• Title/Summary/Keyword: Biological safety

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The Role of Process Systems Engineering for Sustainability in the Chemical Industries (화학공정 산업에서의 지속가능성과 공정시스템 공학)

  • Jang, Namjin;Dan, Seungkyu;Shin, Dongil;Lee, Gibaek;Yoon, En Sup
    • Korean Chemical Engineering Research
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    • v.51 no.2
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    • pp.221-225
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    • 2013
  • Sustainability, in general, means the protection of environmental resources and economic prosperity, with the consideration of the social, economic and environmental effect, as well as human health and the enhancement of life. Profound consideration about sustainability has to handle the overall cycle of feedstock, resource extraction, transportation and production in addition to the environmental effect. Sustainable development of the chemical industries should be carried out complementarily by strengthening the chemical process safety of the industries. In this respect, chemical process safety can be called an opportunity to enhance the compatibility internationally. Changing new paradigm in chemical process safety is formed from the overall life cycle considering basic design of existing systems and production processes. To improve the chemical process safety, the integrated smart system is necessary, comprising various chemical safety database and knowledge base and improved methods of quantitative risk analysis, including management system. This paper discussed the necessity of overall life cycle in chemical process safety and proposed new technology to improve the sustainability. To develop the sustainable industries in process systems engineering, three S, which include Safety, Stability and Security, will have to be combined appropriate.

Measurement and Analysis of Rodent Biological Signals using Telemetry System (원격측정장치를 이용한 설치류의 생체신호 측정 및 분석)

  • Kim, Chang-Hwan;Hur, Gyeong-Haeng
    • Journal of the Korea Institute of Military Science and Technology
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    • v.14 no.6
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    • pp.1159-1165
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    • 2011
  • Telemetry techniques of rats have been used for assessing safety pharmacology of drugs and chemicals. Biological signals including blood pressure and heart rate measured under anesthesia were significantly different from those obtained under normal conditions. The stress of restraint in awake animals can also affect the accuracy of physiological evaluation. This paper details the surgery required to allow key cardiovascular parameters to be determined. The telemetric measurement of cardiovascular parameters such as blood pressure, heart rate, electrocardiograph(ECG) established. We carried out the continuous monitoring of cardiovascular parameters using the telemetry system in F344 rats. During the measurement, no significant changes were observed in the heart rate and blood pressure. ECG signals and body temperature were also constant during the measurement of biological signals. With the results of this study, we conclude that this telemetry system can be applied usefully for the assesment of biological parameters in the rats.

Life Cycle and Host Specificity of Tanysphyrus (Tanysphyroides) major Roelofs (Coleoptera : Curculionidae), a Possible Candidate Agent for the Biological Control of Monochoria vaginalis var. plantaginea (물달개비의 생물학적 방제인자 물달개비바구미의 생활사 및 기주특이성)

  • Park, Jin-Young;Park, Jae-Eup;Lee, In-Yong;Kwon, Oh-Seok;Park, Jong-Kyun
    • Korean Journal of Weed Science
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    • v.31 no.1
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    • pp.103-111
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    • 2011
  • Monochoria vaginalis var. plantaginea (Pontederiaceae) is one of the most problematic weed in the rice field in Korea. Tanysphyrus (Tanysphyroides) major was selected as a potential biological control agent for M. vaginalis. Continuous rearing of T. (T.) major was carried out from 2006 to 2007, and its morphological characteristics and ecological characteristics were investigated. This species has a single generation per year, over-wintering as an adult stage. The emergence of adults starts in later June and last until September. These observations indicate that T. (T.) major takes $22{\pm}0.7$ days to develop from egg to adulthood. Host specificity test showed that finally selected this species was suitable candidates for the biological control of M. vaginalis var. plantaginea since it showed negative host specificity against major 60 test crops.

Investigating the potential exposure risk to indium compounds of target manufacturing workers through an analysis of biological specimens (생물학적 노출평가를 통한 타겟 제조업 근로자의 공정별 인듐 노출위험성 조사)

  • Won, Yong Lim;Choi, Yoon Jung;Choi, Sungyeul;Kim, Eun-A
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.24 no.3
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    • pp.263-271
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    • 2014
  • Objectives: Along with the several cases of pulmonary disorders caused by exposure to indium that have been reported in Japan, China, and the United States, cases of Korean workers involved in processes that require handling of indium compounds with potential risk of exposure to indium compounds have also been reported. We performed biological monitoring for workers in various target manufacturing processes of indium, indium oxide, and indium tin oxide(ITO)/indium zinc oxide(IZO) in domestic factories. Materials: As biological exposure indices, we measured serum concentrations of indium using inductively coupled plasma mass spectrometry, and Krebs von den Lungen 6(KL-6) and surfactant protein D(SP-D) using enzyme-linked immunosorbent assays. We classified the ITO/IZO target manufacturing process into powdering, mixing, molding, sintering, polishing, bonding, and finishing. Results: The powdering process workers showed the highest serum indium level. The mixing and polishing process workers also showed high serum indium levels. In the powdering process, the mean indium serum concentration in the workers exceeded $3{\mu}g/L$, the reference value in Japan. Of the powdering, mixing, and polishing process workers, 83.3%, 50.0%, and 24.5%, respectively, had values exceeding the reference value in Japan. We suppose that the reason of the higher prevalence of high indium concentrations in powder processing workers was that most of the particles in the powdering process were respirable dust smaller than $10{\mu}m$. The mean KL-6 and SP-D concentrations were high in the powdering, mixing, and polishing process workers. Therefore, the workers in these processes who were at greater risk of exposure to indium powder were those who had higher serum levels of indium, as well as KL-6 and SP-D. We observed significant differences in serum indium, KL-6, and SP-D levels between the process groups. Conclusions: Five among the seven reported cases of "indium lung" in Japan involved polishing process workers. Polishing process workers in Korea also had high serum levels of indium, KL-6, and SP-D. The outcomes of this study can be used as essential bases for establishing biological monitoring measures for workers handling indium compounds, and for developing health-care guidelines and special medical surveillance in Korea.

Study on the Subacute Toxicity of Complex of Pine Needle Oil and Korean Medicinal Herbs against Rats

  • Park, Kap Joo;Ahn, Ki Heung;Lee, Hyung Hoan
    • Korean Journal of Environmental Biology
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    • v.22 no.4
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    • pp.513-518
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    • 2004
  • Pine needle oil and Korean medicinal herbs (KMH) are known as effective therapeutic agents on various blood vessel disease. We have already reported the ameliorative effect of complex of pine needle oil and Korean medicinal herbs against hyperlipidemia. But safety and non - toxicity of pine needle oil and Korean medicinal herbs to normal animal cells have not been studied clearly. In this study, we investigated whether pine needle oil and Korean medicinal herbs show side effects on rat or not. These materials were administered to rats, and subacute toxicity was examined by measuring the hematological values, CBC differentiation, biochemical levels of blood (TP, total protein; albumin; ALP, alkaline phosphotase; AST, aspatate aminotrans- ferase; ALT, alanine aminotransferase; T-Chol., total cholesterol; T-Bil., total bilirubin) and urine analysis, suggesting that the sample have no side effects and cytotoxicity. These results indicate that the complex of pine needle oil and Korean medicinal herbs may effective non- toxic, safety therapeutic agents on hepatocytes and hyperlipidemia.

A Study on the Detecting of Noncontact Biosignal using UWB Radar (UWB 레이더를 이용한 비접촉 생체신호 검출에 관한 연구)

  • Lee, Yonggyu;Cho, Joonggil;Kim, Taesung
    • Journal of the Korea Safety Management & Science
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    • v.21 no.4
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    • pp.1-6
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    • 2019
  • This study relates to acquiring biological signal without attaching directly to the user using UWB(Ultra Wide Band) radar. The collected information is the respiratory rate, heart rate, and the degree of movement during sleep, and this information is used to measure the sleep state. A breathing measurement algorithm and a sleep state detection algorithm were developed to graph the measured data. Information about the sleep state will be used as a personalized diagnosis by connecting with the medical institution and contribute to the prevention of sleep related diseases. In addition, biological signal will be linked to various sensors in the era of the 4th industrial revolution, leading to smart healthcare, which will make human life more enriching.

Trends in infection-related patient safety incident reporting before and during the COVID-19 pandemic in Korea (COVID-19 대유행 시기 전후 국내 감염관련 환자안전 사고 보고 현황 분석)

  • Eun-Jin Kim;Yeon-Hwan Park
    • Journal of Korean Biological Nursing Science
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    • v.25 no.2
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    • pp.95-104
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    • 2023
  • Purpose: The purpose of this study was to analyze the trends and characteristics of infection-related patient safety incident reporting before and during the coronavirus disease 2019 (COVID-19) pandemic in Korea, and to provide basic data for preventing infection-related patient safety incidents and improving their management. Methods: A cross-sectional analysis of secondary national data (Patient Safety Reporting Data) was conducted. In total, 517 infection-related patient safety incidents reported from 2018 to 2021 were analyzed. Changes in the number of reports before and during the COVID-19 pandemic and differences in variables related to infection-related patient safety incidents were analyzed using the chi-square test and independent t-test in SPSS 29.0. Results: This study found that infection-related patient safety incidents decreased during the COVID-19 pandemic compared to before the pandemic. Furthermore, incident-related characteristics, such as the type of healthcare organization, severity of harm, and post-incident actions, changed during the COVID-19 pandemic. Conclusion: The many changes in the infection control system and practices during the COVID-19 pandemic may have contributed to a decrease in the reporting of infection-related patient safety incidents. It is hoped that longitudinal studies on patient safety incidents related to the pandemic and analytical studies on factors influencing patient safety incidents will continue to be conducted to prevent and improve patient safety incidents.

The Degradation Patterns of Benzimidazole Pesticides in Korean Lettuce by Cultivation (시설재배 상추에서 Benzimidazole계 농약의 분해특성)

  • Kim, Jong-Pil;Seo, Jung-Mi;Lee, Hyang-Hee;Oh, Mu-Sul;Ha, Dong-Ryong;Shin, Hyeon-Wo;Kim, Eun-Sun
    • Journal of Food Hygiene and Safety
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    • v.23 no.2
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    • pp.129-136
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    • 2008
  • Three benzimidazole pesticides commonly used in korean lettuce were subjected to a field residue trial to ensure safety of terminal residue in the harvest. The residual patterns of three benzimidazole pesticides, which were carbendazim, benomyl and thiophanate-methyl were examined after applying with the recommended dose in two types of korean lettuce (Chima and Chuckmeon) and their DT50 were calculated. In Chima lettuce, biological half-lives of carbendazim, benomyl and thiophanate-methyl were 2.56, 1.37 and 2.54 days, respectively and their required time under MRL(5.0 mg/kg as carbendazim) were 4.5, 2.2 and 1.0days. In Chuckmeon lettuce, biological half-lives of them were 3.41, 1.70 and 4.20 days, respectively and their required time under MRL were 5.4, 1.9 and 0.5days.

Biological Safety and B Cells Activation Effects of Stephania delavayi Diels

  • Park, Dae-Hun;Li, Yong-Chun;Shim, Jae-Gal;Xu, Hong-De;Li, Lan;Lee, Min-Jae;Kwon, Myung-Sang
    • Molecular & Cellular Toxicology
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    • v.5 no.1
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    • pp.93-98
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    • 2009
  • Stephania delavayi Diels. has been used as an immune activator or an anti-inflammatory drug in China. We examined the immune modulation effect and 7-days repeated-dose toxicity to validate its biological safety and efficiency. Mice were repeatedly administrated with 50 mg/kg S. delavayi Diels. daily by I.P for 7 days. S. delavayi Diels. induced B cell activation but had no effect on other immune cells such as T cell, natural killer (NK) cell, and macrophage ($M{\varphi}$). S. delavayi Diels.-treated group exhibited no statistical significance from the control group in physical conditions; body weight, complete blood count (CBC), serum biochemical indexes etc. There was no difference between the control group and S. delavayi Diels.-treated group in gross findings such as histopathological alteration. In conclusion, S. delavayi Diels. is safe above the dose of immune modulation.

Pemetrexed is Mildly Active with Good Tolerability in Treating Patients with Gastric Cancer

  • Lan, Hai;Lin, Cong-Yao;Li, Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.17
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    • pp.7137-7139
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    • 2014
  • Background: This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic gastric cancer (MGC) as a salvage chemotherapy. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with gastric cancer were identified by using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In pemetrexed based regimens, 4 clinical studies including 171 patients with advanced gastric cancer were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 25.1% (43/171) in pemetrexed based regimens. Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred in pemetrexed based treatment. Conclusion: This systemic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with MGC.