• 제목/요약/키워드: Biocompatible

검색결과 448건 처리시간 0.026초

생체적합성 고분자의 개발과 응용(II) ―Phosphoryl choline기를 가진 키토산 그래프트공중합체의 생체적합성― (Development and Application of Biocompatible Polymers(II) ―Biocompatibility of Chitosan Graft Copolymer with Phosphoryl Choline groups―)

  • Lee, Mi Kyung;Park, Heung Sup;Kim, Eun Young;Park, Soo Min
    • 한국염색가공학회지
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    • 제7권2호
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    • pp.63-69
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    • 1995
  • To improve the blood compatibility of chitosan membranes, 2-(methacryloyloxy)-ethyl-2-(trimethylammonium)ethyl phosphate(MTP), which is a methacrylate with phospholipid polar groups, was grafted on the surface of chitosan membranes and the biocompatibility of MTP-grafted chitosan membranes was investigated. The permeation coefficient gradually decreased with increasing in molecular weights of biocomponents below 10$^{4}$, and drastically decreased above 10$^{4}$. This result corresponds with the permeability of solutes in case of hemodialysis membranes. The MTP-grafted chitosan membranes displayed less blood cell adhesion than the chitosan membranes. This may due to the formation of biomembrane4ike surface by adsorption and arrangement of phospholipid molecules from serum onto the MTP copolymer surface.

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MPCE copolymer와 습식 폴리우레탄의 블렌드에 의한 투습방수 나일론 직물의 제반 물성변화에 관한 연구 (Property Evaluation of Breathable Blend Fabric of MPCE Copolymer and Wet Coagulated Polyurethane)

  • 이종우;채애정;배진석
    • 한국염색가공학회지
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    • 제26권4호
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    • pp.322-330
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    • 2014
  • The phospholipid-based MPCE(2-Methacryloxyethyl Phosphoryl Chlorine) copolymer was mixed with wet polyurethane for coating of nylon fabrics. The substitution rate of water in coagulation bath with DMF was changed under control of the size of formed hydrophilic microporous cell enable to manufacture excellent breathable, anti-bacterial and moisture control fabrics. Biocompatible property, vapor permeability, hydrostatic pressure, moisture management and anti-bacterial property were investigated for treated nylon fabrics. In result, increased moisture transmission rates, decreased water resistance and outstanding moisture control property could be confirmed by enhanced hydrophilicity of wet-coated nylon fabric with MPCE copolymer.

Nanoplasmonics: An Enabling Platform for Integrated Photonics and Biosensing

  • Lee, Jihye;Yeo, Jong-Souk
    • Applied Science and Convergence Technology
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    • 제25권1호
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    • pp.7-14
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    • 2016
  • Nanoplasmonics is a developing field that offers attractive optical, electrical, and thermal properties for a wide range of potential applications. Based on the compelling characteristics of this field, researchers have shed light on the possibilities of integrated photonics and biosensing platforms using nanoplasmonic principles. Single and unique nanostructures with plasmons can act as individual transducers that convert desired information into measurable and readable signals. In this review, we will discuss nanoplasmonic sensors, especially those in relation to photodetectors for future optical interconnects, and bioinformation sensing platforms based on nanoplasmonics, thus providing a viable approach by which to create sensors corresponding to target applications. In addition, we also discuss scalable fabrication processes for the creation of unconventional nanoplasmonic devices, which will enable next-generation plasmonic devices for wearable, flexible, and biocompatible systems.

가교 폴록사머 하이드로겔 물성 및 약물 조절 방출 (Characteristics and Drug Release Control of Crosslinked Poloxamer Hydrogel)

  • 변은정;이승진;김길수
    • Journal of Pharmaceutical Investigation
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    • 제26권3호
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    • pp.201-205
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    • 1996
  • Poloxamer, block copolymers of ethylene oxide and propylene oxide was crosslinked by diisocyanates and triisocyanates to form water-swellable, physically strong, rubber-like elastic, high biocompatible polyurethanes. The isocyanate-hydroxyl stoichiometry was kept 1:1, but the crosslinking density was varied. The variations examined were the ratio of diisocyanate and triisocyanate. The delivery of two drugs of different water solubilities from hydrogel matrices was studied. It appeared that the drug nature greatly influenced its release kinetics possibly due to drug-polymer interactions. The release profiles, however, could be modified to a great extent by adjusting the polymer network structure Generally the high crosslinking density was required for prolonged drug delivery.

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3DP 프린팅 타입의 생체친화용 기능성 소재 개발 (Bioinspired strategy to biocompatible materials for 3D printing technology)

  • 최태종;조원진;이헌주;문명운
    • 한국표면공학회:학술대회논문집
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    • 한국표면공학회 2015년도 추계학술대회 논문집
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    • pp.341-342
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    • 2015
  • 3D printer는 현재 세계적으로 시장이 확대됨에 따라 다방면으로 연구가 진행되고 있다. 이중에서 3DP (Three Dimensional Printing) 방식은 석고타입의 분말 powder가 도포된 층 위에 binder가 잉크젯 헤드를 통해 분사되어 powder 층과 층 사이를 붙여가며 형상을 제작하는 적층 방식의 일종이다. 반면 한정된 소재와 비싼 가격 때문에 보편적으로 사용하기에 한계가 있으며 대부분의 소재가 인체 유해한 성질을 보유하고 있어 활용 범위가 제한적이다. 본 연구에서는 인체 무해하고 다양한 기능이 내재된 생체 친화용 기능성 소재를 개발하고 3DP 방식의 프린터 제작을 통해 생체 친화적 기능성 형상을 제작하는 기술을 개발하였다.

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고분자량 교대배열 폴리비닐알코올/고분자량 혼성배열 폴리비닐알코올 블렌드 용액의 유변학적 특성 (Rheological Properties of High Molecular Weight (HMW) Syndiotactic poly(vinyl alcohol) (PVA)/HMW Atactic PVA Blend Solutions)

  • Yeum, Jeong-Hyun;Ji, Byung-Chul;Lyoo, Won-Seok
    • 한국섬유공학회:학술대회논문집
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    • 한국섬유공학회 2003년도 가을 학술발표회 논문집
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    • pp.74-75
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    • 2003
  • Recently, people are gradually concerned about environmental issue, bionics, environmental-friendly or biocompatible materials. Poly(vinyl alcohol) (PVA) is suitable for these materials, because it is typically water-soluble polymer that have linear-flexible chains, a material of no toxicity for human, and biodegradable polymer[1]. One of the most effective factors that dominate the properties of PVAs is tacticity. (omitted)

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생체 친화적인 원소를 함유한 티타늄합금의 미세조직과 탄성계수 (Microstructures and Elastic Moduli of the Alloys Containing the Biocompatible Alloying Elements)

  • 정희원;김승언;현용택;이용태
    • 연구논문집
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    • 통권33호
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    • pp.157-165
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    • 2003
  • New titanium alloys with a low elastic modulus have been developed for biomedical applications to avoid the stress shielding effect of the artificial prosthesis. The newly developed alloys contained the transition elements like Zr, Hf, Nb, Ta which were non-cytotoxicity elements and $\beta$ stabilizers. In the present paper the elastic moduli of Ti-xM containing Zr, Hf, Nb, Ta were evaluated by measuring the acoustic velocity (PEG). The effectiveness of the alloying elements for lowering the elastic modulus was investigated. In addition, the dominant factors for the low modulus were discussed. Ta was the most effective in lowering the elastic modulus of the alloys. The effectiveness of Hf was not acceptable for decreasing the elastic modulus. The dominant factor was the lattice parameter for Zr, and the poisson's ratio for Nb, Ta, respectively.

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초임계 반용매법을 이용한 폴리비닐피롤리돈 미세입자의 제조 (Preparation of Poly(N-vinyl-2-pyrrolidone) Microparticles Using Supercritical Anti-solvent)

  • 신문삼;김화용
    • 청정기술
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    • 제14권4호
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    • pp.242-247
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    • 2008
  • 화장품, 의약품, 전자소재 분야에서 생체적합, 생분해성 고분자로 널리 사용되는 폴리비닐피롤리돈(PVP)을 에어로젤 용매추출 방법에 의해 미세입자를 제조하였다. 용매로는 이 염화메탄올, 반용매로는 초임계 이산화탄소가 사용되었다. 온도, 압력, 이산화탄소 유량, 용액유량의 작업조건에 따라 0.184 - $0.249\;{\mu}m$입자크기를 얻었고, 그 입자크기에 영향을 미치는 초기구형 입자크기와의 상관관계를 규명하였다.

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Albumin-conjugated Cadmium Sulfide Nanoparticles and their Interaction with KB Cells

  • Selim, K.M. Kamruzzaman;Kang, Inn-Kyu;Guo, Haiqing
    • Macromolecular Research
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    • 제17권6호
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    • pp.403-410
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    • 2009
  • Cytotoxicity is a severe problem of cadmium sulfide nanoparticles(CSNPs) for use in biological systems. In the present study, mercaptoacetic acid-coated CSNPs were conjugated with bovine serum albumin (BSA) to improve biocompatibility. The surface properties of the CSNPs and albumin-conjugated CSNPs (ACSNPs) were characterized by XRD, UV, FTIR, EA, TEM and DLS. Human breast cancer cells (KB cells) were then cultured in the presence of the nanoparticles to evaluate the cytotoxicity of CSNPs and ACSNPs. Finally, the fluorescence intensity of the nanoparticles' aqueous solution was examined using a fluorescence spectrometer. The results showed that the cell compatibility and fluorescence intensity of ACSNPs were higher than those of CSNPs. The strongly luminescent features of the biocompatible ACSNPs are promising for use in biological fields such as cellular labeling, intracellular tracking and molecular imaging.

Highly Homogeneous Carbon Nanotube-Polycaprolactone Composites with Various and Controllable Concentrations of Ionically-Modified-MWCNTs

  • Lee, Hae-Hyoung;Shin, Ueon-Sang;Jin, Guang-Zhen;Kim, Hae-Won
    • Bulletin of the Korean Chemical Society
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    • 제32권1호
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    • pp.157-161
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    • 2011
  • For the fabrication of multifunctional biopolymer nanocomposites in the combination of carbon nanotubes (CNTs), recently increasing attention has been paid to an effective homogenization of CNTs within polymer matrices and a fine tuning of the concentration. We developed an efficient method to produce homogeneous CNT-polycaprolactone nanocomposites with various and controllable CNT concentrations using an ionically-modified multi-walled CNT, MWCNT-Cl. The modified MWCNTs could be homogeneously dispersed in tetrahydrofuran (THF). Polycaprolactone (PCL) as a biodegradable and biocompatible polymer was smoothly dissolved in the homogeneous MWCNT-Cl/THF solution without agglomeration of MWCNT-Cl. The physicochemical and mechanical properties of the resultant nanocomposites were examined and the biological usefulness was briefly assessed.