• Title/Summary/Keyword: Bed forms

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Controlled Release of Nifedipine from Osmotic Pellet Based on Porous Membrane (니페디핀을 포함한 삼투성펠렛의 제조와 다공성막을 통한 약물방출제어)

  • Youn, Ju-Yong;Ku, Jeong;Kim, Byung-Soo;Kim, Moon-Suk;Lee, Bong;Khang, Gil-Son;Lee, Hai-Bang
    • Polymer(Korea)
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    • v.32 no.4
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    • pp.328-333
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    • 2008
  • The osmotic delivery systems are based on osmosis. The transverse diffusion of water through a porous membrane from a medium with a low osmotic pressure to a medium with a high osmotic pressure. Nifedipine tablet dosage forms of Procardia $XL^{(R)}$(Pfizer) and $Adalat^{(R)}$(Bayer) are commercialized systems of this type that push-pull osmotic tablet operates successfully in delivering water-insoluble drugs. We prepared osmotic pellet system by fluidized bed coating method, and model-drug used nifedipine. The osmotic pellet system was composed of the core material. the swelling and osmotic pressure layer, the drug coating layer, and the porous membrane. This work is performed to investigate the effect of different factors, such as composition and thickness of membrane. The osmotic pellet has been successfully prepared by fluidized bed coating technology. The drug release behavior depended on the increase of CA ratio and thickness in porous membrane. The morphology of the osmotic pellet before and after the dissolution test were observed by SEM. In conclusion, we found that the drug release of osmotic pellet depended on the composition and coating thickness of porous membrane.

An Eclogical Study on the Aquatic Animals in Jungrang Stream of Seoul (중랑천의 수서동물에 관한 생태학적 연구)

  • 배경석;박종태;조기찬;길혜경;신재영
    • Journal of Environmental Health Sciences
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    • v.23 no.2
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    • pp.89-97
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    • 1997
  • Most of urban streams in Korea have been changed channel forms and suffered from direct inflow of domestic sewage, etc. Therefore, maintenance of structure and function of those ecosystem are hard. The present study was carried out to examine the life survival maintenance ability of the stream by community analysis of aquatic animals in typical urban stream (Jungrang stream) in Seoul. The aquatic animals were composed of 31 species, 18 families, 8 orders, 5 classes in 4 phyla. Seasonal species number showed big fluctuation between 8 species in Winter and 24 species in Autumn. Major dominant species in Jungrang stream were Tubificidae sp.1, Chironomidae sp.1, Chironomidae sp.2 and Physa acuta, and above endurance species for water pollution occupied very high dominance indices. But, Cercion hieroglyphicum, Ischnura asiatica, Rantra chinensis, Herochares striatus, Agabus japonicus in benthic macroinvertebrates of a few individuals are appeared. Also, fry of Carassius auratus and Silurus asotus in fish are occurred. Therefore, we can be inferred on posibility of growth and spawning of above species in the stream. Jungrang stream has a small quantity of natural riffle areas, ponds and watergrass areas by channel form of water course. Aquatic animals in Jungrang stream has been suffered by reduction of self-purification reaction ability and have mass production of attached algae on the stream bed. For analysis of fluctuation of life survival maintenance ability in Jungrang stream, long-term survey is needed.

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A Study on the Propulsion and Braking Performance of the High Speed Freight Train with Composing the Rolling Stocks Formation (차량편성구성에 따른 고속화물열차의 추진 및 제동성능 분석 연구)

  • Han, Seong-Ho
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.65 no.4
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    • pp.298-302
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    • 2016
  • Currently, logistics are in small quantities and in diverse forms, and the amounts are continuously increasing. Railway logistics however are losing their market share every year mainly due to low operation speed and loading time, which means the trucks are covering the most of the freights. In order to solve these situations, this paper proposed the high speed freight train as working multi-modality with other modes to make effective transshipment. The high speed freight train has maximum operation speed of 300km/h and electric power to run centralized power supply. There are large dual door system, bogie system covering fluctuating load of 15[ton], automatic loading device, ULD(unit load device) bed and ULD locking system in this freight rolling stock. We calculated the performance of powering and braking capacity for this train and proposed how many vehicles are composed of train set. The results in this paper can help to make a decision to define the technical specification of High-speed freight train for the efficiency of rail freight service.

The Analysis of the Type and Characteristics of Playable Furniture for Preschool Children (미취학 아동의 놀이가구 유형 및 특성 분석)

  • Kim, Ja Kyung
    • Korean Institute of Interior Design Journal
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    • v.21 no.5
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    • pp.189-199
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    • 2012
  • The interest and expenditure for children is increasing than in the past because the number of nuclear family is growing, the children's space is configured independently in most homes from infancy, therefore, the market of children's furniture is expanding in spite of the reduction in the population of children. There are not many products considering age, gender, and play behavior in children's furniture market in Korea. The bed, desk, chair, and closet for children under 2 years hold a large majority of children's furniture, there are not a lot of preschool children's furniture for the children aged 4 to 7. As the children aged 4 to 7 experience physical, emotional, and cognitive growth at the same time, the space configuration and furniture choice for these children is educationally very important. Therefore, in this study, we present the importance and necessity of playable furniture to promote the physical, social, emotional, linguistic, and cognitive development of the children aged 4 to 7 among preschool children. We found the concept and basic condition of playable furniture to collect the base data for developing playable furniture and provided the basic data for the development of an ideal playable furniture by comparing and analyzing the cases of 157 items of 14 domestic playable furniture companies and 365 items of 30 overseas in aspect of play functions, forms, materials and colors.

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Channel change of the Naesung Stream during 2012~201 (2012~2016년 기간 내성천의 하도 변화)

  • Lee, Chanjoo;Kim, Donggu;Kim, Ji-Sung
    • Proceedings of the Korea Water Resources Association Conference
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    • 2017.05a
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    • pp.333-333
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    • 2017
  • Recently, long-lasting landscape of the Naesung Stream has been changed due to encroachment of vegetation. To analyze patterns and causes of these changes, Korea Institute of Civil Engineering and Building Technology (KICT) has been carried out long-term monitoring research for the 56.8 km long study reach of the Naeseong Stream. Using the consecutive airborne LiDAR survey data obtained from 2012~2016, changes of channel bed forms such as bars could be detected. For the last four years of monitoring, mid-channel bars has been formed along the straight reaches and the existing bars showed vertical accretion caused by deposition on the vegetated surfaces.

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Investigation of Temperature-Dependent Microscopic Morphological Variation of PEEK Powder for a 3D Printer using Dissipative Particle and Molecular Dynamics Simulations (소산입자동역학과 분자동역학을 이용한 3D 프린터용 PEEK 분말에 대한 온도에 따른 미시적 구조변화에 대한 연구)

  • Kim, Namwon;Yi, Taeil
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.5
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    • pp.117-122
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    • 2018
  • 3D printing technology and its applications have grown rapidly in academia and industry. We consider a 3D printing system designed for the selective laser sintering (SLS) method, which is one of the powder bed fusion (PBF) techniques to build up the final product by layering sintered powder slices. Thermal distortion of printing products is a critical challenge in 3D printing. This study investigates temperature-dependent conformational behaviors of 3D printed samples of sintered poly-ether-ether-ketone (PEEK) powders using molecular dynamics simulations. The wear and chemical resistance properties of PEEK are understood, as it is a well-known biocompatible material used for implants. However, studies on physical phenomena at nanoscale in PEEK are rarely published in public. We simulate dissipative particle dynamics to elucidate how a cavity regime forms in PEEK at different system temperatures. We demonstrate how PEEK structures deform subject to the system temperature distribution.

The corrosion of aluminium alloy and release of intermetallic particles in nuclear reactor emergency core coolant: Implications for clogging of sump strainers

  • Huang, Junlin;Lister, Derek;Uchida, Shunsuke;Liu, Lihui
    • Nuclear Engineering and Technology
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    • v.51 no.5
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    • pp.1345-1354
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    • 2019
  • Clogging of sump strainers that filter the recirculation water in containment after a loss-of-coolant accident (LOCA) seriously impedes the continued cooling of nuclear reactor cores. In experiments examining the corrosion of aluminium alloy 6061, a common material in containment equipment, in borated solutions simulating the water chemistry of sump water after a LOCA, we found that Fe-bearing intermetallic particles, which were initially buried in the Al matrix, were progressively exposed as corrosion continued. Their cathodic nature $vis-{\grave{a}}-vis$ the Al matrix provoked continuous trenching around them until they were finally released into the test solution. Such particles released from Al alloy components in a reactor containment after a LOCA will be transported to the sump entrance with the recirculation flow and trapped by the debris bed that typically forms on the strainer surface, potentially aggravating strainer clogging. These Fe-bearing intermetallic particles, many of which had a rod or thin strip-like geometry, were identified to be mainly the cubic phase ${\alpha}_c-Al(Fe,Mn)Si$ with an average size of about $2.15{\mu}m$; 11.5 g of particles with a volume of about $3.2cm^3$ would be released with the dissolution of every 1 kg 6061 aluminium alloy.

A study on the bedrock erosional forms at Dutayeon, Yanggu (양구 두타연 인근 지역의 기반암 하상지형 연구)

  • KIM, Jong Yeon;KIM, Chang Hwan
    • Journal of The Geomorphological Association of Korea
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    • v.19 no.2
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    • pp.31-49
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    • 2012
  • Satae cheon, a tributary of the Suip cheon in Yanggu, Gangwon province, is an international river extended to North Korea. Most of drainage basin area of the river was the fierce battle field during the Korean War(1950-1953) and hard to access as it located between the MDL(Military Demarcation Line) and the CCZ(Civilian Control Zone: about 10km south from MDL). By the restriction of access to the sites, most of natural landscape have been well conserved except limited use for military activities. Even the landfoms in that area were not studied, except the government's heritage reports. Satae Cheon's channel follows the Imdang fault line(N-S) to Satae-ri and flow to west to the Dutayeon area. The river meanders along geological structure or weak line at the Dutayeon area. The meandering channel was shorten by the meander cut which linked the thalweg line of meander loop ant the meander neck. As a result of this cut, the river cliff formed by the Satae cheon became the part of newly formed channel bed and the S-forms are formed. After the channel route stabilized, channel incised the rock with large potholes and undulating walls were formed. The channel width changes from 1m to 10m with restriction of the undulating walls, so this part can be regarded as inner channel or inner gorge. From the point of planar forms it also can be slot-type canyon.

Microstructure of ZnO Thin Film on Nano-Scale Diamond Powder Using ALD (나노급 다이아몬드 파우더에 ALD로 제조된 ZnO 박막 연구)

  • Park, S.J.;Song, S.O.
    • Journal of the Korean Vacuum Society
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    • v.17 no.6
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    • pp.538-543
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    • 2008
  • Recently a nano-scale diamond is possible to manufacture forms of powder(below 100 nm) by new processing of explosion or deposition method. Using a sintering of nano-scale diamond is possible to manufacture of grinding tools. We have need of a processing development of coated uniformly inorganic to prevent an abnormal grain growth of nano-crystal and bonding obstacle caused by sintering process. This paper, in order to improve the sintering property of nano-scale diamond, we coated ZnO thin films(thickness: $20{\sim}30\;nm$) in a vacuum by ALD(atomic layer deposition) Economically, in order to deposit ZnO all over the surface of nano-scale diamond powder, we used a new modified fluidized bed processing replaced mechanical vibration effect or fluidized bed reactor which utilized diamond floating owing to pressure of pulse(or purge) processing after inserted diamond powders in quartz tube(L: 20 mm) then closed quartz tube by porosity glass filter. We deposited ZnO thin films by ALD in closed both sides of quartz tube by porosity glass filter by ALD(precursor: DEZn($C_4H_{10}Zn$), reaction gas: $H_2O$) at $10^{\circ}C$(in canister). Processing procedure and injection time of reaction materials set up DEZn pulse-0.1 sec, DEZn purge-20 sec, $H_2O$ pulse-0.1 sec, $H_2O$ purge-40 sec and we put in operation repetitive 100 cycles(1 cycle is 4 steps) We confirmed microstructure of diamond powder and diamond powder doped ZnO thin film by TEM(transmission electron microscope) Through TEM analysis, we confirmed that diamond powder diameter was some $70{\sim}120\;nm$ and shape was tetragonal, hexagonal, etc before ALD. We confirmed that diameter of diamond powders doped ZnO thin film was some $70{\sim}120\;nm$ and uniform ZnO(thickness: $20{\sim}30\;nm$) thin film was successfully deposited on diamond powder surface according to brightness difference between diamond powder and ZnO.

A Study on Hydromorphology and Vegetation Features Depending on Typology of Natural Streams in Korea (국내 자연하천의 유형별 물리적 구조 및 식생 특성 연구)

  • Kim, Hyea-Ju;Shin, Beom-Kyun;Kim, Won
    • Korean Journal of Environment and Ecology
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    • v.28 no.2
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    • pp.215-234
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    • 2014
  • The purpose of this study is to identify the type and characteristics of the domestic natural streams in order to establish a basis for stream restoration and evaluation. To this end, 95 domestic natural stream areas, which have various natural environments, were selected except for the province of island and then the characteristics of natural environment, hydromorpholoy, plant and vegetation were investigated and analyzed in each stream area. As a result, 95 stream areas were classified into total 24 types according to 3 criteria such as stream size (4 types), altitude (3 types), bed material (5 types). Depending on altitude class that is the environmental factor showing the highest correlation with each stream types, the emergence of vegetation and plant, 24 stream types were reclassified into 3 types such as lowland (altitude less than 200m), mountain (altitude from 200m to 500m), highland (altitude more than 500m), and hydromorpholoy, plant and vegetation characteristics of each stream type were compared. First, when compared to the mountain and highland streams, the typical features of lowland streams were as follows: Stream size was large but bed material size was small and there were many valley forms where flood plane were developed well. In addition, the more large stream size was, the more cross-section width variability, bars and sinuosity were in good conditions. In lowland stream, representative vegetation community was Salix koreensis community. On the other hand, when compared to the lowland streams, the typical features of mountain and highland streams were as follows: Stream size was small but bed material was coarse-grained and its size was large. Mountain and highland streams valley form where flood plane was not developed well was narrow, and sinuosity and bars development were weak. Representative vegetation communities of mountain streams were Quercus serrata -, Quercus variabilis -, Styrax japonica community and representative vegetation communities of highland streams were Pinus densiflora -, Quercus mongolica -, Fraxinus rhynchophylla community.