• Journal of Environmental Impact Assessment
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• v.12 no.1
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• pp.1-8
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• 2003

The Master Plan of Natural Environment Conservation in Korea by Ministry of Environment has been carried out since 1986. The 2nd 10-year survey started in 1997, and there are three major parts in the Master Plan : First, the basic natural environment survey, second, sites in special features of ecological characteristics such as uninhabitable islands, wetlands, etc, and third, biological species featuring status of habitat, and population dynamics. However the information in the Master Plan is very fragmented and collected data are not so abundant due to insufficient man-power and unsynchronized survey time/season. In this regard this paper examined the similar National Biological Survey in USA and compared the differences with the Master Plan in Korea. The Master Plan in Korea should separate the management zone based on hydrological characteristics, and in each zone we should set a management goal in the long term basis. Secondly the species list is not so meaningful that we must concentrate more on research activities. In each taxonomical group we set up hypotheses and research goals. Thirdly local residents and communities should be involved in research so that enhanced biological diversity should benefit people in areas. Lastly legislation and laws should be reexamined and rectified to provide information to the managers that deals with natural resources, expecially when conflicting with economic matters.

• Mycobiology
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• v.45 no.4
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• pp.327-337
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• 2017

Three new records of Ascomycota species (Chaetomium acropullum, Phialemonium globosum, Phialemonium atrogriseum) from field soils in Korea are presented in this study. These newly discovered fungal isolates were isolated from field soils from various places across Gyeongnam, Korea in 2016. All the isolates were identified and described based on morphological characteristics, and rDNA internal transcribed spacer and ${\beta}$-tubulin gene sequence data. Morphological features of these fungal species were studied on different agar media: potato dextrose agar, oatmeal agar, malt extract agar, Czapek yeast extract agar, and yeast extract sucrose agar. Full description and illustrations of their morphological characters are provided. These fungal species have not officially been previously reported in Korea.

• Journal of Life Science
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• v.10 no.2
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• pp.45-49
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• 2000

Long terminal repeat (LTR) of human endogenous retrovirus K family (HERV-K) has been found to be coexpressed with sequences of closely located genes. We examined the transcribed HERV-K LTR elements in human liver and kidney tissues. Using the cDNA synthesized from mRNA of human liver and kidney, we performed PCR amplification and identified six HERV-K LTR elements. Those LTR elements showed a high degree of sequence similarity (93.3∼96.6%) with human-specific LTR. A phylogenetic tree obtained by the neighbor-joining method revealed that HERV-K LTR elements (Liv-1, 2, 3 and Kid-1, 2, 3) were belonged to group I. Our data suggests that HERV-K LTR elements are active on human liver and kidney tissues and may represent a source of genetic variation connected to human disease.

• Molecules and Cells
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• v.42 no.11
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• pp.804-809
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• 2019

Oncogenic gain-of-function mutations are clinical biomarkers for most targeted therapies, as well as represent direct targets for drug treatment. Although loss-of-function mutations involving the tumor suppressor gene, STK11 (LKB1) are important in lung cancer progression, STK11 is not the direct target for anticancer agents. We attempted to identify cancer transcriptome signatures associated with STK11 loss-of-function mutations. Several new sensitive and specific gene expression markers (ENO3, TTC39C, LGALS3, and MAML2) were identified using two orthogonal measures, i.e., fold change and odds ratio analyses of transcriptome data from cell lines and tissue samples. Among the markers identified, the ENO3 gene over-expression was found to be the direct consequence of STK11 loss-of-function. Furthermore, the knockdown of ENO3 expression exhibited selective anticancer effect in STK11 mutant cells compared with STK11 wild type (or recovered) cells. These findings suggest that ENO3-based targeted therapy might be promising for patients with lung cancer harboring STK11 mutations.

• Molecules and Cells
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• v.45 no.8
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• pp.522-530
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• 2022

Transposable elements (TEs) account for approximately 45% of the human genome. TEs have proliferated randomly and integrated into functional genes during hominoid radiation. They appear as right-handed B-DNA double helices and slightly elongated left-handed Z-DNAs. Human endogenous retrovirus (HERV) families are widely distributed in human chromosomes at a ratio of 8%. They contain a 5'-long terminal repeat (LTR)-gag-pol-env-3'-LTR structure. LTRs contain the U3 enhancer and promoter region, transcribed R region, and U5 region. LTRs can influence host gene expression by acting as regulatory elements. In this review, we describe the alternative promoters derived from LTR elements that overlap Z-DNA by comparing Z-hunt and DeepZ data for human functional genes. We also present evidence showing the regulatory activity of LTR elements containing Z-DNA in GSDML. Taken together, the regulatory activity of LTR elements with Z-DNA allows us to understand gene function in relation to various human diseases.

• Journal of the Korea Society of Computer and Information
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• v.21 no.1
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• pp.85-90
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• 2016

In this paper, the biometric data is transmitted in real time from the IoT environment is runoff, forgery, alteration, prevention of the factors that can be generated from a denial-of-service in advance, and the security strategy for the biometric data to protect the biometric data secure from security threats offer. The convenience of living in our surroundings to life with the development of ubiquitous computing and smart devices are available in real-time. And is also increasing interest in the IOT. IOT environment is giving the convenience of life. However, security threats to privacy also are exposed for 24 hours. This paper examines the security threats to biological data to be transmitted in real time from IOT environment. The technology for such security requirements and security technology according to the analysis of the threat. And with respect to the biometric data transmitted in real time on the IoT environment proposes a security strategy to ensure the stability against security threats and described with respect to its efficiency.

• Journal of Species Research
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• v.12 no.1
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• pp.68-89
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• 2023

This is the second catalog listing unrecorded invertebrates discovered during the research project 'Discovery of Korean Indigenous Species'. The data to compile the catalog were primarily gathered from the final reports of the project, between 2013 and 2021. We present 38 previously undocumented species, belonging to four phyla (Platyhelminthes, Annelida, Rotifera and Arthropoda). Samples were collected from intertidal coastal waters, soil, freshwater ponds, reservoirs and hosts in South Korea. In this study, we provide brief taxonomic information, including collection site (GPS), diagnosis, specimen vouchers, figures of representative individuals and the Korean name newly assigned, for each species. All data were reviewed and updated by experts working on the respective taxonomic group. The aim of the present study is to publish species that have been previously reported through the project. Upon publication, these species will be added to the 'National Species List of Korea', curated by the National Institute of Biological Resources(NIBR).

• Molecules and Cells
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• v.27 no.5
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• pp.547-556
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• 2009

Parathyroid hormone is the most important endocrine regulator of calcium concentration. Its N-terminal fragment (1-34) has sufficient activity for biological function. Recently, site-directed mutagenesis studies demonstrated that substitutions at several positions within shorter analogues (1-14) can enhance the bioactivity to greater than that of PTH (1-34). However, designing the optimal sequence combination is not simple due to complex combinatorial problems. In this study, support vector machines were introduced to predict the biological activity of modified PTH (1-14) analogues using mono-substituted experimental data and to analyze the key physicochemical properties at each position that correlated with bioactivity. This systematic approach can reduce the time and effort needed to obtain desirable molecules by bench experiments and provide useful information in the design of simpler activating molecules.

• Asian-Australasian Journal of Animal Sciences
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• v.4 no.1
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• pp.1-5
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• 1991

Responsiveness of the testis to pregnant mare's serum gonadotropin (PMSG) was studied in immature Nili-Ravi buffalo bulls. Four month old bull calves weighing between 66 to 100 kg raised under uniform condition, were treated with 1000 IU PMSG or vehicle, daily, for six days. PMSG induced an increase in the size of the testis, enlargement of the seminiferous tubules and activation of the spermatogonia. The number of differentiated Leydig cells in the testis of gonadotropin treated animals increased considerably over that of the control testes. A significant increase in plasma testosterone concentrations was observed 24 h following the first injection of PMSG and the levels continued to increase until day 6. In vehicle treated animals plasma testosterone levels remained more or less at pretreatment values. The data suggest that buffalo bull testis is functionally responsive to gonadotropin at an early stage of prepubertal development.

• Journal of Microbiology
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• v.41 no.2
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• pp.83-88
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• 2003

The taxonomic position of actinomycete strain SCNU5$\^$T/, isolated from extensive foam in the aeration basin of an activated sludge process, was clarified by phenotypic, chemotaxonomic and phylogenetic analyses. The strain possesses wall chemotype IV, MK-9(H$\^$0/), as the major menaquinone, and contains saturated, monounsaturated and 10-methyl branched fatty acids. The G+C content of its DNA is 68.1 mol%. Phenotypic data and DNA relatedness to known species indicate that the strain SCNU5$\^$T/ represents a new species within the genus Tsukamurella, for which we propose the name Tsukamurella sunchonensis SP. NOV. The type Strain Of T. sunchonensis is SCNU5$\^$T/ (=KCTC 9827$\^$T/).