• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8311-8317
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• 2014

Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.

• 한국농촌건축학회논문집
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• 제22권2호
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• pp.35-42
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• 2020

The new urbanization is one of prestige growth engines to lead the next generation of China economy, it promotes new sustainable urban development models guided by various planning polices to improve urban livability and sustainability in accommodation with economy, social, and environmental consideration. The expanding urban periphery to rural area should leverages existing assets, infrastructure, local context and plans as a showcase of environmental and economic balance in a responsibly high-density, green community designed to human development and ecological settlement. The Beijing Chaoyang District and Tianjin Binhai area are a strategic advancement in the policy of building one of the most powerful economic regions, the Bohai Rim. Recently released 'Jingjinji development plan' supports various urbanization policies and encourages sustainable developments including 2 significant city center projects which are under way in global attention. The study compared on the characters of development policies and the cutting-edge smart design strategies by which they are applied, the master plan of the Beijing Chaoyang District expansion plan and Tianjin Yujiapu CBD project embrace innovative sustainable technologies.

• Journal of Ginseng Research
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• 제48권1호
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• pp.40-51
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• 2024

Background: Ginsenoside 20(S)-Rg3 shows promising tumor-suppressive effects in ovarian cancer via inhibiting NF-kB signaling. This study aimed to explore the downstream tumor suppressive mechanisms of ginsenoside Rg3 via this signaling pathway. Materials and methods: A systematical screening was applied to examine the expression profile of 41 kinesin family member genes in ovarian cancer. The regulatory effect of ginsenoside Rg3 on KIF20A expression was studied. In addition, we explored interacting proteins of KIF20A and their molecular regulations in ovarian cancer. RNA-seq data from The Cancer Genome Atlas (TCGA) was used for bioinformatic analysis. Epithelial ovarian cancer cell lines SKOV3 and A2780 were used as in vitro and in vivo cell models. Commercial human ovarian cancer tissue arrays were used for immunohistochemistry staining. Results: KIF20A is a biomarker of poor prognosis among the kinesin genes. It promotes ovarian cancer cell growth in vitro and in vivo. Ginsenoside Rg3 can suppress the transcription of KIF20A. GST pull-down and co-immunoprecipitation (IP) assays confirmed that KIF20A physically interacts with BTRC (β-TrCP1), a substrate recognition subunit for SCF^β-TrCP E3 ubiquitin ligase. In vitro ubiquitination and cycloheximide (CHX) chase assays showed that via interacting with BTRC, KIF20A reduces BTRC-mediated CDC25A poly-ubiquitination and enhances its stability. Ginsenoside Rg3 treatment partly abrogates KIF20A overexpression-induced CDC25A upregulation. Conclusion: This study revealed a novel anti-tumor mechanism of ginsenoside Rg3. It can inhibit KIF20A transcription and promote CDC25A proteasomal degradation in epithelial ovarian cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6733-6738
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• 2013

Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (PCa). As PCa risk SNPs may also influence disease outcome, we studied here eight 8q24 risk alleles, and evaluated their role in PCa clinical covariates in northern Chinese men. Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=289) and from age-matched normal controls (n=288). Eight 8q24 SNPs were genotyped by polymerase chain reaction-high- resolution melting analysis in 577 subjects. We examined the prevalence distribution of 8q24 risk alleles and analyzed the associations between the risk allele and PCa and clinical covariates to infer their impact on aggressive PCa. Three of the eight SNPs were associated with PCa risk in northern Chinese men, including rs16901966 (OR 1.31, 95% CI 1.01-1.70, p=0.042), rs1447295 (OR 1.47, 95% CI 1.09-1.98, p=0.011) and rs10090154 (OR 1.55, 95% CI 1.14-2.12, p=0.005). Haplotype analysis based association with the risk alleles revealed significant differences between cases and controls (OR 1.43, 95%CI 0.99-2.06, p=0.049). The risk alleles rs16901966, rs1447295 and rs10090154 were associated with age at diagnosis and tumor stage as compared with controls, while rs16901966 was associated with aggressive PCa (OR 1.43, 95% CI 1.01-2.03, p=0.042). The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates. The three SNPs at 8q24 could be PCa susceptible genetic markers in northern Chinese men.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권2호
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• pp.907-923
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• 2020

For the severe haze situation in the Beijing-Tianjin-Hebei region, conventional fine particulate matter (PM2.5) concentration prediction methods based on pollutant data face problems such as incomplete data, which may lead to poor prediction performance. Therefore, this paper proposes a method of predicting the PM2.5 concentration based on image analysis technology that combines image data, which can reflect the original weather conditions, with currently popular machine learning methods. First, based on local parameter estimation, autoregressive (AR) model analysis and local estimation of the increase in image blur, we extract features from the weather images using an approach inspired by free energy and a no-reference robust metric model. Next, we compare the coefficient energy and contrast difference of each pixel in the AR model and then use the percentages to calculate the image sharpness to derive the overall mass fraction. Furthermore, the results are compared. The relationship between residual value and PM2.5 concentration is fitted by generalized Gauss distribution (GGD) model. Finally, nonlinear mapping is performed via the wavelet neural network (WNN) method to obtain the PM2.5 concentration. Experimental results obtained on real data show that the proposed method offers an improved prediction accuracy and lower root mean square error (RMSE).

• Parasites, Hosts and Diseases
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• 제55권2호
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• pp.129-135
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• 2017

A total of 60 samples were collected from 35 swimming pools in Beijing, China, and the presence of Cryptosporidium and Giardia were investigated. The results showed that 16.7% and 15.0% of samples were positive for Cryptosporidium oocyst and Giardia cysts, respectively, with a mean concentration of 0.30 oocysts/10 L and 0.27 cysts/10 L. The oocysts and cysts were found to have higher rates of occurrence in August than in May. Genotyping confirmed the presence of Cryptosporidium hominis, C. parvum, and Giardia assemblages A and B, all of which were associated with human infections. The predominant species/assemblages were C. hominis and Giardia assemblage A. Analyses of the relationships between parasite oocysts/cysts, indicator bacteria, and physical-chemical parameters revealed that there was no correlation between 2 parasites and fecal bacterial indicators, whilst there was a significant correlation between protozoa and urea concentration, which indicates that urea concentration rather than fecal bacterial indicators might be an appropriate index for chlorine-resistant protozoa in swimming pools. This study provides useful information to improve the safety of swimming pool water and deduce the risk of protozoan infections.

• Steel and Composite Structures
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• 제18권1호
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• pp.71-90
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• 2015

Axial compression tests have been carried out on 18 rectangular concrete-filled cold-formed steel tubular (CFST) columns with the aim of investigating the axial behaviour of rectangular CFST columns under different loading methods (steel loaded-first and full-section loaded methods). The influence of different loading methods on the ultimate strength of the specimens was compared and the development of Poisson's Ratio as it responds to an increasing load was reported and analysed. Then, the relationship between the constraining factor and the strength index, and the relationship between the constraining factor and ductility index of the specimens, were both discussed. Furthermore, the test results of the full-section loaded specimens were compared with five international code predicted values, and an equation was derived to predict the axial carrying capacity for rectangular CFST columns with a steel loaded-first loading method.

• Earthquakes and Structures
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• 제7권6호
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• pp.937-953
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• 2014

A semi-active control platform comprising the mechanical model of magnetorheological (MR) dampers, the bang-bang control law and damage material models is developed, and the simulation method of steel plate shear wall (SPSW) and optimization method for capacity design of MR dampers are proposed. A 15-story steel frame-SPSW structure is analyzed to evaluate the seismic performance of nonlinear semi-active controlled structures with optimal designed MR dampers, results indicate that the control platform and simulation method are stable and fast, and the damage accumulation effects of uncontrolled structure are largely reduced, and the seismic performance of controlled structures has been improved.

• Journal of applied mathematics & informatics
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• 제27권1_2호
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• pp.79-87
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• 2009

This paper deals with the multipoint boundary value problem for one dimensional p-Laplacian $({\phi}_p(u'))'(t)$ + f(t,u(t)) = 0, $t{\in}$ (0, 1), subject to the boundary value conditions: u'(0) - $\sum\limits^n_{i=1}{\alpha_i}u({\xi}_i)$ = 0, u'(1) + $\sum\limits^n_{i=1}{\alpha_i}u({\eta}_i)$ = 0. Using a fixed point theorem for operators on a cone, we provide sufficient conditions for the existence of multiple (at least three) positive solutions to the above boundary value problem.

• 한국조경학회지
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• 제50권4호
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• pp.1-19
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• 2022

산업구조의 변화와 함께 도시공간구조가 재편되는 것은 세계적인 현상이고, 중국은 대표적인 국가 가운데 하나이다. 중국의 수도권이라고 할 수 있는 북경-천진-당산으로 이어지는 경진당(京津唐) 지역은 공장과 공업단지들이 이전하고 남겨진 산업 이전적지들의 재생 프로젝트가 활발하게 진행되고 있다. 경진당(京津唐) 지역의 산업 이전적지 재생 사례들을 분석하여 사업의 특징과 목표, 설계 철학과 전략을 정리하고 시사점을 도출하여 향후 유사한 프로젝트를 위한 기초 자료를 제공하고자 하는 것이 본 연구의 목적이다. 연구 방법은 경진당 지역의 산업 이전적지 재생 프로젝트를 현지 답사를 통해 조사, 분석하고 문헌연구를 통해 귀납적으로 결과를 도출하였다. 연구의 결과는 다음과 같다. 첫째, 경진당 지역의 산업 이전적지 재생프로젝트는 산업 유산 보호, 문화적 창의성, 공동체성 증진 같은 다원화된 목표를 추구하고 있다. 둘째, 대상지의 공간적, 장소적 특성과 산업유산을 존중하는 디자인 전략을 통해 새로운 디자인 내용과 대상지의 고유성이 조화되어 장소적 특징과 경관 효과를 최대화하고 있다. 셋째, 산업 이전적지의 생태적 복원에 초점을 두어 오염된 토양에 적응성 있는 식물과 자생식물을 위주로 식재하고 있다. 넷째, 조경 디자인은 조각이나 그래피티 같은 현대예술과 결합하여 대상지를 풍요롭게 하고 활성화를 촉진한다. 다섯째, 재생된 장소의 활성화 측면에서 도시적 이벤트와 대중 활동 프로그램을 적극 도입하고 있다.