• Integrative Medicine Research
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• v.6 no.2
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• pp.165-178
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• 2017

Background: Traditional Korean Sasang constitutional (SC) medicine categorizes individuals into four constitutional types [Tae-eum (TE), So-eum (SE), Tae-yang (TY), or So-yang (SY)] based on biological and physiological characteristics. As these characteristics are closely related to the bioenergetics of the human body, we assessed the correlation between SC type and energy metabolism features. Methods: Forty healthy, young ($22.3{\pm}1.4$ years) males volunteered to participate in this study. Participants answered an SC questionnaire, and their face shape, voice tone, and body shape were assessed using an SC analysis tool. Thirty-one participants (10 TE, 10 SE, 3 TY, and 8 SY) were selected for further analysis. Collected blood samples were subjected to blood composition analysis, mitochondrial function analysis, and whole-exome sequencing. Results: The SY type showed significantly lower total cholesterol and high-density lipoprotein cholesterol levels than the SE type. Cellular and mitochondrial Adenosine triphosphate (ATP) levels were similar across types. All types showed similar basal mitochondrial oxygen consumption rates, whereas the TE type showed a significantly lower ATP-linked oxygen consumption rate than the other types. Whole-exome sequencing identified several genes variants that were exclusively detected in particular SC types, including 19 for SE, seven for SY, 11 for TE, and six for TY. Conclusion: SC type-specific differences in mitochondrial function and gene mutations were detected in a small group of healthy, young Korean males. These results are expected to greatly improve the accurate screening and utilization of SC medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.41-55
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• 2007

Purpose: This study is to examine anti-obesity effect and cytotoxicity of the long-term oral administration of Sinomenium acutum (Bang-gi, SA) Methods: Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and DNA chip expression and cytotoxicity of the long-term oral administration of this herbal extract were investigated. Results: The herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. SA fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of SA treatments. However, we found significant changes in gene expression profile in SA treated group by micro-array analysis. In case of SA group, up-regulated genes were 1,213 and down-regulated ones were 2,558. Some of lipid metabolism related genes also significantly changed in both treatment groups. Conclusion: SA had effects of increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.3
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• pp.91-100
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• 2009

Objectives : The purpose of this study was to find the characteristics of Sasang Constitution, Soeumin, Soyangin and Taeumin, Using Regular Medical Inspection. Methods : Subjects of our study were 325 cases who took regular medical inspection. We collected the data of body composition analysis, 7-zone-diagnostic system, blood analysis, and analyzed by Sasang Constitution, Soeumin, Soyangin and Taeumin. Results and Conclusions : 1. In body composition analysis, Taeumin was significantly higher than Soeumin and Soyangin about soft lean mass, body fat mass, waist-hip ratio, body water index, body mass index and basal metabolic rate. In blood analysis, Taeumin was significantly highest about total protein, albumin, GPT, hemoglobin, WBC, triglyceride. In 7-zone-diagnostic system, Taeumin had the highest level at Zone 1, 2. 2. Taeumin had more significant differences than other Sasang constitutions about the parameters of regular medical inspection. 3. Body composition analysis had the most parameters that showed differences among the constitutions, followed by blood analysis and 7-zone-diagnostic system.

• The Korean Journal of Pharmacology
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• v.2 no.1 s.2
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• pp.83-97
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• 1966

Attempts have been made upon the temperature response of the rat induced by some central nervous system depressants as well as stimulants, so as to secure some hidden facets of Panax Ginseng acting upon central nervous system. Although considerable works have been done with regard to Panax Ginseng, it is quite apparent that neither definite implication in terms of its effective chemical constituents is with us nor its pharmacological activity thus far. The author could, however, arrive at some results through procedures preceded by intraperitoneal administration of various drugs in combination with Panax Ginseng in albino rats, that is: (1) Nembutal and chlorpromazine displayed a highly inhibitory effect upon temperature response in the presence of Panax Ginseng, while meprobamate, reserpine, phenacetin and aspirin exerted potentiation actions upon hypothermia. Phenobarbital, serotonin and histamine, on the contrary, did not appear to produce any effect of significance. (2) Nembutal with Panax Ginseng caused prolongation of hypnosis in rat, whereas sodium phenobarbital did not have any effect on it. (3) $LD_{-50}$ in each experimental group of administration of central nervous system stimulants such as strychnine, picrotoxin with Panax Ginseng, necessitated marked increase in the lethal doses. The observations from this study seemed to imply that the complicated mechanism of action of Panax Ginseng might be referred to both central nervous depressive action and influence to basal metabolic rate of mammalian.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.4
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• pp.167-179
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• 2011

Objectives: In this study, we used with visceral fat area(VFA)/subcutaneous fat area(SFA) ratio(V/S ratio) and bioelectrical impedence analysis(BIA) for a comparative study between VFA measured from several abdominal computed tomography(CT) images and obesity indexes, such as body mass index(BM), waist circumference(WC), and waist-hip ratio(WHR). Methods: A group of 63 test subjects were gathered in the oriental medical hospital of Kyung-Won university. BIA for body composition and body size for obesity indexes were estimated to evaluate the obesity indexes. Pearson correlation coefficients and regression analysis were used to select useful obesity index. Results: The VFA-CT was significantly related to BMI, SFA, WC, hip circumference(HC), body fat mass(BFM), basal metabolic rate(BMR), and VFA-BIA. Especially, we found that the VFA-BIA and BMI were significantly correlated to VFA-CT. Conclusions: VFA-BIA index is an optimized index for diagnosis and evaluation of obesity. Finally, we found that the BMI is optimized to represent VFA.

• Journal of Sasang Constitutional Medicine
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• v.12 no.2
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• pp.132-142
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• 2000

Purpose In Sasang Constitution Medicine, persons are divided into four types such as Taeyangin, Taeumin, Soyangin and Soeumin according to their appearance, moral nature and characteristic of constitutional symptoms. In teenager group, diagnosis of constitution based on their appearance was so difficult that we adopted new diagnostic method which measures and compares body compositions. Methods 180 middle school students who live in Pusan were studied from 20th of March, 1999 to 20th of March, 2000. After practicing Questionnaire(I), QSCC(Questionnaire of Sasang Constitution) I , QSCCII, we have measured the height and body compositions with Inbody 3.0, five times. Results 1. The results of Sasang Constitution analysis showed 91 students were classified as Taeumin(50.3%), 75 as Soyangin(41.4%), 14 as Soeumin(7.7%), and 1 as Taeyangin(0.6%). 2. The level of total body water, muscle area, BMR(Basal Metabolic Rate), BCM(Body Cell Mass), and AMC(Arm Muscle Circumference) were increased during spring and summer. That of body weight, fat body weight, fat body weight ratio, waist hip ratio, and BMI(Body Mass Index were increased during fall and winter. 3. In Taeumin and Soyangin groups, the changed capacity of total body water, muscle area and BMR were increased with statistical significance. 4. Waist hip ratio of Soeumin group was reduced more than those of Taeumin, Soyangin groups with statistical significance.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.65-80
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• 2007

Purpose: This study is to examine anti-obesity effect and cytotoxicity of the long-term oral administration of Ephedra Sinica(Ma-hwang, ES) Methods: Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and DNA chip expression and cytotoxicity of the long-term oral administration of this herbal extract were investigated. Results: The herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. ES fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of ES treatments. However, we found significant changes in gene expression profile in ES treated group by micro-array analysis. In case of ES group, up-regulated genes were 113 and down-regulated were 120. Some of lipid metabolism related genes also significantly changed in treatment groups. Conclusion: ES had effects of increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.4
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• pp.209-214
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• 2020

The association of cold-heat (CH) pattern and anthropometry/body composition has been suggested in that they are related to thermoregulation. We aimed to study the association of CH pattern and anthropometry/body composition. A total of 1479 individuals aged 50-80 years were included in the study, and their CH pattern were evaluated by a self-administered questionnaire. After adjustment for age and sex, the CH score were significantly correlated with weight, BMI (body mass index), body surface area, waist-hip ratio, fat free mass, body fat mass, body cell mass, intracellular water, extracellular water, and basal metabolic rate; however, the correlation coefficients were mostly low (0.15-0.24). The selected variables for predicting CH score were various according to the methods used for variable selection; however, the adjusted R-squared of the final models were all around 0.12. Thus the most parsimonious model could be the one that includes sex and BMI. In conclusion, various anthropometry and body composition indices were associated with CH pattern. Future studies are necessary to improve the performance of the prediction model.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.1
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• pp.9-14
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• 2015

We investigated the sweating response during passive heating (partial submersion up to the umbilical line in $42{\pm}0.5^{\circ}C$ water, 30 min) after summer and winter seasonal acclimatization (SA). Testing was performed in July during the summer, 2011 [summer-SA; temp, $25.6{\pm}1.8^{\circ}C;$ relative humidity (RH), $82.1{\pm}8.2%$] and in January during the winter, 2012 (winter-SA; temp, $-2.7{\pm}2.9^{\circ};$ RH, $65.0{\pm}13.1%$) in Cheonan ($126^{\circ}52^{\prime}N$, 33.38'E), Republic of Korea. All experiments were carried out in an automated climatic chamber (temp, $25.0{\pm}0.5^{\circ}C$: RH, $60.0{\pm}3.0%$). Fifteen healthy men (age, $23.4{\pm}2.5$ years; height, $175.0{\pm}5.9cm;$ weight, $65.3{\pm}6.1kg$) participated in the study. Local sweat onset time was delayed during winter-SA compared to that after summer-SA (p<0.001). Local sweat volume, whole body sweat volume, and evaporative loss volume decreased significantly after winter-SA compared to those after summer-SA (p<0.001). Changes in basal metabolic rate increased significantly after winter-SA (p<0.001), and tympanic temperature and mean body temperature were significantly lower after summer-SA (p<0.05). In conclusion, central sudomotor acitivity becomes sensitive to summer-SA and blunt to winter-SA in Rebubic of Korea. These results suggest that the body adjusts its temperature by economically controlling the sweating rate but does not lower the thermal dissipation rate through a more effective evaporation scheme after summer-SA than that after winter-SA.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.7
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• pp.1067-1075
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• 2007

Twenty eight 3-4 month old castrated Black Bengal kids (Capra hircus) were used to determine the effects of source and level of dietary copper (Cu) concentration on their performance and nutrient utilization. Cu was supplemented (0, 10, 20 and 30 mg/kg diet DM) as copper sulfate ($CuSO_4$, $5H_2O$) or copper proteinate (Cu-P). Kids were fed a basal diet containing maize (19.5%), soybean (17.0%), deoiled rice bran (56.5%), molasses (4.0%), di-calcium phosphate and salt (1.0% each) and mineral and vitamin mixture (0.5% each) supplements at 3.5% of body weight to meet NRC (1981) requirements for protein, energy, macro minerals and micro minerals, excluding Cu. The basal diet contained 5.7 mg Cu/kg, 122.5 mg Fe/kg, 110 mg Zn/kg, 0.26 mg Mo/kg and 0.32% S. $CuSO_4$ or Cu-P was added to the basal diet at the rate of 10, 20 and 30 mg/kg. Kids were housed in a well ventilated shed with facilities for individual feeding in aluminum plated metabolic cages. Blood samples were collected from the jugular vein on d 0, 30, 60 and 90 to determine hemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), total leukocyte count (TLC) and serum enzymes (alkaline phosphatase, alanine transferase and aspertate transferase). A metabolism trial of 6 days duration was conducted after 90 days of experimental feeding. Statistical analysis revealed that source and level of Cu supplementation improved live weight gain (p<0.04) and average daily gain (p<0.01). No significant contribution of source and level of Cu to alter serum serum enzymes was evident. Goats fed Cu-P tended to have higher Hb, PCV and TEC than with $CuSO_4$ supplementation. Cu-P increased digestibility of ether extract (EE, p<0.02) and crude fiber (p<0.05) and showed an increasing trend (p<0.09) for digested crude protein (CP) and crude fiber (CF). Supplemental dose of Cu linearly improved (p<0.02) digestibilities of dry matter (DM), organic matter (OM), EE and nitrogen free extract (NFE). Though the absorption of nitrogen (N) was not affected (p>0.10) by both source and dose of Cu, N retention was affected (p<0.04) and there was a significant $Source{\times}Dose$ interaction (p<0.05). Final body weight (BW) was not influenced (p>0.10) by the source of Cu but increasing dose of Cu increased (p<0.04) the BW of kids. TDN intake (g/kg $W^{0.75}$) was higher (p<0.05) with the increased dose of Cu and there was a significant $Source{\times}Dose$ interaction. It was concluded that supplementation of Cu from different sources and varying dose level in a concentrate based diet may improve performance, nutrient utilization and plane of nutrition in castrated Black Bengal kids. The effects on performance and nutrient utilization are more pronounced with Cu-P than $CuSO_4$ supplementation. Higher dose of Cu showed better result than lower dose.