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Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women

  • Lee, Hye-Ok;Yim, Jung-Eun;Kim, Young-Seol;Choue, Ryowon
    • Nutrition Research and Practice
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    • v.8 no.4
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    • pp.469-475
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    • 2014
  • BACKGROUND/OBJECTIVE: The goal of the present study was to investigate the effects of moderate caloric restriction on ${\beta}$-cell function and insulin sensitivity in middle-aged obese Korean women. SUBJECTS/METHODS: Fifty-seven obese pre-menopausal Korean women participated in a 12-week calorie restriction program. Data on total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and fasting serum levels of glucose, insulin, C-peptide, blood pressure, leptin and anthropometrics were collected. A dietary intake assessment was based on three days of food recording. Additionally, ${\beta}$-cell function [homeostasis model assessment of ${\beta}$-cell (HOMA-${\beta}$), insulinogenic index (ISI), C-peptide:glucose ratio, and area under curve insulin/glucose ($AUC_{ins/glu}$)] and insulin sensitivity [homeostasis model assessment for insulin resistance (HOMA-IR), Quantitative insulin-sensitivity check index (QUICKI) and Matsuda index (MI)] were recorded. RESULTS: When calories were reduced by an average of 422 kcal/day for 12 weeks, BMI (-2.7%), body fat mass (-10.2%), and waist circumference (-5%) all decreased significantly (P < 0.05). After calorie restriction, weight, body fat percentage, hip circumference, BP, TC, HDL-C, LDL-C, plasma glucose at fasting, insulin at fasting and 120 min, $AUC_{glu}$ and the insulin area under the curve all decreased significantly (all P < 0.05), while insulin sensitivity (HOMA-IR, QUICKI and Matsuda index) measured by OGTT improved significantly (P < 0.01). CONCLUSIONS: Moderate weight loss due to caloric restriction with reduction in insulin resistance improves glucose tolerance and insulin sensitivity in middle-aged obese women and thereby may help prevent the development of type 2 diabetes mellitus.

Study on Ethnic Style Shown in Anna Sui's Collections (안나 수이 컬렉션에 나타난 에스닉 스타일에 관한 연구)

  • Byun, Mi-Yeon;Lee, Ji-Eun;Lee, In-Soeng
    • The Research Journal of the Costume Culture
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    • v.15 no.1 s.66
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    • pp.127-136
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    • 2007
  • Modern society shares new culture derived from the fusion of various cultures unlike the past culture regulating one phenomenon of certain field as the representative icon of the era. Especially, the phenomenon of globalization acts as the catalytic agent to receive coexistence of variousness easily. Especially, in fashion industry, these flows and the view of naturalism are harmonized and new fashion trend called 'Ethnic' was embossed. As it reflects internal spirit of human being that wants to return to the memory due to expansion of material civilization, the interest in the designer pursuing it is increasing. This study tries to consider the Ethnic style displayed by Chinese American designer, Anna Sui, who pursues the eastern style with full wit and individuality. Anna Sui, who was praised by New York Times for 'the superb harmony of houte couture style and up-to-date style', created another fashion trend, romanticism in New York and she is the worldwide designer representing Ethnic. Like it, the consideration on her Ethnic style reanalyzing as eastern style provides guidance to check how designer's fashion philosophy appears in one category of America and China and new study material that enables us to understand the third world culture code as well as Anna Sui. This confirmation has the meaning as the basic material for the endless challenge to the new style that fashion will go on in the future. Anna Sui was confirmed to have been recognized as a designer who represented the ethnic collection in the United States, exerting the influence with her unique oriental background. Moreover, her design could identify the pivotal point of ethnic image by developing her unique style which is distinct from other designers in terms of silhouette, color, fabric, detail, and so on. This kind of study can provide the basic data required to understand the fashion world of designer in the future.

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The Changes of Blood Pressure, Heart Rate and Heart Rate Variability after Stellate Ganglion Block (성상신경절 차단 시 혈압, 맥박수 및 심박수 변이도의 변화)

  • Kweon, Tae Dong;Han, Chung Mi;Kim, So Yeun;Lee, Youn-Woo
    • The Korean Journal of Pain
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    • v.19 no.2
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    • pp.202-206
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    • 2006
  • Background: Stellate ganglion block (SGB) might be associated with changes in the blood pressure (BP) and heart rate (HR). The heart rate variability (HRV) shows the balance state between sympathetic and parasympathetic activities of the heart. The changes in these parameters of the HRV were studied to evaluate the possible mechanism of SGB in changing the BP. Methods: SGB was performed on 26 patients, using a paratracheal technique at the C6 level, and 8 ml of 1% mepivacaine injected. The success was confirmed by check the Horner's syndrome. The BP, HR and HRV were measured before and 5, 15, 30, 45 and 60 minutes after the SGB. Results: The increases in the BP from the baseline throughout the study period were statistically, but not clinically significant. The HR and LF/HF (low frequency/high frequency) ratio were increased at 5 and 45 min, respectively, after the administration of the SGB. In a comparison of left and right SGB, no significant differences were found in the BP, HR and HRV. A correlation analysis showed that an increased BP was significantly related with the changes in the LF/HF ratio and LF at 15 and 30 minutes, respectively, after the SGB. Dividing the patients into two groups; an increased BP greater and less than 20% of that at the baseline INC and NOT groups, respectively, hoarseness occurred more often in the INC group (P = 0.02). Conclusions: It was concluded that SGB itself does not clinically increase the BP and HR in normal hemodynamic patients. However, the loss of balance between the sympathetic and parasympathetic nerve system, attenuation of the baroreceptor reflex and hoarseness are minor causes of the increase in the BP following SGB; therefore, further studies will be required.

Surgical Treatment of Carpal Tunnel Syndrome through a Minimal Incision on the Distal Wrist Crease: An Anatomical and Clinical Study

  • Yoo, Hye Mi;Lee, Kyoung Suk;Kim, Jun Sik;Kim, Nam Gyun
    • Archives of Plastic Surgery
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    • v.42 no.3
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    • pp.327-333
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    • 2015
  • Background An anatomical analysis of the transverse carpal ligament (TCL) and the surrounding structures might help in identifying effective measures to minimize complications. Here, we present a surgical technique based on an anatomical study that was successfully applied in clinical settings. Methods Using 13 hands from 8 formalin-fixed cadavers, we measured the TCL length and thickness, correlation between the distal wrist crease and the proximal end of the TCL, and distance between the distal end of the TCL and the palmar arch; the TCL cross sections and the thickest parts were also examined. Clinically, fasciotomy was performed on the relevant parts of 15 hands from 13 patients by making a minimally invasive incision on the distal wrist crease. Postoperatively, a two-point discrimination check was conducted in which the sensations of the first, second, and third fingertips and the palmar cutaneous branch injuries were monitored (average duration, 7 months). Results In the 13 cadaveric hands, the distal wrist crease and the proximal end of the TCL were placed in the same location. The average length of the TCL and the distance from the distal TCL to the superficial palmar arch were $35.30{\pm}2.59mm$ and $9.50{\pm}2.13mm$, respectively. The thickest part of the TCL was a region 25 mm distal to the distal wrist crease (average thickness, $4.00{\pm}0.57mm$). The 13 surgeries performed in the clinical settings yielded satisfactory results. Conclusions This peri-TCL anatomical study confirmed the safety of fasciotomy with a minimally invasive incision of the distal wrist crease. The clinical application of the technique indicated that the minimally invasive incision of the distal wrist crease was efficacious in the treatment of the carpal tunnel syndrome.

Analysis of Factors Influencing the Obesity of Adolescents in South Korea (우리나라 청소년의 비만에 영향을 미치는 요인 분석)

  • Jung, Myung-Hee;Yi, Jee-Seon;Jung, Hye-Sun
    • Journal of the Korean Society of School Health
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    • v.29 no.1
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    • pp.11-21
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    • 2016
  • Purpose: The purposes of this study were to check the obesity of middle and high school students in the nation and identify factors influencing their obesity. Methods: The present study is a secondary analysis research that obtained permission to use the primitive data of 10th (2014) Online Survey on Adolescents' Health Behaviors by the Korea Centers for Disease Control and Prevention and analyzed the primitive data according to the purposes. Results: The findings show that the BMI of middle and high school students in the nation was $20.7kg/m^2$ with the obesity and non-obesity group recording $27.0kg/m^2$ and $19.9kg/m^2$, respectively. Factors influencing the obesity of adolescents include gender, grade, educational background of parent, school grades for the last 12 months, satisfaction with sleep, fast food consumption, ramen consumption, intense and muscle exercise three times a week or more, subjective sense of health, stress, suicidal ideation, and hours of Internet usage per week. Conclusion: For the management of adolescent obesity, there is a need for obesity management programs taking the characteristics of male students into consideration. The possibilities of obesity grow according to the grades, which means that both the teachers and parents should offer more guidance on weight control in upper grades. The adjustment of adolescent obesity requires psychological health management including stress and suicidal ideation as well as diet control and exercise. It is also needed to apply a stepwise obesity management program according to the hours of internet usage and dependence on the internet

중수로 환형기체 계통의 방사능 inventory 평가

  • Kim, Jin-Tae;Kang, Deok-Won;Son, Uk
    • Proceedings of the Korean Radioactive Waste Society Conference
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    • 2003.11a
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    • pp.90-95
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    • 2003
  • Chemical management of annulus gas system is carried out for the purpose of ensuring the safety and reliability of the system via securing the integrity of the system, detecting the D$_2$O in-leakage of coolant and/or moderator, and reducing the radiation dose. Since the quality of CO_2$ gas, which is used as a filling gas for annulus gas system at CANDU plants, has a propound effect on the integrity of the system material and the radiation dose, CO_2$ gas of high quality is needed. If the quality of CO_2$ gas does not meet the specification, it may give rise to undesirable effect not only on the annulus gas system, but also on the environment due to the production of radioactive nuclei. Therefore, it is very important to check the impurities of CO_2$ gas. Based on this background, the inventories of C-14 and Ar-41 in CO_2$ gas that is supplied as annulus gas were estimated using the data on concentrations of the impurities of $CO_2$ such as C, N_2$ and Ar. The results of this study is expect to give useful information on optimization of CO_2$ impurities maintenance and management of gaseous radioactive wastes produced at CANDU plants.

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Long-term cognitive, executive, and behavioral outcomes of moderate and late preterm at school age

  • Jin, Ju Hyun;Yoon, Shin Won;Song, Jungeun;Kim, Seong Woo;Chung, Hee Jung
    • Clinical and Experimental Pediatrics
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    • v.63 no.6
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    • pp.219-225
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    • 2020
  • Background: There is increasing concern that moderate preterm (32-33 weeks' gestation) and late preterm (34-36 weeks' gestation) birth may be associated with minor neurodevelopmental problems affecting poor school performance. Purpose: We explored the cognitive function, cognitive visual function, executive function, and behavioral problems at school age in moderate to late preterm infants. Methods: Children aged 7-10 years who were born at 32+0 to 36+6 weeks of gestation and admitted to the neonatal intensive care unit from August 2006 to July 2011 at the National Health Insurance Service Ilsan Hospital were included. We excluded children with severe neurologic impairments, congenital malformations, or chromosomal abnormalities. Neuropsychological assessments consisted of 5 neuropsychological tests and 3 questionnaires. Results: A total of 37 children (mean age, 9.1±1.2 years) participated. The mean gestational age at birth was 34.6±7.5 weeks, while the mean birth weight was 2,229.2±472.8 g. The mean full-scale intelligence quotient was 92.89±11.90; 24.3% scored between 70 and 85 (borderline intelligence functioning). An abnormal score was noted for at least one of the variables on the attention deficit hyperactivity disorder diagnostic system for 65% of the children. Scores below borderline function for executive quotient and memory quotient were 32.4% and 24.3%, respectively. Borderline or clinically relevant internalizing problems were noted in 13.5% on the Child Behavior Check List. There were no significant associations between perinatal factors or socioeconomic status and cognitive, visual perception, executive function, or behavior outcomes. Conclusion: Moderate to late preterm infants are at risk of developing borderline intelligence functioning and attention problems at early school age. Cognitive and executive functions that are important for academic performance must be carefully monitored and continuously followed up in moderate to late preterm infants.

A Study on Functional Movement Screen and Automobile Worker's Musculoskeletal Disorders

  • Shin, Eulsu;Kim, Yuchang
    • Journal of the Ergonomics Society of Korea
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    • v.35 no.3
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    • pp.125-133
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    • 2016
  • Objective: The aim of this study is to figure out the level of Functional Movement Screen (FMS) of 122 automobile manufacturing workers and to set the FMS score for predicting risk of musculoskeletal disorders. Background: Although today's industrial sites have been becoming automated rapidly, the risks of work-related musculoskeletal disorders (WMSDs) have been on the rise. In the case of WMSDs, it is important to control WMSDs at the early stage. Early detection of WMSDs is very important for the successful treatment. However, the medical examination puts a great financial burden on most workers. To reduce their burden, there is one test to check the musculoskeletal functional condition and to predict the risk of injury, which is called FMS. Method: This research tested the FMS score of 122 workers at a motor company, and also conducted a questionnaire survey of individual characteristics and job characteristics. Results: For the 122 subjects, the average score of FMS is $14.63{\pm}2.27$. There is a negative correlation between FMS and their ages and BMI (p <0.05). FMS is higher when exercising regularly (p <0.05). The FMS scores of musculoskeletal disorder patients are lower than those of normal workers (p <0.05). While it is more likely to become a musculoskeletal disorder patient when FMS score is less than 14, it is more likely to become a normal worker when FMS score is more than or equal to 14. Conclusion: According to the result of FMS test, there is a score difference between individuals with musculoskeletal disorders and normal ones. FMS scores can also predict and identify workers with risk of the musculoskeletal disorders. Application: According to this study, FMS can be expected to have a positive effect on the prevention of WMSDs in worksites.

Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study (당뇨병전기 성인의 신체운동과 류마티스 발생률)

  • Sin, Hye Yeon
    • Korean Journal of Clinical Pharmacy
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    • v.29 no.4
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    • pp.278-285
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    • 2019
  • Background: Rheumatoid arthritis is highly prevalent in overweight patients with type 2 diabetes mellitus and can be reduced by physical activity via altered proinflammatory parameters. However, the association between the frequency of physical activity and the prevalence of rheumatoid arthritis in prediabetic patients remains unclear and was evaluated in this study. Methods: Utilizing the Korean National Health Insurance Sharing Service database, 58,391 adults, who met the research criteria and underwent a general medical check-up between 2009 and 2013, were selected for this study. To analyze the data, a logistic regression with a proc survey logistic procedure was used. Results: The study revealed that the cumulative rheumatoid arthritis prevalence was lower in prediabetic patients compared to that in the control group (OR, 0.64; 95% CI, 0.483-0.840; p=0.001). More frequent physical activity (≥3 days/week) was significantly associated with a reduced rheumatoid arthritis prevalence in both groups (OR, 0.28; 95% CI, 0.039-0.521; p=0.044 vs. OR, 0.15; 95% CI, 0.063-0.237; p=0.007). Additionally, a 3.8-fold higher risk of rheumatoid arthritis development was observed in prediabetic adults with less frequent baseline physical activity (≤2 days/week). Overall, in prediabetes, the prevalence of rheumatoid arthritis was associated with the frequency of physical activity and not with the fasting plasma glucose levels. Conclusion: More frequent physical activity is associated with a low risk of developing rheumatoid arthritis in prediabetic patients. Thus, further studies are needed to confirm the clinical outcomes of frequent physical activity in rheumatoid arthritis prevention and control.

Quantitative Evaluation of Radiation Dose Rates for Depleted Uranium in PRIDE Facility

  • Cho, Il Je;Sim, Jee Hyung;Kim, Yong Soo
    • Journal of Radiation Protection and Research
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    • v.41 no.4
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    • pp.378-383
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    • 2016
  • Background: Radiation dose rates in PRIDE facility is evaluated quantitatively for assessing radiation safety of workers because of large amounts of depleted uranium being handled in PRIDE facility. Even if direct radiation from depleted uranium is very low and will not expose a worker to significant amounts of external radiation. Materials and Methods: ORIGEN-ARP code was used for calculating the neutron and gamma source term being generated from depleted uranium (DU), and the MCNP5 code was used for calculating the neutron and gamma fluxes and dose rates. Results and Discussion: The neutron and gamma fluxes and dose rates due to DU on spherical surface of 30 cm radius were calculated with the variation of DU mass and density. In this calculation, an imaginary case in which DU density is zero was added to check the self-shielding effect of DU. In this case, the DU sphere was modeled as a point. In case of DU mixed with molten salt of 50-250 g, the neutron and gamma fluxes were calculated respectively. It was found that the molten salt contents in DU had little effect on the neutron and the gamma fluxes. The neutron and the gamma fluxes, under the respective conditions of 1 and 5 kg mass of DU, and 5 and $19.1g{\cdot}cm^{-3}$ density of DU, were calculated with the molten salt (LiCl+KCl) of 50 g fixed, and compared with the source term. As the results, similar tendency was found in neutron and gamma fluxes with the variation of DU mass and density when compared with source spectra, except their magnitudes. Conclusion: In the case of the DU mass over 5 kg, the dose rate was shown to be higher than the environmental dose rate. From these results, it is concluded that if a worker would do an experiment with DU having over 5 kg of mass, the worker should be careful in order not to be exposed to the radiation.