• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.2
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• pp.1-9
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• 2005

Background: Liu-Yuan-Lei(陸淵雷) said that a medical record is both the marks of treatments and arts made by a excellent practitioner and the essence of TCM(Traditional Chinese Medicine). Jiang-Guan(江瓘) also said that reading medical records is one of the best way to develop one’s abilities If curing a disease without perfect clinical practice. Objectives: study on the special treatment about metrostaxis(崩漏) based on the Yi-Da-Gan(易大艮)’s medical records. and study on the differentiation of abnormal symptoms and signs about cold syndrome with pesudo-heat(眞寒假熱) based on the Yu-Chang(喩昌)'s medical records. Methods: First, read and study the medical records on metrostaxis(崩漏) of that made a profound study by Yi-Da-Gan(易大艮) and cold syndrome with pesudo-heat(眞寒假熱) of that made a profound study by Yu-Chang(喩昌). The next, write a paper on results and conclusions. Results and Conclusions: First, Yi-Da-Gan(易大艮) insist that must control the Qi under the blood disease conditions, taking the case of metrostaxis(崩漏). Secondly, we must study more on estimating the changing condition of Qi and the blood as time goes by, also study on the pulse and pulse condition in the four seasons(四時脈). Thirdly, Yu-Chang(喩昌) insist that be more careful in differentiation of symptoms and signs, taking the case of cold syndrome with pesudo-heat(眞寒假熱). Fourthly, Yu-Chang(喩昌) give an example that in condition of cold syndrome with pesudo-heat(眞寒假熱), sometimes, the pulse and pulse condition can be strong.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.2
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• pp.145-151
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• 2005

Background and purpose: The cold-heat patternization is one of the most frequently use for diagnostic method in oriental medicine. But it is still an unclear scientific mechanism and the objective index. the aim of this study is to search the objective index of the cold-heat patternization, comparing with ordinary health test. Method: The study group comprised 101 Korean, male:female ratio 51:50, with a mean age of 49.74 years. The results of the questionnaires for cold-heat patternization were compared with the western health test that it consist of height, weight, muscle mass, body fat, WBC, Hb, ALT, AST, TG, Total cholesterol, glucose, HDL-cholesterol, free-T4 and TSH, measured in the health promotion center of the hospital of Chungnam university Result: The cold patternization were significantly higher in the women than the man. The somothing of the questionmaires for the heat patternization were positive correlated with TG, TSH, glucose, Hb, free T4, weight, musle mass(p<0.05). But there were no correlation in the gross. The somothing of the questionnaires for the cold patternization were negative correlated with the weight, musle mass, body fat, glucose, Hb and ALT(p<0.05), Especially there were strong negative correlation with the weight and muscle mass(p<0,01). Conclusion: The present study shows there is no definitive index for the cold-heat patternization in the ordinary health test. But the weight and muscle mass can be useful index of the cold patternization.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.2
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• pp.96-115
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• 2007

Background and Purpose: Electroencephalogram(EEG) is a multi-scaled signal consisting of several components of time series with different origins. Recently, because of the absence of an identified metric which quantifies the complex amount of information, there are many limitations in using such a linear method. According to chaos theory, irregular signals of EEG can also result from low dimensional deterministic chaos. Chaotic nonlinear dynamics in the EEG can be studied by calculating the correlation dimension. The aim of this study is to analyze correlation between the correlation dimension of EEG and psychological Test (TCI). Methods: Before and after moxibustion treatment, EEG raw data were measured by moving windows during 15 minutes. The correlation dimension(D2) was calculated from stabilized 40 seconds in 15 minutes data. 8 channels EEG study on the Fp, F, T, P was carried out in 30 subjects. Results: Correlation analysis of TCI test is calculated with deterministic non-linear data and stochastic non-linear data. 1. Novelty seeking in temperament is positive correlated with D2 of EEG on Fp. 2. reward dependence in temperament is positive correlated with D2 of EEG on T3,T4 and negative correlated with D2 of EEG on P3,P4. 3. self directedness in character is positive correlated with D2 of EEG on F4, P3. 4. Harm avoidance is negative correlated with D2 of EEG on Fp2, T3, P3. Conclusion: These results suggest that nonlinear analysis of EEG can quantify dynamic state of brain abolut psychological Test (TCI).

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.2
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• pp.11-19
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• 2013

Objectives The purpose of this study was to identify the importance of goodness of fit in mother-child temperamental interaction (MCTI) and the child problem behaviors. Methods The behavior problem of 180 child outpatients from traditional Korean medical clinic was measured with Korean version of Child Behavior Checklists, and the temperament of child and their mother was measured with Junior Temperament and Character Inventory and Temperament and Character Inventory-Revised-Short. The MCTI was calculated as the difference of the temperament score between mother and child. The correlation and linear regression analysis was performed to examine the effects of temperament on Child Behavior Checklists. Results The MCTI on Harm-Avoidance was the significant factor for explaining the internalizing problem (B=-.154, t=-10.130, p<.001), externalizing problem (B=-.045, t=-3.340, p=.001) and total problem (B=-.298, t=-7.574, p<.001). We also confirmed that the temperament of mother and child significantly correlated with the child behavior problems as provided previously. Conclusions These results showed that the temperament interaction between mother and child is an important factor for predicting problem behaviors in child clinical sample. The goodness of fit in MCTI and problem behavior should be considered as pivotal element in traditional Korean pediatrics.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.2
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• pp.1-10
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• 2013

Objectives The aim of this study was to explore the effect of parental attitude on the behavioral problems in children who visited the traditional Korean pediatrics clinic. Methods The subjects were consist of 190 outpatients ($56.6{\pm}12.9$ months) and their mother. The Behavior problems of children were measured with Korean version of Child Behavior Checklist for Ages 1.5-5 (K-CBCL1.5-5) while parental perception of child vulnerability, parent overprotection, parenting stress were measured by Child Vulnerability Scale (CVS), Parent Protection Scale (PPS), Korean-Parenting Stress Index-Short Form scale (K-PSI-SF), respectively. Correlation and multiple regression were conducted for the analysis. Results Significant correlations between child total problems score and child vulnerability (r=.272, p<.001), parent overprotection (r=.243, p=.001), and parenting stress (r=.597, p<.001) were reported. Multiple regression analysis revealed that the parenting stress (${\beta}$=.548, p<.001) was a major predictor for the child behavior problems rather than child vulnerability and parent overprotection. Conclusions It was shown that the parenting stress has a significant influence on the emotional and behavioral development of children. These results can be useful for improving clinical diagnosis and treatment in traditional Korean pediatrics.

• Journal of Oriental Neuropsychiatry
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• v.28 no.2
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• pp.61-72
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• 2017

Objectives: The Yin-Yang temperament and the Sasang Personality Questionnaire (SPQ) were reported to have relations with psychopathological problems in adolescents. The purpose of this study was to examine how domains of Yin-Yang temperament influence on problem behaviors in Korean middle school students. Methods: Subjects of 681 Korean middle school students completed the SPQ for measuring Yin-Yang temperament and the Youth Self-Report (YSR) for measuring problem behaviors. The differences of problem behaviors between Yin and Yang temperament groups were tested with T-test and profile analysis. The associations of the SPQ subscales on problem behaviors was also examined with Pearson's correlation and regression analysis. Results: Yang temperament was related to the externalizing problem while Yin temperament to the internalizing problem. The Emotionality and Behavior dimension of Yin-Yang temperament were found to be a factor of susceptibility and resilience for problem behaviors, respectively. Three dimensions of Yin-Yang temperament have different influences on externalizing and internalizing problems depending on the sex and Yin-Yang temperament groups of subjects. Conclusions: The Yin-Yang temperament would be useful for predicting and preventing the problem behaviors of middle school students. This study would be useful for screening the psychopathological problems and helping Korean adolescents to develop healthy character.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.3
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• pp.117-125
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• 2020

The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD -1.20 [95% CI -1.46 to -0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.

• Journal of Nutrition and Health
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• v.38 no.7
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• pp.503-511
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• 2005

In this study we investigated the biological activity of Chondria Crassicaulis (CC) on the human cancer cells. CC was extracted with methanol and further fractionated into four different types: hexane (CCMH), methanol (CCMM), butanol (CCMB), and aqueous (CCMA) partition layers. We determined the cytotoxic effect of these layers on human cancer cells by MTT assay. Among various partition layers of CC, the CCMM and CCMB showed the strong cytotoxic effects at 150 ${\mu}g$/ml which resulted $98.91\%$, $92.96\%$ on HeLa cell lines and $95.47\%$, $77.05\%$ on MCF-7 cell lines. And, the anti-proliferative effect of CC was accompanied by a marked inhibition of cyclooxygenase (COX-2), Caspase-3 and IAP (cIAP-1, cIAP-2 and XIAP) protein and concomitant induction of p53, p21 and Survivin protein. However, CC did not affect the level of Bax, Bcl-2 and Bcl-XL- protein. Also, we observed quinone reductase (QR) induced effects in all fraction layers of CC on HepG2 cells. The QR induced effects of the CCMH and CCMM on HePG2 cells at 120 ${\mu}g$/mL concentration indicated 3.73 and 2.45 with the control value of 1.0. Although further studies are needed, the present work suggests that CC may be a chemopreventive agent for the treatment of human cancer cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.1
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• pp.22-27
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• 2021

This study conducted a questionnaire for students of Pusan National University Graduate School of Korean Medicine who practiced using the Oriental Medicine Diagnosis System (ODS). From the questionnaire, this study investigated current state of application and perception of AI in Korean Medicine and explored the direction of ODS improvement and utilization. The survey questions consisted of six questions examining the satisfaction of the diagnostic expert system, five questions evaluating the availability of the diagnostic expert system, and six questions to predict the impact of AI on the Korean medicine community. The survey analysis showed high satisfaction with practice using ODS. On the other hand, the possibility of using ODS, especially in clinical use, was evaluated as relatively low compared to the satisfaction of the practice. Therefore, the overall impact of AI on the Korean medical community is not expected to be large. Although there are difficulties in standardization of clinical data due to the academic characteristics of Korean medicine, it is necessary to continue attempts to apply AI. By actively introducing educational tools using the latest AI techniques to the diagnosis experience and doctor-patient role in a practice, students will be able to increase their satisfaction with their practice and respond appropriately to the state-of-the-art medical environment.

• Herbal Formula Science
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• v.32 no.1
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• pp.29-37
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• 2024

Objectives : The purpose of this study was to examine the effects of insurance herbal medicines on colonic interstitial Cells of Cajal (ICC) in mice. Methods : Among the insurance herbal medicines, we chose Gamisoyo-san (GSS), Banhasasim-tang (BHSST) and Bojungikki-tang (BGIKT). We made the ICC culture in large intestine in mice and used the electrophysiological method to record pacemaker potentials. Also we used MTT assay to check cell viability and examined the ICC protein expression by western blot. Results : 1. GSS (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.99 mg/ml. BHSST (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.76 mg/ml. BGIKT (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 4.49 mg/ml. 2. GSS, BHSST and BGIKT had no effects on cell viability in colonic ICC. 3. GSS and BGIKT increased the Anoctamin-1 (ANO1) protein expression and BHSST increased the transient receptor potential melastatin-subfamily member 7 (TRPM7) protein expression in colonic ICC. Conclusions : These results suggest that GSS, BHSST, and BGIKT have shown the potential to regulate gastrointestinal (GI) motility by regulating colonic ICC and may show the potential to treat colon-derived GI diseases such as irritable bowel syndrome (IBS).