• Title/Summary/Keyword: Balanced condition

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Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice

  • Ahn, Kun No;Ahn, Jeong Yeol;Kim, Jae-Hyung;Cho, Kyoungrok;Koo, Kyo-In;Senok, Solomon S.;Goo, Yong Sook
    • The Korean Journal of Physiology and Pharmacology
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    • v.19 no.2
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    • pp.167-175
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    • 2015
  • A retinal prosthesis is being developed for the restoration of vision in patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking retinal ganglion cell (RGC) responses. Retinal degeneration (rd1) mice were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an $8{\times}8$ multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than $10{\mu}A$ and charge balanced condition is satisfied by lengthening the duration of the pulse. For intensities (or duration) modulation, duration (or amplitude) of the pulse was fixed to $500{\mu}s$($30{\mu}A$), changing the intensities (or duration) from 2 to $60{\mu}A$(60 to $1000{\mu}s$). RGCs were classified as response-positive when PSTH showed multiple (3~4) peaks within 400 ms post stimulus and the number of spikes was at least 30% more than that for the immediate pre-stimulus 400 ms period. RGC responses were well modulated both with anodic and cathodic phase-1st biphasic pulses. Cathodic phase-1st pulses produced significantly better modulation of RGC activity than anodic phase-1st pulses regardless of symmetry of the pulse.

Cancer survivor's dietary safety management awareness and competency type (암 생존자의 식생활 안전관리 인식과 역량 유형)

  • Kim, Yun Hwa
    • Journal of Nutrition and Health
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    • v.53 no.5
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    • pp.532-546
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    • 2020
  • Purpose: Although the number of cancer survivors is increasing because of early diagnosis and better treatment, they are worried about relapses and metastasis. This study examined the dietary safety management awareness, capacity, and behavior of cancer survivors. Methods: Data were collected from 233 cancer survivors in Daegu and Gyeongbuk areas using a self-administered 5-Likert questionnaire from March to May 2018. Frequency analysis, one-way analysis of variance, factor analysis, reliability analysis, and correlation analysis were analyzed using the SPSS. Results: The average score for each factor was as follows: importance of weight management (3.83), education requirement (3.79), unhealthy diet (reverse, 3.64), food safety anxiety (3.34), lack of awareness of over and malnutrition (reverse, 3.26), obsession (3.23), cooking capacity (3.16), health-function pursuit (3.04), balanced diet (2.93), and chronic disease anxiety (2.64). The average dietary safety competency factors were significantly lower among the male survivors, aged 60-80 years, lower economic condition, and less nutritional supplement intake. Female survivors comprised the highest proportion with high health management and cooking capacity, while men had the lowest of all the factors (p < 0.001). The group that was low in all three capacity factors had a significantly lower average score of difficulty in acquiring knowledge (reverse), lack of awareness of over- and malnutrition (reverse), importance of weight management, education requirement, knowledge, balanced diet, and health-functional pursuit compared to the other groups (p < 0.001). Conclusion: To effectively manage health, dietary safety management education should be differentiated and actively conducted according to sex, age, cancer diagnosis time, economic status, nutritional supplement intake, and the capacity cluster of cancer survivors.

Refurbishment of a 3.6 m earth-pressure balanced shield TBM with a domestic cutterhead and its field verification (국산 커터헤드를 장착한 직경 3.6 m 토압식 쉴드TBM의 제작과 현장적용성 분석)

  • Bae, Gyu-Jin;Chang, Soo-Ho;Choi, Soon-Wook;Kang, Tae Ho;Kwon, Jun-Yong;Shin, Min-Sik
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.17 no.4
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    • pp.457-471
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    • 2015
  • A domestic cutterhead with the diameter of 3.6 m was designed and manufactured in this study. Then, it was attached to an existing earth-pressure balanced shield TBM to excavate a cable tunnel with the length of 1,275 m. Especially, the procedures for TBM cutterhead design and its corresponding performance prediction were also summarized. From field data analyses of the refurbished shield TBM, its maximum advance rate was recorded as 14.4 m/day. Penetration depths of disc cutters were found to be approximately 4 mm/rev, which is equal to the maximum penetration depth designed for the strongest rock strength condition in the target tunnel. Every TBM operating thrust and cutter normal force during TBM driving was much smaller than their corresponding maximum capacities. When cutter acting forces recorded in the field were analyzed, their prediction errors by the CSM model were very high for weak rock conditions. In addition, rock strength showed very close relationships with cutter normal force and penetration depth.

Effect of High CO2 Concentration on Activation of Sexual Development in Aspergillus nidulans (고농도 CO2 노출에 의한 Aspergillus nidulans의 유성생식 촉진효과)

  • Han, Kap-Hoon;Yang, Yeong-Seok;Kim, Jong-Hwa
    • The Korean Journal of Mycology
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    • v.41 no.3
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    • pp.192-196
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    • 2013
  • Fungal development is largely affected by many environmental factors. In a model filamentous fungus Aspergillus nidulans, asexual development is promoted by exposure of light, presence of salt and non-fermentable sugars. In other hand, sexual development is largely induced by absence of light, fermentable sugars and hypoxic condition. Also, some important genes including veA and nsdD play positive roles in activating sexual development. Here, we reported that the effect of high concentration of $CO_2$ on developmental decision in A. nidulans. When wild-type $veA^+$ strain was cultured in normal condition, sexual and asexual development occurred in balanced manner. However, high concentration of $CO_2$ (~5%) strongly activated sexual development and inhibited asexual development. Furthermore, this $CO_2$ effect was controlled by the veA or nsdD gene. High $CO_2$ culture of $veA^-$ or $nsdD^-$ mutant didn't activate sexual development, suggesting that the activation of sexual development induced by high $CO_2$ cannot overcome the genetic requirement of sexual development such as veA or nsdD. Since 5% $CO_2$ is an important condition for human pathogenic fungi for surviving and adapting in human body, this developmental pattern of A. nidulans affected by $CO_2$ concentration may provide interesting clues for comparative study with human fungal pathogens including Aspergillus fumigatus.

Study on Developing Program for Efficient Landscape Woody Plants Management - Mainly Focused on the Development of a Tree Inventory System - (조경수목의 효율적 관리를 위한 프로그램 개발에 관한 연구 - 관리대장(Tree Inventory) 개발을 중심으로 -)

  • 조영환;곽행구
    • Journal of the Korean Institute of Landscape Architecture
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    • v.24 no.4
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    • pp.1-22
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    • 1997
  • This paper was focused on the efficient management of landscape woody plants, and concerned itself with their important role in the urban environment. Based on the philosophy that there is nothing that can be done without an inventory, the purpose of this study was to develop an inventory system and iris proper application to a site for establishing a management plan Two different approaches were used, The first was to make a newly structured inventory system through collecting, analyzing, and evaluating various types of inventories used in Korea, the U. S. A., and Japan. The second approach was to apply a newly designed inventory system to the case study area. using GIS 'as a tool of spacial analysis and statistics for making decisions. The results could be summarized as follows; 1. In Korea, most of the Landscape Woozy Plants Inventories had datas which represented possession of trees, and only the work which they had done according to their traditional ways, There was no data related to the conditions, management needs, and site conditions of individual trees, This is essential information for organizing an inventory system . 2. There needs to be data which is balanced, containing tree characteristics and site characteristics. Through such information the management needs could be adjusted properly. The inventory list described in this paper was determined by botanical identity, placement condition, condition of tree, and types of work for maintaining as well as improving the condition of each tree One of the most important things was to determine the location data of each tree so as to compare data with other trees. The data gained from the field survey still had some problems because of lack of scientific method for supporting objective views, and because of actual situations, especially in the field of evaluating site conditions and management needs. All data should be revised to fit a computer data management system , if possible 3. The GIS(Geographic Information System) application showed good performance in handling inventory data for decision making. All the data used for the GIS application was divided into location and non-spatial data. Using the location data, it was easy to find the exact location of each tree on the monitor and on the maps generated by the computer even in the actual managed trite, along with various attribute data. Therefore it could be said that the entire management plan should start from data of individual trees with their exact locations, for making concrete management goals through actual budget planning.

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Comparison of Lifestyle and Nutrient Intake by Number of Components of Insulin Resistance Syndrome in the Daegu Community (대구지역 인슐린저항성증후군의 생활습관 및 영양섭취상태 비교)

  • 이희자;윤진숙
    • Korean Journal of Community Nutrition
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    • v.6 no.3
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    • pp.317-330
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    • 2001
  • The purpose of this study was to figure out the characteristics of dietary habits and lifestyles related to the development of insulin resistance syndrome(IRS). The participants in this study were 595 adults with one or more abnormal data from a health examination and 215 normal adults. When IRS was defined as a condition in which the subjects have 2 or more abnormalities among obesity, hyperlipidemia, hypertension and hyperglycemia, the prevalence rate was 37.8%. We classified the 595 adults by the number of components of IRS components they had, the higher age and obesity index they had. Total cholesterol and glucose levels in the blood were also positively related to the number of IRS components. IRS subjects tended to practice less habitual drinking and more exercise and weight control. Coffee consumption and dining out frequency were also lower in the IRS group. An analysis of food habits by odds ratio indicated that total food score was better in the IRS group. However, it appeared that food habits such as \"frequent snacking\" and \"never rejecting offered foods\" need to be improved in IRS subjects. Other undesirable food habits were related to the consumption of eggs, dairy products, fried foods, garlic and onion. Dietary intake of Ca, Fe, riboflavin, Vit A, and energy were less than 75% of the Korean recommended allowance for more than half of the subjects. Nutrient intake was lower, Ca/P ratio from food intake was worse in the IRS group. Our results indicated that nutrition counseling for IRS need to be focused on balanced food intake to supply sufficient amount of each nutrient.nt of each nutrient.

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A Comparative Study of Alternative Medicine with Oriental Medicine (대체의학(代替醫學)과 한의학(韓醫學)의 비교연구(比較硏究))

  • Lyu Young-Su
    • Journal of Oriental Neuropsychiatry
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    • v.8 no.2
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    • pp.1-12
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    • 1997
  • As there has recently been growing interest in Alternative Medicine, Oriental Medicals have been trying to incorporate Alternative Medicine into Oriental Medicine evolutionarily. The purpose of this study is to make a comparative study of the historical background and present condition, the view of life, the principle of therapeutics, and the various therapeutics in Alterative Medicine and Oriental Medicine from the viewpoint of Oriental Medicine. The conclusion of this study is; 1. Although Alternative Medicine has become influential mainly in the effort of finding a solution the limit of western medicine, the clinical effect of Alternative Medicine should be verified continuously. 2. Alternative Medicine includes all of the therapeutics such as Traditional Medicine, Naturopathy, Complementary Medicine and Selective Medicine whose characters are different from Western Medicine and Oriental Medicine can be regarded as a sort of Alternative Medicine. 3. The holistic, systematic view of life of Alternative Medicine, from which viewpoint human considered as a harmonious vital existence, is a sort of recurrence to the view of Hipporcrates. 4. From the viewpoint of Alternative Medicine, a disease is not partial but holistic disorder and is treated by utilizing natural products as a medicine based on the principle that pursues harmonious and balanced psychosomatic function. This principle of therapeutic is the same as Oriental Medicine is based on. 5. Alternative Medicine may be classified largely five category, (1) Eastern Therapy, (2) Manipulative Therapy, (3) Natural Therapy, (4) Active Therapy, (5) Therapy Involving External Powers. 6. Besides Alternative Medicine which is used in clinical treatment, Massage, Homeopathy, Bach Flower remedies, Meditation, and other Music Therapy and Color Therapy is relatively accordant with therapeutics in Oriental Medicine and should be more actively accepted in clinics and improved.

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A Study on the Actual Condition for Portion Control of Meal Served by Food Service Operation (단체급식소에서 제공되는 음식의 적정분량 설정에 관한 연구(II) - 산업체급식소와 대학기숙사 급식소를 대상으로 -)

  • Kim, Heh-Young;Kim, Choon-Mae;Ko, Sung-Hee
    • Journal of the Korean Society of Food Culture
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    • v.12 no.1
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    • pp.79-86
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    • 1997
  • Well-balanced meal is very important in its quantity and quality. Especially on the quantity field it becomes difficult for a foodservice operation to decide proper portion for individuals uniformly. These study was focused to setting up a proper portion by each food service operation. The results obtained were: 1. Individual consumption size from dormitory food service of college: cooked rice 282 g, soups 161 g, pot stewes 162 g, stir fries 53 g, stews 32 g, kimchies 47 g, fresh and boiled salads 43 g, one course dishies 477 g, pan broiles 44 g, meunieres 124 g. Individual consumption size from industry foodservice (white collar worker): cooked rices 228 g, soups 205 g, pot stewes 251 g, stir fries 20 g, stewes 76 g, kimchies 57 g, fresh and boiled salads 36 g, one course dishies 423 g, pan broiles 63 g, meunieres 38 g. 2. Proper portion of meal based on a statistical data is as follows: at college foodservice - cooked rices $280{\sim}290$ g, soups $155{\sim}170$ g, pot stewes 170 g, stir fries 60 g, stewes 35 g, kimchies $40{\sim}60$ g, fresh and boiled salads 50 g, one course dishies 480 g, pan broiles 50 g, meunieres 130 g and at industry foodservice (white collar worker) - cooked rices $220{\sim}250$ g, soups 210 g, pot stewes 250 g, stir fries 20 g, stewes 80 g, kimchies 60 g, fresh and boiled salads 40 g, one course dishies 430 g, pan broiles 70 g, meunieres 40 g.

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Three-Phase Four-Wire Inverter Topology with Neutral Point Voltage Stable Module for Unbalanced Load Inhibition

  • Cai, Chunwei;An, Pufeng;Guo, Yuxing;Meng, Fangang
    • Journal of Power Electronics
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    • v.18 no.5
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    • pp.1315-1324
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    • 2018
  • A novel three-phase four-wire inverter topology is presented in this paper. This topology is equipped with a special capacitor balance grid without magnetic saturation. In response to unbalanced load and unequal split DC-link capacitors problems, a qusi-full-bridge DC/DC topology is applied in the balance grid. By using a high-frequency transformer, the energy transfer within the two split dc-link capacitors is realized. The novel topology makes the voltage across two split dc-link capacitors balanced so that the neutral point voltage ripple is inhibited. Under the condition of a stable neutral point voltage, the three-phase four-wire inverter can be equivalent to three independent single phase inverters. As a result, the three-phase inverter can produce symmetrical voltage waves with an unbalanced load. To avoid forward transformer magnetic saturation, the voltages of the primary and secondary windings are controlled to reverse once during each switching period. Furthermore, an improved mode chosen operating principle for this novel topology is designed and analyzed in detail. The simulated results verified the feasibility of this topology and an experimental inverter has been built to test the power quality produced by this topology. Finally, simulation results verify that the novel topology can effectively improve the inhibition of an inverter with a three-phase unbalanced load while decreasing the value of the split capacitor.

A Study on the Environmental Color Planning Method and Design Process -Centering on the Exterior Color in Apartment- (환경색채 계획 방법과 디자인 과정에 관한 연구 -아파트 외벽색채를 중심으로 -)

  • 박경애
    • Korean Institute of Interior Design Journal
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    • no.3
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    • pp.26-32
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    • 1994
  • The aim of this study is to provide practical guide for exterior design in apartment and to propose a device to improve the quality of residential environment by the color planning. Color is a language of context and used as a visual aid to recognize the objects and spaces in the world around us. In this sense, each color perception is unique to its own setting and not subject to any universal rules of thumbs, Therefore, when designing with color, each setting will demand its own specific set of rules. A balanced color scheme has to make the environment more pleasant for people to live in . Fro the exterior in housing the use of color has to be considered not just in its wider context of the architecture or surrounding but as an element of the life of the inhabitant. So it is considered on the type of people who will live in and visual condition of site. In this study , the objective model of systematic design process for environmental color planning is proposed on the basis of theroetical background and references investigated, By the existing thesis, resident's preference of the exterior color and foumular of composition in apartment was invastigated . In general theories, based on the theory Birren's color harmony for color coordination an design principles, a device of exterior color design in apartment was suggested by the course of reasonable design process. Color in environment plays many different roles. It integrates the architecture with the site. If color is use well, it can soften architecture that is too harsh, it can give a sense of identity to different part of site and improve a city's image. The environmental color is effective media to enhance the aesthetic value of architecture and environment.

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