• Journal of Korean Medical classics
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• v.24 no.4
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• pp.23-32
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• 2011

The texts of "Hwangjenaegyeong(黃帝內經)" explains Hakjil(瘧疾) in detail, especially in the "Jahak(刺瘧)" chapter, where bloodletting treatment is applied in many cases. The following paper categorized and organized Hakjil(瘧疾) cases treated by bloodletting methods, then analyzed applicable subjects and appropriate time for the procedure based on the texts. Afterwards, the mechanism for the cessation of Hakjil(瘧疾) seizures was examined. The findings of this research are as follows. 1. In the contents of "Hwangjenaegyeong(黃帝內經)", the appropriate time for acupuncture and bloodletting procedure is when Hakjil(瘧疾) seizures start to present themselves. 2. When a seizure takes place as a symptom of the body getting rid of the Hak(瘧) pathogen, Yanggi(陽氣) rushes to the locus of the pathogen, causing congestion of Gi(氣) and Blood(血) resulting in static blood[瘀血]. Therefore, bloodletting at the time of seizure initiation helps the flow of Gi(氣) and Blood(血), preventing the rush of Yanggi(陽氣). This is a restoration of the balancing function of Eum(陰) and Yang(陽), which indicates that bloodletting not only promotes smooth flow of Gi(氣) and Blood(血), but extends its effects to mental functions that balances Eum(陰) and Yang(陽). 3. Although Hakjil(瘧疾) seizures are presented in terms of Gi(氣) and Blood(血) in symptoms such as chill and fever[寒熱], static blood[瘀血], pain, etc., a fundamental disturbance in mental functions that control cold and heat seems to be present.

• Journal of the Korea Society of Computer and Information
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• v.12 no.5
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• pp.131-137
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• 2007

Recently, Ant Colony Optimization (ACO) is emerged as a simple yet powerful optimization algorithm for routing and load-balancing of both wired and wireless networks. However, there are few researches trying to adopt ACO to enhance routing performance in WSN owing to difficulties in applying ACO to WSN because of stagnation effect. In this paper, we propose an energy-efficient path selection algorithm based on ACO for WSN. The algorithm is not by simply applying ACO to routing algorithm but by introducing a mechanism to alleviate the influence of stagnation. By the simulation result, the proposed algorithm shows better performance in data propagation delay and energy efficiency over Directed Diffusion which is one of the outstanding schemes in multi-hop flat routing protocols for WSN. Moreover, we checked that the proposed algorithm is able to mitigate stagnation effect than simple ACO adoption to WSN.

• Journal of KIISE
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• v.42 no.1
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• pp.15-22
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• 2015

In this paper, we present a case study for a drug repositioning simulation based on distributed supercomputing technology that requires highly efficient processing of large-scale computations. Drug repositioning is the application of known drugs and compounds to new indications (i.e., new diseases), and this process requires efficient processing of a large number of docking tasks with relatively short per-task execution times. This mechanism shows the main characteristics of a Many-Task Computing (MTC) application, and as a representative case of MTC applications, we have applied a drug repositioning simulation in our HTCaaS system which can leverage distributed supercomputing infrastructure, and show that efficient task dispatching, dynamic resource allocation and load balancing, reliability, and seamless integration of multiple computing resources are crucial to support these challenging scientific applications.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.53-53
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• 2015

Basin-scale motions in a stratified lake rely on interactions of spatially and temporally varying wind force, bathymetry, density variation, and earth's rotation. These motions provide a major driving force for vertical and horizontal mixing of inorganic and organic materials, dissolved oxygen, storm water and floating debris in stratified lakes. In Lake Tahoe, located between California and Nevada, USA, basin-scale circulations are obviously important because they are directly associated with the fate of the suspended particulate materials that degrade the clarity of the lake. A three-dimensional hydrodynamic model, ELCOM, was applied to Lake Tahoe to investigate the underlying mechanisms that determine the characteristics of basin-scale circulations. Numerical experiments were designed to examine the relative effects of various mechanisms responsible for the horizontal circulations for two different seasons, summer and winter. The unique double gyre, a cyclonic northern gyre and an anti-cyclonic southern gyre, occurred during the winter cooling season when wind stress curl, stratification, and Coriolis effect were all incorporated. The horizontal structure of the upwelling and downwelling formed due to basin-scale internal waves found to be closely related to the rotating direction of each gyre. In the summer, the spatially varying wind field and the Coriolis effect caused a dominant anti-cyclonic gyre to develop in the center of the lake. In the winter, a significant wind event excited internal waves, and a persistent (2 week long) cyclonic gyre formed near the upwelling zone. Mechanism of the persistent cyclonic gyre is explained as a geostrophic circulation ensued by balancing of the baroclinc pressure gradient (or baroclinic instability) and Coriolis effect. Topographic effect, examined by simulating a flat bathymetry with constant depth of 300m, was found to be significant during the winter cooling season but not as significant as the wind curl and baroclinic effects.

• Hanyang Medical Reviews
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• v.33 no.1
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• pp.10-16
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• 2013

Follicular helper T cells (Tfh) play a significant role in providing T cell help to B cells during the germinal center reaction, where somatic hypermutation, affinity maturation, isotype class switching, and the differentiation of memory B cells and long-lived plasma cells occur. Antigen-specific T cells with IL-6 and IL-21 upregulate CXCR5, which is required for the migration of T cells into B cell follicles, where these T cells mature into Tfh. The surface markers including PD-1, ICOS, and CD40L play a significant role in providing T cell help to B cells. The upregulation of transcription factor Bcl-6 induces the expression of CXCR5, which is an important factor for Tfh differentiation, by inhibiting the expression of other lineage-specific transcription factors such as T-bet, GATA3, and RORγt. Surprisingly, recent evidence suggests that CD4 T cells already committed to Th1, Th2, and Th17 cells obtain flexibility in their differentiation programs by downregulating T-bet, GATA3, and RORγt, upregulating Bcl-6 and thus convert into Tfh. Limiting the numbers of Tfh within germinal centers is important in the regulation of the autoantibody production that is central to autoimmune diseases. Recently, it was revealed that the germinal center reaction and the size of the Tfh population are also regulated by thymus-derived follicular regulatory T cells (Tfr) expressing CXCR5 and Foxp3. Dysregulation of Tfh appears to be a pathogenic cause of autoimmune disease suggesting that tight regulation of Tfh and germinal center reaction by Tfr is essential for maintaining immune tolerance. Therefore, the balance between Tfh and Tfr appears to be a critical peripheral tolerance mechanism that can inhibit autoimmune disorders.

• Journal of Biosystems Engineering
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• v.2 no.1
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• pp.7-24
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• 1977

This paper is the forth and fifth one of the study on balanced type oscillating mole drainer. In the light of the results from previous reports about the model tests, some design criteria were established and a prototype machine was set up for experimental purpose. Motion characteristics and functionof the each parts of the machine were checked and analyzed. After that, performance tests of the prototype machine were carried out in thefield. Obtained results are summarized as follows ; 1. Ten centimeter of the bullet diameter was determined so as to be able to attach it to the tractors with capacity of 30 PS to 40 PS. 2. To maintain the balance between the moments of the front shank and rear shank, the oscillating amplitude of the rear bullet was determined to be larger than that of the front bullet. At the same time , the oscillating direction of the rear bullet was designed with the inclines of ten to thirty degrees. 3. An octagonal dynamo transduced was developed for measuring the compressive force of the upper link is measuring the draft force of the machine. Acceptable linear relationship between forces and strain responses from O.D.T. was obtained. 4. Analysing the balancing mechanism of the acting part of the machine , it was found that the total draft force of the machine was equal to the difference between the sum of the draft force produced from the right and left side bending moments of the lower drawber and the compressive force on the upper link. 5. There are acceptable linear relationship between the strain and twisting moment by driving shaft, and between strain and shank moment. Above results enable us to carry out the field experiment with prototype machine. 6. When the test machine was used in the field, it was possible to reduce the oscillating acceleration by forty percent in average as compared it with the single bullet mole drainer. 7. When the test machine was used under the oscillating condition, the dratt torce was reduced by 27 percent to 59 percent as compared it with the test machine under non-oscillating condition, while the draft force was increased by 7 percent to 20 percent as compared it with the mole drainer having oscillating single bullet. The reasoning behind this fact was considered as the resistance force due to the rear shank and bullet. 8. As the amplitude and frequency of the bullet were increased, the torque was increased accordingly. This tendency could be varied with the various characteristics of the given soils. And the larger frequency and amplitute, the more increasing oscil\ulcornerlating power but decreasing draft brce were needed, and draft force was increased as the velocity was increased.9. When the amplitude of the rear bullet was designed to be larger than that of the front bullet, the minimum value of the moment was lowered and oscillating acceleration was reduced. And when the oscillating direction of the rear bullet was declined back\ulcornerwards, oscillating acceleration was increased along with the increasing angle of decli\ulcornernation. When the test machine was operated in high speed, the difference between maximum moments and minimum ones became narrow. This varying magnitude of moments appeared on the moment oscillogram seems to be correlated to the oscillating acceleration and draft force. 10. From the analysis of variance, it was found that those factors such as frequency, amplitude, and operating velocity significantly affected in the oscillating acceleration, the draft resistance, the torque, the moment, and the total power required. And interaction between frequency and amplitude affected in the oscillating acceleration. 11. Within the given situation of this study, the most preferable operating conditions of the test machine were 7 Hz in oscillating frequency, 0.54 m/sec in operating velocity, and 39.1 mm in oscillating amplitude of front and rear bullets. However, it is necessary to select the proper frequency and magnitude of oscillation depending on the soil properties of the field in which the mole drainer is practiced by use of a bal1nced type oscillating mole drainer. 12. It is recommended that a comparative study of the mole drainers would be performed in the near future using two separate balanced oscillating bullet with the one which is operated by oscillating the movable bullet in a single cylinder or other balanced type which may be single oscillating bullet with spring, damper or balancing weight, and that of thing. To expand the applicability of the balanced type oscillating mole drainer in practical use, it is suggested to develop a new mechanism which perform mole drain with vinyl pipe or filling material such as rice hull.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.11 no.4
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• pp.331-339
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• 2018

The IEEE 1588, commonly known as a precision time protocol (PTP), is a standard for precise clock synchronization that maintains networked measurements and control systems. The best master clock (BMC) algorithm is currently used to establish the master-slave hierarchy for PTP. The BMC allows a slave clock to automatically take over the duties of the master when the slave is disconnected due to a link failure and loses its synchronization; the slave clock depends on a timer to compensate for the failure of the master. However, the BMC algorithm does not provide a fast recovery mechanism in the case of a master failure. In this paper, we propose a technique that combines the IEEE 1588 with network bonding to provide a faster recovery mechanism in the case of a master failure. This technique is implemented by utilizing a pre-existing library PTP daemon (Ptpd) in Linux system, with a specific profile of the IEEE 1588 and it's controlled through bonding modes. Network bonding is a process of combining or joining two or more network interfaces together into a single interface. Network bonding offers performance improvements and redundancy. If one link fails, the other link will work immediately. It can be used in situations where fault tolerance, redundancy, or load balancing networks are needed. The results show combining IEEE 1588 with network bonding enables an incredible shorter recovery time than simply just relying on the IEEE 1588 recovery method alone.

• Journal of KIISE:Information Networking
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• v.30 no.3
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• pp.293-306
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• 2003

In recent years, distributed computing environments have been radically changing to a structure of global, heterogeneous, federative and wide-area systems. This structure's environments consist of a let of objects which are implemented on telecommunication network to provide a wide range of services. Furthermore, all of objects existing on the earth have the duplicated characteristics according to how to categorize their own names or properties. But, the existing naming or trading mechanism has not supported the binding services of duplicated objects, because of deficiency of independent location service. Also, if the duplicated objects which is existing on different nodes provide the same service, it is possible to distribute the client requests considering each system's load. For this reason, we designed and implemented a new model that can not only support the location management of replication objects, but also provide the dynamic binding service of objects located in a system with minimum overload for maintaining load balancing among nodes in wide-area object computing environments. Our model is functionally divided into two parts; one part is to obtain an unique object handle of replicated objects with same property as a naming and trading service, and the other is to search one or more contact addresses by a location service using a given object handle. From a given model mentioned above, we present the procedures for the integrated binding mechanism in design phase, that is, Naming/Trading Service and Location Service. And then, we described in details the architecture of components for Integrated Binding Service implemented. Finally, we showed our implement environment and executing result of our model.

• Journal of KIISE
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• v.43 no.12
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• pp.1428-1436
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• 2016

A multipath routing in wireless sensor networks (WSNs) provides advantage such as reliability improvement and load balancing by transmitting data through divided paths. For these reasons, existing multipath routing protocols divide path appropriately or create independent paths efficiently. However, when the sink node moves to avoid hotspot problem or satisfy the requirement of the applications, the existing protocols have to reconstruct multipath or exploit foot-print chaining mechanism. As a result, the existing protocols will shorten the lifetime of a network due to excessive energy consumption, and lose the advantage of multipath routing due to the merging of paths. To solve this problem, we propose a multipath creation and maintenance scheme to support the mobile sink node. The proposed protocol can be used to construct local grid structure with restricted area and exploit grid structure for constructing the multipath. The grid structure can also be extended depending on the movement of the sink node. In addition, the multipath can be partially reconstructed to prevent merging paths. Simulation results show that the proposed protocol is superior to the existing protocols in terms of energy efficiency and packet delivery ratio.

• The KIPS Transactions:PartA
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• v.9A no.2
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• pp.241-248
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• 2002

With the structure of tilde-area computing system which Is specified by a researching team in Vrije University, Netherlands, lots of researchers and developers have been progressing the studies of global location and interconnection services of distributed objects existing in global sites. Most of them halve focused on binding services of only non-duplicated computational objects existing wide-area computing sites without any consideration of duplication problems. But all of objects existing on the earth rave the duplicated characteristics according to how to categorize their own names or properties. These objects with the same property can define as duplicated computational objects. Up to now, the existing naming or trading mechanism has not supported the binding services of duplicated objects, because of deficiency of independent location service. For this reason, we suggest a new model that can not only manages locations of duplicated objects In wide-area computing environments, but also provide minimum binding time by considering both the optimal selection of one of duplicated objects and load balance among distributed systems. Our model is functionally divided into 2 parts, one part to obtain an unique object handle of duplicated objects with same property as a naming and trading service, and the other to search one or more contact addresses by a node manager using a liven object handle, as a location service For location transparency, these services are independently executing each other. Based on our model, we described structure of wide-area integrated tree and algorithms for searching and updating contact address of distributed object on this tree. finally, we showed a federation structure that can globally bind distributed objects located on different regions from an arbitrary client object.