• Archives of Pharmacal Research
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• 제27권6호
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• pp.676-681
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• 2004

Acetyl-L-camitine (ALC), a naturally occurring endogenous compound, has been shown to improve the cognitive performance of patients with senile dementia Alzheimer＇s type, and to be involved in cholinergic neurotransmission. Because ALC is an endogenous compound, valida-tion of the analytical methods of ALC in the biological fluids is very important and difficult. This study was presented validation and correction for plasma ALC concentrations and pharmacok-inetics after oral administration of ALC to human volunteers. ALC concentrations in human plasma were corrected by subtracting the concentration of blank plasma from each sample. Precision and accuracy (bias %) for uncorrected ALC concentrations were below 2.6 and 6.5% for intra-days, and 4.0 and 9.4% for inter-days, respectively. Precision and accuracy (bias %)for corrected ALC concentrations were below 10.9 and 6.0% for intra-days, and 10.5 and 16.9% for inter-days, respectively. Quantitation limit was $0.1{\;}\mu\textrm{g}／mL$. After oral administration of a 500 mg ALC tablet to 8 healthy volunteers, the principle pharmacokinetic parameters were 4.2 h of the half-life$ (t_{1/2},{\beta})$, the area under the curve $(AUC_{0{\rightarrow}8){\;}of{\;}9.88{\;}\mu\textrm{g}{\cdot}h/mL$, and 3.1 h of the time ($T_{max}$) to reach $C_{max}$. This study first describes the pharmacokinetic study after oral admin-istration of a single dose of ALC in human volunteers.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2016년도 학술발표회
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• pp.203-203
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• 2016

The linkage between climate change and water security, i.e., the response of water resource to the future climate change, have been of great concern to both scientific community and policy makers. In this study, the impact of future climate on water resources in Yellow River Basin in North of China has been investigated using the Coupled Land surface and Hydrology Model System (CLHMS) and IPCC AR5 projected future climate change in the basin. Firstly, the performances of 14 IPCC AR5 models in reproducing the observed precipitation and temperature in China, especially in North of China, have been evaluated, and it's suggested most climate models do show systematic bias compared with the observation, however, CNRM-CM5、HadCM5 and IPSL-CM5 model are generally the best models among those 14 models. Taking the daily projection results from the CNRM-CM5, along with the bias-correction technique, the response of water resources in Yellow river basin to the future climate change in different emission scenarios have been investigated. All the simulation results indicate a reduction in water resources. The current situation of water shortage since 1980s will keep continue, the water resources reduction varies between 28 and 23% for RCP 2.6 and 4.5 scenarios. RCP 8.5 scenario simulation shows a decrease of water resources in the early and mid 21th century, but after 2080, with the increase of rainfall, the extreme flood events tends to increase.

• 한국지구과학회지
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• 제36권1호
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• pp.109-124
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• 2015

레이더 반사도를 이용한 강수추정의 개선을 위해 새로운 접근 방식인 경북대학교에서 개발한 하이브리드 고도면을 이용한 강수량 추정기법(Hybrid Surface Rainfall, KNU-HSR)을 사용하였다. KNU-HSR기법은 지형에코와 레이더 빔차폐의 영향을 받지 않는 2차원 하이브리드 고도면에서의 반사도를 이용하여 강수량을 추정한다. 본 연구에서는 정적 HSR 및 동적 HSR기법이 사용되었으며 비교 검증되었다. 정적 HSR은 빔차폐지도와 지형에코지도를 사용하며, 동적 HSR은 정적 HSR에 추가적으로 실시간 퍼지로직 품질관리를 통한 품질지수지도를 사용한다. 검증을 위해 상관계수(correlation coefficient), 총비율(total ratio), 평균편의(mean bias), 정규화된 표준편차(normalized standard deviation), 평균 상대오차(mean relative error)를 사용하였으며, 10개 강우사례의 지상우량계 강우자료를 이용하여 두 HSR의 강우추정 성능을 평가하였다. 모든 검증지수에서 동적 HSR은 반사도 보정을 하지 않은 정적 HSR에 비해 더 우수한 성능을 보였다. 동적 HSR은 레이더로부터 근거리에서는 과대추정하였으며 원거리에서는 빔 폭 확장 및 빔 고도증가로 인해 과소추정하였다. 동적 HSR의 정규화된 표준편차와 평균상대오차는 레이더로부터의 거리에 관계없이 가장 좋은 결과를 보였다. 정적 HSR은 약한 강우강도에서 상당히 과대추정하였으나 동적 HSR은 모든 강우강도에서 1.0에 총비율을 보였다. 반사도의 시스템오차 보정 후, 동적 HSR의 정규화된 표준편차와 평균상대오차는 각각 약 20%와 15%로 개선되었다.

• 대한방사선기술학회지:방사선기술과학
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• 제41권3호
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• pp.193-199
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• 2018

The purpose of this study was to evaluate the convenience and image quality of patients with acute lumbar pain patients at a general hospital in Daejeon using ancillary devices for postural changes and correction. The results of the study are summarized as follows. First, the Turbo S pin Echo technique(TS E) using ancillary equipment has the highest image evaluation rating with an average score of 4.440, which is highly valuable on a diagnosis. Second, the average score for patient the questionnaire 'When using ancillary equipment, I feel that my body is calibrated to side without bias.' was shown as 4.440, which is very useful for the correction of the patient's body when using ancillary equipment. Finally, Breath Hold technique(BH) is very effective in shortening test time of acute lumbar pain patients, because it can reduce test time 86.4% faster than Turbo Spin Echo technique(TSE). The results of the study showed that the use of ancillary equipment to perform the test through the side lying postures helped to reduce the pain and control the patient's breathing, and the diagnostic value of the image was high.

• 전력전자학회논문지
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• 제20권3호
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• pp.214-222
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• 2015

The superiority of gallium nitride FET (GaN FET) over silicon MOSFET is examined in this paper. One of the outstanding features of GaN FET is low reverse-recovery charge, which enables continuous conduction mode operation of totem-pole bridgeless boost power factor correction (PFC) circuit. Among many bridgeless topologies, totem-pole bridgeless shows high efficiency and low conducted electromagnetic interference performance, with low cost and simple control scheme. The operation principle, control scheme, and circuit implementation of the proposed topology are provided. The converter is driven in two-module interleaved topology to operate at a power level of 5.5 kW, whereas phase-shedding control is adopted for light load efficiency improvement. Negative bias circuit is used in gate drivers to avoid the shoot-through induced by high speed switching. The superiority of GaN FET is verified by constructing a 5.5 kW prototype of two-module interleaved totem-pole bridgeless boost PFC converter. The experiment results show the highest efficiency of 98.7% at 1.6 kW load and an efficiency of 97.7% at the rated load.

• 대한공간정보학회지
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• 제20권3호
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• pp.19-27
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• 2012

바람은 기상, 기후, 신재생 에너지 등 다양한 분야에서 널리 활용되는 매우 중요한 요소 중 하나이다. 이 연구에서는 우선, 중규모 기상모델 WRF를 이용하여 우리나라의 전역에 대하여 2006년도를 대상으로 수치 시뮬레이션을 수행하여, 시공간적 상세 바람정보를 생산하였다. 수치모의 된 풍속은 관측풍속과 비교하여 공간적 및 계절적 특징을 비교적 잘 나타내었으나, 전반적으로 다소 과대 모의되는 경향을 보였다. 이러한 예측오차를 줄이기 위하여, 위성원격탐사로부터 생산된 지표특성 변수인 LST와 NDWI를 사용한 예측풍속의 통계적 보정 알고리즘을 개발하고, 다중회귀분석에 의하여 보정식의 토지피복별 상수와 계수를 도출하였다. 제안된 보정 알고리즘에 의하여 최종적으로 보정된 풍속은 관측풍속과 비교하여 높은 상관관계, 0.4 m/s 미만의 RMSE, 0에 가까운 BIAS로 매우 높은 일치성을 보였다. 따라서, 이 연구에서 제안한 위성원격탐사자료를 활용한 통계적 보정 알고리즘은 중규모 수치모의에 의한 예측오차를 개선하고 보다 정확한 한반도 바람정보를 생산하는데 있어서 간략하고 유용한 수단이 될 수 있으리라 기대된다.

• 대기
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• 제31권5호
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• pp.637-656
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• 2021

The United States has been known as the world's major producer of crops such as wheat, corn, and soybeans. Therefore, using meteorological long-term forecast data to project reliable crop yields in the United States is important for planning domestic food policies. The current study is part of an effort to improve the seasonal predictability of regional-scale precipitation across the United States for estimating crop production in the country. For the purpose, a dynamic downscaling method using Weather Research and Forecasting (WRF) model is utilized. The WRF simulation covers the crop-growing period (March to October) during 2000-2020. The initial and lateral boundary conditions of WRF are derived from the Pusan National University Coupled General Circulation Model (PNU CGCM), a participant model of Asia-Pacific Economic Cooperation Climate Center (APCC) Long-Term Multi-Model Ensemble Prediction System. For bias correction of downscaled daily precipitation, empirical quantile mapping (EQM) is applied. The downscaled data set without and with correction are called WRF_UC and WRF_C, respectively. In terms of mean precipitation, the EQM effectively reduces the wet biases over most of the United States and improves the spatial correlation coefficient with observation. The daily precipitation of WRF_C shows the better performance in terms of frequency and extreme precipitation intensity compared to WRF_UC. In addition, WRF_C shows a more reasonable performance in predicting drought frequency according to intensity than WRF_UC.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2020년도 학술발표회
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• pp.202-202
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• 2020

산지 및 도시에서 발생하는 돌발홍수가 대상인 예경보는 홍수 도달시간이 짧고, 수위가 급격하게 상승하는 특성 때문에 1시간 선행시간 확보를 목표로 한다(MOLIT, 2016). 그러나 현재 돌발홍수 예경보 process에 소요되는 시간은 그 이상으로 확인되고 있다. 또한, 돌발홍수 예경보시스템으로부터 출력된 예측 결과를 사람이 직접 확인해야 한다는 단점도 있다. 본 연구에서는 돌발홍수 예경보 선행시간 1시간 확보를 목표로 backward-forward tracking 기법 기반 예측강우 편의보정기법을 제안하고자 한다. 이 기법은 현재 시점보다 이전에 보정계수를 결정함으로써 돌발홍수 예경보 소요시간을 크게 줄여 돌발홍수 대피시간을 확보할 수 있게 한다. 또한, 보정계수의 결정과 적용이 연속적으로 이루어짐에 따라 10분 간격으로 생성되는 MAPLE의 지속적인 편의보정이 가능하다. 예측강우에 대한 보정계수는 현재보다 10분 이전에 결정한다. 즉, 10분 이전 시점에 생성된 10분, 70분 선행 예측강우에 backward tracking을 적용하여 현재 시점의 호우 위치인 target window를 찾는다. 그리고 target window에서 보정계수를 결정한다. 결정된 보정계수는 돌발홍수발령 대상지역인 correction window의 현재 생성된 60분 선행 예측강우에 적용한다. 이 과정에서 과거 시점 10분 선행 예측강우와 현재 시점에 생성된 60분 선행 예측강우와의 forward tracking이 수행된다. Storm tracking 기법으로는 두 예측강우의 호우패턴에 대한 유사성을 정량화한 패턴상관계수를 이용하였다. 대상 호우사상으로는 2016년에 발생한 주요 호우사상을 선정하였다. 본 연구에서 제안하는 기법을 적용하고, 편의보정 결과를 기존 편의보정기법 적용 결과와 비교하였다.

• 대기
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• 제34권1호
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• pp.23-34
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• 2024

The Korea Meteorological Administration has improved medium-range weather forecasts by implementing post-processing methods to minimize numerical model errors. In this study, we employ a statistical correction technique known as the minimum continuous ranked probability score (CRPS) to refine medium-range forecast guidance. This technique quantifies the similarity between the predicted values and the observed cumulative distribution function of the Unified Model Ensemble Prediction System for Global (UM EPSG). We evaluated the performance of the medium-range forecast guidance for surface air temperature and relative humidity, noting significant enhancements in seasonal bias and root mean squared error compared to observations. Notably, compared to the existing the medium-range forecast guidance, temperature forecasts exhibit 17.5% improvement in summer and 21.5% improvement in winter. Humidity forecasts also show 12% improvement in summer and 23% improvement in winter. The results indicate that utilizing the minimum CRPS for medium-range forecast guidance provide more reliable and improved performance than UM EPSG.

• Journal of Positioning, Navigation, and Timing
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• 제13권1호
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• pp.85-92
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• 2024

This study develops a Global Positioning System (GPS) Code Multipath Grid Map (CMGM) of each individual domestic reference station from the extracted code multipath of measurement data. Multipath corresponds to signal reflection/refraction caused by obstacles around the receiver antenna, and it is a major source of error that cannot be eliminated by differencing. From the receiver-independent exchange format (RINEX) data for two days, the associated code multipath of a satellite tracking arc is extracted. These code multipath data go through bias correction and interpolation to yield the CMGM with respect to the azimuth and elevation angles. The effect of the CMGM on multipath mitigation is then quantitatively analyzed to improve the Root Mean Square (RMS) of averaged pseudo multipath. Furthermore, the single point positioning (SPP) accuracy is analyzed in terms of the RMS of the horizontal and vertical errors. During two weeks in February 2023, the RMSs of the averaged pseudo multipath for five reference stations decreased by about 40% on average after CMGM application. Also, the SPP accuracies increased by about 7% for horizontal errors and about 10% for vertical errors on average after CMGM application. The overall quantitative analysis indicates that the proposed approach will reduce the convergence time of Differential Global Navigation Satellite System (DGNSS), Real-Time Kinematic (RTK), and Precise Point Positioning (PPP)-RTK correction information in real-time to use measurement data whose code multipath is corrected and mitigated by the CMGM.