• Journal of Pharmacopuncture
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• v.12 no.3
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• pp.81-88
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• 2009

Objective : This study was to report Bell's palsy patients with severe pain back of the ear treated by Bee Venom Pharmacopuncture therapy. Methods : The patients was treated by Bee Venom Pharmacopuncture therapy to relieve the severe pain back of the ear. Visual Analog Scale(VAS) was used as an outcome measurement. Results : After Bee Venom Pharmacopuncture therapy, VAS were decreased at all case. Conclusion : Bee Venom Pharmacopuncture therapy can be available for relieving severe pain back of the ear even inducing insomnia.

• The Journal of Korean Medicine
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• v.41 no.3
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• pp.247-259
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• 2020

Objectives: This review aims to investigate clinical studies related to bee venom pharmacopuncture for cancer patients and to analyze the research trend for further study. Methods: We searched for clinical studies using bee venom pharmacopuncture therapy on patients with cancer through the electronic databases including Pubmed, Cochrane library, OASIS, KISS, NDSL, and KMBASE. There was no restriction on language and publication date, and after selection/exclusion process, the study design, target disease, intervention details including acupoints, treatment frequency and period, outcomes, study results and adverse events were extracted. Results: Thirteen clinical studies were finally selected. There were a randomized controlled trial RCT about the effect of sweet bee venom pharmacopuncture on cancer-related pain, and three case series about chemotherapy-induced peripheral neuropathy. In case reports, there were nine studies about oligodendroglioma, plexiform neurofibroma, breast cancer, prostate cancer, lung cancer, urachal adenocarcinoma, malignant melanoma, and atypical squamous cells of undetermined significance. The bee venom therapy affected the improvement of outcomes such as symptoms, quality of life, tumor response, and lab findings. Conclusions: The present study found that bee venom therapy is applicable to the treatment of cancer patients, and showed some effect on various symptoms. However, due to insufficient number and quality of studies, well designed and high-quality clinical trials are necessary to confirm the effectiveness and safety of bee venom pharmacopuncture therapy in patients with cancer.

• Journal of Acupuncture Research
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• v.28 no.3
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• pp.21-31
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• 2011

Objectives : The purpose of this study was to evaluate the effect of bee venom pharmacopuncture therapy in patients with lumbar spinal stenosis. Methods : This clinical study was carried out on 119 patients with lumbar spinal stenosis, who had been admitted from May, 2009 to March, 2011. Patients were sorted into two groups ; One group(bee venom pharmacopuncture group) was treated with bee venom pharmacopuncture and acupuncture therapy, the other(non-bee venom pharmacopuncture group) with acupuncture therapy only. Verbal numerical rating scale(VNRS) and Oswestry disability index(ODI) were used to evaluate the effectiveness of the treatment in both groups. VNRS and ODI scores of the two groups were statistically compared. Results : The bee venom pharmacopuncture group demonstrated a more significant improvement than non-bee venom pharmacopuncture group when evaluated with VNRS and ODI. Conclusions : In the case of the patients with spinal stenosis, it was found that treatment with combination of bee venom pharmacopuncture and acupuncture was more effective in improving the conditions of the patients (subsidence of the symptoms) than the acupuncture treatment only.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.97-106
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• 2008

Objectives : This study was designed to evaluate the effects of Bee Venom Pharmacopuncture therapy in patients with lumbar spinal stenosis. Methods : We investigated 16 patients with lumbar spinal stenosis. We divided patients into two groups : Bee Venom Pharmacopuncture was performed with acupuncture therapy for one group, and the other group received acupuncture therapy only. To evaluate the effectiveness of the treatment applied to the two groups, we used the Visual Analog Scale(VAS) and the Oswestry Low-back Pain Disability Index(ODI). We compared the VAS and ODI scores of the two groups statistically. Results : The Bee Venom Pharmacopuncture group received more effective relief than the acupunctureonly group as measured by decreasedpain and disability reported on the VAS and ODI by patients with lumbar spinal stenosis. Conclusions: Bee Venom Pharmacopuncture therapy can be used in addition to acupuncture therapy for highly effective treatment of patients with lumbar spinal stenosis. Further clinical studies are needed to verify these findings.

• Journal of Acupuncture Research
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• v.27 no.4
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• pp.179-185
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• 2010

Objectives : This study was to investigate the effectiveness of Bee Venom Pharmacopuncture therapy at Yepung($TE_{17}$) on peripheral facial paralysis. Methods : We investigated 36cases of patients with Peripheral Facial Paralysis, and devided patients into two groups : We treated one group by complex oriental medical treatment with Bee Venom Pharmacopuncture therapy at local point with Yepung(VY), and did the other group by complex oriental medical treatment with Bee Venom pharmacopuncture therapy at local point without Yepung(VL). To evaluate the effectiveness of treatment applied for two groups, we used Gross Grading System of House-Brackmann(HB score), Yanagihara's Unweighed Grading System(Y score) at baseline and final. Results : 1. In VY and VL, compared with baseline, at final, HB score was significantly decreased and Y score was significantly increased. 2. At final, VY showed significant decrease on HB score and significant increase on Y score compared with VL. Conclusions : Bee Venom Pharmacopuncture therapy at Yepung can be available for relieving symptoms related with peripheral facial paralysis.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.4
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• pp.155-161
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• 2017

The purpose of this study is to research and report the effect of Bee Venom pharmacopuncture therapy at facet joint for the two patients who was diagnosed as herniated intervertebral disc (HIVD) of lumbar spine. Two patients were hospitalized and treated with Complex Korean Medical treatment such as acupuncture, herbal medicine and Essential bee venom (EBV) pharmacopuncture in Dongsuwon hospital of oriental medicine. We measured their pain and function of daily life by numerical rating scale (NRS), straight leg rasing test (SLRT), Roland-morris disability questionnaire (RMDQ). As the result, we found the improvement of gait disturbance, functional disorder, and pain. This study suggested that Bee Venom pharmacopuncture therapy at facet joint is considered to conservative treatment for HIVD of lumbar spine. But further clinical studies are needed to clarify the effect of Bee Venom pharmacopuncture therapy at facet joint for the two patients with HIVD of lumbar spine.

• Journal of Acupuncture Research
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• v.26 no.4
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• pp.29-37
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• 2009

Objectives : This study was to investigate the effectiveness of Bee Venom Pharmacopuncture complex therapy on peripheral facial paralysis. Methods : We investigated 30 cases of patients with Peripheral Facial Paralysis, and devided patients into two groups : We treated one group by complex oriental medical treatment with Bee Venom Pharmacopuncture therapy, and did the other group by complex oriental medical treatment without Bee Venom pharmacopuncture therapy. To investigate the effectiveness of treatment applied for two groups, we used Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System at baseline, 3 weeks and final. Results : 1. Male, Female is same ratio in distribution of sex, the number of left side is more than that of right side in distribution of lesion, the average age is 49.33. 2. Pain back of the ear showed the highest frequency among Bell's palsy related symptoms at onset, the overwork was a major cause of Bell's palsy in distribution of cause. 3. As a result of evaluation by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System, treatment score after 3weeks was marked higher than that before treatment and treatment score after final treatment was also marked higher than that after 3weeks within each group. 4. After final treatment, Bee Venom Pharmacopuncture therapy group showed signficant difference on Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System compared with Acupuncture therapy group. Conclusions : Bee Venom Pharmacopuncture therapy can be available for relieving symptoms related with peripheral facial paralysis.

• Journal of Acupuncture Research
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• v.30 no.5
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• pp.41-50
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• 2013

Objectives : This study was performed to compare the effects of Shinbaro pharmacopuncture therapy and bee venom pharmacopuncture therapy in lumbar disc herniation Methods : We compared treatment efficacy of 12 patients with Shinbaro pharmacopuncture therapy and 10 patients with bee venom pharmacopuncture therapy, all of whom were diagnosed with lumbar disc herniation using computed tomography(CT) or magnetic resonance imaging(MRI). We performed a retrospective comparison and analysis during the course of 21 days since admission. To evaluate the treatment efficacy, we recorded the temperatures of the opposite back, hip, and legs with visual analog scale(VAS, back and legs), pain rating scale(PRS), Oswestry disability index(ODI) and digital infrared thermal imaging(DITI) based on patients' medical records. Results : Both treatments were effective in reducing pain and improving functions for lumbar disc herniation patients in terms of VAS, PRS, ODI, DITI. Shinbaro pharmacopuncture group showed slightly better results than the bee venom pharmacopuncture group, but the difference was not significant. Conclusions : For the treatment of lumbar disc herniation, it is suggested that Shinbaro pharmacopuncture therapy is thought to be as effective as bee venom pharmacopuncture therapy without side effects, although further study would be necessary.

• Journal of Pharmacopuncture
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• v.9 no.2
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• pp.93-97
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• 2006

Objective : This study was to evaluate the effectiveness of Bee Venom acupuncture therapy on external epicondylitis. Methods : We divided chronic arthritis of ankle patient into 2 groups; one group combined bee venom acupuncture therapy and acupuncture therapy, another group was only acupuncture therapy. To estimate the effectiveness of treatment that applied for two groups, we used visual analog scale(VAS). We compared the VAS score of two groups statistically. Results : 1. As a result of evaluation by using visual analog scale(VAS), treatment score at final was marked more higher than score before treatment on each groups. 2. treatment at final, acupuncture and bee venom acupuncture therapy group had significant result on visual analog scale(VAS) compared with acupuncture therapy group. Conclusion : Bee Venom acupuncture therapy can be used with acupuncture therapy for highly effective treatment for external epicondylitis.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.101-123
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• 2011

Objectives : The aim was to study the effect of bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model. Methods : We enforced a bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model by the intradermal injection of chicken type II collagen emulsified. 14 days after the onset of the rheumatoid arthritis rat model, a fixed volume of bee venom was daily injected to ST-35 acupoint in the rat's knee joint for 2-3 weeks. The hind paw volume, arthritic index, arthritic flexion pain test, pain threshold, and serum analysis (CRP, $PGE_2$, ALT, AST) were analyzed, and the expression profiles of COX-2, c-fos, and substance-P at the dorsal horn region of the spinal cord and subchondral bone of the knee joint were also analyzed by using the immunohistochemistry. Results : After the treatment of rheumatoid arthritis rats with bee venom pharmacopuncture, the paw volume of edema of arthritic rats were almost restored to the level of normal group, and behavior tests were very effective. Also the evaluation on the blood serum analysis was remarkable. COX-2, c-fos, and substance-P positive cells in the immunohistological section of dorsal horn region of the spinal cord and subchondral bone of the knee joints were significantly decreased. also the bee venom pharmacopuncture was effective to alleviate their rheumatoid arthritic inflammation cytokine inhibition as regards to the behavior tests and joint histological appearance. Conclusions : Based on the results in this study, bee venom pharmacopuncture with concentrated treatment condition was very effective in low fixed quantity and progressive low increased quantity.