• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.5
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• pp.51-57
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• 2015

In this paper, in order to design the A / D converter with a high resolution of 14 bits or more for the biological signal processing, CMOS delta sigma modulator that is a 1.8V power supply voltage - were designed. we propose a new structure of The fourth order delta-sigma modulator that needs four op amps but we use only two op amps. By using a time -interleaving technique, we can re-construct the circuit and reuse the op amps. Also, we proposed a KT/C noise reduction circuit to reduce the thermal noise from a noisy resistor. We adjust the size of sampling capacitor between sampling time and integrating time, so we can reduce almost a half of KT/C noise. The measurement results of the chip is fabricated using a Magna 0.18um CMOS n-well1 poly 6 metal process. Power consumption is $828{\mu}W$ from a 1.8V supply voltage. The peak SNDR is measured as a 75.7dB and 81.3dB of DR at 1kHz input frequency and 256kHz sampling frequency. Measurement results show that KT/C noise reduction circuit enhance the 3dB of SNDR. FOM of the circuit is calculated to be 142dB and 41pJ / step.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.5
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• pp.23-29
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• 2015

In this study, human is the subject of driving a car, the actual EEG is a biological information in a number of reactions that are displayed while driving the vehicle by using a measuring device, occurs during travel of the road EEG to be collected, number of experiments the collected material on the basis of changes associated with running time, extracts the factors such as changes due to road geometry, and analysis was performed. The required changes in the EEG occurring during traveling experiment analysis alpha (${\alpha}$) waves, beta (${\beta}$) wave, after the primary extraction in the form of gamma (${\gamma}$) faction, the brain wave frequency of the entire period of the experiment change rate extracts, to calculate the change in frequency in response to EEG characteristics by applying the regression model to observe a learning effect in response to an increase in the number of experiments, as a result, depending on the number of experiments, EEG changes due to individual differences. The show, by repeatedly driving a section like this, it was possible to verify that comfortably travels driver accustomed in accordance with the stored road geometry and signal, safety facilities.

• Journal of Biomedical Engineering Research
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• v.22 no.5
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• pp.439-448
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• 2001

This paper considers the acoustical characteristics of the closing click sounds of the mechanical valves employed in an implantable biventricular assist device (BYAD) and their re1evance to the Physical states of the valved. Bj rk Shiley Convexo Concave tilting disk valve was chosen for the study and acoustic measurement was made for the BYAD operated in a mock circulatory system as well as implanted in an animal (sheep). In the BYAD operated in the mock circulatory system. three different states of the valve were examined, ie. normal. mechanically damaged. pseudo-thrombus attached. Microphone measurement for the BVAD implanted in the animal was carried out for five days at a regular time interval from one day after implantation. Characteristic spectrum of the sound from the valve was estimated using Multiple Signal Classification (MUSIC) in which the optimal order was determined according to Bayesian Information Criterion (BIC) . It was observed that the mechanical damage of the valve resulted in changes of the structure of the acoustic spectrum. In contrast. the thrombus formed on the valve did not change much the basic structure of the spectrum but brought about altering the spectral Peak frequencies and energies. Maximum spectral Peak (MSP) with the greatest energy was seen at 2 kHz for the normal valve and it was shifted to 3 kHz for the calve attaching the Pseudo-thrombus. Unlike the normal valve, strong spectral Peak appeared around 7 kHz in the sound from the valve mechanically damaged. In the case of the BYAD implanted in the animal. as the thrombus grew, acoustic energy was reduced relatively more in the low frequency components (〈 2 kHz) and the frequencies of the 1st, 2nd and 3rd MSP were increased little. The thrombus formation would result in reduction in both the variability of the 1st, 2nd and 3rd MSP and the value of the BIC optimal order.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.2
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• pp.82-94
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• 2014

The purpose of this study is to investigate the cause of increasing dry zones through analyzing relationships between land cover and Vegetation Temperature Condition Index(VTCI) using Landsat 4-5 TM satellite images in Central Dry Zones of Myanmar. As a result of land cover classifications, while vegetation areas gradually decrease, residential area and cropland were increased. VTCI analysis shows that region (a) showed a gradual decrease in the area of severely arid, and increase in the area of moderate dry and wet, which sums up to a slight decrease in aridity. Region (b) also showed to increase in dry areas and severe aridity. The result of relational analysis between VTCI and land cover change showed high ratio of land cover change, from severe arid area to forest and residential farmland. The average VTCI decreased in the changed land covers, which indicates the relationship between aridity and land cover change and a gradual increase in the arid area was identified.

• Ecology and Resilient Infrastructure
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• v.3 no.3
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• pp.189-200
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• 2016

The species distribution model would be a useful tool for understanding how invasive alien species spread over the country and what environmental variables contribute to their distributions. This study is focused on the potential distribution of two invasive alien species, the common ragweed (Ambrosia artemisiifolia) and knotgrass (Paspalum distichum) in the Korean Peninsula. The maximum entropy (Maxent) model was used for the prediction of their distribution by inferring their climatic environmental requirements from localities where they are currently known to occur. We obtained their presence data from the Global Biodiversity Information Facility and the Korean plant species databases and bioclimatic data from the WorldClim dataset. As a results of the modelling, the potential distribution predicted by global occurrence data was more accurate than that by native occurrence data. The variables determining the common ragweed distribution were precipitation of the driest month and annual mean temperature. Both annual and the coldest quarter mean temperatures were critical factors in determining the knotgrass distribution. The Maxent model could be a useful tool for the prediction of alien species invasion and the management of their expansion.

• Journal of Korean society of Dental Hygiene
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• v.16 no.3
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• pp.471-477
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• 2016

Objectives: Fluoride is widely used in the prevention and control of dental caries. The purpose of this study is to examine the biological effects of Sodium fluoride on the proliferation of oral normal cell in vitro(MDPC-23, HaCaT, HGF-1 cells). Methods: The proliferation of normal cells and the cyto-skeletal change of normal cells were assessed by WST-1 assay and F-actin stain assay. The statistical significances of the resulting data were analyzed using SPSS(Window 12.0). Results: The sodium fluoride(0-12 mM) treatment decreased the cell viability in a dose and time dependent manner: HaCaT(6 h): $100{\pm}0$, $98{\pm}0.39$, $82{\pm}2.68$, $75{\pm}0.83$, $69{\pm}1$, $67{\pm}1.42%$(p<0.005); HaCaT(24 h): $100{\pm}0$, $98{\pm}1.85$, $54{\pm}0.64$, $43{\pm}0.4$, $38{\pm}0.32$, $36{\pm}0.13%$(p<0.006), MDPC-23(6 h): $100{\pm}0$, $93{\pm}1.48$, $85{\pm}0.28$, $82{\pm}1.58$, $79{\pm}1.48$, $76{\pm}1.93%$(p<0.009); MDPC-23(24 h): $100{\pm}0$, $91{\pm}1.26$, $58{\pm}0.65$, $49{\pm}1$, $44{\pm}0.74$, $2{\pm}0.05%$(p<0.005), HGF-1(6 h): $100{\pm}0$, $97{\pm}2.93$, $89{\pm}5$, $71{\pm}5.42$, $58{\pm}4.82$, $43{\pm}3.47%$(p<0.009); HGF-1(24 h): $100{\pm}0$, $97{\pm}2.05$, $73{\pm}1.73$, $22{\pm}1.61$, $14{\pm}1.73$, $7{\pm}0.85%$(p<0.005). Thus, changes in cell morphology and disruption of filamentous(F)-actin organization were observed in higher concentration. Conclusions: These results suggest that higher concentrations of fluoride lead to a reduce the number of cells and morphology change of normal cell.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.46-54
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• 2007

Objective: The first aim of this study is to determine the effects of acupuncture on the autonomic nervous system (ANS) via Heart Rate (HR) and Pupil Size (PS), and to compare the effects of acupuncture on the subjects' ANS when they are in a sitting position with the effects when they are in a supine position. Methods: Ten healthy male subjects were randomized to receive either verum acupuncture stimulation in a sitting position (SitV), verum acupuncture stimulation in a supine position (SupV), sham acupuncture stimulation in a sitting position (SitS), and sham acupuncture stimulation in a supine position (SupS). Acupuncture stimulation was applied to Neguan point (PC6) on the forearm. The subject's electrocardiogram (ECG) and pupil size were recorded continuously from 5 min before stimulation to 12 min after stimulation. Results: Verum and sham acupuncture stimulation were found to have reduced heart rate (p<0.01) and to have increased pupil size (p<0.01) in all the subjects. But when the reduction in HR and the increment in PS after verum acupuncture stimulation (both sitting and supine position) were compared with those after sham acupuncture stimulation, it was found that the reduction in HR (74.48 and 73.47 bpm, p<0.063) and the increment of PS (7.32 and, 6.10 mm, p<0.001) after verum acupuncture stimulation were greater than those after sham acupuncture stimulation, and that the corresponding values were statistically significant. In addition, at the baseline, it was found that the subjects had a larger PS and a faster HR in a sitting position than when they did so in a supine position. And then the reduction and increment ratio in the subject's HR and PS when they underwent acupuncture stimulation in a sitting position was significantly different from the reduction and increment in their HR and PS when they underwent the procedure in a supine position-i.e., the reduction ratio in HR was greater when they underwent the procedure in a sitting position, and such reduction ratio was statistically significant (p<0.05). As for the increment in PS, it was greater when the subjects underwent the procedure in a supine position, and such increment was significant (p<0.05). Conclusion: Manual acupuncture stimulation on Neguan point (PC6) has more significant influence on the autonomic nervous system rather than sham acupuncture (tactile stimulation). And the position-induced different states of ANS have different influence on the acupuncture effect.

• Journal of KIISE:Software and Applications
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• v.33 no.4
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• pp.365-377
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• 2006

Proteins are known to perform a biological function by interacting with other proteins or compounds. Since protein interaction is intrinsic to most cellular processes, prediction of protein interaction is an important issue in post-genomic biology where abundant interaction data have been produced by many research groups. In this paper, we present an associative feature mining method to predict implicit protein-protein interactions of Saccharomyces cerevisiae from public protein interaction data. We discretized continuous-valued features by maximal interdependence-based discretization approach. We also employed feature dimension reduction filter (FDRF) method which is based on the information theory to select optimal informative features, to boost prediction accuracy and overall mining speed, and to overcome the dimensionality problem of conventional data mining approaches. We used association rule discovery algorithm for associative feature and rule mining to predict protein interaction. Using the discovered associative feature we predicted implicit protein interactions which have not been observed in training data. According to the experimental results, the proposed method accomplished about 96.5% prediction accuracy with reduced computation time which is about 29.4% faster than conventional method with no feature filter in association rule mining.

• Korean Journal of Agricultural Science
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• v.37 no.3
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• pp.399-404
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• 2010

Single nucleotide polymorphisms (SNPs) in chicken lysozyme (LYZ) gene were investigated in this study. The identification of SNPs in both exon and intron in LYZ gene has led to understanding of evolution for the domestic chicken populations. A total of 24 samples from two Korean native commercial chicken populations (CCPs) were used for the initial identification of SNPs by mixing three DNA samples for sequencing experiments. By comparing with red jungle fowl (RJF), two commercial chicken populations have 18 common polymorphisms. Between two commercial chicken populations, 15 polymorphisms were identified. Of the 33 polymorphisms identified, two indels (21 and 4 bp) were found. Whereas, only one polymorphism in exon 2 at the bp position 1426 was a non-synonymous substitution (p.Ala49Val), indicating the amino acid changes. The identified non-synonymous substitution (p.Ala49Val) is located close to the catalytic sites of the enzyme, which might affect its activity. In our investigation, the polymorphisms in LYZ gene can provide broad ideas for the variation of Korean native chicken populations from the ancestor of chicken breeds as well as the some biological functions of the LYZ gene.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.548-549
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• 2015

무인 잠수정은 자율 무인잠수정(이하 'AUV' 또는 '자율무인잠수정'을 혼용)과 원격조정잠수정(이하 'ROV'로 지칭)으로 분류를 할 수 있다. ROV는 테더 게이블로 인한 작업 범위의 한계와 운동성능 효율이 떨어지는 단점을 지니고 있어, 테더 케이블이 필요 없는 AUV에 대한 필요성이 증대되고 있다. 추측 항법 시스템인 관성 항법 시스템(inertial navigation system, 이하 'INS'로 지칭)은 외부 도움없이 관성측정 장치(inertial measurement unit, 이하 'IMU'로 지칭)를 활용하여 구성된 시스템을 말한다. IMU는 자이로 스코프(gyroscope), 가속도계(accelerometer), 지자기(magnetic)센서로 구성된 측정 장치로 3개의 센서를 사용하여 상호 보정을 통한 기동 체의 위치, 속도 및 자세 정보를 제공한다. 복합항법시스템은 추측항법시스템이 가지는 누적오차와 측위 항법시스템이 가지는 외부환경에 대한 단점을 상호 보완하는 방법으로 연구가 진행 중이다. 하지만 심해서 또는 해양의 특성에 따라 측위 시스템이 사용되지 못하기 때문에 추측 항법시스템의 다양한 관성 센서를 활용한 상로 보완과 신호처리 방법을 통한 연구 개발이 진행 중이다. 다양한 센서 정보를 통합하는 목적으로 칼만 필터와 같은 최적 필터기법이 보편적으로 사용되고 있다. 칼만 필터는 확률 선형 시스템에 대하여 공정잡음 및 측정 잡음이 가우시안 확률 분포를 따를 때 최적의 추정자가 된다. 또한 가우시안 조건을 만족하지 않는 경우에도 선형 추정자 중에 추정 오차의 분산이 가장 작은 추정자이다. 칼만 필터가 최상의 성능을 발휘 하려면 공정잡음과 측정 잡음의 실제 값을 정확히 알아내는 것이 중요하다. 잡음 수준에 대한 정보가 부정확 할 경우 칼만 필터는 발산 할 수 있기 때문에 시스템에서 잡음 수준의 공산은 칼만 필터의 최적 이득을 결정하는 중요한 요소로 추정치에 큰 영향을 준다. 따라서 칼만 필터를 추측항법시스템에 적용 시킬 경우 실제 모텔의 잡음 공분산을 정확히 추정할 수 있는 기법이 요구된다. 추측항법시스템은 다양한 센서를 활용하기 때문에 움직이는 기동 표적에 적용시 잡음공분상이 변하기 때문에 항법시스템이 저하 될 수 있다. 본 연구에서는 다양한 센서를 융합하여 해양 생체 로봇의 정밀 자세 제어가 가능한 시스템을 제안하고자 한다.