• Title/Summary/Keyword: Biological Effects

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Rationale and Definition of The Criteria of The Efficiency of The Biological Activity of Optical Radiation on Animal Organism.

  • Chervinsky, Leonid S.
    • The Korean Journal of Food & Health Convergence
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    • v.4 no.3
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    • pp.1-5
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    • 2018

  • In today's technological development of human society more and more influence on the lives of biological organisms different electromagnetic radiation. Therefore, the study and analysis of the mechanisms of their effects is an urgent task. The purpose of research - the study of the primary mechanisms of interaction of photons of optical radiation with the structures of biological objects, using the laws of quantum mechanics and biophysics. Photobiological basis of the mechanism of action of EMR optical range is the energy absorption of light quanta (photons) by atoms and molecules of biological structures (law Grotgus-Draper), which resulted in the formation of electronically excited states of these molecules with the transfer of photon energy (internal photoeffect). This is accompanied by electrolytic dissociation and ionization of biological molecules. The degree of manifestation of photobiological effects in the body depends on the intensity of the optical radiation, which is inversely proportional to the square of the distance from the source to the irradiated surface. Accordingly, in practice, determine not the intensity and irradiation dose at a certain distance from the source of exposure by the exposure time.

  • https://doi.org/10.13106/kjfhc.2018.vol4.no3.1 인용 PDF

Anti-Melanogenic Activities of Ranunculus chinensis Bunge via ERK1/2-Mediated MITF Downregulation

  • Min-Jin Kim;Yong Tae Jeong;Buyng Su Hwang;Yong Hwang;Dae Won Jeong;Yeong Taek Oh
    • Korean Journal of Plant Resources
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    • v.35 no.6
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    • pp.704-712
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    • 2022

  • Research on whitening materials using natural alternatives is actively being conducted. The aim of this study was to investigate the in vitro inhibitory effects of Ranunculus chinensis Bunge (RCB) on melanogenesis and associated enzymes, such as tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 in B16F10 murine melanoma cells. We found that RCB extract significantly attenuated melanin synthesis and reduced the activity of intracellular tyrosinase, a rate-limiting melanogenic enzyme. Western blot analysis showed that RCB extract decreased the protein expression of tyrosinase and TRP-1. In addition, it significantly decreased the expression of microphthalmia-associated transcription factor (MITF), a key regulator of melanogenesis. Extracellular signal-regulated kinase (ERK) activation has been reported to be involved in the inhibition of melanogenesis. Thus, we investigated whether the hypopigmentary effects of RCB extract were related to the activation of ERK. RCB extract induced ERK phosphorylation in a dose-dependent manner. Furthermore, it markedly inhibited body pigmentation in a zebrafish model. Our results suggest that RCB extract inhibits melanogenesis by activating ERK pathway-mediated suppression of MITF and its downstream target genes, including tyrosinase. Therefore, RCB extract can be used as a whitening agent in the development of functional cosmetics.

  • https://doi.org/10.7732/kjpr.2022.35.6.704 인용 PDF KSCI