• Korean Journal of Acupuncture
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• v.31 no.4
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• pp.225-228
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• 2014

Objectives : The purpose of this report is to show the clinical efficiency of korean medical treatments with Bee Venom pharmacopuncture therapy on patient of Trigeminal Neuralgia. Methods : The patient was treated with Bee Venom pharmacopuncture, acupuncture, electroacupuncture, cupping venesection treatment, and herbal medicine. Visual Analog Scale was used to evaluate the improvement of pain after all treatments. Results : Visual Analog Scale was improved from 10 to 2 after korean medical treatment including Bee Venom pharmacopuncture. Conclusions : Korean medical treatments with Bee Venom pharmacopuncture can be effective for improving symptoms of Trigeminal Neuralgia.

• Korean Journal of Acupuncture
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• v.37 no.2
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• pp.76-87
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• 2020

Objectives : Bee venom has been widely practiced in many countries around the world. The number of clinical trials and biochemical researches on bee venom has been constantly increasing. The objective of this study is to analyze the trend of research on bee venom using bibliometric approach, a quantitative analytical method. Methods : We searched articles about bee venom which were published from 2000 to 2019 from Web of Science Database. Original and review articles published in English were included and data were extracted in terms of publication year, country, journal, keywords, organizations, and authors. Trends in bee venom research were visualized using VOSviewer program. Results : 1,547 English articles about bee venom were identified and analyzed. South Korea is a main hub in the field of bee venom research. Research organizations in South Korea showed high link strength with domestic organizations as well as with international organizations. A keyword analysis showed the following three major types of studies: studies on components of bee venom, studies on allergy and immune response, and clinical research of bee venom therapy. Conclusions : This study provides a macroscopic overview of the research on bee venom. This bibliometric analysis has identified influential authors and organizations in the field on bee venom research and provides a useful guideline to researchers who are in search of contributory research topics.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.227-249
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• 1995

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

• Journal of Pharmacopuncture
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• v.9 no.3 s.21
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• pp.61-77
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• 2006

Objectives : Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom in which the allergy causing enzyme is removed. Methods : 95 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of bee venom pharmacopuncture and Sweet BV pharmacopuncture was equally at 0.1mg/ml and the experiment was conducted as the double blind test. Experiment groups were classified into low dosage groups(0.1ml for both bee venom pharmacopuncture and Sweet BV) and high dosage groups where 0.4ml of respective administrations were rendered made observations for allergic responses. Results : Participants of the study was comprised of 71 men and 24 women with the average age of 29.0 years. According to results of the low dosage groups, Sweet BV group showed significant reduction in pain after 4 hours and 24 hours compared to the bee venom pharmacopuncture group. Other allergic responses were insignificant between the groups. For the high dosage groups, Sweet bee venom group showed reduction in pain after 30 minutes and 4 hours. Other allergic responses such as edema, itchiness, dizziness from hypersensitivity, and fatigue were significantly lower in the Sweet bee venom administered group after 30 minutes. Conclusions : As a result of removed allergen, Sweet bee venom significantly inhibits allergic responses both locally and throughout the body. This indicates wider and easier application of Sweet bee venom for the symptoms applicable to the bee venom pharmacopuncture. Further comparative studies should be conducted to yield more objective verification.

• Journal of Acupuncture Research
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• v.18 no.6
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• pp.232-239
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• 2001

Objective & Method : To identify current state of bee venom therapy(BVT) research as a treatment of autoimmune diseases, we reviewed the PubMed electronic database. 9 articles with clinical implications were discussed. Results : BVT is reported as effective in the treatment of such autoimmune related diseases as rheumatoid arthritis and insulin dependent diabetes mellitus in animal experiment, The lack of evidence on BVT as a treatment of multiple sclerosis deters us from reaching any determination. There also lacks firm evidences of immune response regulative or anti inflammatory mechanism of BVT. No clinicla trial was found. Conculsion : This review raises the urgent need of study to provide scientific and clinical evidences.

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.197-204
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• 2008

Objectives : This is a clinical report about the 47-year-old female patient with Trigeminal Neuralgia(TN) treated by oriental medicine treatment including Bee Venom Pharmacopuncture therapy(BVP), without any western medical treatment. Methods : The patient was treated by acupuncture, herb medication, and BVP. The improvement of the patient was judged by Visual Analog Scale(VAS). Results : The pain was gradually reduced and VAS became 0 after 8 days of treatment. Since then the pain didn't reappeared for 6 months. Conclusions : Oriental medicine treatment including BVP was very effective to improve the TN patient's symptoms. It is necessary to have more observation and many cases of patients with TN.

• Journal of Pharmacopuncture
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• v.8 no.3
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• pp.99-105
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• 2005

Objectives : The purpose of this study is to analyze the functional and clinical improvement effect on temporomandibular disorder by additional Hominis Placenta and bee venom herbal acupuncture treatment. Methods : A patient was treated with Hominis Placenta, bee venom herbal acupuncture, simple acupuncture, chiropractic therapy, and herbal medicine. We evaluated the improvement by visual analogue scale(VAS) score, mouth opening range, and X-ray image. Results : The VAS score was significantly decreased and mouth opening range was increased after treatment. X-ray image showed improved change after treatments. Conclusions : We think Hominis Placenta and bee venom herbal acupuncture treatment mainly contributed to the improvement of temporomandibular disorders. Further study is needed for the confirmation of this effect of on temporomandibular disorders.

• Journal of Pharmacopuncture
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• v.7 no.2
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• pp.75-81
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• 2004

Objective : The purpose of this study is to report the efficiency of Bee Venom Therapy by managering of radial nerve palsy patients. Method : Three patients were treatmented by Bee Venom therapy and acupucture therapy. And we took pictures of someone's wrist and checked the power of muscles by the improving phase. Results : Almost cases shows the improvement in the movement of wrist and the numbness of hand. By using acuputure and Bee Venom therapy, the symptoms of radial nerv palsy was more fastly recovered.

• Journal of Pharmacopuncture
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• v.12 no.2
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• pp.99-105
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• 2009

Objective : This is a clinical report about allergic rhinitis patients. Method : The two patients were treated by Bee Venom Pharmacopuncture and needle acupuncture together from June 2007 to September 2007. Result : As using these treatments, all patients decreased in sneezing, rhinorrhea and nasal congestion notably. And further, all patients had no side effects. Conclusion : The results suggest that Bee Venom Pharmacopuncture and needle acupuncture have an useful effect on allergic rhinitis patients.

• Journal of Pharmacopuncture
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• v.11 no.2
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• pp.55-62
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• 2008

Objective Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom(SBV) and New Sweet Bee Venom(NSBV) removed enzymes and compounds of low molecular weight. Methods 84 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of Normal Saline, SBV and NSBV pharmacopuncture was equally at 0.1mg/mL and the experiment was conducted as the double blind test. Results Participants of the study was comprised of 63 men and 21 women with the average age of 28.3 years. According to results of pain sense, SBV group showed significant higher score compared with NS group and NSBV group using VAS in treating time. And SBV and NSBV group showed significant higher score compared with NS group after 30 minutes. Other allergic responses were insignificant between the groups. Conclusions As a result of removed allergen and compounds of low molecular weight, NSBV significantly inhibits pain sense in treating time compared with SBV. This indicates wider and easier application of NSBV for the useful application in clinical treatment. Further comparative studies should be conducted to yield more objective verification.