• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.687-687
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• 2003

• Journal of Advanced Navigation Technology
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• v.13 no.4
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• pp.482-489
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• 2009

This paper proposes a CW(Continuous-Wave) bio-radar applying a new adaptive noise canceller based on ALE(Adaptive Line Enhancer) which can remove the Gaussian noise and system noise. Recently the research works on this CW bio-radar which can be used to detect heartbeat and respiration are advanced by the university and research facility. Although the researches describe CW bio-radar not only is vulnerable for the Gaussian noise but also has a disadvantage of decreasing the heart-rate accuracy due to the noise, the researches do not demonstrate the effective method for removing the noise component in a baseband signal. In this paper, a CW bio-radar applying the new adaptive noise canceller based on ALE which can remove the noise component is proposed. This paper compares and analyzes the performance for increasing the heart-rate accuracy according to removing the Gaussian noise and system noise in the baseband signal through the quadrature receiver which can alleviate the demodulation sensitivity to target position.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.2B
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• pp.232-243
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• 2010

In this paper, various physiological signals of humans were measured and analyzed to inference their psychological state and biological information, and Bio-Signal Context aware system (BSC), which recognizes the current context of its users as well as the information of exterior environment and offers the service appropriate for them, was designed and implemented. The BSC extracts and analyzes the features from bio-signals, such as the measured electroencephalogram (EEG), electrocardiogram (ECG), and galvanic skin response (GSR), with its different sensors, has the input of the analyzed results, and discriminates four psychological states of rest, concentration, tension and melancholy. In addition to the results of the discriminated psychological states, the information of biological condition analyzed from the user's bio-signals, for example, heart rate variability (HRV), Galvanic skin response (GSR) and body temperature, and the information of external environment related to the user's are collected to offer the service fit for the user's present biological condition by inferring and recognizing the user's present situation.

• Mycobiology
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• v.49 no.6
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• pp.582-588
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• 2021

The interaction of mating pheromone and pheromone receptor from the B mating-type locus is the first step in the activation of the mushroom mating signal transduction pathway. The B mating-type locus of Lentinula edodes is composed of Bα and Bβ subloci, each of which contains genes for mating pheromone and pheromone receptor. Allelic variations in both subloci generate multiple B mating-types through which L. edodes maintains genetic diversity. In addition to the B mating-type locus, our genomic sequence analysis revealed the presence of a novel chromosomal locus 43.3 kb away from the B mating-type locus, containing genes for a pair of mating pheromones (PHBN1 and PHBN2) and a pheromone receptor (RCBN). The new locus (Bα-N) was homologous to the Bα sublocus, but unlike the multiallelic Bα sublocus, it was highly conserved across the wild and cultivated strains. The interactions of RcbN with various mating pheromones from the B and Bα-N mating-type loci were investigated using yeast model that replaced endogenous yeast mating pheromone receptor STE2 with RCBN. The yeast mating signal transduction pathway was only activated in the presence of PHBN1 or PHBN2 in the RcbN producing yeast, indicating that RcbN interacts with self-pheromones (PHBN1 and PHBN2), not with pheromones from the B mating-type locus. The biological function of the Bα-N locus was suggested to control the expression of A mating-type genes, as evidenced by the increased expression of two A-genes HD1 and HD2 upon the treatment of synthetic PHBN1 and PHBN2 peptides to the monokaryotic strain of L. edodes.

• Journal of Oriental Neuropsychiatry
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• v.31 no.2
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• pp.89-99
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• 2020

Objectives: The purpose of this study was to identify the needs of bio-signal devices for the diagnosis, assessment, and analysis of neurocognitive disorder in Korean medicine (KM) hospitals and clinics. Methods: A questionnaire was developed to survey the current status of medical device use, and diagnosis and interventions for patients with cognitive disorders in KM hospitals and clinics. November 11~December 2, 2019, 114 responses (71.9% completed) were collected by internet-based questionnaires from the members of the Korean society of Oriental Neuropsychiatry. Results: The clinical requests were in the descending order of hematology analyzer, ultrasound imaging system, and electroencephalography among the 15 most commonly used devices of which research would support for their clinical usability. The biosignal-based devices showed the highest research demands for patients with mild cognitive impairment rather than more severe stages of cognitive impairment. Prevention rather than diagnosis, or several treatment regimens was the strongest clinical area of the KM for patients with neurodegenerative cognitive impairment. Many responded that five to 10 minutes of test duration and 20,000 won to 30,000 won of cost would be appropriated for a new device to be developed. Conclusions: There were strong demands for the development of bio-signal devices for neurocognitive disorders among the KM doctors. Specifically, it showed high needs for the technology that can be used in the prevention area of cognitive disorders. Additionally, new medical devices to assess cognitive functions and to obtain KM pattern-related information were the high needs.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.6
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• pp.91-98
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• 2013

Magnetic sensor chip for measuring bio-magnetism is implemented in $0.18{\mu}m$ CMOS technology. The magnetic sensor chip consists of a small-sized high inductance coil sensor and an instrumentation amplifier (IA). High inductance coil sensor with suitable sensitivity and bandwidth for measurement of bio-magnetic signal is designed using electromagnetic field simulation. Low gm operational transconductance amplifier (OTA) using transconductance reduction techniques is designed for on-chip solution. Output signal sensitivity of magnetic sensor chip is $3.25fT/{\mu}V$ and reference noise of 21.1fT/${\surd}$Hz. Proposed IA is designed along with band pass filters(BPF) to reduce magnetic signal noise by using current feedback techniques. Proposed IA achieves a common mode rejection ratio of 117.5dB while the input noise referred is kept below $0.87{\mu}V$.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.4
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• pp.617-624
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• 2021

The accurate estimation of the number of signals included in the received signal is required for the AOA(: Angle-of-Arrival) estimation, the interference suppression, the signal reception, etc. AIC(: Akaike Information Criterion) and MDL(: Minimum Description Length) algorithms, which are known as the typical algorithms to estimate the signal number, estimate the number of signals according to the minimum of each criterion. As the number of antenna elements increased, the estimation performance is enhanced, but the computational complexity is increased because values of criteria for entire antenna elements should be calculated for finding their minimum. In order to improve this problem, in this paper, we propose AIC and MDL algorithms based on the beamspace, which efficiently estimate the number of signals while reducing the computational complexity by reducing the dimension of an array antenna through the beamspace processing. In addition, we provide computer simulation results based on various scenarios for evaluating and analysing the estimation performance of the proposed algorithms.

• Journal of electromagnetic engineering and science
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• v.10 no.4
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• pp.250-255
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• 2010

This paper presents a non-contact measurement method of vital signal by the use of multiple-input multiple-output (MIMO) bio-radar system, configured with two antennas that are separated by a certain distance. The direction of arrival (DOA) estimation algorithm for coherent sources was applied to detect vital signals coming from different spatial angles. The proposed MIMO bio-radar system was composed of two identical transceivers sharing single VCO with a PLL. In order to verify the performance of the system, the DOA estimation experiment was completed with respect to the human target at angles varying between $-50^{\circ}$ and $50^{\circ}$ where the bio-radar system was placed at distances (corresponding to 50 cm and 95 cm) in front of a human target. The proposed MIMO bio-radar system can successfully find the direction of a human target.

• Journal of the Institute of Convergence Signal Processing
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• v.22 no.2
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• pp.45-50
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• 2021

With the recent development of IT technology, research and interest in various bio-signal measuring devices are increasing. But studies related to ECG(electrocardiogram), which is one of the most representative bio-signals, particularly arrhythmic signal detection, are incomplete. Since arrhythmia has various causes and has a poor prognosis after onset, preventive treatment through early diagnosis is best. However, the 24-hour Holter electrocardiogram, a tool for diagnosing arrhythmia, has disadvantages in the limitation of use time, difficulty in analyzing motion artifact due to daily life, and the user's real-time alarm function in danger. In this study, an ECG and pulse monitoring device capable of continuous measurement for a long time, a real-time monitoring app, and software for analysis were developed, and the trend of the measured values was confirmed. In future studies, research on derivation of quantitative results of ECG signal measurement analysis is required, and further research on the development of an arrhythmic signal detection algorithm based on this is required.

• Progress in Medical Physics
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• v.5 no.2
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• pp.35-43
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• 1994

Electromagnetic wave may induce effect and damage on the bio-body, either by electric fields of magnetic fields. We measure electrophysiological changs in rabbit's brain exposed to 2.45GHz micro wave(power density 40mW/cm$^2$) which distance 30cm from the source. In order to process the bio-electrical signal (EEG), used pre-amplifier module with self-made and Digtal analyzer computer system. Spectal analysis of the EEG showed variable power in the frequency range(1～30Hz) through each exposure time(10min, 20min, 30min) before and after. In effectively measured by the bio-electrical signal processing and can found threshold of minmal permissible exposure and lethal exposure.