• Biomolecules & Therapeutics
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• 제27권2호
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• pp.168-177
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• 2019

Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There is ample evidence that overstimulation of NMDA-dependent neurotransmission may induce neurobehavioral abnormalities, such as repetitive behaviors and hypersensitization to nociception and cognitive disruption, pharmacological modeling using NMDA has been limited due to the induction of neurotoxicity and blood brain barrier breakdown, especially in young animals. In this study, we examined the effects of intraperitoneal NMDA-administration on nociceptive and repetitive behaviors in ICR mice. Intraperitoneal injection of NMDA induced repetitive grooming and tail biting/licking behaviors in a dose- and age-dependent manner. Nociceptive and repetitive behaviors were more prominent in juvenile mice than adult mice. We did not observe extensive blood brain barrier breakdown or neuronal cell death after peritoneal injection of NMDA, indicating limited neurotoxic effects despite a significant increase in NMDA concentration in the cerebrospinal fluid. These findings suggest that the observed behavioral changes were not mediated by general NMDA toxicity. In the hot plate test, we found that the latency of paw licking and jumping decreased in the NMDA-exposed mice especially in the 75 mg/kg group, suggesting increased nociceptive sensitivity in NMDA-treated animals. Repetitive behaviors and increased pain sensitivity are often comorbid in psychiatric disorders (e.g., autism spectrum disorder). Therefore, the behavioral characteristics of intraperitoneal NMDA-administered mice described herein may be valuable for studying the mechanisms underlying relevant disorders and screening candidate therapeutic molecules.

• 한국간호교육학회지
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• 제27권1호
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• pp.39-48
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• 2021

Purpose: This study aimed to explore factors influencing on the preventive behaviors of dementia in older Koreans enrolled in senior welfare centers to provide basic information on dementia prevention. Methods: A total of 182 older Koreans participated in this study, which employed a cross-sectional design. Data were collected using questionnaires with items related to general characteristics, depression, self-esteem, knowledge and attitudes about dementia, preventive behaviors of dementia, dementia management self-efficacy, and anxiety about dementia. Using SPSS WIN 23.0, data were analyzed by descriptive statistics, t-test, ANOVA, Scheffé test, Pearson's correlation coefficient, and multiple regression. Results: Living with a spouse (p=.013), a higher monthly income (p=.018), better nutrition (p=.010), not having a sleep disorder (p<.001), and higher number of participating programs (p=.001) were associated with better dementia prevention behaviors. Attitudes about dementia (��=.18, p=.006) and the number of programs older Koreans were participating in (��=.17, p=.006) influenced positively on the preventive behaviors of dementia, while depression (��=-.41, p<.001) and sleep disorders (��=-.17, p=.006) influenced negatively on dementia preventive behaviors. Overall, approximately 35% of the variability in dementia preventive behaviors was explained by these four variables in this study (F=24.97, p<.001). Conclusion: The findings of this study suggest that depression reduction, good attitudes about dementia, program participation, and good sleep should be encouraged to promote dementia prevention. In addition, effective and structured educational programs should be developed for older Koreans to encourage dementia preventive behaviors to reduce the risk of dementia.

• 디지털융복합연구
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• 제19권2호
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• pp.531-538
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• 2021

이 연구는 무용전공 고등학생의 자기관리가 섭식태도와 섭식장애에 미치는 영향을 규명하는데 목적이 있다. 연구대상은 서울과 경기도, 충청도에 소재하고 있는 예술고등학교 무용전공 고등학생 239명으로, 조사도구는 설문지를 사용하였다. 자료 분석은 다중회귀분석과 위계적 회귀분석을 실시하여 다음과 같은 결과를 도출하였다. 첫째, 무용전공 고등학생의 대인관리는 절제된 섭식에 영향을 미치며, 몸 관리는 외부적 섭식과 정서적 섭식에 영향을 미친다. 둘째, 무용전공 고등학생의 자기관리는 거식증에 유의한 영향을 미친다. 셋째, 무용전공 고등학생의 섭식태도는 자기관리와 섭식장애를 강력하게 매개한다. 이상의 결과는 무용전공 고등학생들의 지나친 신체에 대한 관리는 섭식태도와 거식증에 높은 영향을 미친다는 것을 의미한다. 이에 따라 학생들의 올바른 섭식행동을 위한 지도자들의 세심한 지도가 필요한 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.69-77
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• 2021

Objective : Classification systems for cervical ossification of the posterior longitudinal ligament (OPLL) have traditionally focused on the morphological characteristics of ossification. Although the classification describes many clinical features associated with the shape of the ossification, including the concept of spondylosis seems necessary because of the similarity in age distribution. Methods : Patients diagnosed with OPLL who presented with increase signal intensity (ISI) on magnetic resonance imaging were surgically treated in our department. The patients were divided into two groups (pure versus degenerative) according to the presence of disc degeneration. Results : Of 141 patients enrolled in this study, more than half (61%) were classified into the degenerative group. The pure group showed a profound male predominance, early presentation of myelopathy, and a different predilection for ISI compared to the degenerative group. The mean canal compromise ratio (CC) of the ISI was 47% in the degenerative group versus 61% in the pure group (p<0.0000). On the contrary, the global and segment motions were significantly larger in the degenerative group (p<0.0000 and p=0.003, respectively). The canal diameters and global angles did not differ between groups. Conclusion : Classifying cervical OPLL based on the presence of combined disc degeneration is beneficial for understanding the disorder's behavior. CC appears to be the main factor in the development of myelopathy in the pure group, whereas additional dynamic factors appear to affect its development in the degenerative group.

• 한국산학기술학회논문지
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• 제22권6호
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• pp.375-384
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• 2021

본 연구는 조현병 관련 기사에 나타난 키워드와 주요 주제의 변화를 파악하는 의미연결망 분석, 계량적 내용분석 연구이다. 연구대상은 강남역 살인사건 전후 5년간 보도된 조현병 관련 신문기사이다. 수집된 자료는 NetMiner 프로그램 4.4.1을 이용하여 네트워크 통계분석을 시행하였다. 2013년부터 2018년까지 8개 중앙지에서 610개의 신문기사가 검색되었다. 출현빈도가 가장 높은 주요 키워드는 강남역 살인사건 이전에는 '치료', 사건 이후에는 '사건'으로 나타났다. 사건 이전에는 '편견으로 치료시기를 놓치면 만성화 됨', '조기 치료하면 치료가 가능함', '약물치료로 정상적인 생활이 가능함', '심신미약 상태에서 살인 혐의로 기소됨'이라는 네 가지 주제가 도출되었다. 반면, 사건 이후 '여성혐오주의자가 아니라 피해망상이 심해져 살인을 저지름', '약물치료 중단으로 충동적인 행동이 유발됨', '범행 후 심신미약으로 인한 감형을 주장함', '흉기 난동에 출동한 경찰을 살해함'이라는 네 가지 주제가 도출되었다. 이러한 결과는 신문기사가 조현병 및 기타 정신질환자에 대한 편견과 낙인을 줄이기 위해 조현병에 대한 정확한 정보를 제공해야 함을 시사한다.

• 한국결정성장학회지
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• 제30권6호
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• pp.215-219
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• 2020

A-자리 결함 이중 Perovskite La1/3TaO3 단결정 시편을 제작하여 10~800 K 온도범위에서 유전특성을 조사하였다. 500 K 이하에서는 상유전성 거동이 나타났으며, 550 K 이상에서 유전이상과 유전상수의 열이력(thermal hysterisis)가 나타났다. 교류전도도 측정에 의한 활성화 에너지는 560 K 이하 영역에서 1.83 eV로 가장 크며, 560~690 K 영역에서 0.35 eV, 690 K 이상인 고온 영역에서 0.28 eV로 나타났다 이러한 결과로부터 500 K 이하 영역에서는 La3+-이온과 공공-자리가 무질서하게 배열하여 상유전상을 유지하며, 가장 높은 활성화 에너지를 나타낸 560 K 부근 영역에서는 La3+-이온이 공공-자리로의 전도 혹은 점프에 의한 재배열에 기인하여 유전이상이 나타난 것으로 판단된다.

• 한국임상약학회지
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• 제31권1호
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• pp.21-26
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• 2021

Background: Pharmacogenomics is the study of how genetic mutations in patients affect their response to drugs. Pharmacogenomic studies aim to maximize drug effects and minimize adverse drug events. The Food and Drug Administration and the European Medicine Agency published guidelines for pharmacogenetics in 2005 and 2006, respectively; the Korean Ministry of Food and Drug Safety followed suit in 2015. Methods: This study analyzed pharmacogenomic information in the Korean Ministry of Food and Drug Safety's integrated drug information system to evaluate whether domestic pharmaceutical products reflect the current research on pharmacogenomic differences. Results: In June 2020, the Korean pharmacogenomic database contained genomic data on 90 compounds. Of these, 45 compounds were classified as "Antineoplastic and immunomodulating agents." The other 45 non-antineoplastic agents were in the following categories: Anti-infectives, Mental & behavior disorder, Hormone & metabolism related diseases, Cardiovascular system, Skin & subcutaneous tissue disease, Genito-urinary system and sex hormones, Blood and blood forming organs, Nervous system, Alimentary tract and metabolism, Musculo-skeletal system, and Other conditions including the respiratory system. In addition, 30 additives unrelated to the main ingredient were associated with genetic precautions. Conclusion: This study showed that antineoplastic and immunomodulating agents accounted for half the drugs associated with pharmacogenetic information. For antitumor and immunomodulatory drugs, genomic tests were recommended depending on the indication; this was in contrast to genomic testing recommendations for non-antineoplastic medications. Genomic tests were rarely requested or recommended for non-antineoplastic medications because the relationships between genotype and efficacy among those drugs were relatively weak.

• 한국식생활문화학회지
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• 제37권4호
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• pp.363-375
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• 2022

Galactosemia is a rare, hereditary metabolic disorder caused by the accumulation of galactose and its metabolites in the body due to a lack of enzymes that convert galactose to glucose. This study aimed to investigate the dietary behaviors and nutritional statuses of patients with galactosemia and to provide basic information on the development of nutrition education programs to improve quality of dietary life. A survey was conducted on 13 parents of (<11 years of age) children with galactosemia and 26 parents of (<11 years of age) children without galactosemia. Mean body mass index was greater for school-age children with galactosemia (18.77 kg/m²) than for corresponding normal children (16.55 kg/m²). Underweight and obesity rates of children with galactosemia were greater than those of children without galactosemia. In addition, children with galactosemia had a higher food neophobia rate and thus consumed less food. Normal children exhibited a greater range of food preferences than those with galactosemia, especially for milk and dairy products (p= .001) and fats and sweets (p= .04). Reliable food databases and appropriate dietary recommendations are required to ensure the proper growth of children with galactosemia.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.105-110
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• 2022

The microdeletion syndrome of chromosome 2p15p16.1 (MIM: 612513) is an extremely rare contiguous gene deletion syndrome. Microdeletions of varying sizes in the 2p15-16.1 region are associated with developmental delay, intellectual disability, autism spectrum disorder, hypotonia, and craniofacial dysmorphism. Previous studies have identified two critical regions: the proximal 2p15 and distal 2p16.1 regions. BCL11A, PAPOLG, and REL genes play crucial roles in patients with 2p16.1 microdeletion. To our knowledge, only 39 patients have been reported as having 2p15p16.1 microdeletion syndrome. Here, we present another patient with 2p15p16.1 microdeletion syndrome. A nine-month-old boy was referred to our clinic for the psychomotor delay, facial dysmorphism, and congenital hypothyroidism. During his follow-up visits, he was diagnosed with global developmental delay, intellectual disability, abnormal behavior, hypotonia, microcephaly, and abnormal electroencephalography. Using a chromosomal microarray for genetic analysis, a novel, de novo, 622 kb microdeletion of 2p16.1 was identified as one of the critical regions of the 2p15p16.1 microdeletion syndrome. This is the first case of its kind in Korea. We have discussed our case and literature reviews to clarify the relationship between the genes involved and clinical phenotypes in 2p15p16.1 microdeletion syndrome.

• 문화기술의 융합
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• 제10권4호
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• pp.367-372
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• 2024

발달장애는 전체 장애인 수 중에 비교적 낮은 수치에 해당되지만 장애의 정도에서 전반적으로 중증 장애로 분류되고 있다. 이러한 발달장애는 초기에 발견이 된다면 적응력과 초기 대응에 의한 치료 효과가 향상될 수 있지만, 대부분의 부모들은 자신의 아이에게서 징후를 발견하지 못하거나 치료시기를 놓치는 경우가 대다수이다. 본 논문에서는 특이적 행동특성을 기반으로 하는 초기 발달장애 징후를 객관적으로 볼 수 없는 부모나 유아기관 관계자들을 위해 발달장애 초기 특이행동 중 손 퍼덕대기(Hand-Flapping)를 인식할 수 있는 발달장애 진단 알고리듬개발의 선행연구를 수행하였다. 인지영역과 손가락을 정확하게 인식하여, 손퍼덕임 수를 정확하게 카운트하는 것을확인할 수 있었다. 빅데이터를 활용한 알고리듬의 고도화 및 기능적 성능 확장을 통해 다양한 행동패턴의 진단이 가능한 알고리듬 연구가 지속적으로 수행 및 확대될 것으로 전망된다.