• 제목/요약/키워드: Batman

검색결과 27건 처리시간 0.022초

인삼(人蔘)과 홍삼(紅蔘)의 네트워크 약리학적 분석 결과 비교 (Comparison of network pharmacology based analysis on White Ginseng and Red Ginseng)

  • 박소현;이병호;진명호;조수인
    • 대한한의학방제학회지
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    • 제28권3호
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    • pp.243-254
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    • 2020
  • Objectives : Network pharmacology analysis is commonly used to investigate the synergies and potential mechanisms of multiple compounds by analyzing complex, multi-layered networks. We used TCMSP and BATMAN-TCM databases to compare results of network pharmacological analysis between White Ginseng(WG) and Red Ginseng(RG). Methods : WG and RG were compared with components and their target molecules using TCMSP database, and compound-target-pathway/disease networks were compared using BATMAN-TCM database. Results : Through TCMSP, 104 kinds of target molecules were derived from WG and 38 kinds were derived from RG. Using the BATMAN-TCM database, target pathways and diseases were screened, and more target pathways and diseases were screened compared to RG due to the high composition of WG ingredients. Analysis of component-target-pathway/disease network using network analysis tools provided by BATMAN-TCM showed that WG formed more networks than RG. Conclusions : Network pharmacology analysis can be effectively performed using various databases used in system biology research, and although the materials that have been reported in the past can be used efficiently for research on diseases related to targets, the results are unreliable if prior studies are focused on limited or narrow research areas.

SYMMETRIC AND PSEUDO-SYMMETRIC NUMERICAL SEMIGROUPS VIA YOUNG DIAGRAMS AND THEIR SEMIGROUP RINGS

  • Suer, Meral;Yesil, Mehmet
    • 대한수학회지
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    • 제58권6호
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    • pp.1367-1383
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    • 2021
  • This paper studies Young diagrams of symmetric and pseudo-symmetric numerical semigroups and describes new operations on Young diagrams as well as numerical semigroups. These provide new decompositions of symmetric and pseudo-symmetric semigroups into a numerical semigroup and its dual. It is also given exactly for what kind of numerical semigroup S, the semigroup ring 𝕜⟦S⟧ has at least one Gorenstein subring and has at least one Kunz subring.

슈퍼 히어로 액션 스릴러 <다크 나이트>의 연출 분석 (Analysis of Directing Super Hero Action Thriller )

  • 이정국
    • 한국콘텐츠학회논문지
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    • 제11권4호
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    • pp.140-154
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    • 2011
  • 이 글의 목적은 개봉 당시 비평과 흥행 양면에 성공한 <다크 나이트>를 통해 할리우드 슈퍼히어로를 주인공으로 한 액션 스릴러를 연출적인 관점에서 분석하고자 하는데 있다. 크리스토퍼 놀란의 <다크나이트>는 과거 슈퍼히어로 액션물의 기본적인 내러티브 원리에 충실하면서도 그 주제의 진지함과 시각적 표현력에 있어 한 단계 업그레이드된 명품 액션스릴러라고 할 수 있다. 연출 분석은 크게 내용과 형식으로 나뉜다. 내용에 있어서는, 선악의 존재론적 딜레마를 다룬 주제, 과거 배트맨 시리즈보다 깊고 강해진 캐릭터, 5막 구성, 특히 조커의 게임을 활용한 극적 구성, 그리고 다양한 아이러니와 모티프 활용이 돋보인다. 형식에 있어서는 아이맥스 카메라의 효과적인 활용, 특히 카 체이스와 격투액션 등의 액션 연출이 뛰어나다. 편집, 음악, 미술 역시 전편을 뛰어 넘는다. 이 작품이 높이 평가받을 수 있었던 가장 큰 요인은 슈퍼히어로의 액션스릴러라는 블록버스터에 철학적인 주제를 깊이 있게 담아내는데 성공했다는 점이다. 무엇보다도 오랜 역사를 거친 할리우드의 슈퍼히어로 전통과 액션 스릴러의 진화된 기술력이 정점에 이른 시점에 놀란 감독이 뛰어난 연출력이 영화적 스타일과 극적으로 조화를 이뤘기에 가능했던 것이라고 본다.

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

  • Yildirim, Mustafa;Demirpence, Ozlem;Kaya, Vildan;Suren, Dinc;Karaca, Mehmet;Evliyaoglu, Osman;Yilmaz, Necat;Gunduz, Seyda
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권15호
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    • pp.6233-6237
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    • 2014
  • Background: Intraperitoneal spread of gynecologic cancers is a major cause of mortality and morbidity and often presents with malignant ascites. Microscopic tumor spread can be demonstrated by a peritoneal wash cytology and help assess the prognosis of the disease. In our study, the roles of paraoxonase and ceruloplasmin, measured in peritoneal washing fluid of patients operated for gynecologic pathologies in differential diagnosis was investigated. Materials and Methods: Patients operated for malign or benign gynecologic pathologies in Antalya Education and Research Hospital Gynecology Clinic between 2010-2012 were included in the study. Samples were obtained during surgery. Results: A statistically significant difference was detected between patients with benign and malign diseases with regards to PON1 levels measured in peritoneal washing fluid (p:0.044), the average values being $64.2{\pm}30.8$ (Range 10.8-187.2) and $41.4{\pm}21.4$ (Range 10.4-95.5), respectively. No significant variation was evident for ceruloplasmin. Conclusions: Paraoxonase levels measured in peritoneal washing fluid may contribute to the differentiation of malign-benign diseases in gynecologic pathologies.

THE CATENARY DEGREE OF THE SATURATED NUMERICAL SEMIGROUPS WITH PRIME MULTIPLICITY

  • Meral Suer
    • 대한수학회보
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    • 제60권2호
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    • pp.515-528
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    • 2023
  • In this paper, we formulate the set of all saturated numerical semigroups with prime multiplicity. We characterize the catenary degrees of elements of the semigroups we obtained which are important invariants in factorization theory. We also give the proper characterizations of the semigroups under consideration.

판타지 영화의 캐릭터 분장 코디네이션에 나타난 포스트모던 특성 - Tim Burton 감독의 작품을 중심으로 - (Post-modern Characteristics Expressed on Characters' Make-up Coordination of Fantasy Movies - Focused on the works of Tim Burton -)

  • 장미숙
    • 한국의류산업학회지
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    • 제11권2호
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    • pp.219-230
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    • 2009
  • The purpose of this paper is to study characters' make-up coordination that changes the narrative of the fantasy movies to a visual fantasy, especially it focuses on the post-modern features from the works of Tim Burton, a post-modernist. The contents of the study are, firstly, studying post-modernism that influenced the works of Tim Burton, secondly, researching (1988), (1989), (1990), (1992), (2003) and (2005) and their main characters' make-up design. Thirdly, analyzing the otherness and plural-code that are the post-modern characteristics expressed on characters' make-up coordination of fantasy movies. The otherness means the division of the middle and the surroundings and the rise of the outsiders. Fantasy characters that scares off human such as ghosts, aliens, apes, kidults, mutations, man-made men are in the middle. The plural-code takes the symbolic and pluralistic dimension in to the movie, mixes the sign system, and which natural and supernatural system cross over. In the movies, Beetle Juice who was both ghost and devil expresses life and death, Bat man, Cat woman, Penguin man expresses human and animal, and Edward means human and inhuman. Willy Wonka's makeup makes him look younger, but his grown-up-like clothes show doubleness. For that matter, make-up coordination is the mirror of reflection of period and human being's inner life.

SUBORDINATION RESULTS FOR CERTAIN SUBCLASSES BY USING INTEGRAL OPERATOR DEFINED IN THE SPACE OF ANALYTIC FUNCTIONS

  • Sakar, F. Muge;Guney, H. Ozlem
    • 호남수학학술지
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    • 제40권2호
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    • pp.315-323
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    • 2018
  • In this study, firstly we introduce generalized differential and integral operator, also using integral operator two classes are presented. Furthermore, some subordination results involving the Hadamard product (Convolution) for these subclasses of analytic function are proved. A number of consequences of some of these subordination results are also discussed.

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

  • Yildirim, Mustafa;Kaya, Vildan;Yildiz, Mustafa;Demirpence, Ozlem;Gunduz, Seyda;Dilli, Utku Donem
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권6호
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    • pp.2821-2823
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    • 2014
  • Background: Esophageal and gastric cancer generally have a poor prognosis and may share common risk factors. It has been demonstrated that the pesticide usage may contribute to development of many cancer types. In this study, the relation between amount of pesticides used in agriculture and esophageal and gastric cancer incidence was researched. Materials and Methods: Findings from the data bank of the Ministry of Health Provincial Health Directorate Cancer Records Center between the years of 1998-2010 were used. All patients who were diagnosed with gastric and esophageal cancer histopathologically were included. Data for annual pesticide usage were obtained from Provincial Agriculture Directorate for the same time period. Statistical analysis was performed using the Spearman test. Results: One thousand eight hundred and ninety-six patients were involved in the study, 1,233 males (65%) and 663 females (35%), 230 with esophageal cancer (12.1%) and 1,666 with gastric cancer (87.9%). No statistically significant relation was apparent between pesticide amount used and esophageal cancer (p: 0.87). Conclusions: In our study, there was no relationship between pesticide usage and esophageal or gastric cancer. However, the time between pesticide usage and cancer development was not known, qualifying the comparison.

Prognostic Significance of p53 in Gastric Cancer: a Meta-Analysis

  • Yildirim, Mustafa;Kaya, Vildan;Demirpence, Ozlem;Gunduz, Seyda;Bozcuk, Hakan
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권1호
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    • pp.327-332
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    • 2015
  • Background: Gastric cancer is one of the frequently seen cancers in the world and it is the second most common reason for death due to cancer. The prognostic role of expression of p53 detected by immunohistochemistry in gastric cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Materials and Methods: We systematically searched for studies investigating the relationships between expression of p53 detected by immunohistochemistry and prognosis of gastric cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios for overall survival and disease-free survival. Results: A total of 4.330 patients from 21 studies were included in the analysis. Our results showed tissue p53 overexpression in patients with gastric cancer to be associated with poor prognosis in terms of overall survival (HR, 1.610; 95% CI, 1.394 -5.235; p:<0.001). Pooled hazard ratio for disease free survival showed that p53 positivity or negativity were not statitistically significant (HR, 1.219; 95%CI, 0.782-1.899; p:0.382). Conclusions: The present meta-analysis indicated overexpression of p53 detected by immunohistochemistry to be associated with a poor prognosis in patients with gastric cancer.

Prognostic Significance of Basic Laboratory Methods in Non-Small-Cell-Lung Cancer

  • Kaya, Vildan;Yildirim, Mustafa;Demirpence, Ozlem;Yildiz, Mustafa;Yalcin, Aysen Yesim
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권9호
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    • pp.5473-5476
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    • 2013
  • Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.