• 대한환경공학회지
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• 제29권9호
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• pp.1044-1050
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• 2007

본 연구는 대표적인 유기성 폐기물인 음식물쓰레기와 폐활성슬러지를 처리함과 동시에 수소를 생물학적인 방법으로 생성하기 위하여 운전인자인 가용화 방법, pH, VFAs 및 음식물쓰레기와 폐활성슬러지의 최적 혼합비율을 도출하고자 하였다. 폐활성슬러지의 수소 생성량을 높이기 위해 다양한 가용화 방법을 적용하여 그에 따른 수소 수율을 비교한 결과 알칼리와 초음파처리 한 병합처리에서 4.3 mL $H_2/g$ $VS_{consumed}$로 가장 높았으며, 음식물쓰레기와 가용화 된 폐활성슬러지를 혼합한 경우에도 병합처리 한 가용화 방법에서 수소 수율이 13.8 mL $H_2/g$ $VS_{consumed}$로 가장 높았다. 또한 pH는 $5.0\sim5.5$에서 운전시 가장 높은 수소 생성량을 보였으며, 음식물쓰레기와 가용화 된 폐활성슬러지의 최적 혼합비율은 2 : 1에서 수소 생성량이 5.0 L $H_2/L/d$로 가장 높았다. 생물학적 수소 생성이 많을수록 VFAs는 프로피온산의 농도가 낮았고, 부티르산이 아세트산보다 높은 비율로 생산되었다.

• 한국자원식물학회지
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• 제30권4호
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• pp.372-377
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• 2017

본 연구는 설앵초의 종 보존과 활용성 증대를 위해 종자를 이용한 대량 번식법을 개발하고자 수행되었다. 종자는 2011년 제주도 일대에서 채종하여 정선한 다음 $4{\pm}1.0^{\circ}C$에서 건조 상태로 저장하면서 연구에 사용하였다. 종자의 크기는 $0.44{\pm}0.07{\times}0.61{\pm}0.04mm$, 1,000립중은 $51.78{\pm}0.021mg$이었으며, 미세종자로 분류되었다. 설앵초 종자의 휴면특성은 생리적 휴면(physiological dormancy)성을 갖는 것으로 판단되었다. 한편 종자는 광조건에서 발아가 되는 광발아성 종자로, 적정온도는 $20^{\circ}C$로 나타났다. $GA_3$는 조자의 휴면타파 및 발아력 향상에 크게 효과가 있었는데, 농도가 높아줄수록 그 효과가 크게 나타났다. 특히 $GA_3$ 200~500 mg/L 처리구에서 발아율 및 발아세가 90% 이상으로 매우 높게 조사되었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권6호
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• pp.694-700
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• 2007

It is a gel type high functional toothpaste containing vitamin C, E, propolis extract and the rest of herb with a nanoemulsion state. Vitamin C, E is known as the material with an eminent anti-oxidation effect. Propolis is known as the material with an antimicrobial and anti-inflammatory effect. We have been succeeding in making nanoemulsion of vitamin C, E and propolis through the high pressure homogenizer using stable oil and lecithin and the gel type high functional tooth paste were made from nanoemulsion of vitamin C, E and propolis. We observed the process of wound protecting effect and cure effect for a wound of soft tissue, gingival tissue and mucous membrane showing ulcer and inflammation in oral cavity after applying a gel type high functional toothpaste to patient. As a result, the wound were healed very fast and any side effects were not shown. We confirmed that a gel type high functional toothpaste with nanoemulsion of vitamin C, E and propolis extract has good effect not only for wound healing but also for treatment of ulcer-like lesion in oral cavity. So we report our cases with review of literatures.

• Natural Product Sciences
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• 제21권2호
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• pp.104-110
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• 2015

The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis of leaves of Acanthopanax gracilistylus W.W. Smith (AGS). The cytotoxicity and inhibition of NO on LPS-induced RAW 264.7 cells of the extract and triterpenoids were determined. Optimal conditions of HPLC analysis were established as follows. The separation was performed with an ODS-C₁₈ column at $30^{\circ}C$, the detected wavelength was 210 nm, the flow rate was 1 mL/min, and the mobile phase consisted of acetonitrile (0.05% phosphoric acid)-0.05% phosphoric acid solution with gradient elution. Our results showed that impressic acid and acankoreaogenin was more effective on the inhibition of NO than the methanol extract and other compounds. There were seventeen peaks coexisted with similarities above 0.95 and nine lupane-triterpenoids including acankoreaogenin and impressic acid detected and identified. The result of anti-inflammatory activities provides a potential explanation for the use of AGS leaves as a herbal medicine in the treatment of inflammatory diseases. Our results also show that acankoreanogenin and impressic acid may be potentially useful in developing new anti-inflammatory agents. In addition, the fingerprint chromatography clearly illustrated and confirmed the material basis for the anti-inflammatory activities of this plant.

• 벤처창업연구
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• 제7권2호
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• pp.129-140
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• 2012

한국원자력연구원이 기술 출자로 설립한 연구소기업인 (주)선바이오텍은 2006년 3월 '대덕연구개발특구 등의 육성에 관한 특별법' 의 제1호 연구소기업으로 선정되었다. 이 회사의 대표적 제품인 헤모힘은 항암치료 보조 기능성식품이다. 이 기술은 미국, 유럽, 일본 등에 특허를 획득한 3극 특허(Triad Patent Families)이기도 하다. 본 기술개발사례는 기존 선진기술을 습득하는 대신 새로운 기술을 개발하는 선진형 기술혁신이며, 소비재 사업화로서 기술개발이 소비자들이 직접 먹고 마시는 건강기능식품과 관련된다. 본 연구는 (주)선바이오텍이 천연 생약복합 조성물로 면역조절기능이 탁월한 '헤모힘'의 사업화 과정을 심층 분석하여 그 과정에서 나타난 성공요인, 문제점, 해결노력 등을 파악해 본다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권2호
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• pp.113-118
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• 2008

Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. We've got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.

• 농약과학회지
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• 제15권3호
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• pp.303-309
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• 2011

본 연구는 충북지역 포도원에서 꽂매미(Lycorma delicatula)의 발생소장과 방제약제 선발을 목적으로 시판되고 있는 10종 친환경농자재에 대한 잔효성 및 방제효과를 평가 하였다. 2010년도 꽃매미의 발생은 5월 하순경부터 부회를 시작으로 5월 말부터 8월 말까지 약충이 발생하여 6월 초순에 발생최성기였던 반면, 성충은 7월 말부터 11월까지 발생하였고 산란을 위해 포도원에 집중되는 9월 말에 증가추세를 보여 10월 초순에 발생량이 가장 많았다. 꽃매미 3~4령약충과 성충에 대해서 Spider, Jindikap-plus, Byejin-${\alpha}$가 100% 살충활성을 보였고, Seoncho가 48 hr에서 96.7%를 보였다. 약제 간 잔효성 비교는 Spider가 추천농도에서 7일차에 55.5%의 살충효과를 보였던 반면 나머지 약제는 효과가 낮았다. 노지 포도원에서 5종 약제로 실시한 방제실험 결과 약충은 Jindikap-plus와 Spider가 3일차에 모두 99%의 방제가를 나타냈고 7일까지 2약제 모두 90%의 방제가를 보였다. 성충은 3일차에서 Jindikap-plus와 Spider가 각각 100%, 98.2%의 방제효과를 보였고 7일차 에서는 각각 90.6%와 84.6%의 치사율을 보인 반면, 나머지 약제는 효과가 낮았다. 작물보호제인 대조약제 Acetamiprid WP와 비교해 Jindikap-plus와 Spider는 방제효과가 우수하였다.

• Advances in Traditional Medicine
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• 제5권2호
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• pp.100-109
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• 2005

In South America, natural products with unknown drug effects are used as folk remedies and for preventive medicine. Among South American natural products, we directed our attention to Propolis, which have been known as medicinal plants, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse. When the antioxidant activities of Propolis were examined by the DPPH and Rhoudan iron methods, since Propolis contains high levels of flavonoids, it is thought that flavonoids may be responsible for the antioxidant activity in this study. In the examination of immunoenhancement activity, we measured lymphocyte versus polymorphonuclear leukocyte ratios (L/P activity). The number of lymphocytes was significantly increased in groups treated with Proplolis. Specifically, slightly high levels of $IFN-{\gamma}$ were measured in mice bearing the S-180 carcinoma, after administration of Propolis. This strongly suggests that cellular immunity is especially activated by treatment with Propolis, because production of $IFN-{\alpha}$ is limited to the T cells and NK cells stimulated by mitogen and sensitized antigen. $TNF-{\alpha}$ shows a different extent and mechanism of action depending on the target cells. When $TNF-{\alpha}$ was measured in mice bearing the S-180 carcinoma, mice treated with Propolis showed slightly higher $TNF-{\alpha}$ levels as compared to the control group. This suggests that activated macrophages produce $TNF-{\alpha}$ in mice treated with Prapolis, since activated macrophages and lymphocytes are the source of most $TNF-{\alpha}$. When anti-tumor action was examined using two kinds of sarcoma (Ehrlich solid carcinoma and Sarcoma-180 carcinoma), tumor-suppressive ratios after treatment with Propolis was 29.1%. When Sarcoma-180 solid carcinoma was used, tumor-suppressive ratios were 62%. Thus, Propolis showed strong anti-tumor activity against two kinds of solid carcinoma. Taken altogether, this strongly suggests that Propolis enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth.

• Asian-Australasian Journal of Animal Sciences
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• 제29권3호
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• pp.404-412
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• 2016

We hypothesized that supplementing finishing diets with palm oil would promote adipogenic gene expression and stearoyl-CoA desaturase (SCD) gene expression in subcutaneous (s.c.) and intramuscular (i.m.) adipose tissues of feedlot steers. Eighteen Angus and Angus crossbred steers were assigned to three groups of 6 steers and fed a basal diet (control), with 3% palm oil, or with 3% soybean oil, for 70 d, top-dressed daily. Tailhead s.c. adipose tissue was obtained by biopsy at 14 d before the initiation of dietary treatments and at 35 d of dietary treatments. At slaughter, after 70 d of dietary treatment, tailhead s.c. adipose tissue and i.m. adipose tissue were obtained from the longissimus thoracis muscle. Palm oil increased plasma palmitic acid and soybean oil increased plasma linoleic acid and ${\alpha}$-linolenic acid relative to the initial sampling time. Expression of AMP-activated protein kinase alpha ($AMPK{\alpha}$) and peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) increased between the initial and intermediate biopsies and declined thereafter (p<0.03). SCD gene expression did not change between the initial and intermediate biopsies but declined by over 75% by the final period (p = 0.04), and G-coupled protein receptor 43 (GPR43) gene expression was unaffected by diet or time on trial. Soybean oil decreased (p = 0.01) $PPAR{\gamma}$ gene expression at the intermediate sample time. At the terminal sample time, $PPAR{\gamma}$ and SCD gene expression was less in i.m. adipose tissue than in s.c. adipose tissue (p<0.05). $AMPK{\alpha}$ gene expression was less in s.c. adipose tissue of palm oil-fed steers than in control steers (p = 0.04) and CCAAT enhancer binding protein-beta ($CEBP{\beta}$) gene expression was less in s.c. and i.m. adipose tissues of palm oil-fed steers than in soybean oil-fed steers (p<0.03). Soybean oil decreased SCD gene expression in s.c. adipose tissue (p = 0.05); SCD gene expression in palm oil-fed steers was intermediate between control and soybean oil-fed steers. Contrary to our original hypothesis, palm oil did not promote adipogenic gene expression in s.c. and i.m. adipose tissue.

• 한국결정성장학회지
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• 제31권1호
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• pp.8-15
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• 2021

TiO2는 물리적, 화학적 안정성이 높고, 신체에 무해하여 태양전지, 치과용 임플란트 및 광촉매 같은 다양한 분야에서 사용되어 왔다. 비표면적이 큰 TiO2 나노섬유는 생체 친화성 제품에서 좋은 반응성과 공기 및 수질 정화시 우수한 광촉매 특성을 보여주었다. TiO2 나노섬유를 제조하기 위해 전기방사법을 사용하였으며, 제조 변수에 따른 직경 변화를 관찰하기 위해 precursor 성분 변수와 공정 변수로 구분하여 미세구조 변화를 분석하였다. Precursor 성분 변수로는 PVP(Polyvinylpyrrolidone) 및 TTIP(Titanium(IV) isopropoxide)의 농도를 선택하였고, 공정 변수로는 주입 속도와 인가 전압을 선택하였다. TiO2 나노섬유의 미세구조와 결정구조는 FE-SEM(Field emission scanning electron microscope)와 XRD(X-ray diffraction)을 이용하여 분석하였다. 450℃에서 3시간 열처리 공정을 통해, 평균 직경 약 0.27 ㎛에서 1.31 ㎛를 갖는 asspun TiO2 나노섬유가 0.22 ㎛에서부터 0.78 ㎛의 평균 직경을 갖는 anatase 상의 TiO2 나노섬유로 상전이 됨을 확인할 수 있었다. 평균 직경 0.22 ㎛의 anatase TiO2 나노섬유는 비 표면적 증대에 의한 광촉매 특성 향상을 기대할 수 있다. 또한 TiO2 나노섬유의 직경 변화를 위해서는 주입 속도 및 인가 전압과 같은 공정 변수보다는 PVP 농도 및 TTIP 농도와 같은 precursor 성분 변수를 제어하는 것이 더욱 효과적이었다.