow the detection of changes in cell signal transduction, and the regulatory mechanism of cell differentiation. LC-MS/MS-based quantitative methods can be used with labeling strategies, such as SILAC, iTRAQ, TMT and enzymatic labeling. When used in combination with specific protein enrichment strategies, quantitative proteomics methods can identify various signaling molecules and modulators, and their interacting proteins in bone metabolism, to elucidate biological functions for the newly identified proteins in the cellular context. In this article, we will briefly review recent major advances in the application of proteomics for bone biology, especially from the aspect of cellular signaling.

• IMMUNE NETWORK
• /
• v.9 no.3
• /
• pp.84-89
• /
• 2009

The main stream of CD137 studies has been directed to the function of CD137 in $CD8^+$ T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which proves to be of a great therapeutic potential for animal models of a variety of autoimmune and inflammatory diseases. Recent studies, however, add complexes to the biology of CD137. Accumulating is evidence supporting that there exists a bidirectional signal transduction pathway for the CD137 receptor and its ligand (CD137L). CD137/CD137L interactions are involved in the network of hematopoietic and nonhematopoietic cells in addition to the well characterized antigen-presenting cell-T cell interactions. Signaling through CD137L plays a critical role in the differentiation of myeloid cells and their cellular activities, suggesting that CD137L signals trigger and sustain inflammation. The overall consequence might be that the amplified inflammation by CD137L enhances the T-cell activity together with CD137 signals by upregulating costimulatory molecules, MHC molecules, cell adhesion molecules, cytokines, and chemokines. Solving this outstanding issue is urgent and will have an important clinical implication.

• YAKHAK HOEJI
• /
• v.47 no.6
• /
• pp.398-403
• /
• 2003

To investigate the relationship between structure and biological activity of phenylpropanoids, we measured effects of phenylpropanoids on anti-oxidant and whitening activity, In DPPH radical scavenging activity, caffeic acid analogues showed the significant anti-oxidant activity. Although phenylpropanoids did not inhibit purified-tyrosinase activity, they significantly inhibited tyrosinase activity and melanin production in MSH-stimulated B16 melanoma cells. However, phenylpropanoids did not affect tyrosinase expression in MSH-stimulated B16 melanoma cells, which suggest that inhibition of MSH-induced melanin production was due to tyrosinase inhibition mediated via other signal pathways but not expression of tyrosinase. Phenylpropanoids also significantly inhibited both hyaluronidase and elastase activity, suggesting that phenylpropanoids may be used as whitening, hydration and anti-wrinkling agents. Hydroxyl residue of aromatic ring in phenylpropanoids plays an important role in anti-oxidant and whitening activity.

• Genomics & Informatics
• /
• v.4 no.2
• /
• pp.57-64
• /
• 2006

We identified differentially expressed genes in RAW264.7 cells in response to single and double ligand treatments (LPS, $IFN{\gamma}$, 2MA, LPS plus $IFN{\gamma}$, and LPS plus 2MA). The majority of the regulated transcripts responded additively to dual ligand treatment. However, a significant fraction responded in a non-additive fashion. Several cytokines showing non-additive transcriptional responses to dual ligand treatment also showed non-additive protein production/secretion responses in separately performed experiments. Many of the genes with non-additive responses to LPS plus 2MA showed enhanced responses and encoded pro-inflammatory proteins. LPS plus $IFN{\gamma}$ appeared to induce both non-additive enhancement and non-additive attenuation of gene expression. The affected genes were associated with a variety of biological functions. These experiments reveal both dependent and independent regulatory pathways and point out the specific nature of the regulatory interactions.

• Journal of Embryo Transfer
• /
• v.24 no.4
• /
• pp.237-247
• /
• 2009

Melatonin (N-acetyl-5-methoxytryptamine) is the major neurohormone secreted during the night by the vertebrate pineal gland. The circadian pattern of pineal melatonin secretion is related to the biological clock within the suprachiasmatic nucleus (SCN) of the hypothalamus in mammals. The SCN coordinates the body's rhythms to the environmental light-dark cycle in response to light perceived by the retina, which acts mainly on retinal ganglion cells that contain the photopigment melanopsin. Calbindin-D9k (CaBP-9k) is a member of the S100 family of intracellular calcium- binding proteins, and in this review, we discuss the involvement of melatonin and CaBP-9k with respect to calcium homeostasis and apoptotic cell death. In future studies, we hope to provide important information on the roles played by CaBP-9k in cell signal transduction, cell proliferation, and $Ca^{2+}$ homeostasis in vivo and in vitro.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.05
• /
• pp.143-146
• /
• 1996

An adaptive digital filtering of the electroencophalogram(EEG) is a successful way of suppressing mains interference, but it affects some of the frequency components of the signal, an artifact which not be acceptable in some cases of automatic EEG processing. The types of electrical artifact seen on EEG records is described. Those are the EOG and the PVC roller pump noise. And we study the method for cancelling these artifacts. The method does not need the reference channel, and are obtained by cascading the linear predictor and the noise canceller. The simulation results illustrate the performances of the presented method in terms of the capability of interferences suppression.