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검색결과 731건 처리시간 0.025초

Diversification of the molecular clockwork for tissue-specific function: insight from a novel Drosophila Clock mutant homologous to a mouse Clock allele

  • Cho, Eunjoo;Lee, Euna;Kim, Eun Young
    • BMB Reports
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    • 제49권11호
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    • pp.587-589
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    • 2016
  • The circadian clock system enables organisms to anticipate the rhythmic environmental changes and to manifest behavior and physiology at advantageous times of the day. Transcriptional/translational feedback loop (TTFL) is the basic feature of the eukaryotic circadian clock and is based on the rhythmic association of circadian transcriptional activator and repressor. In Drosophila, repression of dCLOCK/CYCLE (dCLK/CYC) mediated transcription by PERIOD (PER) is critical for inducing circadian rhythms of gene expression. Pacemaker neurons in the brain control specific circadian behaviors upon environmental timing cues such as light and temperature cycle. We show that amino acids 657-707 of dCLK are important for the transcriptional activation and the association with PER both in vitro and in vivo. Flies expressing dCLK lacking AA657-707 in $Clk^{out}$ genetic background, homologous to the mouse Clock allele where exon 19 region is deleted, display pacemaker-neuron-dependent perturbation of the molecular clockwork. The molecular rhythms in light-cycle-sensitive pacemaker neurons such as ventral lateral neurons ($LN_vs$) were significantly disrupted, but those in temperature-cycle-sensitive pacemaker neurons such as dorsal neurons (DNs) were robust. Our results suggest that the dCLK-controlled TTFL diversify in a pacemaker-neuron-dependent manner which may contribute to specific functions such as different sensitivities to entraining cues.

현대 패션에 나타난 신체의 미의식에 관한 연구 (A Study on the Aesthetic Consciousness for Body expressed by Modern Fashion)

  • 김소영;이병화
    • 복식
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    • 제54권3호
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    • pp.129-143
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    • 2004
  • The beauty of the body could separately be defined from area to area, but there can't be any universal definition of it that is applicable throughout the world. The modern discourses on the body have frequently dealt with that, and the beauty of the body should be studied in light of sociocultural background. In today's world fashion industry, the body is represented in various ways, and how to express the body itself is considered from diverse perspectives. As it's now required to approach to fashion from the sociocultural standpoint of the body. a semiotic interpretation method was introduced. The reason was that from the viewpoint of semiotics, the beauty of the body has different implications for society as cultural sign, and they also could be regarded as sociocultural codes. In order to improve new light on the aesthetic consciousness of the body and how it's represented in modern fashion, earlier studies and existing theories were examined. The semiotic interpretation method was used to find out what the aesthetic consciousness of the body stood for and what implication it had for fashion. And in which way fashion represented aesthetic consciousness, including satire, pleasure, grotesque and decadence, through the body was examined. Fashion creates an artificial beauty of the body, and change in the body is followed by change in fashion.

감시경계 로봇의 그래픽 사용자 인터페이스 설계 (A Graphical User Interface Design for Surveillance and Security Robot)

  • 최덕규;이춘우;이춘주
    • 로봇학회논문지
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    • 제10권1호
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    • pp.24-32
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    • 2015
  • This paper introduces a graphical user interface design that is aimed to apply to the surveillance and security robot, which is the pilot program for the army unmanned light combat vehicle. It is essential to consider the activities of robot users under the changing security environment in order to design the efficient graphical user interface between user and robot to accomplish the designated mission. The proposed design approach firstly identifies the user activities to accomplish the mission in the standardized scenarios of military surveillance and security operation and then develops the hierarchy of the interface elements that are required to execute the tasks in the surveillance and security scenarios. The developed graphical user interface includes input control component, navigation component, information display component, and accordion and verified by the potential users from the various skilled levels with the military background. The assessment said that the newly developed user interface includes all the critical elements to execute the mission and is simpler and more intuitive compared to the legacy interface design that was more focused on the technical and functional information and informative to the system developing engineers rather than field users.

Light and Electron Microscopic Characterization of Husk from Korean Rice

  • Adya P. Singh;Park, Byung-Dae;Wi, Seung-Gon;Lee, Kwang-Ho;Yoon, Tae-Ho;Kim, Yoon-Soo
    • Plant Resources
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    • 제5권2호
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    • pp.95-103
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    • 2002
  • Microscopic techniques were used to observe the microstructure of rice husk. Microscopic examination showed that two main components of husk, lemma and palea consisted of outer epidermis, layers of fibers, vascular bundles, parenchyma cells, and inner epidermis, in sequence from the outer to the inner surface. The outer epidermal walls were extremely thick, highly convoluted and lignified. The underlying fibers were also thick-walled and lignified. Parenchyma cells were thin-walled and unlignified. Inner epidermal cells were also unlignified. The outer surface of both lemma and palea were conspicuously ridged, but the lower surface had a flat appearance. As part of a detailed study to characterize rice husk using microscopic and micro-analytical techniques, distribution of silica was also examined, and is presented elsewhere. Rice husk can potentially be used as a raw material for making composite products and the observations presented here form valuable background information for our future work related to product development.

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RNA 형광 검출을 위한 Finger형 PIN 광다이오드의 제작 및 평가 (Development and Characterization of Finger-type PIN Photodiode for Fluorescence Detection of RNA)

  • 김주환;오명환;주병권
    • 센서학회지
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    • 제13권2호
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    • pp.85-89
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    • 2004
  • This paper represents the development of high sensitivity photo-sensor for the fluorescence detection in the integrated biological analysis system. The finger-type PIN photodiodes were fabricated as the photo-sensor, and had a high sensitivity ($I_{light}/I_{dark}$ = 8720). The interference filter consisted of $TiO_{2}$ and $SiO_{2}$ was directly deposited on the photodiodes. Deposited filter with 95.5% reflection under 532 nm and 98% transmission over 580 nm exceedingly decreased the magnitude of background signal in the detection. The PDMS micro-fluidic channels are bonded on the photodiode by $O_{2}$ plasma treatment. The detection current was proportional to two primary parameters (light intensity, concentration), and the on-chip detection system could detect fluorescence signals down to 100 nM concentration (LOD = Limit of detection of rhodamine).

주요 국산재 10가지 수종에 대한 Bi-Sn 저온용융 합금주입 목재복합체의 도장 효과 (Coating Effect of Low Temperature Melting Bi-Sn Metalized Wood Composites on 10 Different Korean Wood Species)

  • 박계신;서인수;이화형;강석구
    • 한국가구학회지
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    • 제25권3호
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    • pp.223-232
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    • 2014
  • To make metalized wood composites of 10 different korean wood species, it was tested by Low temperature melting Bi-Sn alloy injection method at high temperature and high pressure condition. Metalized wood composite of each wood species had light ash color, but still maintained its own natural wood grain and wood figures. It was evaluated on coating properties. Furthermore, it also was check on effect of coating as like a changes of main color, wood grain and wood figures. The results of test were following as; a coating properties as like a cold resistance, heat resistance, acid resistance, alkali resistance, durability of abrasion, and cross-cut test was proper on the conditions of the KS standard. And, In aspect of color changes, the metalized wood composites of 10 different korean wood species had a light ash color, but still maintained its own natural wood grain and wood figures. Also, the more weight per gain of alloy is, the more grey background of metalized wood composite is.

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빛의 반사 및 굴절 시뮬레이션 코스웨어 설계 및 구현 (Simulated Courseware Design and Materialization of Light Reflection and Refraction)

  • 조용준;박덕원
    • 한국컴퓨터정보학회논문지
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    • 제4권3호
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    • pp.60-66
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    • 1999
  • 본 논문은 새로운 교육환경에 부응하는 학습자 중심의 시뮬레이션 코스웨어를 설계 구현하였다. 그 소재는 고등학교 물리과목의 빛의 반사와 굴절로 한다. 이 논문에서는 코스웨어의 유형과 학생 중심 학습 신념이나 대체 개념을 교수-학습에 고려한 구성주의 학습 개념을 정의하고 이론적 배경을 소개한다. 컴퓨터 시뮬레이션의 교수-이론 구조 절차를 살펴보았으며. 빛의 반사와 굴절에 대한 기본적인 개념을 다루고, 구면거을의 상과 렌즈의 상을 간단한 원리와 관계식 모형으로 설명한다. 구성주의 학습이론에 근간한 컴퓨터시뮬레이션 코스웨어 설계절차를 제시하고 구현함으로써 빛의 반사와 굴절시 물체의 거리와 초점거리의 변화에 따라 상의 종류 상의 형태상의 거리가 변화함을 보여주고 있다.

Subpulse-VPPM 변조를 이용한 잡음에 강한 가시광통신 (Noise-Resistant Visible Light Communications Using Subpulse-VPPM)

  • 김종훈;이승우;주민철;박영일
    • 한국통신학회논문지
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    • 제40권2호
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    • pp.385-389
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    • 2015
  • 배경 잡음이 강한 실내 환경에서 가시광통신을 이용하기 위해서는 저주파대역 잡음을 피해야 한다. 또한 통신을 하면서도 LED 조명의 장점을 유지하기 위해서는 조명등의 깜박임이 없어야 하며, 밝기를 조절할 수 있어야 한다. 본 논문에서는 위 기능을 수행하기 위해 신호 스펙트럼을 고주파 영역으로 이동하여 전송을 수행하였다. 특히 송수신을 모두 디지털회로만으로 구현 가능하도록 Subpulse-VPPM 변조방법을 제안하고, 전송 성능 측정을 위해 테스트베드를 제작하였다.

근적외선 형광 영상 시스템용 다채널 영상 모듈 개발 및 패키징 (Development and Packaging of Multi-channel Imaging Module for Near-infrared Fluorescence Imaging System)

  • 김태훈;서경환;이학근;정명영
    • 마이크로전자및패키징학회지
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    • 제26권2호
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    • pp.59-64
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    • 2019
  • 본 논문에서는 근적외선 다채널 형광 영상 시스템을 소개하고, 노출시간, 작동거리, 여기광의 강도에 따른 형광 영상 시스템의 특성에 대해 분석하였다. 노출시간이 길수록, 작동거리가 짧을수록, 여기광의 강도가 강할수록 형광신호가 증가하였다. 필터의 적절한 구성과 영상 모듈의 정밀한 패키징으로 배경신호의 증가를 억제하여 SBR이 증가하는 것을 확인하였다. 본 연구의 결과를 바탕으로 다채널 형광 영상 시스템을 활용할 수 있는 방안에 대해 제안하였다.

Awareness of occupational hazards and personal protective equipment use among dental hygienists

  • Choi, Hyun-Ju;Hwang, Tae-Yoon;Jeon, Man-Joong
    • Journal of Yeungnam Medical Science
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    • 제36권1호
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    • pp.20-25
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    • 2019
  • Background: The aim of this study was to evaluate the awareness of occupational hazards and personal protective equipment use among dental hygienists (DHs). Methods: A total of 271 self-administered questionnaires were obtained from 280 DHs working at dental hospitals or clinics in Daegu and Gyeongsangbuk-do, Korea. Results: The occupational hazards included work involving dust (94.1%), volatile substances (86.0%), noise (97.0%), and light-curing units (96.7%). The proportion of dental hygiene tasks that participants perceived as harmful were 42.4%, 51.7%, 9.2%, and 31.4% in the same order as above. The proportion of participants who used dust-proof masks during work involving dust was 1.1%. Those who wore gas-proof masks and gloves for work using volatile substances were 0.7% and 31.2%, respectively. Participants who used goggles for work involving light-curing units were 31.0%. None of the participants used ear plugs for work involving noise. A total of 22.9% of the participants recognized the Material Safety Data Sheet, while 79.7% had never been educated about harmful work environments. Conclusion: When compared to exposure status and perception of occupational hazards, the level of protective equipment use was very low. Extra measures to increase DHs' use of personal protective equipment are necessary.