• Advances in pediatric surgery
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• 제13권2호
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• pp.135-143
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• 2007

Biliary atresia (BA) is an uncommon neonatal surgical disease that has a fatal outcome if not properly treated. The survival rates of the patients with native liver after Kasai's operation in countries outside Japan are not so good. We reviewed the results of 22 cases of biliary atresia treated in Kosin University Hospital between October 1987 and March 2001. There were 13 males and 9 females aged from 21 to 106 days (mean 52 days). There were 3 cases of Type I (13.6%), and 3 of Type II (13.6%), and 16 Type III (72.7%). The operative methods were resection of the common bile duct remnant and cyst followed by Roux-en-Y hepaticojejunostomy in 3 cases for Type I BA; Kasai I in 15 cases, Kasai II in 1 case, and Ueda's operation in 3 cases for Types II and III BA. There was no death within the first 30 days after operation. We were able to follow 21 of the 22 patients (95.4%) for more than 5 years. The actual 5 year survival rate (YSR) was 40.9%. One Type I case received a living-related liver transplantation at 6 years of age because of the multiple intrahepatic stones and liver cirrhosis. Five YSR after biliostomy group (Kasai II and Ueda op.) was 75 % (3/4) while that of Kasai I was 20% (3/15). One case had no bile duct in the resected fibrotic plaque on microscopic review and died 8 months after Kasai I operation, would have been a strong candidate for early liver transplantation. From the above result, our conclusions are as follows; (1) early liver transplantation should be considered for cases of no bile duct after pathologic examination of the resected specimen, (2) measures to prevent postoperative cholangitis and prevention of postoperative liver cirrhosis are needed, (3) liver transplantation program should be available for failed cases.

• 대한후두음성언어의학회지
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• 제30권1호
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• pp.39-47
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• 2019

Background and Objectives : Pediatric vocal health problems are relatively common. However, it is not yet well studied whether uniform diagnosis and treatment is done properly in South Korea. The purpose of this study was to investigate the methods that the Korean speech therapists use to diagnose and treat pediatric voice problem. Materials and Method : An anonymous online questionnaire was administered to 32 speech language therapists registered at the Korean laryngeal speech linguistics society detailing demographics, employment institution, general management of pediatric patients with vocal problem including assessment and treatment procedures. Results : Current practice patterns were analyzed on 32 speech language therapists providing services in South Korea mostly working at tertiary university hospital. One third of pediatric patients were assessed without proceeding to treatment. One fifth of patients were treated without assessment. Perceptual assessment was the main pretreatment assessment methods used. Treatment was done in the following order : Voice rest, SOVT, yawn-sigh and resonant voice. Post-treatment evaluation was used in the following order : Instrumental assessment, clinical judgment, and recording comparison. Conclusion : Speech language therapists practice in South Korea mostly follows the ASHA practice guidelines. However, there are still great amount of cases in which only the evaluation was done without appropriate treatment. Further research is needed to make SPLs more systematic and efficient for evaluating and treating pediatric vocal patients.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.367-379
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• 2019

Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in the immune regulation, but the roles of muscle cells in AD are poorly understood. We aimed to identify the relationship between mitochondria and atopy by genome-wide analysis of skeletal muscles in mice. We induced AD-like symptoms using house dust mite (HDM) extract in NC/Nga mice. The transcriptional profiles of the untreated group and HDM-induced AD-like group were analyzed and compared using microarray, differentially expressed gene and functional pathway analyses, and protein interaction network construction. Our microarray analysis demonstrated that immune response-, calcium handling-, and mitochondrial metabolism-related genes were differentially expressed. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology pathway analyses, immune response pathways involved in cytokine interaction, nuclear factor-kappa B, and T-cell receptor signaling, calcium handling pathways, and mitochondria metabolism pathways involved in the citrate cycle were significantly upregulated. In protein interaction network analysis, chemokine family-, muscle contraction process-, and immune response-related genes were identified as hub genes with many interactions. In addition, mitochondrial pathways involved in calcium signaling, cardiac muscle contraction, tricarboxylic acid cycle, oxidation-reduction process, and calcium-mediated signaling were significantly stimulated in KEGG and Gene Ontology analyses. Our results provide a comprehensive understanding of the genome-wide transcriptional changes of HDM-induced AD-like symptoms and the indicated genes that could be used as AD clinical biomarkers.

• 대한조선학회논문집
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• 제58권4호
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• pp.262-270
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• 2021

Consumption of Liquefied Natural Gas (LNG) has increased due to environmental pollution; therefore, the need for LNG carriers can efficiently transport large quantities of LNG, is increased. In various types of LNG Cargo Containment System (CCS), Membrane-type MARK-III composed of composite materials is generally employed in the construction of an LNG carrier. Among composite materials in a Mark-III system, glass-fiber composites act as a secondary barrier to prevent the inner hull structure from leakage of LNG when the primary barrier is damaged. Nevertheless, several cases of damage to the secondary barriers have been reported and if damage occurs, LNG can flow into the inner hull structure, causing a brittle fracture. To prevent those problems, this study conducted the applicability assessment of composite material manufactured by bonding glass-fiber and aluminum with epoxy resin and increasing layer from three-ply (triplex) to five-ply (pentaplex). Tensile tests were performed in five temperature points (25, -20, -70, -120, and -170℃) considering temperature gradient in CCS. Scanning Electron Microscopy (SEM) and Coefficient of Thermal Expansion (CTE) analyses were carried out to evaluate the microstructure and thermos-mechanical properties of the pentaplex. The results showed epoxy resin and increasing layer number contributed to improving the mechanical properties over the whole temperature range.

• 한국버섯학회지
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• 제19권1호
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• pp.71-75
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• 2021

느타리 1 kg 봉지재배를 통해 살균배지의 주요 화학성과 2주기까지의 버섯 수량간 관계를 분석한 결과, 버섯수확량은 pH, 총질소 함량, CN율과 2차 함수식에서 매우 높은 상관을 보였다. pH는 4.9~5.0의 범위에서, 총 질소량은 2.0~2.2%에서, CN율은 20~22.5에서 가장 높은 수량성을 보였다. 1주기 버섯은 pH, 총질소량 및 CN율과 높은 상관을 보였고 2주기 버섯은 CN율 외에는 상관이 나타나지 않았다. 그러나 수량합계가 1주기 수량보다 3종의 화학성과의 관계에서 모두 더 높은 상관이 나타났다. 그리하여 본 연구에서 배지의 pH, 총질소 함량 및 CN율은 전 수확기간에 걸쳐서 버섯수량에 큰 영향을 미친다는 결론을 얻을 수 있었다.

• 한국구조물진단유지관리공학회 논문집
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• 제27권6호
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• pp.172-181
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• 2023

본 연구에서는 케이블의 손상에 대한 사장교의 실시간 손상평가를 진행하였다. 사장교의 실시간 손상평가를 위한 센서는 가속도 센서를 사용하였으며, KEOT(Kinetic Energy Optimization Techniques)를 이용하여 센서의 위치와 수량에 대한 최적의 조건을 선정했다. KEOT는 구조물이 외력에 의해서 진동할 때, 최대변형에너지의 값을 계측하여 최적 계측 위치와 센서의 수량을 결정한다. 본 연구에서의 손상 조건은 케이블의 파단으로 제한하였으며 사장교를 4개의 구간으로 나누어 구간별 케이블 손상을 주었다. 사장교 케이블의 실시간 손상평가 방법은 FE 구조해석을 통하여 실제 모델과 유사한 가상의 모델을 만들었다. 생성된 가상 모델과 모형 구조물에 랜덤 가진파를 가한 이후 모형 구조물의 케이블 손상을 주었다. 가상 모델에서 출력되는 응답을 무손상 상태의 응답으로 정의하고 실제 모델에서 계측되는 응답을 손상 상태의 데이터로 정의하여 두 데이터를 비교하였다. 무손상 상태의 사장교의 데이터로부터 손상 상태의 사장교의 데이터를 IMD(Improved Mahalanobis Distance) 이론에 적용하여 손상의 정도를 평가하였다. IMD 이론으로 손상을 평가한 결과 구간별 손상을 실시간으로 적절하게 찾아내어 실시간 모니터링에 적용할 수 있는 유용한 손상평가 기술로 확인되었다.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.690-702
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• 2023

Objective : To analyze the outcomes of coil embolization (CE) for unruptured intracranial aneurysm (UIA) according to region and hospital size based on National Health Insurance Service data in South Korea. Methods : The incidence of complications, including intracranial hemorrhage (ICRH) and cerebral infarction (CI), occurring within 3 months and the 1-year mortality rates in UIA patients who underwent CE in 2018 were analyzed. Hospitals were classified as tertiary referral general hospitals (TRGHs), general hospitals (GHs) or semigeneral hospitals (sGHs) according to their size, and the administrative districts of South Korea were divided into 15 regions. Results : In 2018, 8425 (TRGHs, 4438; GHs, 3617; sGHs, 370) CEs were performed for UIAs. Complications occurred in 5.69% of patients seen at TRGHs, 13.48% at GHs, and 20.45% at sGHs. The complication rate in TRGHs was significantly lower than that in GHs (p=0.039) or sGHs (p=0.005), and that in GHs was significantly lower than that in sGHs (p=0.030). The mortality rates in TRGHs, GHs, and sGHs were 0.81%, 2.16%, and 3.92%, respectively, with no significant difference. Despite no significant difference in the mortality rates, the complication rate significantly increased as the number of CE procedures per hospital decreased (p=0.001; rho=-0.635). Among the hospitals where more than 30 CEs were performed for UIAs, the incidence of CIs (p=0.096, rho=-0.205) and the mortality rates (3 months, p=0.048, rho=-0.243; 1 year, p=0.009, rho=-0.315) significantly decreased as the number of CEs that were performed increased and no significant difference in the incidence of post-CE ICRH was observed. Conclusion : The complication rate in patients who underwent CE for UIA increased as the hospital size and physicians' experience in conducting CEs decreased. We recommend nationwide quality control policies CEs for UIAs.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.329-340
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• 2024

Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study aimed to evaluate whether mangiferin could protect human RPE ARPE-19 cells from oxidative injury mimicked by hydrogen peroxide (H₂O₂). The results showed that mangiferin attenuated H₂O₂-induced cell viability reduction and DNA damage, while inhibiting reactive oxygen species (ROS) production and preserving diminished glutathione (GSH). Mangiferin also antagonized H₂O₂-induced inhibition of the expression and activity of antioxidant enzymes such as manganese superoxide dismutase and GSH peroxidase, which was associated with inhibition of mitochondrial ROS production. In addition, mangiferin protected ARPE-19 cells from H₂O₂-induced apoptosis by increasing the Bcl-2/Bax ratio, decreasing caspase-3 activation, and blocking poly(ADP-ribose) polymerase cleavage. Moreover, mangiferin suppressed the release of cytochrome c into the cytosol, which was achieved by interfering with mitochondrial membrane disruption. Furthermore, mangiferin increased the expression and activity of heme oxygenase-1 (HO-1) and nuclear factor-erythroid-2 related factor 2 (Nrf2). However, the inhibition of ROS production, cytoprotective and anti-apoptotic effects of mangiferin were significantly attenuated by the HO-1 inhibitor, indicating that mangiferin promoted Nrf2-mediated HO-1 activity to prevent ARPE-19 cells from oxidative injury. The results of this study suggest that mangiferin, as an Nrf2 activator, has potent ROS scavenging activity and may have the potential to protect oxidative stress-mediated ocular diseases.

• 헤리티지:역사와 과학
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• 제42권3호
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• pp.154-175
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• 2009

현재 경복궁에 대한 연구는 건축사 문헌사 미술사를 중심으로 이루어지고 있는데, 이와 같은 연구는 현전(現傳)하는 건물과 기록에만 의존할 수밖에 없음으로 궁궐 전체를 연구하는 데는 한계가 있다. 그러나 현재까지도 양호한 상태로 잔존해 있는 경복궁 건물지 유구, 특히'적심(積心)'은 이러한 연구의 공백을 채워줄 수 있는 중요한 고고(考古)학 자료라 할 수 있겠다. 본고에서는 이러한 경복궁의 '적심'에 대하여 분석하여, 형태 규모 재료 축조방식에 따라 그 형식을 분류하고, 이것이 건물 기초로써 상부 건물과 어떤 관계를 가지는지 알아보기 위하여 궁궐 건물 유형별 사용된 적심을 검토하고, 시기별 변천양상을 살펴보았다. 그 결과, 경복궁 건물지 적심은 총 21가지 형식으로 구분되는데, 각 건물 유형에 따라 건물의 기초 즉 적심도 달리 축조되며, 시기별로도 적심의 축조방식 및 재료 등이 변화하여, 특정 시기에 유행하는 적심의 형식이 있음을 확인할 수 있었다. 경복궁 적심은 평면 형태에 따라 원형(I), 말각방형(II), 세장방형(III), 방형(IV), 통적심(V)으로 분류할 수 있으며, 다시 축조방식과 사용된 재료에 따라 21가지 형식으로 세분된다. 특히 조선전기 14~16세기에는 원형 잡석 적심(I-1), 말각방형 장대석(II-1), 말각방형 잡석+와전(II-2a) 세 가지 형식의 적심만 축조되다가, 조선후기 19세기에 들어 21가지 분류한 모든 적심이 다양하게 축조된다. 19세기 고종연간 내에서도 연대별로 각기 다른 형식의 적심을 사용하고 있는데, 특히 재료에서 두드러진 차이점이 확인된다. 경복궁을 재건한 고종 2년(1865)~고종 5년(1868)에 축조된 적심 10가지 형식 중 무려 7가지가 와전편을 섞어 넣은 형식인 반면, 고종 10년(1873)과 고종 13년(1876) 혹은 고종 25년(1888)에는 축조된 5가지 형식 중 3가지가 강회를 섞어 넣은 사질토를 사용한 형식으로 대조를 이룬다. 궁궐 건물은 '주인의 신분과 용도'에 따라 건물의 서열이 정해지고, 건물의 이름 뒤에 가장 중요하고 격이 높은 순서대로 전(殿), 당(堂), 합(閤), 각(閣), 재(齋), 헌(軒), 누(樓), 정(亭) 등의 명칭이 붙어 그 유형이 구분되며, 그 격에 맞추어 건축물이 축조된다. 이 건물 유형별 사용된 적심을 검토한 결과, 건물의 유형(전(殿), 당(堂), 합(閤), 각(閣), 재(齋), 헌(軒), 누(樓), 정(亭))에 따라 그 기초, 즉 적심도 달리 축조되는 것을 확인할 수 있었다. 현 자료의 한계 상'전', '당', '각', '방'등 일부 건물 유형만 확인되었는데, '전'과 '각'의 경우 장대석으로 축조한 방형 적심(IV)이, '당'과 '방'의 경우 기와와 잡석을 사용하여 축조한 말각방형 적심(II)이 많이 사용되었으며, 기타 건물명을 알 수 없는 경우는 대부분 조선전기 선대(先代) 건물지의 적심임으로, 조선전기에 원형 잡석 적심(I-1)이 많이 축조된 것을 알 수 있었다. 이를 통해 주인의 신분이 높고 격이 높은 건물일수록 건축물도 격이 높듯이, 그 기초부, 즉 적심 또한 가장 견고하고 좋은 재료를 사용하여 축조한 것으로 추정해 볼 수 있다. 또한 '당'과 '방'은 같은 말각방형 적심이 사용되었지만, '당'은 잡석과 와전편을 주재료로 사용한 II-2a(잡석+와전편 말각방형 적심)형식이, '방'은 II-2a형식의 상면에 15~20cm 가량 와전편을 깐 II-2b(와전편+(잡석+와전편 말각방형적심)) 형식이 많아 차이가 있었다. 이러한 건물 유형별 적심은 시기별로 축조되는 형식에 변화가 있는 것으로 확인되었다. '전'과 '각'의 경우 모두 14~15세기 조선전기에는 I-1형식(원형 잡석)의 적심을 축조하다가, 19세기 조선후기에는 다양한 형식의 적심이 축조되는데, 그 중에서도 특히 방형 적심(IV)이 많이 축조되었음을 알 수 있었다. '당'의 경우 조선후기의 변천양상만을 확인할 수 있었는데, 고종 4년(1867) 축조된 적심은 잡석과 와전편을 섞어 넣은 형식의 적심이 많이 축조되고, 이후 고종 13년(1876) 혹은 고종 25년(1888)에는 다른 건물 유형에서 확인되지 않는 강회사질토 및 탄축 적심이라는 독자적인 형식이 사용되었다. 본 연구를 통해 조선전기에 비해 후기에 적심의 다양한 축조방식과 재료가 개발되었음을 알 수 있었으며, 이는 당시 궁궐건물 기초 축조 기술 수준의 변화가 있었음을 대변해 준다. 또한 건물 유형별로 사용되는 적심의 형식이 다른 것이 확인되어, 건물의 기초를 축조할 때 미리 계산된 건축 공법을 적용하였음을 알 수 있었다.

• 한국의사학회지
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• 제14권2호
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• pp.109-152
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• 2001

Throughout this paper, I adjusted the study of 'Qian Yi'(錢乙)'s Medical Thought, and the following is the summary. 1. 'Qian Yi' wrote 'Xiao Er Yao Zheng Zhi Jue'("小兒藥證直訣", edited by 誾季忠), and there were 'Shang Han Lun Zhi Wei'("傷寒論指微"), 'Ying Ru Lun', however those are loss of the record. 2. Qian Yi's 'Zhi Jue'("直訣") was influenced by 'Lu Xin Jing', yet if we compare the quality of 'Sheng Li, Byeng Li, Bang Jae'(生理, 病理, 方劑), 'Lu Xin Jing' cannot be the foundation of 'Zhi Jue'. He took over 'Nei Jing, Shang Han Lun, Jin Gui Yao Lue, Shen Long Ben Cao Jing, Tai Ping Sheng Hui Fang'("內經", "傷寒論", "金?要略", "神膿本草經", "太平聖惠方") and put them together to the direct clinical experiences of pediatrics. 3. There is no reference regarding the difficulties of pediatric diagnosis and diseases in 'Huang Di Nei Jing'("黃帝內經") Before 'Bei Song'(北宋), regardless of the lack of data related to pediatric diseases, 'Qian Yi' established the pediatric system in 'Xiao Er Yao Zheng Zhi Jue' for the first time. 4. In his diagnosis of the pediatric diseases, he 'Si Zhen He Can'(四診合參), also considered in the eye exam seriously. In addition, he closely combined 'Wu Zang Bian Zheng'(五臟辨證), and diagnosis the pediatric diseases. 5. 'Wu Zang Bian Zheng', what Qian established method was based on 'Zheng Ti Guan'(整體觀) in 'Huang Di Nei Jing'. It was based on clinical experiences and established the perspectives of 'Tian Ren Xiang Ying'(天人相應). First of all, he pinpointed 'Zhu Zheng'(主證) clearly. Secondly, he pinpointed the relationships to symptoms and then, he distinguished a generic character of 'Xu, Shi, Han, Re'(虛, 實, 寒, 熱). Finally, he made an induction from genealogical pediatric physiology. 6. 'Qian Yi' took a serious view of 'Ban Zhen'(斑疹), the inadequate field in those days. At that time, he criticized on the habituation of the misuse of medication. He treated separately which 'Ji Jing'(急驚) as 'Liang Xie'(凉瀉) and 'Man Jing'(慢驚) as 'Wen Bu'(溫補). He proposed 'Cong Gan Zhu Feng, Xin Zhu Jing'(從肝主風, 心主驚) theory and formulated 'Jing Feng'(驚風) theory as well. 7. As an opponent of a tendency to misusage of medicine, 'Qian Yi' made out a prescription with pliant medicine. He emphasized on the treatment to 'Gong Bu Shang Zheng, Bu Bu Zhi Xie, Xiao Bu Jian Shi'(攻不傷正, 補不滯邪, 消補兼施) because he had so lucid demonstration to 'Xu Shi Han Re'(虛實寒熱) of the five viscera in the field of 'Bang Yak'(方藥). 8. There were no pediatrics schools at that time, however, the pediatrics was being made up gradually by 'Jin Yuan Si Da Jia'(金元四大家) who was influenced by 'Qian Yi'. He raised an objection to medical treatment using pliant medicine. 'Qian Yi' applied 'Qu Xia'(驅下) treatment using 'Han Liang'(寒凉) medicine. 'Han Liang Pai'(寒凉派) is greatly influenced by Qian. 'Chen Wen Zhong'(陳文中) had a great impact on 'Han Liang Pai' who used a 'Zao Shu Wen Bu'(燥熟溫補) medicine for treatment. Since 'Song Jin'(宋金), he had a tremendous influence on pediatrics treating patients in both 'Han Wen'(寒溫) ways. 9. 'Qian Yi' had an influence on his medical thoughts on future generations, especially to 'Wan Quan'(萬全) of 'Ming Dai', 'Wu Tang'(吳塘) of 'Qing Dai'(淸代) and 'Yun Shu Jie'(?樹珏) of 'Min Guo'(民國). 'Wan Quan' is an advocate of 'You Yu, Bu Zu Zhi Shuo'(有餘, 不足之說)of 'Xiao Er Wu Zang'(小兒五臟) that he revealed Qian's 'Wu Zang Bian Zheng'(五臟辨證). 'Wu Tang' disclosed Qian's 'Xiao Er Ti Zhi Shuo'(小兒體質說) and 'Xiao Er Ke'(小兒科)'s 'Yong Yao Lun'(用藥論), therefore, he uncovered pediatric physiological characteristics through the advocate of Qian's 'Zang Fu Rou Ruo, Ji Gu Nen Qie, Yi Xu Yi Shi, Yi Han Yi Re' (臟腑柔弱, 肌骨嫩怯, 易虛易實, 易寒易熱). 'Yun Shu Jie' developed intrinsic relationships among time, symptom and 'Tian Ren Xiang Ying Guan'(天人相應觀), What 'Qian Yi' stated about them. And also, he developed Qian's 'Di Huang Wan'(地黃丸), 'Xie Qing Wan'(瀉靑丸), 'Yi Huang San'(益黃散) clinical usages as well. 10. Regarding Qian's 'Wu Zang Xu Shi'(五臟虛實), it has an influence on 'Zhang Yuan Su'(張元素)'s 'Zang Fu Bing Ji Bian Zheng'(臟腑病機辨證). 'Di Huang Wan', 'Xie Qing Wan', 'Xie Xin Tang'(瀉心湯), 'Yi Huang San', 'Xie Huang San'(瀉黃散) are the standard prescription of 'Wu Zang Bu Xie'(五臟補瀉). It is under the influence of Qian's treatment. Besides, 'Qian Yi' took a serious view of 'Xiao Er'(小兒)'s 'Pi Wei'(脾胃). 'Qian Yi' had an impact on 'Li Dong Yuan'(李東垣) one of the member of 'Bu Tu Pai'(補土派). 'Di Huang Wan', which placed great importance on 'Bu Yi Shen Yin'(補益腎陰), had a great impact on 'Da Bu Yin Wan'(大補陰丸) and 'Jin Yuan Si Da Jia' as well. 11. In a theory of Qian's 'Wu Zang Bian Zheng', though it had been stated clearly in 'Wu Zang Bian Zheng', but he neglected in 'Liu Fu Bian Zheng'(六腑辨證). In prescription field, The problem with the medicine is that it is either toxic or mineral, therefore, we are not able to use those medicine in a clinical testing at the present time.