• 대한지역사회영양학회지
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• 제8권6호
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• pp.867-875
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• 2003

The purpose of this study was to investigate the psychosocial factors influencing dairy product consumption of female university students in Daejeon. The Theory of Planned Behavior provided the basis for this study. As a result of the pilot-study, 18 behavioral beliefs, 8 normative beliefs, and 12 control beliefs were identified. The subjects (n=236) were grouped into a high-consumption group (1 serving/day, n=117) and a low consumption group (< 1 serving/day, n=119). The data were analyzed using t-tests or $\chi$$^2$-tests. Among the general characteristics, there were significant differences in the amount of pocket money spent per month, residence type (p<0.01), weight, frequency of exercise and perceived health status (p<0.05) of the subjects. With respect to the 18 behavioral beliefs, the high consumption group responded less negatively on ‘eating dairy foods would not be convenient’ than the low consumption group (p<0.05). None of the subjective normative items were significantly different between the two groups. However, notable differences were found in regard to the control beliefs (8 out of 12 control beliefs). These included overall control over consuming dairy products (p< 0.001), as well as specific beliefs regarding barriers such as easy spoilage of dairy products, the cost, eating them for snacks and dislike for them (p<0.05). In addition, specific situations, such as ‘when I want them I get them’ (p<0.01), eating out and the availability of dairy foods at home (p<0.05) were significantly different between the two groups. The high consumption group showed more control over these barriers or situations. These results suggest that nutritional education for young female adults should incorporate strategies to increase their perceived control over the consumption of dairy products by removing barriers and including environmental approaches which address the availability issues.

• 한국터널지하공간학회 논문집
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• 제13권2호
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• pp.149-158
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• 2011

최근 장기 부식 등 일반적인 건설재료의 문제점을 보완할 수 있는 대체 재료로서, 섬유강화 복합재료의 활용이 증대되고 있다. 하지만 일반적으로 선형의 섬유강화 복합재료를 아치형인 터널구조물의 부재로서 활용하는 데는 많은 문제점이 대두된다. 본 연구에서는 FRP 복합부재의 거동특성 파악을 위한 수치해석적 사전검토 연구를 토대로, 터널 지보구조물로서 활용성 분석을 위한 FRP와 콘크리트 합성부재에 대한 하중재하 실험을 수행하였다. 또한 역학적 거동분석을 위하여 동일 조건에 대한 수치해석을 수행하였다. 하중재하 실험 및 수치해석결과, FRP와 콘크리트 합성부재는 두 부재 계면의 휨 인장에 의한 전단거동에 큰 영향을 받는 것으로 나타났다.

• 한국지반환경공학회 논문집
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• 제22권4호
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• pp.15-23
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• 2021

마이크로파일의 활용증가로 수행되었던 마이크로파일의 관련연구를 통해 다양한 마이크로파일이 개발되어왔다. 개발되고 있는 마이크로파일 공법들 중 최근 수평지지력(내진저항력)의 증가를 위한 목적으로 개발된 삼축 마이크로파일(Triaxial micropile, TMP)이 대표적이라 할 수 있다. 삼축 마이크로파일은 각축에 경사지게 설치된 3개의 마이크로파일이 수평하중에 저항하므로 좀 더 효과적으로 수평하중에 저항할 수 있는 공법의 장점이 있다. 그러나 삼축 마이크로파일에 대한 지지특성에 대한 연구가 부족하여 이 파일공법을 효과적으로 활용하는데 문제가 있다. 즉, 삼축 마이크로파일(TMP)의 효과적인 활용을 위해서는 파일의 수평지 지력에 영향을 주는 요인에 대한 지지력 평가가 요구된다. 이에 본 연구에서는 하중 방향별 현장수평재하시험을 수행하고 3차원 유한요소해석을 통해 현장 재하시험을 검증하고 거동 특성을 고찰하였으며, 수평하중의 방향을 고려한 적정한 수평지지력을 분석하였다.

• Nutrition Research and Practice
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• 제15권2호
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• pp.173-186
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• 2021

BACKGROUD/OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of AD. In this study, we investigated the protective effects conferred by Zizyphus jujuba (Zj) and Zizyphus jujuba fermented by yeast (Zj-Y), on cognitive impairment in an AD mouse model. MATERIALS/METHODS: AD was induced by injecting amyloid beta25-35 (Aβ25-35) in ICR mice, and subsequently 200 mg/kg Zj or Zj-Y was administered daily for 14 days. The cognitive ability of AD mice was observed through behavioral experiments in T-maze, novel object recognition, and Morris water maze tests. We subsequently measured the levels of malondialdehyde (MDA), nitric oxide (NO), aspartate aminotransferase, and alanine aminotransferase in either tissues or serum. RESULTS: In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the Aβ25-35-injected control group compared to the normal group, indicating that Aβ25-35 injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the Aβ25-35-injected control mice. In addition, the Aβ25-35 induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj. CONCLUSIONS: Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by Aβ25-35.

• 한국지반공학회논문집
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• 제38권9호
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• pp.53-67
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• 2022

마이크로파일은 소구경 현장타설말뚝으로, 시공방법이 간단하고 공사비용이 상대적으로 저렴하여 건축물을 비롯한 각종 구조물의 보수보강 및 증축 시 기초보강 등에 활용되고 있다. 시공이 용이하고 간단한 메커니즘의 구조체를 선단에 장착하여 지지력을 증대시키는 선단 확장형 마이크로파일이 개발되었으며, 이에 대한 수치해석, 내구성시험, 원심모형시험 등의 연구가 수행되어 왔다. 본 연구에서는, 기존에 수행된 수치모델링을 고도화하여 연직하중 재하에 의해 연결강봉 근입 시 고정 지압구가 활착되는 거동 메커니즘을 확인하고, 원심모형실험과 동일한 조건에서의 수치해석을 수행하여 그 결과를 비교하였다. 또한, Lab-scale 수치해석 결과를 바탕으로 고정 지압구의 형상 개선안을 도출하고, Field-scale 수치해석을 통해 일반 마이크로파일 대비 지지력 증대효과를 비교·검증하였다.

• 운동영양학회지
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• 제23권3호
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.

• Journal of Ginseng Research
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• 제48권1호
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• pp.59-67
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• 2024

Background: Alzheimer's disease (AD) has memory impairment associated with aggregation of amyloid plaques and neurofibrillary tangles in the brain. Although anti-amyloid β (Aβ) protein antibody and chemical drugs can be prescribed in the clinic, they show adverse effects or low effectiveness. Therefore, the development of a new drug is necessarily needed. We focused on the cognitive function of Panax ginseng and tried to find active ingredient(s). We isolated panaxcerol D, a kind of glycosyl glyceride, from the non-saponin fraction of P. ginseng extract. Methods: We explored effects of acute or sub-chronic administration of panaxcerol D on cognitive function in scopolamine- or Aβ_25-35 peptide-treated mice measured by several behavioral tests. After behavioral tests, we tried to unveil the underlying mechanism of panaxcerol D on its cognitive function by Western blotting. Results: We found that pananxcerol D reversed short-term, long-term and object recognition memory impairments. The decreased extracellular signal-regulated kinases (ERK) or Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) in scopolamine-treated mice was normalized by acute administration of panaxcerol D. Glial fibrillary acidic protein (GFAP), caspase 3, NF-kB p65, synaptophysin and brainderived neurotrophic factor (BDNF) expression levels in Aβ_25-35 peptide-treated mice were modulated by sub-chronic administration of panaxcerol D. Conclusion: Pananxcerol D could improve memory impairments caused by cholinergic blockade or Aβ accumulation through increased phosphorylation level of ERK or its anti-inflammatory effect. Thus, panaxcerol D as one of non-saponin compounds could be used as an active ingredient of P. ginseng for improving cognitive function.

• Nutrition Research and Practice
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• 제18권4호
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• pp.464-478
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• 2024

BACKGROUND/OBJECTIVES: Chronic alcohol consumption causes oxidative stress in the body, which may accumulate excessively and cause a decline in memory; problem-solving, learning, and exercise abilities; and permanent damage to brain structure and function. Consequently, chronic alcohol consumption can cause alcohol-related diseases. MATERIALS/METHODS: In this study, the protective effects of Phyllostachys edulis (Carrière) J. Houz (PE) against alcohol-induced neuroinflammation and cognitive impairment were evaluated using a mouse model. Alcohol (16%, 5 g/kg/day for 6 weeks) and PE (100, 250, and 500 mg/kg/day for 21 days) were administered intragastrically to mice. RESULTS: PE showed a protective effect against memory deficits and cognitive dysfunction caused by alcohol consumption, confirmed through behavioral tests such as the T-maze, object recognition, and Morris water maze tests. Additionally, PE attenuated oxidative stress by reducing lipid oxidation, nitric oxide, and reactive oxygen species levels in the mice's brains, livers, and kidneys. Improvement of neurotrophic factors and downregulation of apoptosis-related proteins were confirmed in the brains of mice fed low and medium concentrations of PE. Additionally, expression of antioxidant enzyme-related proteins GPx-1 and SOD-1 was enhanced in the liver of PE-treated mice, related to their inhibitory effect on oxidative stress. CONCLUSION: This suggests that PE has both neuroregenerative and antioxidant effects. Collectively, these behavioral and histological results confirmed that PE could improve alcohol-induced cognitive deficits through brain neurotrophic and apoptosis protection and modulation of oxidative stress.

• 대한화학회지
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• 제54권6호
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• pp.818-828
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• 2010

대학수학능력시험(수능)이 1994학년도에 처음 시행된 이후 17년이 지나고 여러 번의 모의평가 출제로 인해 문항의 패턴화, 지식 중심의 출제라는 비판이 제기되고 있다. 이러한 문제에 대한 시사점을 얻기 위해 한국과 마찬가지로 국가 중심 교육과정이며 국가 수준에서 이루어지는 선다형 시험 유형을 가진 일본의 대학입시센터시험(센터시험) 문항을 분석하였다. 이 연구에서는 2009년 1월에 시행한 센터시험의 이과시험에서 화학 문항을 수능과 관련하여 내용 요소 및 행동 영역에 따라 분석하고, 문항 유형과 특이 사항을 분석하였다. 또한 한국 수험생의 관점에서 예상 정답률을 추정하여 수능의 화학 문항 출제에 주는 시사점을 도출하였다.

• Communications for Statistical Applications and Methods
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• 제26권2호
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• pp.217-238
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• 2019

With the advent of so-called "default" Bayesian hypothesis tests, scientists in applied fields have gained access to a powerful and principled method for testing hypotheses. However, such default tests usually come with a compromise, requiring the analyst to accept a one-size-fits-all approach to hypothesis testing. Further, such tests may not have the flexibility to test problems the scientist really cares about. In this tutorial, I demonstrate a flexible approach to generalizing one specific default test (the JZS t-test) (Rouder et al., Psychonomic Bulletin & Review, 16, 225-237, 2009) that is becoming increasingly popular in the social and behavioral sciences. The approach uses two results, the Savage-Dickey density ratio (Dickey and Lientz, 1980) and the technique of encompassing priors (Klugkist et al., Statistica Neerlandica, 59, 57-69, 2005) in combination with MCMC sampling via an easy-to-use probabilistic modeling package for R called Greta. Through a comprehensive mathematical description of the techniques as well as illustrative examples, the reader is presented with a general, flexible workflow that can be extended to solve problems relevant to his or her own work.