• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권7호
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• pp.2919-2937
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• 2020

Post-Quantum Cryptography (PQC) is rapidly developing as a stable and reliable quantum-resistant form of cryptography, throughout the industry. Similarly to existing cryptography, however, it does not prevent a third-party from using the secret key when third party obtains the secret key by deception, unauthorized sharing, or unauthorized proxying. The most effective alternative to preventing such illegal use is the utilization of biometrics during the generation of the secret key. In this paper, we propose a biometric-based secret key generation scheme for multivariate quadratic signature schemes, such as Rainbow. This prevents the secret key from being used by an unauthorized third party through biometric recognition. It also generates a shorter secret key by applying Principal Component Analysis (PCA)-based Confidence Interval Analysis (CIA) as a feature extraction method. This scheme's optimized implementation performed well at high speeds.

• 정보보호학회논문지
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• 제28권6호
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• pp.1427-1437
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• 2018

최근 생체 인증 시스템이 확대됨에 따라, 생체 정보를 이용하여 공개키 기반구조(Bio-PKI)에 적용하는 연구들이 진행 중이다. Bio-PKI 시스템에서는 공개키를 생성하기 위해 생체 정보로부터 암호학적 키를 생성하는 과정이 필요하다. 암호학적 키 생성 방법 중 특성 정보를 숫자로 정량화하는 기법은 데이터 손실을 유발하고 이로 인해 키 추출 성능이 저하된다. 이 논문에서는 다중 분류 모델을 이용하여 생체 정보를 분류한 결과를 이용하여 키를 생성하는 방법을 제안한다. 제안하는 기법은 특성 정보의 손실이 없어 높은 키 추출 성능을 보였고, 여러 개의 분류 모델을 이용하기 때문에 충분한 길이의 키를 생성한다.

• 정보보호학회논문지
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• 제27권5호
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• pp.1059-1068
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• 2017

바이오해싱 기법은 생체 인식 템플릿으로부터 효과적으로 비트스트링 키를 생성할 수 있지만, 토큰 같은 사용자 입력 요소에 대한 의존도가 높아 토큰 도난 시 성능이 하락한다. 이러한 한계점을 개선하기 위하여, 본 논문에서는 얼굴 사진과 사용자 입력정보로부터 안전한 키를 생성하는 기법을 제시한다. 바이오해싱 기법과 GPT 기법을 사용하여, 인증 시사용자 입력정보에 대한 의존도를 조정하고, 충분한 길이의 안전한 키를 생성하도록 구성하였다. 제시한 기법을 입증하기 위하여 다양한 실험을 진행하고 결과를 보였다.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.19-27
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• 2022

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in many cancers such as non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck cancer. Mutations such as L858R in exon 21, exon 19 truncation (Del19), exon 20 insertions, and others are responsible for aberrant activation of EGFR in NSCLC. First-generation EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib have clinical benefits for EGFR-sensitive (L858R and Del19) NSCLC patients. However, after 10-12 months of treatment with these inhibitors, a secondary T790M mutation at the gatekeeper position in the kinase domain of EGFR was identified, which limited the clinical benefits. Second-generation EGFR irreversible inhibitors (afatinib and dacomitinib) were developed to overcome this T790M mutation. However, their lack of selectivity toward wild-type EGFR compromised their clinical benefits due to serious adverse events. Recently developed third-generation irreversible EGFR TKIs (osimertinib and lazertinib) are selective toward driving mutations and the T790M mutation, while sparing wild-type EGFR activity. The latest studies have concluded that their efficacy was also compromised by additional acquired mutations, including C797S, the key residue cysteine that forms covalent bonds with irreversible inhibitors. Because second- and third-generation EGFR TKIs are irreversible inhibitors, they are not effective against C797S containing EGFR triple mutations (Del19/T790M/C797S and L858R/T790M/C797S). Therefore, there is an urgent unmet medical need to develop next-generation EGFR TKIs that selectively inhibit EGFR triple mutations via a non-irreversible mechanism.

• Journal of Microbiology and Biotechnology
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• 제18권1호
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• pp.15-22
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• 2008

Four series (S, M, R, and W) of Alternaria longipes isolates were obtained based on consecutive selection with Dimethachlon (Dim) and ultraviolet irradiation. These isolates were then characterized according to their tolerance to Dim, sensitivity to osmotic stress, and phenotypic properties. All the selected Dim-resistant isolates showed a higher osmosensitivity than the parental strains, and the last generation was more resistant than the first generation in the M, R, and W series. In addition, the changes in the Dim resistance and osmotic sensitivity were not found to be directly correlated, and no distinct morphologic characteristics were found among the resistant and sensitive isolates, with the exception of the resistant isolate K-11. Thus, to investigate the molecular basis of the fungicide resistance, a group III two-component histidine kinase (HK) gene, AlHK1, was cloned from nineteen A. longipes isolates. AlHK1p was found to be comprised of a six 92-amino-acid repeat domain (AARD), HK domain, and response regulator domain, similar to the Os-1p from Neurospora crassa. A comparison of the nucleotide sequences of the AlHK1 gene from the Dim-sensitive and -resistant isolates revealed that all the resistant isolates contained a single-point mutation in the AARD of AlHK1p, with the exception of isolate K-11, where the AlHK1p contained a deletion of 107 amino acids. Moreover, the AlHK1p mutations in the isolates of each respective series involved the same amino acid substitution at the same site, although the resistance levels differed significantly in each series. Therefore, these findings suggested that a mutation in the AARD of AlHK1p was not the sole factor responsible for A. longipes resistance to dicarboximide fungicides.

• Journal of Microbiology and Biotechnology
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• 제34권7호
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• pp.1395-1400
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• 2024

The antimicrobial activity of the natural compounds from plant and food have well discovered since the interest on the beneficial effect of the natural compounds was risen. Quercetin, a flavonoid derived from vegetables, including onions, red leaf lettuces and cherries has been studied for diverse biological characteristics as anti-cancer and anti-microbial activities. The aim of current study is to investigate the specific antibacterial modes of action of quercetin against Escherichia coli. Quercetin decreased the E. coli cell viability and induced the severe damages (oxidative stress, DNA fragmentation) leading to cell death. Reactive oxygen species (ROS) generation was observed during the process, which we confirmed that oxidative stress was the key action of antibacterial activity of quercetin exerting its influence potently. Based on the results of Annexin V and Caspace FITC-VAD-FMK assay, the oxidative damage in E. coli has led to the bacterial apoptosis-like death in E. coli. To sum up, the contribution of ROS generation exerts crucial impact in antibacterial activity of quercetin.

• 식품보건융합연구
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• 제10권4호
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• pp.1-8
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• 2024

This study investigates the impact of servicescape elements in franchise fast food restaurants on the attitudes and revisit intentions of Generation MZ. Employing a mixed-methods approach, we surveyed 231 MZ consumers across five major urban centers. Our findings reveal that ambient conditions, spatial layout, and technology integration significantly influence MZ consumers' perceptions and behaviors. Specifically, sustainability-oriented design, customizable spaces, and seamless digital integration emerged as key drivers of positive attitudes and increased revisit intentions. Furthermore, we identify important generational differences, with Gen Z placing higher importance on Instagram-worthy aesthetics and contactless service options compared to Millennials. This research contributes to servicescape theory by proposing a novel framework tailored to MZ consumers in the fast food context. It offers practical implications for franchise operators seeking to attract and retain this crucial demographic. Our study highlights the evolving preferences of younger consumers and underscores the need for adaptable servicescape strategies in the fast food industry. The results suggest that franchises investing in environmentally conscious designs, flexible spaces, and cutting-edge technology are likely to see improved customer satisfaction and loyalty among MZ consumers. Future research could explore the long-term effects of these servicescape elements on brand perception and market share within the competitive fast food landscape.

• 식품보건융합연구
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• 제9권5호
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• pp.7-11
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• 2023

Purpose: The purpose of this study is to analyze current trends in the Korean ice cream industry and determine how these trends affect the competitiveness of each ice cream company. Method: This study was conducted by reviewing existing related literature and collecting and analyzing data from news articles, corporate reports, and existing researchers' studies related to the ice cream industry. Results: The Korean ice cream industry is growing and developing through the collaboration of fun marketing with taste, quality, and fun elements, and the young MZ generation can be said to be the main customer base. In terms of quality, premium ice cream made with high-quality domestic ingredients has recently been gaining popularity, and ice cream with reduced fat and sugar, such as plant-based substitutes, is also gaining popularity among consumers. Conclusions and Implications: The results of this study highlight the need for continued innovation in the Korean ice cream industry. The industry must also capitalize on the growth of online sales and the global appeal of Korean pop culture. Sustainability efforts, technology adoption, and strategic collaboration are key drivers for future industry success, and social media engagement must be integrated into marketing strategies to increase brand awareness and consumer loyalty.

• Korean Circulation Journal
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• 제53권1호
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• pp.1-16
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• 2023

Recently, single cell RNA sequencing (scRNA-seq) technology has enabled the discovery of novel or rare subtypes of cells and their characteristics. This technique has advanced unprecedented biomedical research by enabling the profiling and analysis of the transcriptomes of single cells at high resolution and throughput. Thus, scRNA-seq has contributed to recent advances in cardiovascular research by the generation of cell atlases of heart and blood vessels and the elucidation of mechanisms involved in cardiovascular development and diseases. This review summarizes the overall workflow of the scRNA-seq technique itself and key findings in the cardiovascular development and diseases based on the previous studies. In particular, we focused on how the single-cell sequencing technology can be utilized in clinical field and precision medicine to treat specific diseases.

• 벤처창업연구
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• 제4권1호
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• pp.1-27
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• 2009

바이오산업은 연구개발 비중이 크고 원천기술 확보가 중요한 기술집약적 고부가가치 산업으로서 전 세계 각국이 정책적으로 지원 및 육성하고 있는 차세대 성장 동력 산업이다. 본 연구는 한국 바이오산업의 발전방안 제언을 목표로 동 산업의 발전요인을 도출하고, 계층분석법(AHP)을 적용하여 도출된 요인간의 우선순위 등을 분석하였다. 분석결과 바이오산업의 발전을 위해서는 현재와 2015년 시점 모두에서 기술역량이 가장 핵심요인임을 확인할 수 있었고, 기초원천기술개발과 기술개발 주체인 산학연의 연구개발 및 협력체계 강화를 위한 정책적 지원과 투자가 절실히 필요함을 알 수 있었다. 덧붙여, 바이오산업 핵심원천기술 개발 및 효율적인 연구개발체계 개선, 전통 바이오산업의 보호 육성 및 창의적인 유망 신 시장 개척, 핵심원천기술의 개발을 위한 산학연 및 학제간 긴밀한 협력 관계 구축, 효율적인 지원을 통한 바이오벤처기업 육성 등 5가지의 한국바이오산업 발전방안을 제언하였다.