• Title/Summary/Keyword: Bio-nano

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Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats

  • Choi, Hyeon-Son;Han, JeungHi;Chung, Seungsik;Hong, Yang Hee;Suh, Hyung Joo
    • Food Science of Animal Resources
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    • v.33 no.4
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    • pp.515-521
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    • 2013
  • In this study, we examined the effects of organic types of calcium derived from oyster shell (OS-Ca) and nano-calcium (Nano-Ca) on the bio-availability and physiological responses associated with bone health in ovariectomised rats. Increased body weight, which is one of the physiological effects of ovary removal, was significantly recovered by Nano-Ca treatment (p<0.05). The reduced calcium level in the liver in ovariectomised rat was increased significantly with OS-Ca and Nano-Ca treatment (p<0.05), suggesting improved calcium bio-availability. Alkaline phosphatase (ALP), osteocalcin, and deoxypyridinoline (DPD) were analysed as biochemical markers of bone metabolism and health in the presence or absence of OSCa and Nano-Ca. ALP, osteocalcin, and DPD levels increased following ovary removal and tended to decrease after treatment with Nano-Ca, indicating that Nano-Ca induces favourable bone metabolism. This result was reflected in the recovery of bone mineral density (BMD) and bone mineral content (BMC) of the femur after Nano-Ca treatment following ovary removal. Taken together, our data show that the tested calcium treatments, especially using Nano-Ca, enhanced the bioavailability or absorption of calcium and positively affected bone metabolism in ovariectomised rats.

Recovery of MFB Generated from Dimethyl Terephtalate Production Process (DMT 제조 과정서 발생하는 MFB의 회수에 관한 연구)

  • Kim, Sun Ho;Ryu, Young;Kim, Jong Cheon;Kim, Seok Chan
    • Applied Chemistry for Engineering
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    • v.26 no.5
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    • pp.621-623
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    • 2015
  • This article describes a purification method yielding high purity of MFB produced from DMT production process. Aldehyde functional group of MFB included in side-products were converted to acetal compound via reacting with methanol and further separated. Hydrolysis process of the acetal product was continued under acidic condition and highly pure MFB were obtained with 90% yield. The structure of MFB was analyzed by $^1H$ NMR and $^{13}C$ NMR spectroscopy. Also, the purity of MFB was estimated to be over 99% by GC analysis.

Wool Dyeing with Sepia Melanin (세피아 멜라닌에 의한 양모 염색)

  • Kim, Su-Jin;Kwon, Hye-Ryun;Yoo, Jung-Hwa;Jang, Jin-Ho
    • Textile Coloration and Finishing
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    • v.22 no.1
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    • pp.14-20
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    • 2010
  • Squid ink was purified to melanin powder by repeated treatments with aqueous sodium hydroxide and acetic acid solutions. The exhaustion dyeing conditions of melanin to wool fabrics were investigated in relation with pH, melanin concentration, dyeing temperature and time. The melanin was dyeable to cotton and wool fabrics but higher dyeability of the wool was observed. A K/S of 7 was obtained on the optimally dyed wool fabrics with 5 % owf melanin under pH 4 at $100^{\circ}C$ for 60 minutes. Color fastness to both washing and rubbing was excellent and color fastness to light was also very good probably due to the polymeric nature of the extracted sepia melanin.

Quantitative Label-free Biodetection of Acute Disease Related Proteins Based on Nanomechanical Dynamic Microcantilevers

  • Hwang, Kyo-Seon;Cha, Byung-Hak;Kim, Sang-Kyung;Park, Jung-Ho;Kim, Tae-Song
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.7 no.3
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    • pp.151-160
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    • 2007
  • We report the label-free biomolecules detection based on nanomechanical micro cantilevers operated in dynamic mode for detection of two marker proteins (myoglobin and creatin kinase-MB (CK-MB)) of acute myocardical infarctions. When the specific binding between the antigen and its antibody occurred on the fuctionalized microcantilever surface, mechanical response (i.e. resonant frequency) of microcantilevers was changed in lower frequency range. We performed the label-free biomolecules detection of myoglobin and CK-MB antigen in the low concentration (clinical threshold concentration range) as much as 1 ng/ml from measuring the dynamic response change of micro cantilevers caused by the intermolecular force. Moreover, we estimate the surface stress on the dynamic microcantilevers generated by specific antibody-antigen binding. It is suggested that our dynamic microcantilevers may enable one to use the sensitive label-free biomolecules detection for application to the disease diagnosis system based on mechanical immuno-sensor.

Stereoselective Recognition of Amino Alcohols and Amino Acids by Carbonylurea- and Carbonyguanidinium-based Imine Receptors

  • Nandhakumar, Raju;Ahn, Yun-Soo;Yoon, Hoe-Jin;Kim, Kwan-Mook
    • Bulletin of the Korean Chemical Society
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    • v.30 no.12
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    • pp.2938-2942
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    • 2009
  • New receptors 1-3 that bind stereoselectively amino alcohols and convert chirality of amino acidsvia imine bond formation were synthesized. The receptors have uryl (1), thiouryl (2) and guanidinium (3) groups all with additional phenylcarbonyl motifs, which are effective hydrogen bonding donors and play a key role in the stereoselective recognitions. The stereoselectivities were measured from the integration of $^1HNMR$ peaks. Compound 1 and 2 showed the stereoselectivities for the imine formation with amino alcohols ($K_R/K_S$) in the range of 2${\sim}$4, and compound 3 in the range of 4${\sim}$8. Chirality conversion efficienciesof 1-3 for amino acids, i.e. D/L ratio at equilibrium, are in the range of 1.5${\sim}$5.6, showing a little higher efficiency with 3. The additional phenylcarbonyl motifs in 1-3 were revealed not to contribute to significant enhancement of the selectivities.