• Proceedings of the KIEE Conference
• /
• 2008.07a
• /
• pp.1399-1400
• /
• 2008

본 논문에서는 TSMC 0.18um 공정을 이용하여 2.45GHz 대역에서 동작하는 RFID 리더에 적용 할 수 있는 전압제어 발진기를 설계하였다. 위상 잡음 특성 향상을 위해 PMOS, NMOS 소자를 대칭으로 구성한 complementary cross-coupled LC 발진기 구조로 설계 하였고 MOS 배렉터를 이용하여 주파수를 가변 하였다. 또한 공정에서 사용되는 인덕터에 차폐 도체면(PGS:Patterned Ground Shield) 구조를 삽입했을 때 인덕터의 품질계수가 약 5.82% 향상되었고. 이에 따른 위상 잡음은 1MHz offset 주파수에서 PGS를 삽입하지 않는 구조에서는 -102.666dBc/Hz 이며, PGS 구조를 삽입한 구조는 -104.328dBc/Hz로 약1.662dBc 정도의 성능이 향상 되었다. 전압제어 발진기 Core 사이즈는 900um ${\times}$ 590um이고 주파수 가변 범위는 배렉터 전압 1.2${\sim}$2.1V에서 249MHz로 11.4% 특성을 보였다. 1.8V공급전압에서 5.76mW의 전력소모를 보였다.

• Genomics & Informatics
• /
• v.20 no.4
• /
• pp.42.1-42.11
• /
• 2022

Breast cancer (BC) is a significant threat to female health, with both modifiable and non-modifiable risk factors. It is essential to monitor patients regularly and to raise population awareness. Increasing research also suggests that E-selectin (SELE) may increase tumor angiogenesis and the development of cancer. This study investigated SELE single-nucleotide polymorphisms (SNPs) in the following positions: rs5367T/C, rs5368C/T, rs5362T/G, and rs5362T/C. Using polymerase chain reaction, significant differences in allele and genotype frequencies were found between BC patients and controls. Position rs5368 was associated with an increased risk of BC for the CT and TT genotypes, with odds ratios (ORs) of 16.3 and 6.90 (Fisher probability = 0.0001, p = 0.005). Women with the T allele had a 19.3-fold higher incidence of BC, while allele C may be a protective allele against BC (OR, 0.05). Heterozygous genotypes at rs5367, rs5362, and rs5362 were significantly more common in BC patients, with ORs of 5.70, 4.50, and 3.80, respectively. These SNPs may be associated with the risk of BC, because the frequency of mutant alleles was significantly higher in patients (OR: 4.26, 3.83, and 4.30, respectively) than in controls (OR: 0.23, 0.30, and 0.20, respectively). These SNPs may be considered a common genotype in the Iraqi population, with the wild-type allele having a protective fraction and the mutant allele having an environmental fraction. The results also revealed a 2-fold increase in gene expression in BC patients compared to controls, with a significant effect (p = 0.017). This study's findings confirm the importance of SELE polymorphisms in cancer risk prediction.

• Journal of Veterinary Clinics
• /
• v.25 no.4
• /
• pp.280-285
• /
• 2008

This study evaluated the correlation between the body condition score (BCS) during prepartum, calving and postpartum periods and the reproductive performance of Korean brown cattle. The BCSs of 33 cows who underwent 73 calvings over a two and a half period [the parities of the cows ranged from 1 to 4 ($mean{\pm}SD,\;2.0{\pm}0.9$)] were scored at months 2 and 1 prepartum, calving, and every month postpartum until month 7. A marked prepartum loss of BCS in the month preceding calving was noted. The correlations between the interval from calving to conception and the month 1 prepartum, calving and months 1 and 2 postpartum BCSs were analyzed by Pearson correlation analysis. The correlation between the interval from calving to conception and the prepartum body condition loss was also evaluated. The interval from calving to conception correlated positively with the month 1 prepartum BCS (r = 0.389, P = 0.0007) and the prepartum body condition loss (r = 0.488, P < 0.0001) but did not correlate significantly with the BCS at calving (r=-0.070, P=0.56) or months 1 (r=0.107, P=0.37) or 2 (r=0.102, P=0.39) postpartum. The prepartum body condition loss correlated positively with the month 1 prepartum BCS (r=0.587, P<0.0001). In conclusion, the month 1 prepartum BCS may be a good criterion for predicting subsequent reproductive performance. Moreover, the prevention of obesity and/or excessive prepartum body condition loss may result in higher fertility in Korean brown cattle.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.30 no.2
• /
• pp.131-139
• /
• 1985

Breeders have concerned with the nature of gene action controlling the duration of grain filling period to combine early maturity and acceptable grain yield to fit wheat into multiple cropping systems. The 4 x 4 complete diallel set of F$_1$, F$_2$ and 1/2 (BC$_1$ + BC$_2$) in crosses of winter and spring wheat cultivars was made to determine the nature of gene action involved for duration of grain filling period. Using the Jinks-Hayman model, no maternal effects were noted nor were any non-allelic interactions observed for total duration of grain filling and lag period. The actual grain filling period was influenced to some degree by such interactions. The spring cultivars Red Bobs and Siete Cerros also appeared to have more dominant genes for longer total duration of grain filling and lag period. In contrast, the winter parents Yamhill and Hyslop had more dominant genes for the longer actual grain filling period. The genes appeared to be independently distributed among the parents.

• Journal of IKEEE
• /
• v.3 no.2 s.5
• /
• pp.215-220
• /
• 1999

In fabricated linear power amplifier(LPA), the third-order inter-modulation distortion(IMD) for main amplifier alone is 10.61dBc, and the IMD for LPA with predistorter and feedforward loop combined is 32.50dBc. Therefore, the IMD characteristic results an improvement of approximately 22dB. The main amplifier efficiency with single tone input is close to 30%, and the efficiency of the overall LPA with predistorter is 27.4% and predicted feedforward loop efficiency without predistorter is about 20%. Therefore, LPA with predistorter and feedforward loop combined is improved by 7.4%.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6905-6911
• /
• 2013

Background: Breast cancer (BC) is the top cancer among women worldwide and the most frequent malignancy among Iranian women over the past few decades. The increasing trend and high mortality rate of BC in the developing world necessitates studies concentrating on its characteristics in countries in Asia. The current study focused on clinical and histopathological features of BC among Iranian females. Materials and Methods: This retrospective study involved 714 Iranian patients with histopathologically proven BC undergoing resection of primary tumours and axillary clearance. Demographic, clinical and histopathological data were obtained and studied between ten year age groups (${\leq}40$ years, 41-50 years, 51-60 years, 61-70 years, and ${\leq}71$ years) in four chronologic phases from 1994-2009. Results: Mean age of patients was $49.4{\pm}13.1$ years. Most of cases (33.2%) were in 41-50 group. Mean size of primary tumors was $3.94{\pm}2.47$ cm and 87.1% of cases had infiltrative ductal carcinoma. Modified radical mastectomy was the most common method of surgery carried out (48.8%). Some 57.1% of tumors were in pT2 and tumor size decreased significantly during the period (p<0.05). The most common BC stage was llla (27%). Lower BC stages (0 and 1) constituted 13.9% of the diagnosed tumors. Our series of patients aged ${\leq}40$ had larger tumors (mean $4.73{\pm}3.02$ cm) compared to older age groups (p=0.003). Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ${\leq}40$ had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups. Conclusions: More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.20 no.5
• /
• pp.673-680
• /
• 2017

In the proposed paper, we designed low noise frequency synthesizer with compact size for Multi-Band. The proposed frequency synthesizer consists of fundamental frequency band(2 GHz) and harmonic frequency band(4 GHz). To improve the phase noise and spurious level of frequency synthesizer, we analyze how the configuration of frequency synthesizer affect the phase noise and design the multi-band's structure. The implemented frequency synthesizer reduce both the phase noise and spurious level. The phase noise is -92.17 dBc/Hz at 1 kHz frequency offset in 2 GHz and -90.50 dBc/Hz at 1 kHz frequency offset in 4 GHz. All spurious signals including fundamental frequency are suppressed at least 20 dBc than the second harmonic frequency.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.2 no.1
• /
• pp.41-60
• /
• 1998

This paper derives a consistent and bias corrected extension of Akaike's Information Criterion (AIC), $AIC_{bc}$, based on Kullback-Leibler information. This criterion has terms that penalize the overparametrization more strongly for small and large samples than that of AIC. The overfitting problem of the asymptotically efficient model selection criteria for small and large samples will be overcome. The $AIC_{bc}$ also provides a consistent model order selection. Thus, it is widely applicable to data with small and/or large sample sizes, and to cases where the number of free parameters is a relatively large fraction of the sample size. Relationships with other model selection criteria such as $AIC_c$ of Hurvich, CAICF of Bozdogan and etc. are discussed. Empirical performances of the $AIC_{bc}$ are studied and discussed in better model order choices of a linear regression model using a Monte Carlo experiment.

• Toxicological Research
• /
• v.35 no.1
• /
• pp.45-63
• /
• 2019

In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hansenii. Murine bone marrow-derived macrophages ($BMM{\Phi}$) were treated with different doses of nBC (0.02 and 0.2 mg/mL, respectively 1 and $10{\mu}g$ of fibrils) in absence or presence of 0.2% Carboxymethyl Cellulose (nBCMC). Furthermore, mice were instilled intratracheally with nBC or nBCMC at different concentrations and at different time-points and analyzed up to 6 months after treatments. Microcrystaline $Avicel-plus^{(R)}$ CM 2159, a plant-derived cellulose, was used for comparison. Markers of cellular damage (lactate dehydrogenase release and total protein) and oxidative stress (hydrogen peroxidase, reduced glutathione, lipid peroxidation and glutathione peroxidase activity) as well presence of inflammatory cells were evaluated in brochoalveolar lavage (BAL) fluids. Histological analysis of lungs, heart and liver tissues was also performed. BAL analysis showed that exposure to nBCMC or CMC did not induce major alterations in the assessed markers of cell damage, oxidative stress or inflammatory cell numbers in BAL fluid over time, even following cumulative treatments. $Avicel-plus^{(R)}$ CM 2159 significantly increased LDH release, detected 3 months after 4 weekly administrations. However, histological results revealed a chronic inflammatory response and tissue alterations, being hypertrophy of pulmonary arteries (observed 3 months after nBCMC treatment) of particular concern. These histological alterations remained after 6 months in animals treated with nBC, possibly due to foreign body reaction and the organism's inability to remove the fibers. Overall, despite being a safe and biocompatible biomaterial, BC-derived nanofibrils inhalation may lead to lung pathology and pose significant health risks.

• Journal of Industrial Technology
• /
• v.29 no.B
• /
• pp.101-105
• /
• 2009

A 1.571GHz LC VCO with optimized spiral inductor for GPS receiver is designed in 130nm CMOS process. The phase noise of the VCO has been reduced the use of high Q inductor and on chip filter. It has phase noise of -91dBc/Hz, -111dBc/Hz, and -131dBc/Hz at 10kHz, 100kHz, and 1MHz offset frequencies from the carrier, respectively. This VCO consumes 2mA from a 0.6V supply.