• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.453-459
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• 2014

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a chronic mild stress animal model of depression and anxiety to examine the responses of two strains of mice that have different behavioral responsiveness. An outbred ICR and an inbred C57BL/6 strain of mice were selected because they are widely used strains in behavioral tests. The results showed that the inbred C57BL/6 and outbred ICR mice were similarly responsive to CMS treatment in sucrose intake test (SIT) and open field test (OFT). However, the two strains showed quite different responses in forced swimming test (FST) and novelty-suppressed feeding (NSF) test after 3 weeks of CMS treatment. Only C57BL/6 mice displayed the depression- and anxiety-like behavioral effects in response to CMS treatment in FST and NSF test. Our results suggest that there are differences in responsiveness to CMS according to the different types of strain of mice and behavioral tests. Therefore, these results provide useful information for the selection of appropriate behavioral methods to test depression- and anxiety-like behaviors using CMS in ICR and C57BL/6 mice.

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.5
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• pp.461-469
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• 2021

Background: The global population is aging rapidly, and accordingly, the number of patients with dementia is increasing every year. Although the need for dental treatment increases for various reasons in patients with dementia, they cannot cooperate during dental treatment. Therefore, behavioral management, including sedation (SED) or general anesthesia (GA), is required for patients with dementia. Thus, this study aimed to investigate the trends and effects of SED or GA in patients with dementia undergoing dental treatment in South Korea based on the Korean National Health Insurance claims data. Methods: This study utilized customized health information data provided by the Health Insurance Review and Assessment Service. Among patients with records of using sedative drugs during dental treatment from January 2007 to September 2019, patients with the International Classification of Diseases-10 code for dementia (F00, F01, F02, F03, and G30) were selected. We then analyzed the full insurance claims data for dental care. Age, sex, sedative use, and dental treatment of patients were analyzed yearly. In addition, the number of cases of GA or SED per year was analyzed, and changes in behavioral management methods with increasing age were investigated. Results: Between January 2007 and September 2019, a total of 4,383 (male, 1,454; female, 2,929) patients with dementia received dental treatment under SED or GA. The total number of SED and GA cases were 1,515 (male, 528 ; female, 987 ) and 3,396 (male, 1,119 ; female, 2,277) cases, respectively. The total number of cases of dental treatment for 4,383 patients with dementia was 153,051 cases, of which 2.22% were under GA and 0.98% were under SED. Midazolam was the most commonly used drug for SED. Conclusion: Although gingivitis and pulpitis were the most common reasons for patients with dementia to visit the dentist, GA or SED for patients with dementia was frequently used in oral and maxillofacial or periodontal surgery.

• Sleep Medicine and Psychophysiology
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• v.7 no.1
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• pp.5-9
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• 2000

Several nonpharmacological treatment methods of insomnia and their effects were reviewed. A long-term use of most hypnotics may produce tolerance, dependence, cognitive and psychomotor impairments at daytime, shallow sleep, and rebound insomnia on drug withdrawal. To reduce hypnotic abuse, nonpharmacological strategies have been developed to correct disordered behavioral and cognitive factors. These treatments aim at modifying maladaptive sleep habits, lowering physiological and cognitive arousal levels, and correcting dysfuctional beliefs and attitudes about sleep. These non-pharmacological or cognitive behavior treatments include stimulus control, sleep restriction, relaxation training, sleep hygiene education, cognitive therapy, and light therapy. Among them the stimulus control therapy has been demonstrated most effective as a single treatment or in combination with other treatments. Through nonpharmacological treatments, sleep latency was most significantly reduced and wake time after sleep onset was also reduced. About 50% of insomniacs reported clinical improvements in terms of nearly normalized sleep latency, awakening time, sleep efficiency, and reduction of hypnotic use. Compared to the hypnotic therapy, nonpharmacological treatments are more cost-effective and more readily accepted by patients, and their effects last longer.

• Korean Journal of Pharmacognosy
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• v.8 no.4
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• pp.139-148
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• 1977

It is the purpose of this article to present a brief and systematical behavioral methods in recent developed behavioral pharmacology. Specifically, the present review has been organized around three major topics reflecting both current research emphasis in behavioral pharmacology and methodological applications to the study of psychopharmacological actions of crude drug or herb medicine. The first major topic focuses upon the appropriate experimental design especially in the study of psychopharmacology. A large number of factors should be controlled to have a bearing on design of studies reflecting to psychological effects of drugs. The second section presents several recent methodological developments in behavioral pharmacology involving Turner's screening methods and several types of conditioning techniques. The last section calls specific attention to the observation of behavioral development processes in relation to the activity of pharmacological agents and emphasizes critical period of drug treatment.

• Korean Journal of Psychosomatic Medicine
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• v.3 no.2
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• pp.185-196
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• 1995

The author reviewed cognitive-behavioral approach to A type behavior pattern and hypertension which are known to be risk factors for coronary heart diseases. Those cognitive distortions frequently found in persons with A type behavior include all-nothing thinking, selective attention, personalization, and attribution of causality. Cognitive-behavioral techniques were also described, which can be applied to management of each characteristic of A type behavior pattern such as time urgency, perfectionism, achievement striving, low self-esteem, excessive work involvement, hostility, and depression. Cognitive-behavioral intervention for hypertension might help the patients to recognize and monitor anger-engendering conflicts, identify characteristic styles of responding, and experiment with alternative ways of managing conflict and anger. Since different features predominate in different individuals, it is necessary to develop treatment plan on the basis of individual characteristics and problems.

• Journal of Oral Medicine and Pain
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• v.8 no.1
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• pp.97-106
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• 1983

A reserch scale of 48 items selected from MMPI by McCall et al. was used to compare psychologic aspects of 80 patients with MPDS to control I subjects and control II subjects. For this, study subjects were selected 80 patients of MPDS who visited the Dept. of Dentistry. K.N.U.H., from December in 1982 to September in 1983. Control I subjects were selected 80 outpatients without MPDS who required dental treatment from December in 1982 to September in 1983. And control II subjects were selected 80 persons without MPDS who required no dental treatment and lived in Taegu. The results were as follow : In study subjects,somatic gruop and behavioral group are markedly high than control (I,II)subjects. In somatic group and behavioral group, there was no significant differencd between control I subjects and control II subjects. In somatics group and begavioral group, there was no significant difference between male and female in each subjects: In study subject, general nature somatic category was higher than head, neck, throat and GIT somatic category.(P<0.05) In study subjects, somatic group and behavioral group gradually increased according to increase in number of MPDS symptom.

• Korean Journal of Psychosomatic Medicine
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• v.4 no.1
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• pp.54-63
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• 1996

In this cluster analysis of out-patients with irritable bowel syndrome (IBS) we described the psychological features and personality patterns of these patients. The Minnesota Multiphasic Personality Inventory (MMPI) was administered to 29 IBS patients who received treatment in the gastroenterology department of Ajou University Hospital to produce individual profiles for each patient. The 29 profiles with 13 standard scales, 15 content scales and 11 personality scales were subjected to cluster analysis resulting in three clusters of the original sample. Titles used to describe the psychological features and personality patterns seen in the three clusters included : (1) depression and anxiety : (2) somatization and denial of affect ; (3) anger overcontrol. Future studies on the treatment of IBS patients may well consider these features, as IBS patients have different psychological patterns.

• Korean Journal of Social Welfare
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• v.69 no.3
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• pp.165-191
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• 2017

The purpose of this study is to identify the major predictive factors of intention of drug users to use treatment services. The theoretical framework was used extended Behavioral Model of Health Services Use which integrates the Andersen model and the Theory of Planned Behavior. Thus, this study examined the effects of individual characteristics(predisposing, enabling, need factor) and attitude, subjective norm, perceived behavior control on drug users' intention to use treatment services. Factors with a statistically significant effect were as follows: from the individual characteristics - gender and past treatment experiences of the predisposing factors along with psychiatric diagnosis, anxiety and depression, and severity of drug abuse of need factors. From the Theory of Planned Behavior - subjective norm and perceived behavior control turned out to have impacts on their intention to use treatment services. The study emphasizes that a concern of women, increasing positive experiences of treatment, efforts to change the subjective norms and perceived behavior control of drug users to promote their determination to get treatment.

• International Journal of Oral Biology
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• v.41 no.4
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• pp.191-197
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• 2016

The present study was to evaluate effects of vitamin E on intravenous administration of lidocaine-induced antinociception. Experiments were carried out using male Sprague-Dawley rats. Orofacial formalin-induced nociceptive behavioral responses were used as the orofacial animal pain model. Subcutaneous injection of formalin produced significant nociceptive scratching behavior. Intraperitoneal injection of 5 and 10 mg/kg of lidocaine attenuated formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. Intraperitoneal injection of 1 g/kg of vitamin E also attenuated the formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. However, low dose of vitamin E (0.5 g/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. The present study also investigated effects of intraperitoneal injection of both vitamin E and lidocaine on orofacial formalin-induced behavioral responses. Vehicle treatment affected neither formalin-induced behavioral responses nor lidocaine-induced antinociceptive effects. However, intraperitoneal injection of 0.5 g/kg of vitamin E enhanced the lidocaine-induced antinociceptive effects in the 2nd phase compared to the vehicle-treated group. Intraperitoneal injection of naloxone, an opioid receptor antagonist, did not affect antinociception produced by intraperitoneal injections of both vitamin E and lidocaine. These results suggest that treatment with vitamin E enhances the systemic treatment with lidocaine-induced antinociception and reduces side effects when systemically treated with lidocaine. Therefore, the combined treatment with vitamin E and lidocaine is a potential therapeutic for chronic orofacial pain.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.19 no.3
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• pp.162-167
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• 2008

Objectives: The aim of this study was to identify characteristics of children and adolescents who were victims of sexual assault in Korea. Methods: The subjects were 60 children and adolescents who visited the one-stop center as victims of sexual assault. The medical records of victims of sexual trauma were retrospectively reviewed. We studied the demographic data of the victims, their relationship to their perpetrator, the characteristics of the assault (frequency, duration, place, type), and the process from sexual assault to treatment. We also paid special attention to how the characteristics of the victims or perpetrators affected the characteristics of the assault or follow-up treatment. Results: There were several differences between sexual assaults committed by strangers and those committed by acquaintances. Sexual assaults committed by acquaintances lasted for a longer period of time than those committed by strangers. In addition, it took more time for victims of sexual assaults committed by acquaintances to seek treatment than those who were victims of sexual assaults committed by strangers. The majority (55.0%) of victims were between 10 and 15 years of age. Forty percent of the perpetrators were teenagers, and two of them were under the age of 10. Voluntary discontinuation of treatment was more frequent in adolescents than in children. Conclusion: All teenage victims of sexual assault need some sort of urgent intervention. In addition, approachable methods are needed in order to prevent sexual abuse by strangers or acquaintances.