• Journal of the Korea Institute of Military Science and Technology
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• v.27 no.1
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• pp.116-125
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• 2024

The COVID-19 pandemic is not over despite the emergency use authorization as can see recent COVID-19 daily confirmed cases. The viruses are not only difficult to diagnose and treat due to random mutations, but also pose threat human being because they have the potential to be exploited as biochemical weapons by genetic manipulation. Therefore, it is inevitable to the rapid antibody-based therapeutic platform to quickly respond to future pandemics by new/re-emerging viruses. Although numerous researches have been conducted for the fast development of antibody-based therapeutics, it is sometimes hard to respond rapidly to new viruses because of complicated expression or purification processes for antibody production. In this study, a novel rapid antibody-based therapeutic platform using single B cell sorting method and mRNA-antibody. High immunogenicity was caused to produce antibodies in vivo through mRNA-antigen inoculation. Subsequently, antigen-specific antibody candidates were selected and obtained using isolation of B cells containing antibody at the single cell level. Using the antibody-based therapeutic platform system in this study, it was confirmed that novel antigen-specific antibodies could be obtained in about 40 days, and suggested that the possibility of rapid response to new variant viruses.

• Journal of the Institute of Convergence Signal Processing
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• v.24 no.2
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• pp.90-96
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• 2023

Securing large amounts of training data in deep learning neural networks, including convolutional neural networks, is of importance for avoiding overfitting phenomenon or for the excellent performance. However, securing labeled training data in deep learning neural networks is very limited in reality. To overcome this, several augmentation methods have been proposed in the literature to generate an additional large amount of training data through transformation or manipulation of the already acquired traing data. However, unlike training data such as images and texts, it is barely to find an augmentation method in the literature that additionally generates bio-signal training data for convolutional neural network based human activity recognition. Thus, this study proposes a simple but effective augmentation method of bio-signal training data for convolutional neural network based human activity recognition. The usefulness of the proposed augmentation method is validated by showing that human activity is recognized with high accuracy by convolutional neural network trained with its augmented bio-signal training data.

• Journal of the Korean Society of Industry Convergence
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• v.19 no.4
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• pp.237-244
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• 2016

This paper investigates the possibility to increase the economic value of the thinned young apple trough fermentation process. It is studies the optimal fermentation condition of thinned young apple by manipulating preparation treatment and sugar content. To do this following steps are done. Firstly, different preparation treatment for thinned young apple such as whole apple, cutting apple, and blending apple were done. The different sugar content such as $24^{\circ}Brix$, $15^{\circ}Brix$ and $4^{\circ}Brix$ was added. Secondly, the sugar contents and pH level were measured during fermentation process. Finally, statistical analysis was used to examine the relation between the preparation treatment, sugar content and pH level during the fermentation process. The experimental result shows that the different preparation treatment influences to the fermentation process. The blending apple treatment gave lower pH level compared to other kind treatments. The sugar content of thinned young apple was decrease during the fermentation process. The statistical analysis shows that the manipulation preparation treatment and sugar content affect the final pH level and whole fermentation process. Experimental result shows that the thinned young apple fermentation could be proposed as new alternative product in the market. The best fermentation process was obtained from blending thinned young apple treatment with $24^{\circ}Brix$.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1587-1592
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• 2003

There are three kinds of singularity in controlling redundant manipulators. Kinematic, algorithmic and representation singularities are those. If manipulators fall into any singularity without proper action to avoid it, the control system must go away from our desire, and we can meet a dangerous situation. Hence, we have to deal the singularities very carefully. In this paper, we describe an on-line solution for avoiding the occurrence of both algorithmic and kinematic singularities in task-priority based kinematic controllers of robotic manipulators. Representation singularity can be easily avoided by using proper representation algorithm, so, in this paper, we only consider kinematic and algorithmic singularities. The proposed approach uses a desired task reconstruction and a successive task projection in order to maintain the measure for singularity over a user defined minimum value. It shows a gain in performance and a better task error especially when working in proximity of singular configurations. It is particularly suitable for autonomous systems where an off-line trajectory control scheme is often not applicable. The advantage and performance of the proposed controller is verified by simulation works. And, the experiment with real manipulator is remaining for the future works.

• Journal of Bio-Environment Control
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• v.5 no.2
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• pp.210-214
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• 1996

The measuring system was developed for automation of hydroponic culture. It runs in Windows 3.1 and 95. Main window contains greenhouse screen and menu bars such as system setting, sensor calibration, greenhouse status, actuator control, file management, view, and help. Users can use pop-up menu, tool bar and status bat as well as menu bar for manipulation. Especially it was designed to retain flexibility for researchers, who changed detecting sensors frequently. Users can change storage intervals of files, of which 3 types were prepared to use in other software like as statistical programs, graphic programs and/or spread sheets. This system was adopted to deep flow culture system and evaluated to be appropriate for any kind of hydroponic systems.

• Journal of environmental and Sanitary engineering
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• v.19 no.2
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• pp.23-29
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• 2004

An algicidal effect of endemic algicidal bacterium (Pseudomonas putida) and rotifer zooplankton (Brachionus calyciflorus) on diatom Stephanodiscus hantzschii were examined in the filtered water, and were compared with those of bacterium plus ciliate. Bacteria removed as 80% of the diatom within 3.5 days, while ciliate and zooplankton suppressed 57% and 40% of diatom during the same period, respectively. Mixed treatment of bacteria plus ciliate removed as 54% of diatoms, while that of bacteria plus zooplankton decreased as 85%. Although single bacteria and mixed treatment of bacteria plus zooplankton quickly decreased the diatom in the initial of experiment, bacteria plus ciliate perfectly removed the diatom in culture flask within 5.5 days of the study. On the other hand, other single and mixed treatments did not clear the diatom during the same period, and over 10% of them still remain in culture flask. Predator biomass in the presence of algicidal bacteria showed the growth patterns; zooplankton gradually decreased, and ciliate sustained over 0.5 cells/ml. These results indicated that the addition of ciliate to the algicidal bacterium in controlling the diatom Stephanodiscus hantzschii is more effective than that of zooplankton. Therefore, this synergistic interaction relationship between the bacterium and ciliate play an important role in the bio-manipulation using bio-agents to control the diatomal bloom in freshwater lakes and streams.

• Journal of the Korean Institute of Intelligent Systems
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• v.17 no.7
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• pp.862-868
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• 2007

The planar motion of the index finger in general human hands is usually implemented by the actuation of three joints. This task requires a technique to determine the joint combination for each fingertip position which is well-known as the inverse kinematics problem in robotics. Especially, it is an essential work for grasping and manipulation tasks by robotic and humanoid fingers. In this paper, an intelligent neural learning scheme for solving such inverse kinematics is presented. Specifically, a multi-layered neural network is utilized for effective inverse kinematics, where a dynamic neural learning algorithm is employed for fast learning. Also, a bio-mimetic feature of general human fingers is incorporated to the learning scheme. The usefulness of the proposed approach is verified by simulations.

• Advances in nano research
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• v.14 no.1
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• pp.103-115
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• 2023

Recent developments in the synthesis of nanomagnesia of controlled sizes and shapes that are suitable for various applications are reviewed. Two main methods, based on liquid-phase synthesis, i.e., chemical methods and bio-based methods, are used to synthesize nanomagnesia. Conventionally, nanomagnesia was synthesized by chemical methods such as coprecipitation, sol-gel, combustion method, and so on using different chemical agents and stabilizers which later on become responsible for several biological risks because of the toxicity of used chemicals. Bio-based protocols are growing as another environmental friend method for the synthesis of various nanostructures especially nanomagnesia using biomass, plant extracts, alga, and fungi as a source of precursor material. The ideal method should offer better control of textural properties of nanostructures and decrease the necessity for purification of the synthesized nanoproducts, which sequentially removes the use of large amounts of chemicals and organic solvents and manipulation of products that are unsafe to the environment. Finally, the broad applicability of nanomagnesia in diverse areas is presented. Employment of nanomagnesia reported in several laboratory and industrial fields are valued from the standpoint of the significance of these issues for technological requests, as described in the literature. Nanomagnesia has various applications such as antimicrobial performance, removing pollutants, batteries application, and catalysis.

• Korean Journal of Acupuncture
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• v.21 no.4
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• pp.1-19
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• 2004

Objectives : To understanding biological mechanism of acupuncture therapy, we have proposed a hypothesis. First of all, there exists electric property in meridian and meridian point. Second of all, energy flowing in meridian is related with electric property. Third of all, there is electronic interaction between the operator who performs acupuncture therapy and the receiver who is given acupuncture therapy. Forth of all, acupuncture effects may depend on the electric capacity which is transferred between the operator and the receiver via acupuncture needle. Methods : Under the hypothesis, we studied the effects of electric change in $ST_{37}(+)\;and\;ST_{39}(-)$ generated by Tanchim (彈鍼) manipulation which was stimulated at $ST_{36}$ point. And compared with data on the changes of electric change from the hand of the operator during acupuncture stimulation. Electric charge induced via acupuncture needle from the operator may be important factor that causes the changes of electric change in meridian and acupoint in the receiver. Therefore we investigated the changes of electric charge induced by the operator using Maclab 400 by the following methods. The one was in stable electric circle condition and the other was in unstable electric circle condition. Results : In this experiments, the changes of electric change from the stimulation type of Tanchim manipulation performed in our lab condition in acupuncture therapy was induced at least three factor, one was the difference of bio-potentials between the operator and the receiver of acupuncture therapy, another was the depth of acupuncture insertion from the skin of the receiver, the other was an electromyogram of the receiver. Conclusion : The data imply that the first factor should make a capacitance current when the operator touched the acupuncture needle which was inserted in the receiver. Therefore, the results suggest that capacitance currents stimulus in electronic view may be important factor in acupuncture therapy between the operator and the receiver of acupuncture therapy.

• The KIPS Transactions:PartA
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• v.11A no.1
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• pp.75-80
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• 2004

To interact database data with GRID system, implementation and installation of data manipulation module which manipulates database data and its index is required. Developing a search system searching data on web-based database, and integrating it with grid system, it is possible that searching data on web and use it directly on GRID system without independent data module. So, we can build easy and effective grid system, and the system could have more flexible architecture adapting data change. In this paper, we propose a searching system which interacting web-based database with GRID systems. We integrated the searching system with a bio god system which runs virtual screening jobs. As a result, UB Grid (Universal Bio Grid) is constructed. Developer could reduce time and effort required to integrate web data to GRID system, and user could use UB Grid system easily and effectively.