• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.551-555
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• 2009

A benign pulmonary metastasizing leiomyoma is a recognized clinical entity that has been infrequently reported in the medical literature. We report two cases of a benign pulmonary metastasizing leiomyoma. A 35-year-old woman who underwent myomectomy and a cesarean section approximately 6 years earlier visited our hospital for further evaluation of incidentally revealed multiple lung nodules. A diagnostic percutaneuous biopsy was performed. Finally she was diagnosed with a benign metastasizing leiomyoma. The patient then received LH-RH and has been followed up since. The other 44-year-old woman presented after an initial radiology evaluation revealed the presence of multiple, small-sized lung nodules. She underwent a right middle lung wedge resection to confirm the diagnosis. Finally she diagnosed with a benign metastasizing leiomyoma. The multiple lung nodules have been followed up closely.

• Nuclear Medicine and Molecular Imaging
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• 제41권3호
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• pp.258-259
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• 2007

Benign metastasizing leiomyoma(BML) is a rare condition affecting women with a history of having undergone hysterectomy or myomectomy for a benign uterine fibroid, that is found to have metastasized to extrauterine sites, usually many years after hysterectomy. 1,2) Patient with BML almost always asymptomatic, although if the lesions are large enough, they can cause compressive symptoms. Among several hypothesis of pathogenesis, most plausible theory is that these tumors represent a true metastatic lesion but are very low-grade sarcoma. 3) Because the tumor is responsive to estrogen, menopause and pregnancy have slowed the growth of these lesion 4) and it seems reasonable to perform hysterectomy in patients with a uterine mass and, at the same time, perform oophorectomy for hormonal control. BML is an unusual cause of diffuse pulmonary nodules which should be considered in females with unexplained nodules and a history of surgery for uterine leiomyoma.

• Tuberculosis and Respiratory Diseases
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• 제60권1호
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• pp.92-96
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• 2006

자궁근종으로 자궁절제술을 시행받은 과거력이 있는 43세 여자가 객혈을 주소로 내원하였다. 컴퓨터단층촬영에서 다발성 폐결절이 발견되어 흉강경하에서 조직검사 시행 후 양성 전이성 폐평활근종을 진단받았다. 폐경 전 환자로 GnRH analogues 치료를 시도하였고 3개월 후 추적검사에서 폐결절의 크기는 이전과 변화가 없는 상태를 확인하였고 객혈도 없는 안정된 상태로 경과 관찰중이다.

• Tuberculosis and Respiratory Diseases
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• 제53권2호
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• pp.190-195
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• 2002

저자들은 과거력상 자궁절제술을 시술받은 환자에서 우연히 발견된 다발성 폐결절을 경피적 폐생검술을 시행하여 폐를 침범한 '양성 전이성 폐 평활근종증' 1예를 경험하였기에 이를 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제58권6호
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• pp.614-618
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• 2005

저자들은 자궁근종으로 자궁적출술을 시행받은 과거력이 있는 35세 여자환자가 우연히 발견된 폐의 다발성 결절을 주소로 내원한 후, 폐 생검을 통하여 양성 전이성 폐 평활근종을 진단받고, 이후 개흉술을 통한 전 결절 제거술을 성공적으로 시행 받은 드문 1예를 경험하였고, 이는 국내에서는 처음 시도된 바이기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제50권1호
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• pp.59-63
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• 2017

Pulmonary benign metastasizing leiomyoma (PBML) is defined as metastasis of a leiomyoma to lung tissue. It was first reported in 193 7. PBML is known as a benign disease, but can undergo malignant transformation. Only 1 case of the malignant transformation of PBML to leiomyosarcoma has been reported previously. In this report, we present a case of malignant transformation of PBML.

• Clinical and Experimental Reproductive Medicine
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• 제38권3호
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• pp.174-177
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• 2011

Benign metastasizing leiomyoma (BML) is a rare disease, which usually occurs in women with a history of a prior hysterectomy or myomectomy for benign uterine leiomyoma, and has the potential to metastasize to distant sites, such as the lung, lymph nodes, muscular tissue, heart, or retroperitoneum. These lesions are slow-growing, asymptomatic, and usually found incidentally. The prognosis of BML is also excellent. However, there has been debate on the origin and the correct classification of BML, and there are no guidelines for the treatment of BML. We report here on a rare case of BML in both the retroperitoneal cavity and lung in a 48-year-old woman with a history of hysterectomy due to histologically benign uterine leiomyoma. The patient underwent retroperitoneal mass excision and bilateral salpingo-oophorectomy, and then wedge biopsy of two pulmonary nodules was performed additionally 9 days later. Until now, there has been no sign of recurrence and the patient remains asymptomatic. To our knowledge, pulmonary BML is rare and the co-existence of the retroperitoneal metastases after previous hysterectomy is even rarer.

• Tuberculosis and Respiratory Diseases
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• 제49권2호
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• pp.231-236
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• 2000

10년전 자궁근종으로 자궁전절제술을 시행받은 39세 여자환자로 기침을 주소로 내원하여 흉부 단순촬영, 흉부 전산화 단층촬영상 좌측상엽기관지에 연하여 3$\times$4cm크기 종괴 및 우하부 기저부에 5mm크기의 소결절이 관찰되어, 좌측 상엽 절제술을 시행받았다. 종괴의 병리조직소견상 유사분열을 보이는 세포가 50개의 고배율시야당 2-3개 정도이었으며 세포의 이형성은 관찰할 수 없었고 면역조직화학염색상 Smooth muscle actin, Vimentin, Desmin에 양성반응을 보여 평활근종임을 확인하였다. 수술 후 별다른 증상의 호소는 없었고, 경과 추적 관찰중 우측 폐에 새로운 결절이 발견되어 양성 전이성 평활근종으로 확진하였으며, 이에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제41권6호
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• pp.777-781
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• 2008

양성 전이성 평활근종은 조직학적으로 양성 종양의 소견을 보이나 임상적으로 폐나 다른 장기로 전이하는 매우 드문 질환이다. 저자들은 2개월간 지속된 기침을 주소로 입윈한 53세의 여자환자에서 좌우 다발성으로 퍼져 있는 폐결절들을 가진 전이성 평활근종 1예를 경험하였다. 증례는 과거력상 13년전 자궁근종으로 전자궁적출술을 받았으며, 자궁근종은 병리조직 검사상 평활근종으로 진단되었었다. 환자는 전이성 폐암 의심 하에 흉강경 폐 조직검사를 실시하였다. 폐 결절들은 낮은 세포 분열을 보이는 양성 종양의 소견을 보이며, 평활근 세포의 다발성 결절들로 이루어져 병리학적으로 양성 전이성 평활근종과 일치하는 소견을 보였다. 환자는 현재 별다른 치료 없이 추적 관찰 중이다.

• Journal of Chest Surgery
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• 제34권5호
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• pp.422-425
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• 2001

We performed thoracoscopic resection for diagnosis in 41 year-old-female presenting with multiple pulmonary nodules in both lung fields, which was detected incidentally on routine chest x-ray and followed by additional exmaminations including chest CT scan and percutaneous needle aspiration biopsy under the presumptive diagnosis of metastatic cancer. During thoracoscopy, the result of the frozen section analysis of multiple masses revealed strong evidence of leiomyoma. In her past medical history, she had undergone myomectomy, and hysterectomy, 7 year ago and 10 year ago, respectively. Based on permanent, special staining of specimen, estrogen receptor assay and review of past specimen of uterine myoma the final diagnosis was benign metastasizing leiomyomata from uterine myoma, the report was very uncommon in Korean and English literatures. The patient has been followed up for 2 year without special therapy, such as hormonal therapy.