• 한국전기전자재료학회논문지
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• 제22권11호
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• pp.980-986
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• 2009

In a triple-layered structure of ITO/N,N'-diph enyl-N,N'bis(3-methylphenyl)-1,1' - biphenyl-4,4'-diamine(TPD)/tris(8-hydroxyquinoline)aluminum($Alq_3$)/(2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline(BCP)/Al device, we have studied the electrical and optical characteristics of organic light-emitting diodes(OLEDs) depending on the deposition condition of BCP layer. Several different sizes of holes on boat and several different deposition rates were employed in evaporating the organic materials. And then, electrical properties of the organic light-emitting diodes were measured and the performance of the devices was analyzed. It was found that the hole-size of crucible boat and the evaporation rate affect on the surface roughness of BCP layer as well as the performance of the device. When the hole-size of crucible boat and the deposition rate of BCP are 1.2 mm and $1.0\;{\AA}/s$, respectively, average surface roughness of BCP layer is lower and the efficiency of the device is higher than the ones made with other conditions. From the analysis of current density-luminance-voltage characteristics of a triple layered device, we divided the conductive mechanism by four region according to applied voltage. So we have obtained a coefficient of ${\beta}_{ST}$ in schottky region is $3.85{\times}10^{-24}$, a coefficient of ${\beta}_{PF}$ in Poole-Frenkel region is $7.35{\times}10^{-24}$, and a potential barrier of ${\phi}_{FN}$ in Fower-Nordheim region is 0.39 eV.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.114-121
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• 2014

Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study, we investigated the potential application of herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) based system to inhibit chemoresistant AML cells. We first generated Ara-C resistant K562 cells and doxorubicin-resistant THP-1 cells. We found that the HSV-TK/GCV anticancer system suppressed drug resistant leukemic cells in culture. Chemoresistant AML cell lines displayed similar sensitivity to HSV-TK/GCV. Moreover, HSV-TK/GCV killing of leukemic cells was augmented to a mild but significant extent by all-trans retinoic acid (ATRA) with concomitant upregulation of Connexin 43, a major component of gap junctions. Interestingly, HSV-TK/GCV killing was enhanced by expression of vesicular stomatitis virus G glycoprotein (VSV-G), a fusogenic membrane protein, which also increased leukemic cell fusion. Co-culture resistant cells expressing HSV-TK and cells stably transduced with VSV-G showed that expression of VSV-G could promote the bystander killing effect of HSV-TK/GCV. Furthermore, combination of HSV-TK/GCV with VSV-G plus ATRA produced more pronounced antileukemia effect. These results suggest that the HSV-TK/GCV system in combination with fusogenic membrane proteins and/or ATRA could provide a strategy to mitigate the chemoresistance of AML.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 춘계학술대회
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• pp.515-518
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• 2007

Gas hydrates are ice-like crystalline compounds that form under low temperature and elevated pressure conditions. Recently, gas hydrates present a novel means for natural gas storage and transportation with potential applications in a wide variety of areas. An important property of hydrates that makes them attractive for use in gas storage and transportation is their very high gas-to-sol id ratio. In addition to the high gas content, gas hydrates are remarkably stable. The main barrier to development of gas hydrate technology is the lack of an effective mass production method of gas hydrate in solid form. In this study, some performance comparison among several cases classified by different volume sizes of solution were carried to identify the characteristics due to the volume increment. And it is found that one of the main reasons disturbing hydrate formation is related to the lack of cooling heat transfer due to the volume increase of the solution. So, three kinds of heat transfer plates which have different shapes and cross sectional areas were made and tested for the performance comparison following to the shape and area of each plate. Finally it is clarified that the heat transfer is one of the major factors effecting hydrate formation performance and the installation of heat transfer plate can enhance the formation performance especially not in terms of the quantity but the speed.

• 정보관리학회지
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• 제26권2호
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• pp.127-147
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• 2009

자연언어에서 유사어의 처리는 사람과 컴퓨터간의 의사소통에 적지 않은 장애가 되어왔고, 이는 사용자의 임의적 단어사용에 기반을 두고 있는 웹 2.0 애플리케이션, 특히 소셜태깅 분야에 있어서 그 장애의 정도가 더 심각해질 수 있다. 본 연구는 한 대표적인 웹 2.0 애플리케이션에서 자동 유사어 추출에 관한 문제를 다루고 있다. 더 구체적으로, 가장 널리 사용되는 소셜북마킹 애플리케이션인 딜리셔스를 기반으로, 유사태그를 추출하는 방법(FolkSim)을 제시하고자 한다. 제시한 방법의 평가를 위하여, 문서유사도의 측정을 위해서 쓰여진 고전적 벡터모델에 의거한 유사태그를 추출하는 방법(CosSim)과 그 결과들을 서로 비교분석하여 보았다. 몇 가지 면에서 FolkSim가 더 나은 결과 산출해내는 증거들이 관찰되어졌다. 또한, FolkSim 방법에 의한 유사태그가 만들어지지 않는 경우에 대비하여, 그 대안 또한 제시하고 있다.

• Journal of Microbiology and Biotechnology
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• 제24권12호
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• pp.1736-1743
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• 2014

In this study, we evaluated the effect of Lactobacillus plantarum HY7714 on skin hydration in human dermal fibroblasts and in hairless mice. In Hs68 cells, L. plantarum HY7714 not only increased the serine palmitoyltransferase (SPT) mRNA level, but also decreased the ceramidase mRNA level. In order to confirm the hydrating effects of L. plantarum HY7714 in vivo, we orally administered vehicle or L. plantarum HY7714 at a dose of $1{\times}10^9CFU/day$ to hairless mice for 8 weeks. In hairless mice, L. plantarum HY7714 decreased UVB-induced epidermal thickness. In addition, we found that L. plantarum HY7714 administration suppressed the increase in transepidermal water loss and decrease in skin hydration, which reflects barrier function fluctuations following UV irradiation. In particular, L. plantarum HY7714 administration increased the ceramide level compared with that in the UVB group. In the experiment on SPT and ceramidase mRNA expressions, L. plantarum HY7714 administration improved the reduction in SPT mRNA levels and suppressed the increase in ceramidase mRNA levels caused by UVB in the hairless mice skins. Collectively, these results suggest that L. plantarum HY7714 can be a potential candidate for preserving skin hydration levels against UV irradiation.

• 한국해양환경ㆍ에너지학회지
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• 제1권2호
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• pp.27-39
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• 1998

본 연구에서는 수면 밑 일정한 깊이에 잠긴 유연한 천이 파도중 수평으로 놓여 있을 때 유연막과 파도의 상호작용 문제를 살펴보았다. 파도와 유연막의 상호작용을 고려하기 위하여 선형 유탄성 이론을 사용하였다. 계산 예로 유연막의 형태, 잠긴 깊이 그리고 유연막에 걸리는 초기 장력을 변화시키면서 반사율과 투과율 그리고 유연막의 변형을 살펴보았다. 또한 Texas A&M 대학의 2차원 수조에서 모형실험을 수행하여 실험결과와 해석해를 비교하였다. 실험결과와 해석결과는 정성적으로 잘 일치하고 있음을 확인하였다. 개발된 설계 프로그램을 이용하여 설치 해역의 파랑 특성에 적합한 최적의 유연막 방파제를 설계, 제작할 수 있으리라 사료된다.

• The Korean Journal of Physiology and Pharmacology
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• 제22권1호
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• pp.43-51
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• 2018

Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier to successful therapy. The precise mechanisms underlying the development of cisplatin resistance are not fully understood, but alteration of DNA methylation associated with aberrant gene silencing may play a role. To identify epigenetically regulated genes directly associated with ovarian cancer cisplatin resistance, we compared the expression and methylation profiles of cisplatin-sensitive and -resistant human ovarian cancer cell lines. We identified ${\alpha}$-N-acetylgalactosaminidase (NAGA) as one of the key candidate genes for cisplatin drug response. Interestingly, in cisplatin-resistant cell lines, NAGA was significantly down-regulated and hypermethylated at a promoter CpG site at position +251 relative to the transcriptional start site. Low NAGA expression in cisplatin-resistant cell lines was restored by treatment with a DNA demethylation agent, indicating transcriptional silencing by hyper-DNA methylation. Furthermore, overexpression of NAGA in cisplatin-resistant lines induced cytotoxicity in response to cisplatin, whereas depletion of NAGA expression increased cisplatin chemoresistance, suggesting an essential role of NAGA in sensitizing ovarian cells to cisplatin. These findings indicate that NAGA acts as a cisplatin sensitizer and its gene silencing by hypermethylation confers resistance to cisplatin in ovarian cancer. Therefore, we suggest NAGA may be a promising potential therapeutic target for improvement of sensitivity to cisplatin in ovarian cancer.

• 대한화학회지
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• 제39권10호
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• pp.806-811
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• 1995

정온도저항계수(PTCR) 특성을 지닌 $(Ba,Sr)_{1-x}Y_xTiO_3$(x = 0.001-0.009, BSYT)를 옥살산공침범으로 합성하여 이트륨 혼입량 변화에 따른 전기적 특성을 관찰하였다. 온도변화에 따른 저항을 측정한 결과 이트륨의 농도가 0.3mol%로 증가할때까지는 큰 PTCR 효과를 나타낸 반면 농도가 0.5mol% 이상에서는 적은 PTCR 효과를 나타내었다. 상전이 온도($T_c$) 이상에서 온도와 $1{\varepsilon}$m(T)의 관계를 나타낸 도시에 의하면 유전상수의 변화가 Curie-Wiess 법칙에 잘 따름을 알 수 있었다. 측정한 비저항과 유전상수로부터 계산한 전위장벽위 높이를 온도에 따라 도시한 결과 PTCR 효과와 마찬가지로 이트륨의 혼입량이 0.3mol%로 증가할때까지는 높은 전위장벽이 유지되나 0.5mol% 이상에서는 비교적 낮은 전위장벽을 나타내었다.

• Asian Journal for Public Opinion Research
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• 제4권4호
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• pp.208-245
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• 2017

Background: Attitudes toward breastfeeding in public are one potential barrier to optimal breastfeeding rates and durations. Method: Questions about breastfeeding experience and attitudes toward breastfeeding in public were asked in face-to-face interviews as part of the Korean Academic Multimode Open Survey (KAMOS), May-July, 2017. The response rate was 65.8% (2000 respondents nationwide). Results: A majority of Koreans disagreed (1 or 2 on a 4-point scale) with the statement "Women should not breastfeed their child in open, public places" (53.9%) and agreed (3 or 4 on the 4-part Likert scale) with the statements "I do not feel uncomfortable seeing women breastfeed their child in open, public places" (64.0%) and "Breastfeeding a baby, instead of letting the baby cry, in public places is better for other people" (71.8%). However, despite these generally positive attitudes, the majority also said that they would not breastfeed in public (57.4% of women) or, in the case of men, would not want a close female relative to do so (63.8% of men). Breastfeeding in public was positively correlated with the duration of breastfeeding. People were more positive about breastfeeding in public if they: were parents; did not use formula and breastfeeding a similar amount; had children who had been breastfed in public; were older; were Buddhists rather than Christians. An attempt was made to compare attitudes toward breastfeeding in public and breastfeeding durations internationally, but was inconclusive due to not perfectly comparable data. Conclusion: Our results may be useful in planning public health campaigns in South Korea or future attempts at international comparisons to better understand and address the effect of public opinion regarding breastfeeding in public on breastfeeding rates and durations.

• Bulletin of the Korean Chemical Society
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• 제35권3호
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• pp.839-844
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• 2014

The gas-phase radical-radical reaction $O(^3P)$ + $C_2H_5$ (ethyl) ${\rightarrow}$ $H(^2S)$ + $CH_3CHO$(acetaldehyde) was investigated by applying a combination of vacuum-ultraviolet laser-induced fluorescence spectroscopy in a crossed beam configuration and ab initio calculations. The two radical reactants $O(^3P)$ and $C_2H_5$ were respectively produced by photolysis of $NO_2$ and supersonic flash pyrolysis of the synthesized precursor azoethane. Doppler profile analysis of the nascent H-atom products in the Lyman-${\alpha}$ region revealed that the average translational energy of the products and the average fraction of the total available energy released as translational energy were $5.01{\pm}0.72kcalmol^{-1}$ and 6.1%, respectively. The empirical data combined with CBS-QB3 level ab initio theory and statistical calculations demonstrated that the title exchange reaction is a major channel and proceeds via an addition-elimination mechanism through the formation of a short-lived, dynamical addition complex on the doublet potential energy surface. On the basis of systematic comparison with several exchange reactions of hydrocarbon radicals, the observed small kinetic energy release can be explained in terms of the loose transition state with a product-like geometry and a small reverse activation barrier along the reaction coordinate.