• Journal of Microbiology and Biotechnology
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• 제24권10호
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• pp.1327-1336
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• 2014

Bacillus amyloliquefaciens strain NJZJSB3 has shown antagonism of several phytopathogens in vitro, especially Sclerotinia sclerotiorum. Both the broth culture and cell suspension of strain NJZJSB3 could completely protect the detached leaves of canola (Brassica napus) from S. sclerotiorum infection. In pot experiments, the application of strain NJZJSB3 cell suspension ($10^8CFU/ml$) decreased the disease incidence by 83.3%, a result similar to commercially available fungicide (Dimetachlone). In order to investigate the potential biocontrol mechanisms of strain NJZJSB3, the nonvolatile antifungal compounds it produces were identified as iturin homologs using HPLC-ESI-MS. Antifungal volatile organic compounds were identified by gas chromatography-mass spectrometry. The detected volatiles toluene, phenol, and benzothiazole showed antifungal effects against S. sclerotiorum in chemical control experiments. Strain NJZJSB3 also produced biofilm, siderophores and cell-wall-degrading enzymes (protease and ${\beta}$-1,3-glucanase). These results suggest that strain NJZJSB3 can be a tremendous potential agent for the biological control of sclerotinia stem rot.

• 폴리머
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• 제37권3호
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• pp.269-275
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• 2013

화학적 구조가 다른 thiuram계 TMTD(tetramethyl thiuram disulfide), DPTT(dipenta-methylene thiuram tetrasulfide), thiazole계 MBT(2-mercapto benzothiazole), MBTS(2,2-dithiobis(benzo-thiazole)), sulfenamide계 CBS(n-cyclohexyl benzothiazyl-2-sulfenamide), NOBS(n-oxydiethylene benzo-thiazyl-2-sulfenamide), 아연이 포함된 thiuram계 ZDBC(zinc di-n-butyl-dithiocarbamate)를 사용하여 각각의 촉진제가 실리카와 카본블랙으로 충전된 천연 고무 복합소재의 가황 속도 및 가황 지수에 미치는 영향을 비교 평가하였다. 양 시스템에서 가황 속도는 thiuram계, thiazole계, sulfenamide계의 순서로 동일한 경향을 보였다. 각 촉진제에 대하여 실리카 컴파운드는 카본블랙 컴파운드에 비해 $t_{s2}$, $t_{10}$, $t_{90}$에 도달하는 시간이 느리게 나타났으며 느린 가황 지수(CRI)를 나타내었다.

• BMB Reports
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• 제43권6호
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• pp.413-418
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• 2010

Beta-Amyloid ($A{\beta}$)-induced neuroinflammation is one of the key events in the development of neurodegenerative disease. We previously reported that KHG21834, a benzothiazole derivative, attenuates $A{\beta}$-induced degeneration of cortical and mesencephalic neurons in vitro. In the present work, we show that KHG21834 reduces $A{\beta}$-mediated neuroinflammation in brain. In vivo intracerebroventricular infusion of KHG21834 leads to decreases in the numbers of activated astrocytes and microglia and level of proinflammatory cytokines such as interleukin-$1{\beta}$ and tumor necrosis factor-$\alpha$ induced by $A{\beta}$ in the hippocampus. This suppression of neuroinflammation is associated with decreased neuron loss, restoration of synaptic dysfunction biomarkers in the hippocampus to control level, and diminished amyloid deposition. These results may suggest the potential therapeutic efficacy of KHG21834 for the treatment of $A{\beta}$-mediated neuroinflammation.

• 약학회지
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• 제41권2호
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• pp.187-194
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• 1997

For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hete ro cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50${\mu}g$/ml). On the other hand, the other compounds had no activity.

• 한국응용과학기술학회지
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• 제18권4호
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• pp.292-297
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• 2001

Zinc complexes with Bis[2-(o-hydroxyphenyl) benzothiazolato ligands (ZnPBS-0) and Bis[2- (o-hydroxynaphthyl) benzothiazolato ligands (ZnPBS-05) were synthesized, and luminescent properties of these materials were investigated. The emission band found that it strongly depends on the molecular structure of introduced ligand and was tuned from 525 nm to 535 nm by changing the ligand structures. Spreading of the ${\pi}-conjugation$ in 2-(o-hydroxyphenyl) group gives rise to a blue shift. On the other hand, spreading of the ${\pi}-conjugation$ in benzothiazole groups leads to a red shift. The EL properties also showed good consistency with their differences of ligand structure. Bright-blue EL emission with a maximum luminance of 8300 $cd/m^{2}$ at 11V was obtained from the organic light - emitting diodes (OLEDs) using ZnPBS-0 as emitting layer. It was also found that the newly synthesized materials were suitable to be used as emitting materials in organic EL device.

• 약학회지
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• 제20권1호
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• pp.19-26
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• 1976

Sixteen compounds of 2-aminobenzothiazole derivatives were synthesized from alkyl ($C_{1-5}$) p-aminosalicylate by thiocyanation reaction. The NMR spectra of synthesized compounds showed that they were actually mixture of 5-hydroxy-6-alk-oxycarbonyl-2-aminobenzothiazole [alkoxy=methoxy(Ia), ethoxy (IIa), n-propoxy (IIIa), iso-propoxy (IVa), n-butoxy (Va), iso-butoxy (VIa), n-amoxy (VIIa), iso-amoxy(VIIIa)] and 7-(1b), ethoxy(IIb), n-propoxy(IIIb), iso-propoxy(IVb), n-butoxy(Vb), iso-butpxy (VIb), n-amoxy (VIIb), iso-amoxy (VIIIb)]. The mixtures of two isomeric benzothiazole were separated by two isomers varied with the kind of alkyl chain in alkyl p-aminosalicylate. These compounds were subjected to the test for antimicrobial activities using Staphylococcus aureus and Escherichia coli by tube dilutioin method. The seven compounds, Ia, IIa, IIIa, VIa, IIIb, IVb and Vb showed inhibition of the growth of S. aureus at the concentration of 10${\mu}$g/ml. As to the growth of E. coli, IVb, VIb, VIIb, and VIIIb were observed inhibition at the concentration of 1${\mu}$g/ml. Ia, IIa, IIIa, VIIa, Va, VIIIa, and IIb exhibited potential antimicrobial activities against showed inhibition of the growth of E.coli at the concentration of 100${\mu}$/ml.

• 한국식품영양과학회지
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• 제28권2호
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• pp.305-311
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• 1999

The volatile compounds of soybean pastes(home made soondoenjang, commercial doenjang) were classified into basic, acidic and neutral fractions by dynamic headspace method. The fractionated flavor isolates were analyzed and identified by gas chromatography mass spectrometry. Each peak area of the flavor components was quantified at its ratio to the peak area of internal standard. Sixty one compounds from home made soondoenjang, and forty three compounds from commercial doenjang were identified. The different distribution of volatile compounds between the two soybean paste samples was observed. Ten pyrazines and benzothiazole were identified in the basic fraction of home made soondoenjang. On the other hand, trimethylpyrazine was the only one of nitrogen containing compounds in the commercial doenjang, which was made from soybean(28.3%), wheat(22.2%) and alcohols. The factors which influenced the levels of these identified compounds were considered to be the starting materials of soybean paste. Alcohols, esters and aldehydes in the neutral fraction of both samples were seemed to be characterisitic soybean paste flavor and showed much higher quantities than those of the basic or acidic fractions. Furfural in the commercial doenjang was the highest content (45.28ppm) among all of the compounds identified in the samples.

• 대한화학회지
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• 제40권2호
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• pp.117-121
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• 1996

Crown 고리 근방에 질소, 황원자 를 포함하는 새로운2종의 crown ether를 합성하였다. 4'-Benzothiazolylbenzo-12-crown-4 (1) 4'-Benzothiazolylbenzo-15-crown-5 (2)는 각각 4'-formylbenzo-12-crown-4 (3)및4'-formylbenzo-15-crown-5 (4)와 2-aminothiophenol과의 반응에 의해 합성하였다. (3)과(4)는 3, 4-dihydroxybenzaidehyde와 tri-및 tetraethyleneglycolditosylate와의 반응에 의해 합성하였다. Triethyleneglycolditosylate와 tetraethyleneglycol ditosylate는 NaOH 존재하에서 triethyleneglycol, tetraethyyleneglyco.과 p-toluenesulfonyl chloride의 반응에 의해 합성하였다.

• 공업화학
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• 제22권2호
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• pp.144-148
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• 2011

본 연구에서는 화학적 구조가 다른 thiuram 계 촉진제인 TMTD (tetramethyl thiuram disulfide), thiazole 계 촉진제인 MBTS (2,2-dithiobis(benzothiazole)), sulfenamide 계 촉진제인 CBS (n-cyclohexyl benzothiazyl-2-sulfenamide)를 사용하여 각각의 촉진제가 실리카가 충전된 천연고무의 가황 특성에 미치는 영향을 비교 평가하였다. TMTD는 상대적으로 빠른 가류 속도와 높은 최대 토크값($T_{max}$), 우수한 기계적 물성을 보였고 MBTS는 상대적으로 중간 정도의 가황 시간과 낮은 $T_{max}$, 기계적 물성을 보였다. 마지막으로 CBS는 느린 가황 시간을 나타낸 반면 상대적으로 우수한 $T_{max}$와 기계적 물성을 나타냈다. 유사한 가황 특성 경향은 카본블랙이 충전된 천연고무 컴파운드에서도 찾아볼 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2609-2615
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• 2013

A series of fluorene-carbazole copolymers containing the pendant phosphor chromophore $Ir(absn)_2(acac)$ (absn: 2-(1-naphthyl)benzothiazole; acac: acetylacetone) were designed and synthesized via Yamamoto coupling. In the film state, these copolymers exhibited absorption and emission peaks at approximately 389 and 426 nm, respectively, which originated from the fluorene backbone. However, in electroluminescent (EL) devices, a significantly red-shifted emission at approximately 611 nm was observed, which was attributed to the pendant iridium(III) complex. Using these copolymers as a single emission layer, polymer light-emitting devices with ITO/PEDOT:PSS/polymer:DNTPD/TmPyPb/LiF/Al configurations exhibited a saturated red emission at 611 nm. The attached iridium(III) complex had a significant effect on the EL performance. A maximum luminous efficiency of 0.85 cd/A, maximum external quantum efficiency of 0.77, maximum power efficiency of 0.48 lm/W, and maximum luminance of 883 $cd/m^2$ were achieved from a device fabricated with the copolymer containing the iridium(III) complex in a 2% molar ratio.