• Genomics & Informatics
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• 제15권2호
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• pp.69-80
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• 2017

In this study, cytolethal distending toxin (CDT) producer isolates genome were compared with genome of pathogenic and commensal Escherichia coli strains. Conserved genomic signatures among different types of CDT producer E. coli strains were assessed. It was shown that they could be used as biomarkers for research purposes and clinical diagnosis by polymerase chain reaction, or in vaccine development. cdt genes and several other genetic biomarkers were identified as signature sequences in CDT producer strains. The identified signatures include several individual phage proteins (holins, nucleases, and terminases, and transferases) and multiple members of different protein families (the lambda family, phage-integrase family, phage-tail tape protein family, putative membrane proteins, regulatory proteins, restriction-modification system proteins, tail fiber-assembly proteins, base plate-assembly proteins, and other prophage tail-related proteins). In this study, a sporadic phylogenic pattern was demonstrated in the CDT-producing strains. In conclusion, conserved signature proteins in a wide range of pathogenic bacterial strains can potentially be used in modern vaccine-design strategies.

• 한국강구조학회 논문집
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• 제19권2호
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• pp.223-231
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• 2007

풍속의 확률분포를 고려한 통영생산기지 LNG 하역설비인 Unloading arm의 신뢰성해석을 수행하였다. 기상대의 풍속 관측기록을 이용하여 풍속의 극치분포를 추정하였으며 구조물에 가해지는 풍하중은 풍속과 풍압계수를 적용한 분포하중으로 고려하였다. 하역설비는 판요소와 입체요소를 이용하여 모델링하였고 지면접촉부는 접촉요소를 이용하여 압축력에만 저항하도록 하였다. 신뢰성해석을 위해서 주요부위의 최대응력을 표현하는 응답면을 구하였으며 이 값이 허용응력 및 항복응력을 초과하는지의 여부를 신뢰함수로 정의하여 파괴확률을 구하였다. 또한, 재료강도의 저하가 파괴확률에 미치는 영향을 파악하기 위하여 민감도 분석을 수행하였다.

• 동력기계공학회지
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• 제17권4호
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• pp.86-93
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• 2013

This paper deals with the effects of driving force and material properties on statistical distribution of fatigue crack growth rate (FCGR) for the friction stir welded joints of Al 7075-T651 aluminum plate. In this work, the statistical probability distribution of fatigue crack growth rate was analyzed by using our previous constant stress intensity factor range controlled fatigue crack growth test data. As far as this study are concerned, the statistical probability distribution of fatigue crack growth rate for the friction stir welded (FSWed) joints was found to evaluate the variability of fatigue crack growth rate for base metal (BM), heat affected zone (HAZ) and weld metal (WM) specimens. The probability distribution of fatigue crack growth rate for FSWed joints was found to follow well log-normal distribution. The shape parameter of BM and HAZ was decreased with increasing the driving force, however, the shape parameter of WM was decreased and increased with increasing the driving force. The scale parameter of BM, HAZ and WM was increased with the driving force.

• Korea-Australia Rheology Journal
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• 제15권2호
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• pp.55-61
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• 2003

The steady shear flow properties of vaseline generally used as a base of the pharmaceutical dosage forms were studied in the consideration of wall slip phenomenon. The purpose of this study was to show that how slip may affect the experimental steady-state flow curves of semisolid ointment bases and to discuss the ways to eliminate (or minimize) wall slip effect in a rotational rheometer. Using both a strain-controlled ARES rheometer and a stress-controlled AR1000 rheometer, the steady shear flow behavior was investigated with various experimental conditions ; the surface roughness, sample preparation, plate diameter, gap size, shearing time, and loading methods were varied. A stress-controlled rheometer was suitable for investigating the flow behavior of semisolid ointment bases which show severe wall slip effects. In the conditions of parallel plates attached with sand paper, treated sample, smaller diameter fixture, larger gap size, shorter shearing time, and normal force control loading method, the wall slip effects could be minimized. A critical shear stress for the onset of slip was extended to above 10,000 dyne/$\textrm{cm}^2$. The wall slip effects could not be perfectly eliminated by any experimental conditions. However, the slip was delayed to higher value of shear stress by selecting proper fixture properties and experimental conditions.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.43-46
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• 2005

Micro molding technology is a promising mass production technology for polymer based microstructures. Mass production technologies such as the micro injection/compression molding, hot embossing, and micro reaction molding are already in use. In the present study, we have developed a numerical analysis system to simulate three-dimensional non-isothermal cavity filling for hot embossing, with a special emphasis on the free surface capturing. Precise free surface capturing has been successfully accomplished with the level set method, which is solved by means of the Runge-Kutta discontinuous Galerkin (RKDG) method. The RKDG method turns out to be excellent from the viewpoint of both numerical stability and accuracy of volume conservation. The Stokes equations are solved by the stabilized finite element method using the equal order tri-linear interpolation function. To prevent possible numerical oscillation in temperature Held we employ the streamline upwind Petrov-Galerkin (SUPG) method. With the developed code we investigated the detailed change of free surface shape in time during the mold filling. In the filling simulation of a simple rectangular cavity with repeating protruded parts, we find out that filling patterns are significantly influenced by the geometric characteristics such as the thickness of base plate and the aspect ratio and pitch of repeating microstructures. The numerical analysis system enables us to understand the basic flow and material deformation taking place during the cavity filling stage in microstructure fabrications.

• Journal of Welding and Joining
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• 제7권3호
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• pp.44-54
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• 1989

This study was undertaken to evaluate the allowable welding heat input range for high strength steels manufactured by various processes and to compare the weldability of TMCP steel for high heat input welding with that of conventional Ti-added normalized steel. The allowable welding heat input ranges for conventional 50kg/$mm^2$ steel to guarantee D or E grade of ship structural steel were below 150 and 80kJ/cm respectively. Such a limit in welding heat input was closely related with the formation of undesirable microstructures, such as grain boundary ferrite and ferrite side plate in the coarse grain HAZ. In case of 60 and 80kg/$mm^2$ quenched and tempered steels, for securing toughness in weldments over toughness requirements for base metal, each welding heat input had to be restricted below 60 and 40kJ/cm, that was mainly due to coarsened polygonal ferrite in weld metal and lower temperature transformation products in coarse grain HAZ. The TMCP steel could be appropriate as a grade E ship hull steel up to 200kJ/cm, but the Ti-added normalized steel could be applied only below 130kJ/cm under the same rule. This difference was partly owing to whether uniform and fine intragranular ferrite microstructure was well developed in HAZ or not.

• 한국임상수의학회지
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• 제25권6호
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• pp.545-548
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• 2008

A 3-year-old castrated male Siberian husky was presented for evaluation after being hit by a car. On physical examination, the dog showed open-mouth, displacement of mandible and hypersalivation with blood ting. The base of tongue was transected almost 80% on the bias from right dorsal side to the left ventral side. Radiography demonstrated separation of mandible symphysis, and fracture of right condyle and vertical ramus. After debridement of the necrotic tissue, tongue apposition with simple interrupted suture was performed. Mandibular symphysis, condyle and mandibular vertical ramus fractures were fixed using pin, cerclage wire, T-plate, and K-wires. The mouth was irrigated daily using chlorhexidine after surgery. The sutures that were loose here or untied at tongue were re-sutured under sedation. The transected tongue was healed and recovered its normal movement after 6 weeks.

• Journal of Advanced Marine Engineering and Technology
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• 제28권1호
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• pp.109-115
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• 2004

The spatter and porosity could be occurred during$CO_2$CW laser welding of Primer- coated steel for shipbuilding. This study has suggested an alternative idea by examining of weld-defect formation mechanism. The primer-coated plate induced the spatter humping bead and porosity and these are main part of the welding defect. attributed to the powerful vaporizing pressure of primer attached on the base metal The zinc of Primer has a boiling point that is the lower temperature than melting point of steel zinc vapor will build up at the interface between the two sheets and this tends to deteriorate the quality of the weld by ejecting weld material from lap position or leaving porosity. Therefore introducing a small gap clearance in the lap position. the zinc vapor could escape through it and sound weld beads can be acquired. In conclusion, we suggested the occurred and prevented mechanism of weld defects with searching the factor.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2006년도 하계학술발표대회 논문집
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• pp.182-187
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• 2006

This research presented the heat resistance characteristics of heat sink which is newly designed through the experiment. For the same volume and base plate of heat sinks, the experiment of heat transfer characteristics was conducted for forced convection of layered type heat sink. The heat transfer and pressure drop characteristics of the layered type heat sink were compared for the various kinds of fin pitches, fin heights and heights of heat sink. The results show that thermal resistance is decreased as the height of heat sink increases and the fin height and fin pitch decrease, From the experimental data of layered type heat sink, the correlation equation of Nusselt number was obtained as follows ; $$Nu=0.845{\cdot}Re^{0.393}{\cdot}(\frac{f_h}{D_h})^{0.160}{\cdot}(\frac{f_p}{D_h})^{0.372}{\cdot}(\frac{H_{hs}}{D_h})^{-0.942}$$

• Safety and Health at Work
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• 제7권2호
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• pp.130-137
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• 2016

At a brewery, the base plate-to-shell weld seam of a $90-m^3$ vertical cylindrical steel tank failed catastrophically. The 4 ton tank "took off" like a rocket leaving its contents behind, and landed on a van, crushing it. The top of the tank reached a height of 30 m. The internal overpressure responsible for the failure was an estimated 60 kPa. A rupture disc rated at < 50 kPa provided overpressure protection and thus prevented the tank from being covered by the European Pressure Equipment Directive. This safeguard failed and it was later discovered that the rupture disc had been installed upside down. The organizational root cause of this incident may be a fundamental lack of appreciation of the hazards of large volumes of low-pressure compressed air or gas. A contributing factor may be that the standard piping and instrumentation diagram (P&ID) symbol for a rupture disc may confuse and lead to incorrect installation. Compressed air systems are ubiquitous. The medium is not toxic or flammable. Such systems however, when operated at "slight overpressure" can store a great deal of energy and thus constitute a hazard that ought to be addressed by safety managers.