• 대한치과보철학회지
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• 제54권3호
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• pp.259-266
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• 2016

하악 완전 무치악 환자의 보철수복에 있어 임플란트 식립 후 피개의치 제작은 첫 번째 치료 옵션으로 고려된다. 코너스 타입 부착장치를 이용한 피개의치는 견고한 지지를 제공하고 cross arch stabilization을 이루도록 하여 교합압을 균일하게 분산시키며, 의치에 의한 이차 고정으로 장기간의 안정성을 제공한다. 최근 소개된 팔라듐-은(Pd-Ag) 합금(Innovium)은 팔라듐, 은, 금 등의 귀금속 함량이 72% 이상인 CAD-CAM 시스템 전용 귀금속 합금으로 코너스 타입 부착장치를 제작하는데 적합한 물성을 가지고 있다. 본 증례에서는 완전 무치악 환자에서 상악에는 통상적인 총의치, 하악에는 임플란트를 4개 식립한 후에 코너스 타입 부착장치 피개의치 수복을 하였다. CAD-CAM 시스템을 이용하여 팔라듐-은 합금(Innovium)으로 제작된 코너스 타입 부착장치를 장착하였으며 이를 통해 의치의 유지와 안정을 향상시켰으며 만족할 만한 결과를 얻었기에 보고하고자 한다.

• International Journal of Vascular Biomedical Engineering
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• 제3권2호
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• pp.10-16
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• 2005

Because patients with coronary artery disease (CAD) have depressed vagal modulation and the mortality risk from acute myocardial infarction is lower in patients with higher vagal modulation, methods that can increase vagal modulation are desirable in patients with CAD. We intended to inspect the effect of recumbent posture on vagal modulation. By using angiography, 33 patients with abnormal (CAD group) and 33 patients with normal coronary arteries (control group) were studied. The nonlinear as well as the linear characteristics of heart rate variability (HRV) were analyzed on these patients in three recumbent postures: namely, the supine, right lateral decubitus, and left lateral decubitus postures. The lower the normalized high-frequency power (nHF) in the supine or left lateral decubitus posture, the higher the increase in the nHF when the posture was changed from supine or left lateral decubitus to right lateral decubitus in both groups of patients. Right lateral decubitus posture can lead to the highest vagal modulation and the lowest sympathetic modulation among the three recumbent postures in both normal and patients with CAD. Therefore, the right lateral decubitus posture can be used as an effective physiologic vagal enhancer in patients with CAD.

• 한국정밀공학회지
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• 제26권12호
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• pp.138-145
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• 2009

Custom medical treatment is being widely adapted to lots of medical applications. A technology for 3D modeling is strongly required to fabricate medical implants for individual patient. Needs on true 3D CAD data of a patient is strongly required for tissue engineering and human body simulations. Medical imaging devices show human inner section and 3D volume rendering images of human organs. CT or MRI is one of the popular imaging devices for that use. However, those image data is not sufficient to use for medical fabrication or simulation. This paper mainly deals how to generate 3D geometry data from those medical images. A new image processing technology is introduced to reconstruct 3D geometry of a human body vacancy from the medical images. Then a surface geometry data is reconstructed by using Marching cube algorithm. Resulting CAD data is a custom 3D geometry data of human vacancy. This paper introduces a novel 3D reconstruction process and shows some typical examples with implemented software.

• 구강회복응용과학지
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• 제31권4호
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• pp.364-370
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• 2015

최근 구치부 부분 무치악 환자의 임플란트 보철 수복은 기능적뿐만 아니라 심미적으로도 환자의 만족을 이끌어내야 하는 과제를 안고 있다. 이렇게 환자의 요구가 높아지면서 상실된 자연치아와 유사한 형태의 임플란트 보철을 사용한 구강회복이 보철수복의 중요한 이슈가 되고 있다. 이를 위해서는 기성 지대주 보다는 더 넓은 customized CAD/CAM 지대주를 사용함으로써 자연스러운 출현윤곽을 재현할 수 있다. 넓은 지대주를 지지해주기 위해서는 충분한 폭과 높이를 가지는 각화치은이 존재해야 하는데, 만약 긴 치아상실기간이나 골이식술 등으로 인해 임플란트 주위에 각화치은이 부족한 경우에는 연조직 증대술을 시행하는 것이 추천된다. 이러한 과정을 통해 심미적이고 기능적인 임플란트 보철 제작이 가능하며 구강위생관리를 용이하게 하고 향후 임플란트 주위염의 발생 가능성을 감소시킨다. 본 증례는 구치부 부분 무치악 환자에서 골이식술, 상악동 이식술, 임플란트 식립술 및 연조직 이식술을 사용하여 부족한 치조골과 각화치은 및 협측전정을 회복하였으며, customized CAD/CAM 지대주와 지르코니아 보철물을 이용하여 수복한 증례로 주기적인 내원 및 검사를 통해 기능적, 심미적으로 만족할만한 결과를 얻었기에 이 사례를 보고하고자 한다.

• 한국CDE학회논문집
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• 제12권6호
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• pp.429-440
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• 2007

The purpose of this research is to develop the Human-centered CAD system in which human factors can be considered during the design stage. For this system there are several issues to research, like the digital human modeling technology, the definition of interactions between human and product, the simulation of human motion when using the product, and the bio-mechanical analysis of human, etc. This paper introduces how to construct the kinematical structure of the digital human model. For our digital human model H-ANIM, the international specification of humanoid animation is referenced. And we added the skeleton geometry and the skin surfaces to our model. And it can manipulate its joints by forward kinematics. Also the IKAN inverse kinematics algorithm is adopted to support the posture prediction of the digital human model in the product environment. All of these ideas are implemented using CAD API so that we can apply these functions to the current commercial CAD systems. In this manner, the human factor issues can be effectively taken into account at the early design phase and the costs of bio-mechanical evaluation will be significantly reduced.

• 구강회복응용과학지
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• 제31권3호
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• pp.231-241
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• 2015

환자의 심미적 요구가 증가함에 따라 전치뿐만 아니라 구치부에서도 자연치아와 유사한 색조와 외형을 재현한 보철물에 대한 필요성이 증가하고 있다. 단일 지르코니아와 CAD/CAM 시스템을 통해 이러한 환자의 요구를 만족시키는 보철물 제작이 가능해졌다. 본 증례는 70세 여자환자로 전치부 보철물이 깨져서 보기 싫고 하악 구치부가 없어서 저작이 불편하다는 주소로 내원하였다. 하악 구치의 상실로 교합평면이 붕괴되었으며 과도한 치아 마모 및 수직고경 상실이 관찰되어 치아 상실 부위에 임플란트를 식립하고 수직고경 증가와 함께 지르코니아 고정성 보철물을 이용한 전악 수복 치료를 진행하였다. 치료 후 3년 간 이상적인 교합이 잘 유지되고 기능적, 심미적으로 만족한 결과를 얻었기에 이를 보고하는 바이다.

• Journal of the Korean Wood Science and Technology
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• 제47권4호
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• pp.442-450
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• 2019

Despite its potential as a renewable source for fuels and chemicals, lignin valorization still faces technical challenges in many aspects. Overcoming such challenges associated with the chemical recalcitrance of lignin can provide many opportunities to innovate existing and emerging biorefineries. In this work, we leveraged a biomass genetic engineering technology to produce phenolic aldehyde-rich lignin structure via downregulation of cinnamyl alcohol dehydrogenase (CAD). The structurally altered lignin obtained from the Arabidopsis thaliana CAD mutant was pyrolyzed to understand the effect of structural alteration on thermal behavior of lignin. The pyrolysis was conducted at 400 and $500^{\circ}C$ using an analytical pyrolyzer connected with GC/MS and the products were systematically analyzed. The results indicate that aldehyde-rich lignin undergoes fragmentation reaction during pyrolysis forming a considerable amount of C6 units. Also, it was speculated that highly reactive phenolic aldehydes facilitate secondary repolymerization reaction as described by the lower yield of overall phenolic compounds compared to wild type (WT) lignin. Quantum mechanical calculation clearly shows the higher electrophilicity of transgenic lignin than that of WT, which could promote both fragmentation and recondensation reactions. This work provides mechanistic insights toward biomass genetic engineering and its application to the pyrolysis allowing to establish sustainable biorefinery in the future.

• KSBB Journal
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• 제10권1호
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• pp.97-104
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• 1995

1. 돼지 성장호르몬을 연간 6000Kg을 생산하는 공장의 공정 설계를 Macintosh PC를 사용한 Bio D Designer를 이용해서 공정모사를 해 보았다. 각 단 위공정의 계산자를 정하기 위한 계산을 가정과 플라 스크배양의 결과를 이용하여 up-stream을 설계하고, downstream에서는 25%의 분리정제 수율을 가 정하고 전체공정을 설계하였다. 2. 경제성 분석에 의하연 돼지 성장호르몬의 dose 당 $ 2.00로 할 때 투자상환율 (return on invest­m ment, ROI)이 일 년에 104%이었으며, 투자금액의 상환에 걸리는 시간은 약 1년(0.96\건)이 걸리는 것으로 나왔다. 3. Sensitivity분석에 의하면 투자상환율은 돼 지 성장호르몬의 수율, 가격, 사용량 및 시장잠식율 순서의 변수에 의해 결정되는 것을 알 수 있었다.

• Genomics & Informatics
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• 제12권4호
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• pp.181-186
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• 2014

Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE) data: type 2 diabetes mellitus (DM), hypertension (HT), and coronary artery disease (CAD). We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE). Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

• 한국산업융합학회 논문집
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• 제20권5호
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• pp.359-364
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• 2017

A machine such as bean crusher machine is subjected to different loads and vibration. Due to this vibration there will be certain deformations which affect the performance of the machine in adverse manner. This paper proposed a vibration analysis of bean crusher machine using ANSYS. The Finite Element Method (FEM) analysis is carried out to study the effect of vibration on the structure in order to ensure the safety. This work helps the machine developer make a better product at the early design stage with lower cost and faster development time. To do this, firstly, using Inventor, a CAD model is prepared. Secondly, the analysis is to be carried out using ANSYS 15. The modal analysis and random vibration analysis of the structure was conducted. The analysis shows that the proposed design was successfully shows the minimum deformation when the vibration was applied in normal condition.