• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.1
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• pp.1-8
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• 2009

Recently microscale biofluid flows have been receiving large attention in various research areas. However, most conventional imaging techniques are unsatisfactory due to difficulties encountered in the visualization of microscale biological flows. Recent advances in optics and digital image processing techniques have made it possible to develop several advanced micro-PIV/PTV techniques. They can be used to get quantitative velocity field information of various biofluid flows from visualized images of tracer particles. In this paper, as new advanced micro-PIV techniques suitable for biofluid flow analysis, the basic principle and typical applications of the time-resolved micro-PIV and X-ray micro-PIV methods are explained. As a 3D velocity field measurement technique for measuring microscale flows, holographic micro-PTV method is introduced. These advanced PIV/PTV techniques can be used to reveal the basic physics of various microscale biological flows and will play an important role in visualizing veiled biofluid flow phenomena, for which conventional methods have many difficulties to analyze.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.257-261
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• 2005

Over the past 30 years, numerical methods and simulation tools for fluid dynamic problems have advanced as a new discipline, namely, computational fluid dynamics (CFD). Although a wide spectrum of flow regimes are encountered in many areas of science and engineering, simulation of compressible flow has been the major driver for developing computational algorithms and tools. This Is probably due to a large demand for predicting the aerodynamic performance characteristics of flight vehicles, such as commercial, military, and space vehicles. As flow analysis is required to be more accurate and computationally efficient for both commercial and mission-oriented applications (such as those encountered in meteorology, aerospace vehicle development, general fluid engineering and biofluid analysis) CFD tools for engineering become increasingly important for predicting safety, performance and cost. This paper presents the author's perspective on the maturity of CFD, especially from an aerospace engineering point of view.

• Journal of the Korean Mathematical Society
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• v.59 no.3
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• pp.519-548
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• 2022

In this paper, a stabilized-penalized collocated finite volume (SPCFV) scheme is developed and studied for the stationary generalized Navier-Stokes equations with mixed Dirichlet-traction boundary conditions modelling an incompressible biological fluid flow. This method is based on the lowest order approximation (piecewise constants) for both velocity and pressure unknowns. The stabilization-penalization is performed by adding discrete pressure terms to the approximate formulation. These simultaneously involve discrete jump pressures through the interior volume-boundaries and discrete pressures of volumes on the domain boundary. Stability, existence and uniqueness of discrete solutions are established. Moreover, a convergence analysis of the nonlinear solver is also provided. Numerical results from model tests are performed to demonstrate the stability, optimal convergence in the usual L² and discrete H¹ norms as well as robustness of the proposed scheme with respect to the choice of the given traction vector.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.1
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• pp.24-31
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• 2003

As endothelial cells are subject to flow shear stress, it is important to determine the detailed velocity distribution in microvessels in the study of mechanical interactions between blood and endothelium. This paper describes a velocity field of the arteriole in the rat mesentery using an intravital microscope and high-speed digital video system obtained by a highly accurate PIV technique. Red blood cells (RBCs) velocity distributions with spatial resolutions of $0.8{\times}0.8{\mu}m$ were obtained even near the wall in the center plane of the arteriole. By making ensemble-averaged time-series of velocity distributions, velocity profiles over different cross-sections were calculated for comparison. The shear rate at the vascular wall also evaluated on the basis of the ensemble-averaged profiles. It was shown that the velocity profiles were blunt in the center region of the vessel cross-section while they were steep in the near wall region. The wall shear rates were significantly small, compared with those estimated from the Poiseuille profiles.