• 대한지역사회영양학회지
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• 제9권5호
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• pp.578-588
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• 2004

The present study was conducted to investigate the effect of nutrition education program on nutrition knowledge, eating behaviors, food habit, nutrient intakes in obese children and their parents who live in Gumi city. The subjects were 16 obese boys, 20 obese girls with obesity index over 130% and 36 of their parents. The nutrition education for the subjects was carried out by the professional personnel such as doctors, professors, and dietitians. The children were provided with well-balanced lunch meals and had 40 min-lectures on the reasonable weight management, 40 min-games and also had regular exercises (stretching, swimming) for 90 mins everyday during 2 weeks of the program. The parents had 90 min-lectures on childhood obesity, diet therapy, behavior modification, and exercise for 6 times. The nutrition knowledge, eating behaviors and food habits were surveyed by using questionnaires before and after the education. The nutrition intakes of the children were surveyed before and after the education by 3-day food record method. The nutrition intakes of the parents were surveyed before and after the education by using semi-quantity questionnaires. After the education, the mean nutrition knowledge scores were significantly improved compared with the pretest scores in both children and parents. After the education, all subjects' eating behaviors were significantly changed positively and calorie and carbohydrates intakes were significantly decreased and vit. C was significantly increased in obese children. The food habits of the parents were significantly improved after the education. These findings show that the well-designed nutrition education program for obese children and their parents can be an effective approach to help them to improve their nutrition knowledge and to establish desirable food habits and eating behaviors.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.101-101
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• 2003

Main strategy for a treatment of Parkinson's disease (PD), due to a progressive degeneration of dopaminergic neurons, is a pharmaceutical supplement of dopamine derivatives or ceil replacement therapy. Both of these protocols have pros and cons; former exhibiting a dramatic relief but causing a severe side effects on long-term prescription and latter also having a proven effectiveness but having availability and ethical problems Embryonic stem (ES) cells have several characteristics suitable for this purpose. To investigate a possibility of using ES cells as a carrier of therapeutic gene(s), human ES (hES, MB03) cells were transfected with cDNAs coding for tyrosine hydroxylase (TH) in pcDNA3.1 (+) and the transfectants were selected using neomycin (250 $\mu /ml$). Expression of TH being confirmed, two of the positive clone (MBTH2 & 8) were second transfected with GTP cyclohydrolase 1 (GTPCH 1) in pcDNA3.1 (+)-hyg followed by selection with hygromycin-B (150 $\mu /ml$) and RT-PCR confirmation. By immune-cytochemistry, these genetically modified but undifferentiated dual drug-resistant cells were found to express few of the neuronal markers, such as NF200, $\beta$-tubulin, and MAP2 as well as astroglial marker GFAP. This results suggest that over-production of BH4 by ectopically expressed GTPCH I may be involved in the induction of those markers. Transplantation of the cells into striatum of 6-OHDA- denervated PD animal model relieved symptomatic rotational behaviors of the animals. Immunohistochemical analyses showed the presence of human cells within the striatum of the recipients. These results suggest a possibility of using hES cells as a carrier of therapeutic gene(s).

• Journal of Oral Medicine and Pain
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• 제32권2호
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• pp.241-250
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• 2007

측두하악장애 재발 환자의 증상과 보존적 치료결과에 대하여 알아보고자 1994년부터 2002년까지 부산대학병원 구강내과에 내원하여 측두하악장애로 진단되어 약물요법, 물리치료, 교합안정장치 등 보존적 치료를 받은 환자 104명(원발군, 대조군)과 1991년부터 2001년까지 부산대학병원 구강내과에 내원하여 측두하악장애로 진단되어 보존적 치료를 받은 후에 증상이 재발하여 1992년부터 2002년에 걸쳐 보존적인 방법으로 재치료를 받은 환자 54명(재발군, 실험군)을 대상으로 서로 비교하여 다음과 같은 결과를 얻었다. 1. 원발군과 재발군은 모두 보존적 처치로 증상이 현저히 개선되었다. 2. 원발군과 재발군의 초진시 증상은 통증, 개구제한, 최대 편이개구량은 차이가 없었으나 관절잡음은 원발군에서 높았다. 3. 원발군과 재발군의 치료 종결시 증상은 통증, 개구제한, 최대 편이개구량은 차이가 없었으나 관절잡음은 재발군에서 높았다. 4. 원발군과 재발군 모두 치료방법, 성, 병명에 따른 치료결과의 차이는 없었다. 5. 원발군은 치료기간이 6개월 이상 일수록, 치료횟수가 10회 이상일수록 치료결과가 양호하였다.