• 제목/요약/키워드: Bioinspired

검색결과 47건 처리시간 0.026초

Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation

  • Lee, Da Hyun;Lee, Buhyun;Park, Jeong Su;Lee, Yu Seol;Kim, Jin Hee;Cho, Yejin;Jo, Yoonjung;Kim, Hyun-Seok;Lee, Yong-ho;Nam, Ki Taek;Bae, Soo Han
    • BMB Reports
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    • 제52권3호
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    • pp.190-195
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    • 2019
  • Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt2) is an $NAD^+$-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesis, as well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries.

생체모방 공중로봇의 날개 구조 모델링 (The wing structure modeling of the bioinspired aerial robot)

  • 최연호;조내수;정정은;권우현;이동하
    • 한국태양에너지학회 논문집
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    • 제32권spc3호
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    • pp.269-274
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    • 2012
  • The research of the biological mimics robot which utilizes the operation of the organism is progressed on the ground, aerial, and underwater robot sector. In the field of flying robot, the research for implementing the wing movement structure of the bird and insect is progressed. The joint structure for the wing movement of the bird is implemented. The operation of the wing is simulated. For this purpose, by using the Matlab/Simulink, the joint structure of the wing is modelled. The joint movement of the wing is tested through the simulation.

폐과일껍질을 이용한 친환경 ZnO 나노분말 합성 (Enviroment-Friendly Synthesis of Nanocrystalline Zinc Oxide Particles Using Fruit Peel Extract)

  • ;송재숙;신평우;홍순익
    • 한국재료학회지
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    • 제26권6호
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    • pp.311-319
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    • 2016
  • In this study, an environment-friendly synthetic strategy to process zinc oxide nanocrystals is reported. The biosynthesis method used in this study is simple and cost-effective, with reduced solvent waste via the use of fruit peel extract as a natural ligation agent. The formation of ZnO nanocrystals using a rambutan peel extract was observed in this study. Rambutan peels has the ability to ligate zinc ions as a natural ligation agent, resulting in ZnO nanochain formation due to the presence of an extended polyphenolic system over the whole incubation period. Via transmission electron microscopy, successful formation of zinc oxide nanochains was confirmed. TEM observation revealed that the bioinspired ZnO nanocrystals were spherical and/or hexagonal particles with sizes between 50 and 100 nm.

Self-Assembly of Helical Pores from Nonpolar Dendritic Dipeptides

  • Percec, Virgil
    • 한국고분자학회:학술대회논문집
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    • 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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    • pp.29-30
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    • 2006
  • The synthesis of dendritic dipeptides $(4-3,4-3,5)12G2-CH_{2}-Boc-_{L}-Tyr-X-OMe\;where\;X\;=\;Gly,\;_{L}-Val,\;_{L}-Leu,\;_{L}-Ile,\;_{L}-Phe$, and L-Pro will be discussed. Their self-assembly in bulk and in solution and the structural and retrostructural analysis of their periodic assemblies will be compared to that of the previously reported and currently reinvestigated dendritic dipeptide with $X=_{L}-Ala$. All dendritic dipeptides containing as X nonpolar ${\alpha}-amino$ acids self-assemble into helical porous columns. The principles via which the aliphatic and aromatic substituents of X program the structure of the helical pores indicate synthetic pathways to helical pores with bioinspired functions based on artificial nonpolar ${\alpha}-amino$ acids will be discussed.

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Synthetic approach to the generation of antibody diversity

  • Shim, Hyunbo
    • BMB Reports
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    • 제48권9호
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    • pp.489-494
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    • 2015
  • The in vitro antibody discovery technologies revolutionized the generation of target-specific antibodies that traditionally relied on the humoral response of immunized animals. An antibody library, a large collection of diverse, pre-constructed antibodies, can be rapidly screened using in vitro display technologies such as phage display. One of the keys to successful in vitro antibody discovery is the quality of the library diversity. Antibody diversity can be obtained either from natural B-cell sources or by the synthetic methods that combinatorially generate random nucleotide sequences. While the functionality of a natural antibody library depends largely upon the library size, various other factors can affect the quality of a synthetic antibody library, making the design and construction of synthetic antibody libraries complicated and challenging. In this review, we present various library designs and diversification methods for synthetic antibody library. From simple degenerate oligonucleotide synthesis to trinucleotide synthesis to physicochemically optimized library design, the synthetic approach is evolving beyond the simple emulation of natural antibodies, into a highly sophisticated method that is capable of producing high quality antibodies suitable for therapeutic, diagnostic, and other demanding applications. [BMB Reports 2015; 48(9): 489-494]

생체모방 공중로봇의 날개 구조 모델링 (The wing structure modeling of the bioinspired aerial robot)

  • 최연호;조내수;정정은;권우현;이동하
    • 한국태양에너지학회:학술대회논문집
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    • 한국태양에너지학회 2012년도 춘계학술발표대회 논문집
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    • pp.404-405
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    • 2012
  • The research of the biological mimics robot which utilizes the operation of the organism and which it applies to the robot is progressed on the ground, aerial, and underwater robot sector. In the field of flying robot, the research for implementing the wing movement structure of the bird and insect is progressed. The joint structure for the wing movement of the bird is implemented. The operation of the wing is simulated. For this purpose, by using the Matlab/Simulink, the joint structure of the wing is modelled. The joint movement of the wing is tested through the simulation.

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Bioinspired Nanoengineering of Multifunctional Superhydrophobic Surfaces

  • Choi, Chang-Hwan
    • 한국표면공학회:학술대회논문집
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    • 한국표면공학회 2015년도 추계학술대회 논문집
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    • pp.102-133
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    • 2015
  • Nature, such as plants, insects, and marine animals, uses micro/nano-textured surfaces in their components (e.g., leaves, wings, eyes, legs, and skins) for multiple purposes, such as water-repellency, anti-adhesiveness, and self-cleanness. Such multifunctional surface properties are attributed to three-dimensional surface structures with modulated surface wettability. Especially, hydrophobic surface structures create a composite interface with liquid by retaining air between the structures, minimizing the contact area with liquid. Such non-wetting surface property, so-called superhydrophobicity, can offer numerous application potentials, such as hydrodynamic drag reduction, anti-biofouling, anti-corrosion, anti-fogging, anti-frosting, and anti-icing. Over the last couple of decades, we have witnessed a significant advancement in the understanding of surface superhydrophobicity as well as the design, fabrication, and applications of superhydrophobic coatings/surfaces/materials. In this talk, the designs, fabrications, and applications of superhydrophobic surfaces for multifunctionalities will be presented, including hydrodynamic friction reduction, anti-biofouling, anti-corrosion, and anti-icing.

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