• Clinical and Experimental Pediatrics
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• 제51권11호
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• pp.1236-1240
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• 2008

Smith-Lemli-Opitz 증후군은 콜레스테롤 합성 과정의 장애로 발생하는 상염색체 열성으로 유전되는 드문 질환으로 다양한 기형을 동반한다. 이는 DHCR7 유전자 변이로 인한 활성도 저하로 발생하는 질환으로 7DHC, 8DHC의 증가 및 체내 콜레스테롤의 감소에 따른 임상상을 특징으로 한다. 저자들은 국내에서 최초로 SLO 증후군을 유전자 분석을 통하여 진단하였기에 이를 문헌 고찰과 함께 보고하는 바이다.

• 한국구조물진단유지관리공학회 논문집
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• 제13권2호통권54호
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• pp.172-180
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• 2009

일반적으로 MR 감쇠기를 이용한 준능동 제어 시스템을 구축하기 위해서는 감쇠장치의 동적모델이 요구된다. 여기서, 동적모델링은 감쇠장치의 발생 감쇠력 및 거동 성향 등을 수치적으로 예측하는 것이다. 따라서 본 연구에서는 이러한 MR 감쇠기의 동적거동을 실무적인 관점에서 합리적으로 모델링하기 위하여 다양한 동적모델 중 Power 모델 및 Bingham 모델을 적용해 MR 감쇠기의 동적거동특성을 예측 평가하였다. 이때 활용한 MR 감쇠기의 실험결과는 압착식 형태로 개발된 MR 감쇠기를 대상으로 동하중 실험을 수행하여 획득하였으며, 힘-변위 이력곡선으로부터 준능동 제어장치로의 타당성을 확인하였다. 또한, 각 동적모델의 예측성능을 평가하기 위하여 우선 실험결과를 이용해 각 동적모델 별 모델변수를 규명하였고, 이를 바탕으로 힘-속도 관계곡선 및 예측된 발생 감쇠력의 오차율을 산출하여 개발된 압착식 MR 감쇠기의 실험결과와 상호 비교 평가하였다. 최종적으로 본 연구에서 개발한 압착식 MR 감쇠기는 준능동 제어장치로 활용 가능함을 확인하였고, 평가된 두 가지 동적모델은 모두 우수한 예측성능을 보임으로써 본 연구에서 개발한 압착식 MR 감쇠기는 물론 MR유체를 이용한 다양한 형태의 감쇠장치의 거동특성을 수치적으로 예측하기 위하여 간단히 활용될 수 있는 가능성을 제시하였다.

• Korean Journal of Acupuncture
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• 제22권2호
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• pp.25-41
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• 2005

Objectives : Bambusae Caulis in Liquamen(BCL) has been used to medication for early stroke in the Oriental Medicine. So this study was planned to investigate the effects of BCL on the focal ischemia-induced by intraluminal filament insertion in the rats. Materials and methods: The focal ischemia was induced by Intraluminal Filament insertion into middle cerebral artery. BCL herbal acupuncture at ST36 was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task and neuroprotective effect of BCL acupuncture was observed by Cresyl violet, AchE, ChAT-stain Results : The error rate in the eight-arm radial maze task was significantly decreased in BCL1(0.89mg/kg) herbal acupuncture group compared to control group on 3,4,5days, compared to saline acupuncture group on 3,5days. The rate of correct choice was significantly increased in saline acupuncture, BCL1 herbal acupuncture group, BCL2(0.089mg/kg) herbal acupuncture groups compared to control group. The density of neurons in the hippocampal CA1 was the most increased in BCL1 herbal acupuncture group compared to the others. The density of AchE in the hippocampal CA1 was significantly increased in BCL1 herbal acupuncture, BCL2 herbal acupuncture groups compared to control group, and in BCL2 herbal acupuncture groups increased compared to saline acupuncture, control groups. The density of ChAT in the hippocampal CA1 was significantly increased in BCLl herbal acupuncture group compared to saline acupuncture, control groups. Conclusions : These results suggest that BCL herbal acupuncture could be used as a medication for controlling the early stroke.

• Korean Journal of Acupuncture
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• 제22권3호
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• pp.137-156
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• 2005

Objectives : Cnidium officinale(CO) has been used for medication for stroke in the Oriental Medicine. So this study was planned to investigate the effects of CO on the focal ischemia-induced by Middle Cerebral Artery Occlusion(MCAO) in rats Materials and methods : The focal ischemia was induced by MCAO. CO extracts through oral administration and herbal acupuncture at GB2l was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task. For the neuroprotective effect of CO, we investigated AchE, ChAT, and NGF-expression by immnohistochemical method. Results : The error rate in the eight-arm radial maze task was significantly decreased in normal group compared to control group on 1-6days, OA-CO1(CO oral administration, 0.8g/kg) group on 1-6days, OA-CO2(CO oral administration, 1.6g/kg) group on 1-3,5,6days, HA-CO1(CO herbal acupuncture, 0.016g/kg) group on 2,3,6days, HA-CO2(CO herbal acupuncture, 0.008g/kg) group on 1-3,5,6days. The rate of correct choice was significantly increased in OA-CO1, HA-CO2. The density of neurons in the hippocampal CA1 was the most increased in OA-CO1, HA-CO1, HA-CO2. The density of ChAT in the hippocampal CA1 was increased in OA-CO1, HA-CO2. The density of ChAT in the hippocampal CA1 was significantly increased in OA-CO1, HA-CO2. The density of NGE in the hippocampal CAI was significantly increased in OA-CO1, OA-CO2, HA-CO2. Conclusions : These results suggest that CO oral administration with 0.8g/kg and CO herbal acupuncture with 0.008g/kg might be used as a regulator of cell death of cholinergic system induced by stroke.

• Korean Journal of Acupuncture
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• 제22권4호
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• pp.43-56
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• 2005

Objectives : The acupuncture has been used as treatment of disease in the oriental medicine. In this study, it was investigated at had an effects of Heart JEONGGYEOK(心正格) of SAAM five evolutive phase acupuncture techniques(舍岩五行鑛法) for appling deficiency in the heart induced by experimental focal ischemia. Materials and methods : The focal ischemia was induced by middle cerebral artery occlusion for 2hours. The groups divided into 6 groups, normal(intactness group), control(no therapy group after ischemia-induced), AT1(reinforcing acupoint of Heart JEONGGYEOK : acupuncture therapy group at LR1, HT9 after ischemia-induced), AT2(reinforcing acupoint of Kidney JEONGGYEOK : acupuncture therapy group at LU8, KI7 after ischemia-induced) AT3(combination of reinforcing acupoint of Heart JEONGGYEOK and Kidney JEONGGYEOK : acupuncture therapy group at LR1, HT9, LU8, KI7 after ischemia-induced) AT4(reinforcing and reducing acupoint of Heart JEONGGYEOK : acupuncture therapy group at LR1, HT9, HT3, KI10 after ischemia-induced), AT4(reinforcing and reducing acupoint of Heart JEONGGYEOK : acupuncture therapy group at LRI, HT9, HT3, KI10 after ischemia-induced). Acupuncture therapy was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task and neuropretective effect of acupuncture therapy was observed by Cresyl violet, AchE, ChAT-stain. Results : The error rate in the eight-arm radial maze task was significantly decreased in AT3 group on 3days, in AT1 and AT4 groups on 4days, in AT3 and AT4 groups on 5days compared to the control group. The rate of correct choice was significantly increased AT4 group compared to the control group. The density of neurons in the hippocampal CA1 were significantly increased in all experiment groups, AT1, AT2, AT3 and AT4 groups compared to the control group. The density of AchE in the hippocampal CA1 was significantly increased in AT4 group compared to the control group. The density of ChAT in the hippocampal CA1 were significantly increased in AT1 and AT3 group compared to the control group. Conclusions : These results suggest that reinforcing and reducing acupoint of Heart JEONGGYEOK could be used as a medication for controlling the stroke by deficiency in the heart.

• Korean Journal of Acupuncture
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• 제22권4호
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• pp.67-81
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• 2005

Objectives : Cervus Elaphus(CE) has been used to medication for ischemic stroke in the Oriental Medicine. So this study was planned to investigate the effects of CE herbal acupuncture therapy(CE-HAT) on the focal ischemia-induced by intraluminal filament insertion in the rats. Materials and methods : The focal ischemia was induced by middle cerebral artery occlusion for 2hours. The groups divided into 6 groups, normal(intachess group), control(no theray group after ischemia-induced), CE-HAT1(Cervus Elaphus-herbal acupuncture therapy group at LR1, HT9 after ischemia-induced), CE-HAT2(Cervus Elaphus-herbal acupuncture therapy group at LU8, KI7 after ischemia-induced), CE-HAT3(Cervus Elaphus-herbal acupuncture therapy group at LR1, HT9, LU8, KI7 after ischemia-induced), CE-HAT4(Cervus Elaphus-herbal acupuncture therapy group at LR1, HT9, HT3, KI10 after ischemia-induced). CE-HAT was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task and neuropretective effect of CE-HAT was observed by Cresyl violet, AchE, ChAT-stain. Results : The error rate in the eight-arm radial maze task was significantly decreased in CE-HAT1, CE-HAT2, CE-HAT4 on 3days, CE-HAT4 on 4days, CE-HAT2, CE-HAT4 on 5days, CE-HAT3, CE-HAT4 on 6days. The rate of correct choice was significantly increased in CE-HAT4. The density of neurons in the hippocampal CA1 was significantly increased in CE-HAT1, CE-HAT2, CE-HAT3, CE-HAT4, compared to control group. The density of ChAT in the hippocampal CA1 was significantly increase in CE-HAT4. The density of ChAT in the hippocampal CA1 was significantly increased CE-HAT1. Conrlusions : These results suggest that the Cervus Elaphus-herbal acupuncture therapy could be used as a medication for controlling the stroke induced by deficiency.

• 정보처리학회논문지A
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• 제12A권6호
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• pp.523-530
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• 2005

PCI 2.2 마스터 디바이스가 타겟 디바이스로부터 데이터를 읽어 오고자 할 때 타겟 디바이스는 내부적으로 데이터를 준비해야 함으로 인해 PCI 버스가 데이터 전송 없이 점유되는 상황이 발생한다. 이를 위해 PCI 2.2 사양에서는 지연전송을 제안하여 전송 효율을 향상시켰지만 이 역시 타겟 디바이스가 얼마의 데이터를 미리 준비 해둘지를 알 수 없어 버스 사용 및 데이터 전송 효율을 떨어뜨리는 원인을 제공한다. 이에 앞선 연구에서는 이를 해결하기 위한 프리페치 요구를 이용하는 새로운 방법을 제안하였다. 본 논문에서는 이 방법을 지원하는 PCI 타겟 컨트롤러와 로컬 디바이스를 설계하였다. 설계된 PCI 타겟 컨트롤러는 간단한 로컬 인터페이스를 가질 뿐 아니라 PCI 2.2를 전혀 모르는 사용자도 쉽게 PCI 인터페이스를 지원할 수 있도록 설계되었다. 또한 설계된 하드웨어를 효과적으로 검증하기 위한 방법으로 기본 동작 검증, 설계 기반검증, 그리고 랜덤 테스트 검증을 제안하였다 이러한 검증을 위해 테스트 벤치와 테스트 벤치를 동작시키는 위한 명령어를 제안하였다. 그리고 랜덤 테스트를 위해 참조 모델, 랜덤 발생기, 비교 엔진으로 구성된 테스트 환경을 구축하였으며 이를 이용해 코너 케이스를 효과적으로 검증할 수 있다. 또한 제안된 테스트 환경을 통해 시뮬레이션 한 결과, 프리페치 요구를 이용한 제안된 방법이 지연 전송에 비해 데이터 전송 효율이 평균 $9\%$ 향상되었다.

• 한국항만경제학회지
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• 제25권3호
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• pp.269-282
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• 2009

광양항의 수입컨테이너 물동량은 최근 들어 빠르게 증가율이 둔화되고 있다. 이에 본 고는 광양항의 물동량이 환율과 경기와 같은 경제변수에 대해 어떠한 특성을 갖는가를 전국항과의 비교를 통해 밝힌다. 광양항의 수입물동량은 환율과 경기의 변동에 전국항보다 큰 영향을 받으며, 최근의 환율과 경기의 움직임에 특히 민감하게 반응을 하여 안정적인 물동량을 유지하지 못하고 있음을 보인다. 이와 같이 민감한 반응을 보임에도 불구하고 장기추세로부터 괴리가 있을 경우 회복하는 속도는 전국항보다 늦어 상황에 대처하는 능력이 떨어지고 있다. 예측오류의 역사적 분해를 통해 광양항의 수입물동량은 환율변동에 상당부분을 의존하고 있어서 환율 상승과 같은 악재에 특히 취약할 수 있다. 그리고 환율충격과 경기충격은 상당기간 물동량의 흐름에 영향을 미치나 환율충격은음의 반응을, 경기충격은 양의 반응을 유발한다. 환율 40원 상승과 경기 5 포인트 하락이라는 단기적 충격에 대해 광양항의 수입컨테이너 물동량은 33천 TEU가 감소하며, 이러한 충격이 1년간 유지되면 광양항의 수입물동량은 197천 TEU 감소한다는 것을 보인다.

• 교육시설 논문지
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• 제26권4호
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• pp.3-10
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• 2019

In school facilities, space is the basic framework. The structure and arrangement of space will provide the form and feel of school facilities. In order to become a high-quality school facility, it is necessary to focus on the educational, human and ecological aspects of the instructor and learner until the space is conceived, designed and completed. However, even when public education was introduced in the past, it did not become a school space considering this aspect. The school space, which focuses on efficiency and labor production, is a school space that reflects the characteristics of a factory-type school, which has been occupied by a large number until recently. Although efforts to improve the quality of school facilities have been attempted in recent years, there is also a need to pursue more active changes. Future-oriented and progressive school spaces include flexibility, connectivity, individualization, diversity(creativity). In other words, space should be flexible so that it can be used faithfully according to the educational situation, not the fixed and limited school space as in the past. In the future, the school space should be open and securely linked to the place where it is essential to complete community relations with the community. In addition, space should be flexible so that the school can meet the needs of each student as much as possible. And the school space should be transformed from the space design of the past fixed pattern to reflect the close relationship between spatial, psychological, physiological, and behavioral areas. When school space needs to shift away from the past and change in a new future-oriented direction, the remaining tasks should be presented with specific characteristics and content of the direction. And the function of the consignment should be handled by related research. Although the text of this study reveals the characteristics of future-oriented school space, more concrete and empirical research results should be presented by subsequent research at home and abroad. It is necessary to reduce trial and error in creating a future-oriented school space where both professors and learners can be satisfied by analyzing the common points and differences between the results of the study. In order to do this, it is necessary to make efforts to approach such research based on the participation of the subjects who teach and learn directly at the school site.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.138-147
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• 2021

본 연구는 우리나라 간호사의 건강증진행위 측정을 위한 검증된 도구가 부족한 실정으로 간호사의 간호환경 특성을 반영하면서 그 사용이 검증된 도구 개발이 필요함에 따라 한국 간호사의 건강증진행위 측정도구를 개발하는 것을 목적으로 한다. 본 연구는 2019년 1월부터 12월까지 간호사 총 530명을 대상으로 실시하였으며 연구방법으로는 문헌 고찰 및 포커스 그룹 면담을 실시하고, 타당성과 신뢰성을 측정하기 위해 데이터 분석을 하였으며, IMB(Information-Motivation-Behavioral Skills) 모델을 적용하여 개념 틀을 구성하였다. 그 결과 간호사로서의 자아개념(2 문항), 병원생활관리(4 문항), 건강에 대한 지식 및 정보(5 문항), 신체적·정신적 스트레스관리(3 문항), 근무적응(2 문항)의 5가지 요인 16 문항으로 도출되었다. 모델 적합도는 346.23 (��<.001), PNFI는 .60, PCFI는 .63으로 허용 기준을 충족했으며 RMSEA는 .10이었다. GFI .88, CFI .85, IFI .85는 기준치에 적합한 것으로 확인되었다. 모든 항목은 Cronbach의 �� .85로 안정적인 신뢰성을 확보하였다. 본 연구에서 개발 한 간호사의 건강증진행위 측정도구는 간호 실무 측면에서 간호사의 건강 증진 행동을 측정하는 도구로 사용될 것이며 간호사의 건강 증진 행동을 폭넓게 이해하는 데 도움이 될 것이다.