• Archives of Pharmacal Research
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• 제25권6호
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• pp.781-785
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• 2002

A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50∼100 times greater antitumor activities than the commercial product, Cisplatin.

• Archives of Pharmacal Research
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• 제23권2호
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• pp.99-103
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• 2000

Acid and base catalyzed intramolecular cyclizations of N-benzoylthioureidoacetal, contain-ing four functional groups adjacent to thiourea such as benzocarbamoyl, acetal, thioure and amide, were investigated. The condensation reaction of N-benzoyl thiocarbamoylgly-cine amide in the presence of 10% aqueous NaOH provided 1-(2,2-dimethoxy)ethyl-imi- dazolidine-2-thione exclusively. In the presence of pyridine, it was transformed to 2- thiohydantoin. N-Benzoyl thiocarbamoyl glycine amide was completely transformed to an iminothiazolidine exclusively in the presence of Lewis acid such as borontrifluoride ether-ate or trimethylsilyl iodide. 1-(2,2-Dimethoxy)ethyl-imidazolidine-2-thione was transformed to imidazole[2,1-b]thiazole and pyrazino[5,1-a]imidazole in the presence of $BF_3$.$ET_2$O and formic acid, respectively.

• 농약과학회지
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• 제9권2호
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• pp.153-158
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• 2005

광학활성 1-${\alpha}$-methylbenzylphenylurea 유도체의 bensulfuron-methyl, pyribenzoxim에 대한 약해경감효과를 조사하였다. 대부분의 유도체가 담수토양처리시험에서도 제초제 bensulfuron-methyl에 의한 벼의 근부신장 저해에 대하여 높은 약해경감효과를 나타내었다. 특히, S-이성체의 2,3-diCl 치환체와 2-F-4-Me 치환체는 dymuron 보다 4배 높은 약해경감효과를 나타내었으며 두 치환체들은 동시 혼합처리뿐만 아니라 4일 후의 지연처리에서도 bensulfuron-methyl의 약해를 효과적으로 경감하였다. S-이성체의 2-F-4-Me치환체는 벤조산계 제초제 pyribenzoxim에 대해서도 지상부, 근부 모두 95%의 높은 약해경감효과를 나타내었다.