• Title/Summary/Keyword: Batman

Search Result 27, Processing Time 0.021 seconds

Comparison of network pharmacology based analysis on White Ginseng and Red Ginseng (인삼(人蔘)과 홍삼(紅蔘)의 네트워크 약리학적 분석 결과 비교)

  • Park, Sohyun;Lee, Byoungho;Jin, Myungho;Cho, Suin
    • Herbal Formula Science
    • /
    • v.28 no.3
    • /
    • pp.243-254
    • /
    • 2020
  • Objectives : Network pharmacology analysis is commonly used to investigate the synergies and potential mechanisms of multiple compounds by analyzing complex, multi-layered networks. We used TCMSP and BATMAN-TCM databases to compare results of network pharmacological analysis between White Ginseng(WG) and Red Ginseng(RG). Methods : WG and RG were compared with components and their target molecules using TCMSP database, and compound-target-pathway/disease networks were compared using BATMAN-TCM database. Results : Through TCMSP, 104 kinds of target molecules were derived from WG and 38 kinds were derived from RG. Using the BATMAN-TCM database, target pathways and diseases were screened, and more target pathways and diseases were screened compared to RG due to the high composition of WG ingredients. Analysis of component-target-pathway/disease network using network analysis tools provided by BATMAN-TCM showed that WG formed more networks than RG. Conclusions : Network pharmacology analysis can be effectively performed using various databases used in system biology research, and although the materials that have been reported in the past can be used efficiently for research on diseases related to targets, the results are unreliable if prior studies are focused on limited or narrow research areas.

SYMMETRIC AND PSEUDO-SYMMETRIC NUMERICAL SEMIGROUPS VIA YOUNG DIAGRAMS AND THEIR SEMIGROUP RINGS

  • Suer, Meral;Yesil, Mehmet
    • Journal of the Korean Mathematical Society
    • /
    • v.58 no.6
    • /
    • pp.1367-1383
    • /
    • 2021
  • This paper studies Young diagrams of symmetric and pseudo-symmetric numerical semigroups and describes new operations on Young diagrams as well as numerical semigroups. These provide new decompositions of symmetric and pseudo-symmetric semigroups into a numerical semigroup and its dual. It is also given exactly for what kind of numerical semigroup S, the semigroup ring 𝕜⟦S⟧ has at least one Gorenstein subring and has at least one Kunz subring.

Analysis of Directing Super Hero Action Thriller (슈퍼 히어로 액션 스릴러 <다크 나이트>의 연출 분석)

  • Lee, Jeong-Gook
    • The Journal of the Korea Contents Association
    • /
    • v.11 no.4
    • /
    • pp.140-154
    • /
    • 2011
  • Through this thesis, I intended to analyze superhero action thriller through that achieved in art and box office after the film release. I would to access about it centering around directing viewpoint. of Christoper Nolan is evaluate as 'upgraded excellent action thriller'that have remarkable theme and excellent visual. Analysis of directing'll classify both contents and form. See about contents... theme of existential dilemma about the good and the evel, characters who is grew more powerful, and deeper than Batman series in old times. the fifth plot, especially dramatic plot by Joker's game, and various irony and motif. About form... efficient use of IMAX camera, prominence of action directing about car chase and fighting... better editing and music and art than former super hero series. The most important merit of is it's a philosophical theme. It is dipicted very seriously and successfully. First of all, the film has more advanced technique power and new directing style.

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

  • Yildirim, Mustafa;Demirpence, Ozlem;Kaya, Vildan;Suren, Dinc;Karaca, Mehmet;Evliyaoglu, Osman;Yilmaz, Necat;Gunduz, Seyda
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.15
    • /
    • pp.6233-6237
    • /
    • 2014
  • Background: Intraperitoneal spread of gynecologic cancers is a major cause of mortality and morbidity and often presents with malignant ascites. Microscopic tumor spread can be demonstrated by a peritoneal wash cytology and help assess the prognosis of the disease. In our study, the roles of paraoxonase and ceruloplasmin, measured in peritoneal washing fluid of patients operated for gynecologic pathologies in differential diagnosis was investigated. Materials and Methods: Patients operated for malign or benign gynecologic pathologies in Antalya Education and Research Hospital Gynecology Clinic between 2010-2012 were included in the study. Samples were obtained during surgery. Results: A statistically significant difference was detected between patients with benign and malign diseases with regards to PON1 levels measured in peritoneal washing fluid (p:0.044), the average values being $64.2{\pm}30.8$ (Range 10.8-187.2) and $41.4{\pm}21.4$ (Range 10.4-95.5), respectively. No significant variation was evident for ceruloplasmin. Conclusions: Paraoxonase levels measured in peritoneal washing fluid may contribute to the differentiation of malign-benign diseases in gynecologic pathologies.

THE CATENARY DEGREE OF THE SATURATED NUMERICAL SEMIGROUPS WITH PRIME MULTIPLICITY

  • Meral Suer
    • Bulletin of the Korean Mathematical Society
    • /
    • v.60 no.2
    • /
    • pp.515-528
    • /
    • 2023
  • In this paper, we formulate the set of all saturated numerical semigroups with prime multiplicity. We characterize the catenary degrees of elements of the semigroups we obtained which are important invariants in factorization theory. We also give the proper characterizations of the semigroups under consideration.

Post-modern Characteristics Expressed on Characters' Make-up Coordination of Fantasy Movies - Focused on the works of Tim Burton - (판타지 영화의 캐릭터 분장 코디네이션에 나타난 포스트모던 특성 - Tim Burton 감독의 작품을 중심으로 -)

  • Chang, Mee-Sook
    • Fashion & Textile Research Journal
    • /
    • v.11 no.2
    • /
    • pp.219-230
    • /
    • 2009
  • The purpose of this paper is to study characters' make-up coordination that changes the narrative of the fantasy movies to a visual fantasy, especially it focuses on the post-modern features from the works of Tim Burton, a post-modernist. The contents of the study are, firstly, studying post-modernism that influenced the works of Tim Burton, secondly, researching (1988), (1989), (1990), (1992), (2003) and (2005) and their main characters' make-up design. Thirdly, analyzing the otherness and plural-code that are the post-modern characteristics expressed on characters' make-up coordination of fantasy movies. The otherness means the division of the middle and the surroundings and the rise of the outsiders. Fantasy characters that scares off human such as ghosts, aliens, apes, kidults, mutations, man-made men are in the middle. The plural-code takes the symbolic and pluralistic dimension in to the movie, mixes the sign system, and which natural and supernatural system cross over. In the movies, Beetle Juice who was both ghost and devil expresses life and death, Bat man, Cat woman, Penguin man expresses human and animal, and Edward means human and inhuman. Willy Wonka's makeup makes him look younger, but his grown-up-like clothes show doubleness. For that matter, make-up coordination is the mirror of reflection of period and human being's inner life.

SUBORDINATION RESULTS FOR CERTAIN SUBCLASSES BY USING INTEGRAL OPERATOR DEFINED IN THE SPACE OF ANALYTIC FUNCTIONS

  • Sakar, F. Muge;Guney, H. Ozlem
    • Honam Mathematical Journal
    • /
    • v.40 no.2
    • /
    • pp.315-323
    • /
    • 2018
  • In this study, firstly we introduce generalized differential and integral operator, also using integral operator two classes are presented. Furthermore, some subordination results involving the Hadamard product (Convolution) for these subclasses of analytic function are proved. A number of consequences of some of these subordination results are also discussed.

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

  • Yildirim, Mustafa;Kaya, Vildan;Yildiz, Mustafa;Demirpence, Ozlem;Gunduz, Seyda;Dilli, Utku Donem
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.6
    • /
    • pp.2821-2823
    • /
    • 2014
  • Background: Esophageal and gastric cancer generally have a poor prognosis and may share common risk factors. It has been demonstrated that the pesticide usage may contribute to development of many cancer types. In this study, the relation between amount of pesticides used in agriculture and esophageal and gastric cancer incidence was researched. Materials and Methods: Findings from the data bank of the Ministry of Health Provincial Health Directorate Cancer Records Center between the years of 1998-2010 were used. All patients who were diagnosed with gastric and esophageal cancer histopathologically were included. Data for annual pesticide usage were obtained from Provincial Agriculture Directorate for the same time period. Statistical analysis was performed using the Spearman test. Results: One thousand eight hundred and ninety-six patients were involved in the study, 1,233 males (65%) and 663 females (35%), 230 with esophageal cancer (12.1%) and 1,666 with gastric cancer (87.9%). No statistically significant relation was apparent between pesticide amount used and esophageal cancer (p: 0.87). Conclusions: In our study, there was no relationship between pesticide usage and esophageal or gastric cancer. However, the time between pesticide usage and cancer development was not known, qualifying the comparison.

Prognostic Significance of p53 in Gastric Cancer: a Meta-Analysis

  • Yildirim, Mustafa;Kaya, Vildan;Demirpence, Ozlem;Gunduz, Seyda;Bozcuk, Hakan
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.1
    • /
    • pp.327-332
    • /
    • 2015
  • Background: Gastric cancer is one of the frequently seen cancers in the world and it is the second most common reason for death due to cancer. The prognostic role of expression of p53 detected by immunohistochemistry in gastric cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Materials and Methods: We systematically searched for studies investigating the relationships between expression of p53 detected by immunohistochemistry and prognosis of gastric cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios for overall survival and disease-free survival. Results: A total of 4.330 patients from 21 studies were included in the analysis. Our results showed tissue p53 overexpression in patients with gastric cancer to be associated with poor prognosis in terms of overall survival (HR, 1.610; 95% CI, 1.394 -5.235; p:<0.001). Pooled hazard ratio for disease free survival showed that p53 positivity or negativity were not statitistically significant (HR, 1.219; 95%CI, 0.782-1.899; p:0.382). Conclusions: The present meta-analysis indicated overexpression of p53 detected by immunohistochemistry to be associated with a poor prognosis in patients with gastric cancer.

Prognostic Significance of Basic Laboratory Methods in Non-Small-Cell-Lung Cancer

  • Kaya, Vildan;Yildirim, Mustafa;Demirpence, Ozlem;Yildiz, Mustafa;Yalcin, Aysen Yesim
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.9
    • /
    • pp.5473-5476
    • /
    • 2013
  • Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.