• Title/Summary/Keyword: Biological Information

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Research Using Human Biological Materials and Institutional Review Board Review (인체유래물을 사용하는 연구와 Institutional Review Board 심의 )

  • Mi-Kyung Lee
    • The Journal of KAIRB
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    • v.6 no.2
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    • pp.33-37
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    • 2024
  • Recently, with the development of biotechnology and molecular genetics, research using human biological materials has been receiving attention, and the demand for the use of human- biological materials has also increased significantly. In particular, human biological materials contain the personal information of the person providing them, so special care must be taken to protect personal information throughout the entire process from drafting the human biological materials research plan, Institutional Review Board (IRB) review, and research progress. In addition, it is important to appropriately utilize residual human biological materials obtained during medical diagnosis and treatment at medical institutions to achieve scientific results, while protecting the rights of human biological materials providers and improving the method of expressing consent so as not to damage the trust of human biological materials providers in researchers. To this end, it is necessary to provide sufficient information and education so that researchers and IRB members can understand and apply related laws such as the Bioethics Act and the Personal Information Protection Act.

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Analysis of Ingredients and biological activities confirm Process for Personalized Diet Offering Service: Basic ingredients Analysis and biological Activities of Grifola frondosa

  • Hong, Seok Chan;Hwang, You Jin;Kang, Un Gu
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.8
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    • pp.113-121
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    • 2019
  • The personalized meal service is being developed to prevent and alleviate illnesses according to the individual's health condition. However, the current meal does not provide a fully customized service to individuals and a diet that meets the consumer's information needs. The cause is the lack of information on the ingredients and the difficulty of comparative analysis between the materials. Therefore, in this study, we propose basic analysis process for basic information acquisition and database construction for food composition before providing personalized food. In this study, we investigated the content of carbohydrate, reducing sugar and protein as basic components of Grifola frondosa and investigate the content of polyphenol as a biological active ingredients. Respectively. Studies on the hypoglycemic effect of the diabetic rat model have been carried out in relation to the prevention of diseases. Based on the results of this study, it is also possible to obtain information on the basic ingredients of the food and to analyze the information on the content and activity of the biological active ingredients. Using animal models, information on disease prevention and mitigation was also available. The process introduced in this study is applied to various food materials, accumulating data, and utilizing Database, this results will be an excellent tool for providing more efficient service by providing a proper dietary composition for consumers.

A Study of Query Processing Model to applied Meta Rule in 4-Level Layer based on Hybrid Databases (하이브리드 데이터베이스 기반의 4단계 레이어 계층구조에서 메타규칙을 적용한 질의어 수행 모델에 관한 연구)

  • Oh, Ryum-Duck
    • Journal of the Korea Society of Computer and Information
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    • v.14 no.6
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    • pp.125-134
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    • 2009
  • A biological data acquisition based on web has emerged as a powerful tool for allowing scientists to interactively view entries form different databases, and to navigate from one database to another molecular-biology database links. In this paper, the biological conceptual model is constructed hybrid biological data model to represent interesting entities in the data sources to applying navigation rule property for each biological data source based on four biological data integrating layers to control biological data. When some user's requests for application service are occurred, we can get the data from database and data source via web service. In this paper, we propose a query processing model and execution structure based on integrating data layers that can search information on biological data sources.

Information Storage Devices and Biological Mechanism of Information Storage (정보저장기기와 생물학적 정보저장 매커니즘 비교)

  • Lee, Seung-Yop;Kim, Kyung-Ho;Woosung Yang;Park, Youngphil
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2002.11a
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    • pp.360.1-360
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    • 2002
  • Current information storage devices, such as HDD, CD/DVD-ROM/RW, probe-based memory and cabon nano tubes, are compared with biological information storage mechanisms in DNA and brain memory. Various biological components in living cells are analyzed based on "irreducible complexity" of intelligent design concept. Linear and arel density of information stored in the biological and mechanical storages are compared for the applications and developments of new storage devices.

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Functional Annotation and Analysis of Korean Patented Biological Sequences Using Bioinformatics

  • Lee, Byung Wook;Kim, Tae Hyung;Kim, Seon Kyu;Kim, Sang Soo;Ryu, Gee Chan;Bhak, Jong
    • Molecules and Cells
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    • v.21 no.2
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    • pp.269-275
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    • 2006
  • A recent report of the Korean Intellectual Property Office(KIPO) showed that the number of biological sequence-based patents is rapidly increasing in Korea. We present biological features of Korean patented sequences though bioinformatic analysis. The analysis is divided into two steps. The first is an annotation step in which the patented sequences were annotated with the Reference Sequence (RefSeq) database. The second is an association step in which the patented sequences were linked to genes, diseases, pathway, and biological functions. We used Entrez Gene, Online Mendelian Inheritance in Man (OMIM), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) databases. Through the association analysis, we found that nearly 2.6% of human genes were associated with Korean patenting, compared to 20% of human genes in the U.S. patent. The association between the biological functions and the patented sequences indicated that genes whose products act as hormones on defense responses in the extra-cellular environments were the most highly targeted for patenting. The analysis data are available at http://www.patome.net

Database of National Species List of Korea: the taxonomical systematics platform for managing scientific names of Korean native species

  • Park, Jongsun;An, Jung-Hyun;Kim, Yongsung;Kim, Donghyun;Yang, Byeong-Gug;Kim, Taeho
    • Journal of Species Research
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    • v.9 no.3
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    • pp.233-246
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    • 2020
  • A scientific name is one of changeable terms in biology whenever additional research results of specific taxa is accumulated. The Database of the National Species List of Korea (DBNKo) was developed to manage taxonomic information of Korean species, designed to describe the changeable and complex taxonomical structure and information. A Korean Taxonomical Serial Number (KTSN) was assigned to each taxon, different from the normally used systems that the scientific name was considered as primary key to manage higher rank of taxa systematically. Common names were also treated with the KTSN, reflecting that common name is considered as one type of taxon. Additional taxonomic information (e.g., synonyms, original names, and references) was also added to the database. A web interface with an intuitive dashboard presenting taxonomic hierarchical structure is provided to experts and/or managers of the DBNKo. Currently, several biological databases are available in the National Institute of Biological Resources (NIBR) such as a specimen database, a digital library, a genetic information system, and the shared species data based on the DBNKo. The DBNKo started sharing species information with other institutions such as the Nakdonggang National Institute of Biological Resources. It is an ideal centralized species database to manage standardized information of Korean species.

Triclosan Resistant Bacteria from Sewage Water: Culture Based Diversity Assessments and Co-Resistance Profiling to Other Antibiotics

  • Salman, Muhmmad;Ul Bashar, Noor;Kiran, Uzma;Shafiq, Zuhra;Khan, Fareesa;Khan, Raees;Hussain, Farrukh;Bangash, Sudhair Abbas;Ahmad, Yasin;Ahmad, Shabir
    • Microbiology and Biotechnology Letters
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    • v.50 no.1
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    • pp.89-94
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    • 2022
  • Triclosan (TCS) is an antimicrobial agent used in various human personal care products against both gram-positive and gram-negative bacteria. The purpose of this study was to evaluate the presence of TCS-resistant bacteria in sewage water in Peshawar, Khyber Pakhtunkhwa (KPK), Pakistan, for the first time. TCS-supplemented Luria Bertani (LB) agar was used to isolate TCS-tolerant bacteria. A total of 17 TCS-resistant isolates were randomly selected from a large pool of bacteria that showed growth on TCS-supplemented LB agar. Based on gram staining and physiochemical characteristics, the isolated strains were identified as Salmonella typhi (n = 6), Escherichia coli (n = 4), Citrobacter freundii (n = 4), Proteus mirabilis (n = 1), Enterobacter cloacae (n = 1), and Pseudomonas aeruginosa (n = 1). The Triclosan mean minimum inhibitory concentrations (MICs) for the isolates of Salmonella typhi, Escherichia coli, Citrobacter freundii, Proteus mirabilis, Enterobacter cloacae, and Pseudomonas aeruginosa were 23.66 ㎍ ml-1, 18.75 ㎍ ml-1, 42 ㎍ ml-1, 32 ㎍ ml-1, 64 ㎍ ml-1, and 128 ㎍ ml-1, respectively. The antibiogram revealed that all isolates were resistant to penicillin G (100%) and linezolid (100%), followed by ampicillin (94%), tetracycline (76%), tazobactam (76%), sulbactam/cefoperazone (64%), polymyxin PB (58%), amikacin (29.41%), aztreonam (29.41%), imipenem (5%), and gentamicin (5%). This is the first known study regarding the isolation of TCS-tolerant bacteria from sewage water in Peshawar, KPK, Pakistan. It was concluded that all the TCS-resistant isolates were multidrug resistant (MDR) gram-negative rod-shaped bacteria, mostly belonging to the Enterobacteriaceae family.

Biological Object Downloader (BOD) Service for Easy Download and Management of Biological Databases

  • Park, Dae-Ui;Lee, Jung-Woo;Yoon, Gi-Seok;Gong, Sung-Sam;Bhak, Jong
    • Genomics & Informatics
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    • v.5 no.4
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    • pp.196-199
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    • 2007
  • BOD is an FTP service management tool on the Internet. It was developed for biological researchers in South Korea. It enables easier and faster access of bioinformation without having to go through foreign FTP sites. BOD includes an automatic downloader with a management and email alert service from which the user can easily select and schedule any biological database. Once listed in BOD, the user can check and modify the download status and data from an additional email alert service.

A Study on the Realities and Preventive Countermeasures of Child Abuse Committed by Biological Parents by information analysis.

  • Ryu, Chae-Hyoung;Yoon, Hyun-Seok
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.5
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    • pp.171-177
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    • 2019
  • In this paper, we analyze the current phenomenon of child abuse crimes based on the information gathered by the National Child Protection Agency. The purpose of this paper is to diagnose the seriousness of child abuse by biological parents based on the analyzed information and propose measures against it. Comprehensive and integrated measures are needed for child abuse committed by biological parents due to abuse concealment, continuity of damage, and inactive national intervention by considering punishment on attackers through national intervention, fundamental in-depth psychological counseling, therapeutic care, promoting recovery of victims, and ultimately continuous and regular management and monitoring as a long-terms measure. To do so, developing customized and individual educational programs and make them obligations can be first presented to identify child abuse in advance and build up preventive systems based on the principle of family preservation. In addition, problems should be addressed at a fundamental level by performing various and active therapeutic treatments such as psychological treatment, mental treatment, or drug treatment gradually and through phases for biological parents who commit child abuse and contributing to recovering the relationship. Furthermore, proper protection and treatment service should be provided to children victimized by abuse by extending professional children care facilities and adopting the professional family commission system as measures by separating family.