• Journal of Acupuncture Research
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• v.21 no.3
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• pp.283-302
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• 2004

Background : Angiogenesis is the proliferation of a network of blood vessels emanating from pre-existing vessels, supplying nutrients and oxygen and removing waste products. Angiogenesis occurs in a variety of normal physiologic and pathologic conditions and is regulated by a balance of stimulatory and inhibitory angiogenic factors. Excessive angiogenesis should be suppressed. However, if blood supply is insufficient, it should be encouraged. Hyul-Mek(血脈) or Hyul-Rark(血絡), known as blood vessels in western medicine, is deeply related to Chung-Ki-Hyul(精 氣 血). The goal of this study is to review the effects of herbal medicines on angiogenesis that is involved in wound healing and enhancement of blood supply. Methods : We conducted a systematic and comprehensive literature search for the identification, retrieval, and bibliographic management of independent studies to locate information on the topic. A computerized search of the published literature of Korea(KISS, RISS), China(CNKI), Japan(Kampo medicine, etc), and western countries(MEDLINE) was performed, and further supplemented with manual searches of print sources(1999 to 2003). Results : The herbal medicines with angiogenic activity were mainly found among herbs that carry replenish Shin-Cheng(補腎益精), foster Eum and improve the circulation of blood(養陰活血), or warm and circulate Kyung-Rark(溫經通絡). In particular, herbs with improve the circulation of blood and clear blood(活血化瘀) activity contain a significant amount of tannin, saponin, and pyrazine. Conclusion : Replenish Ki-Hyul(補氣血) and circulate Kyung-Rark(通經絡) could contribute to the induction of angiogenesis because various growth factors and proliferation, differentiation, and migration of vascular endothelial cells are involved in angiogenic activity.

• Journal of Korean Academy of Nursing
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• v.30 no.6
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• pp.1467-1478
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• 2000

The purpose of this study was to develop a curriculum for the oriental clinical nurse specialist program based on the understanding of Korean human beings so as to develop nursing as a profession and promote the client's health. The design of this study was based on literature review and nominal group study. The research was managed by East-West Nursing Research Institute of nursing science college at Kyung Hee University. The research team was composed of 17 professors of nursing departments of oriental medical colleges. We obtained opinions from Oriental Nurses Association, Oriental Nursing Research Association, and professors in oriental medical college. We reviewed articles, curriculums of other clinical nurse specialist programs, medical laws and the curriculum development plan for the oriental clinical nurse specialist program from Korean Nurses Association. We discussed a curriculum thoroughly in numerous meetings. We developed a following curriculum: 1. Educational philosophy was founded on the oriental human view which was based on Chun-In union theory. It was founded on the oriental health view which recognized health being in harmony with nature and the balance of body function with the harmony of Yin-Yang in the five elements. In addition, it was founded on oriental nursing view to promote these health states. 2. Educational goals were to train oriental clinical nurse specialists, oriental nursing educators and oriental nursing researchers who developed knowledge of oriental nursing theory, nursing practice and created a leadership. 3. Curriculum consisted of 48 credits, of which 36 credits are based on lectures and laboratory classes and 12 credits are based on clinical practice. 36 credits consisted of 5 general subject credits and 31 core subject credits. General subjects consisted of nursing theory, nursing research, law and ethics. Students who had earned master's degrees are not required to take the general subjects. Core subjects consisted of 11 subjects such as advanced physical examination and laboratory, oriental nursing theory, original text of oriental nursing, oriental medical nursing, oriental pediatric nursing, oriental gynecologic nursing, oriental gerontologic nursing, oriental pharmacology, oriental constitutional nursing, advanced nursing of channels and acupuncture points and laboratory and oriental rehabilitation nursing and laboratory. In addition, clinical practice in a hospital ward, out patient department, herb prepation room, department of physical therapy and health promotion center in oriental medical hospitals for 12 weeks. To admit this program, students should complete prerequisites of introduction to oriental nursing and nursing of channels and acupuncture points. 4. Course contents of each subjects were developed to include the course's goal and objectives and specific items. 5. Evaluation involved lecture, laboratory and in field practice. We applied various evaluation systems and methods that were based on both knowledge and skills of the students to ensure full credibility and validity.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.3
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• pp.38-51
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• 2020

A bottleneck and congestion occur when a freeway is closed due to maintenance and construction activities on the freeway. Although various traffic managements have been developed to improve the traffic efficiency at freeway work zones, such as merge control, there is a limit to those controls with human drivers. On the other hand, the wireless communication of connected and automated vehicles (CAVs) enables the operation of advanced traffic management. This study developed a traffic control strategy that integrates Dynamic Merge Control (DMC) and Lane Change Control (LCC) in a CAV environment. DMC operates as an either early or late merge based on the occupancy rate of upstream of the work zone. The LCC algorithm determines the number of vehicles that need to change their lane to balance the traffic volume on open lanes. The simulation results showed that integrated control improves the cumulative vehicle count, average speed upstream, and average network travel time.

• Korean Journal of Agricultural and Forest Meteorology
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• v.16 no.4
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• pp.359-367
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• 2014

Drought index can be used to implement an early warning system for drought and to operate a drought monitoring service. In this study, an approach was examined to determine agricultural drought index (ADI) at high spatial resolution, e.g., 270 m. The value of ADI was calculated based on soil water balance between supply and demand of water. Water supply is calculated by the cumulative effective precipitation with the application of the weight to the precipitation from two months ago. Water demand is derived from the actual evapotranspiration, which was calculated applying a crop coefficient to the reference evapotranspiration. The amount of surface runoff on a given soil type was also used to calculate soil residual moisture. Presence of drought was determined based on the probability distribution in the given area. In order to assess the reliability of this index, the amount of residual moisture, which represents severity of drought, was compared with measurements of soil moisture at three experimental between July 2012 and December 2013. As a result, the ADI had greater correlation with measured soil moisture compared with the standardized precipitation index, which suggested that the ADI would be useful for drought warning services.

• Journal of Life Science
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• v.28 no.8
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• pp.992-998
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• 2018

Cancer cells grow in an environment composed of various components that supports tumor growth. Major cell types in the tumor microenvironment are fibroblast, endothelial cells and immune cells. All of these cells communicate with cancer cells. Among infiltrating immune cells as an abundant component of solid tumors, macrophages are a major component of the tumor microenvironment and orchestrates various aspects of immunity. The complex balance between pro-tumoral and anti-tumoral effects of immune cell infiltration can create a chronic inflammatory microenvironment essential for tumor growth and progression. Macrophages express different functional programs in response to microenvironmental signals, defined as M1 and M2 polarization. Tumor-associated macrophages (TAM) secret many cytokines, chemokines and proteases, which also promote tumor angiogenesis, growth, metastasis and immunosuppression. TAM have multifaceted roles in the development of many tumor types. TAM also interact with cancer stem cells. This interaction leads to tumorigenesis, metastasis, and drug resistance. TAM obtain various immunosuppressive functions to maintain the tumor microenvironment. TAM are characterized by their heterogeneity and plasticity, as they can be functionally reprogrammed to polarized phenotypes by exposure to cancer-related factors, stromal factors, infections, or even drug interventions. Because TAMs produce tumor-specific chemokines by the stimulation of stromal factors, chemokines might serve as biomarkers that reflect disease activity. The evidence has shown that cancer tissues with high infiltration of TAM are associated with poor patient prognosis and resistance to therapies. Targeting of TAM in tumors is considered a promising therapeutic strategy for anti-cancer treatment.

• Journal of the Korean earth science society
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• v.27 no.4
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• pp.486-502
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• 2006

Earth Science is the study of Earth, where diverse organisms live, and it mainly focuses on the healthy, wealthy, and comfortable environment for our descendants. UNESCO and IUGS recently established the International Working Group on Medical Geology (1996), IGCP 454 Medical Geology (2000-2004), and International Medical Geology Association (IMGA, 2006) with the primary concerns of increasing awareness of Medical Geology among scientists, medical specialists, and the general public. Medical Geology and IMGA have been very successful in informing(educating) about the relationship between geological factors and health problems in humans and animals in the world through numerous international meetings, seminars, workshops, symposiums, and publications. Since there is a close correlation between Earth Science and Medical/ Dental Sciences as shown in the Medical Geology and IMGA, Earth Science, as with other areas in science, (i.e., Biology, Chemistry and Physics) should be included in the Medical Education Eligibility Test (MEET) and Dental Education Eligibility Test (DEET) for the Medical and Dental Graduate School. In this brief note, services and activities of UNESCO IGCP 454 Medical Geology and IMGA are introduced, sothat the inclusion of Earth Science as a subject requirement in the MEET and DEET can be considered. Such outcome will balance the development of Science Education in Korea.

• Journal of the Korean Association of Geographic Information Studies
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• v.14 no.3
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• pp.36-51
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• 2011

Global climate change is disturbing the water circulation balance by changing rates of precipitation, recharge and discharge, and evapotranspiration. Groundwater, which occupies a considerable portion of the world's water resources, is related to climate change via surface water such as rivers, lakes, and marshes. In this study, the authors selected a relevant climate change scenario, A1B from the Special Report on Emission Scenario (SRES) which is distributed at Korea Meteorological Administration. By using data on temperature, rainfall, soil, and land use, the groundwater recharge rate for the research area was estimated by periodically and embodied as geographic information system (GIS). In order to calculate the groundwater recharge quantity, Visual HELP3 was used as main model, and the physical properties of weather, temperature, and soil layers were used as main input data. General changes to water circulation due to climate change have already been predicted. In order to systematically solve problems of ground circulation system, it may be urgent to recalculate the groundwater recharge quantity and consequent change under future climate change. The space-time calculation of changes of the groundwater recharge quantity in the study area may serve as a foundation to present additional measures to improve domestic groundwater resource management.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.3
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• pp.160-174
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• 2014

The purpose of this paper is to develop a meso-scale grid-based continuous hydrological model and apply to assess the future watershed hydrology by climate change. The model divides the watershed into rectangular cells, and the cell profile is divided into three layered flow components: a surface layer, a subsurface unsaturated layer, and a saturated layer. Soil water balance is calculated for each grid cell of the watershed, and updated daily time step. Evapotranspiration(ET) is calculated by Penman-Monteith method and the surface and subsurface flow adopts lag coefficients for multiple days contribution and recession curve slope for stream discharge. The model was calibrated and verified using 9 years(2001-2009) dam inflow data of two watersheds(Chungju Dam and Soyanggang Dam) with 1km spatial resolution. The average Nash-Sutcliffe model efficiency was 0.57 and 0.71, and the average determination coefficient was 0.65 and 0.72 respectively. For the whole Han river basin, the model was applied to assess the future climate change impact on the river bsain. Five IPCC SRES A1B scenarios of CSIRO MK3, GFDL CM2_1, CONS ECHO-G, MRI CGCM2_3_2, UKMO HADGEMI) showed the results of 7.0%~27.1 increase of runoff and the increase of evapotranspiration with both integrated and distributed model outputs.

• International Commerce and Information Review
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• v.18 no.3
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• pp.47-72
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• 2016

The Government of Korea has always focused on developing and maintaining a surplus on the balance of payments as a successful trade policy. The focus should now be on spatial information hiding, revealing patterns in trade activities that enable viewing trade in a more sophisticated manner. This study utilizes trade statistical data such as the United States-South Korea imports and exports from 2003 to 2015 officially released by the two countries. It allows us to analyze and extract the spatial information pertaining to the origin, transit, and destination. First, in the case of export data to the United States, the origin of the trade goods has expanded and decentralized from the metropolitan area. With regard to transit, in 2003, most of the exported goods were shipped by ocean vessels and arrived at the ports on the western coast of the United States. However, trade patterns have changed over the 12-year period and now more of that trade has moved to the southern ports of the United States. In terms of destination, California and Texas were importing goods from South Korea. With the development of the automotive industry in Georgia and Alabama, these two states also imported huge volumes of automobile parts. Second, in case of import data, most imported goods from the United States originated from California and Texas. In this case, 40% of goods were shipped by air freight and arrived at the Incheon-Seoul International Airport; most ocean freight was handled at the Port of Busan. The purpose of this study is to decompose the spatial information from the trade statistics data between Korea and the United States and to depict visualized bilateral trade structure by origin, transit, and destination.

• International Journal of Oral Biology
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• v.32 no.3
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• pp.85-91
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• 2007

Dlx3 is a homeodomain protein and is known to playa role in development and differentiation of many tissues. Deletion of four base pairs in DLX3 (NT3198) is causally related to tricho-dento-osseous (TDO) syndrome (OMIM # 190320), a genetic disorder manifested by taurodontism, hair abnormalities, and increased bone density in the cranium. Although the observed defects of TDO syndrome involves bone, little is known about the role of Dlx3 in bone remodeling process. In this study, we examined the effect of wild type DLX3 (wtDlx3) expression on osteoclast differentiation and compared it with that of 4-BP DEL DLX3 (TDO mtDlx3). To examine whether Dlx3 is expressed during RANKL-induced osteoclast differentiation, RAW264.7 cells were cultured in the presence of receptor activator of nuclear factor-B ligand (RANKL). Dlx3 protein level increased slightly after RANKL treatment for 1 day and peaked when the fusion of prefusion osteoclasts actively progressed. When wtDlx3 and TDO mtDlx3 were overexpressed in RAW264.7 cells, they enhanced RANKL-induced osteoclastogenesis and the expression of osteoclast differentiation marker genes such as calcitonin receptor, vitronectin receptor and cathepsin K. Since osteoclast differentiation is critically regulated by the balance between RANKL and osteoprotegerin (OPG), we examined the effect of Dlx3 overexpression on expression of RANKL and OPG in C2C12 cells in the presence of bone morphogenetic protein 2. Overexpression of wtDlx3 enhanced RANKL mRNA expression while slightly suppressed OPG expression. However, TDO mtDlx3 did not exert significant effects. This result suggests that inability of TDO mtDlx3 to regulate expression of RANKL and OPG may contribute to increased bone density in TDO syndrome patients. Taken together, it is suggested that Dlx3 playa role as a positive regulator of osteoclast differentiation via up-regulation of osteoclast differentiation-associated genes in osteoclasts, as well as via increasing the ratio of RANKL to OPG in osteoblastic cells.