• Korean Journal of Microbiology
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• v.36 no.4
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• pp.267-272
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• 2000

A 1.7-kb fragment containing the nodD1 genes of Bradyrhizobium sp. (Cassia) CN9135 was amplified by PCR with primers based on B. japonicum USDA110. This fragment was cloned and sequenced. Analysis of the sequence showed open reading frames highly homologous to nodD1 from other bradyrhizobial sources. The sequence showed higher homology to nodD1 gene of B. elkanii than to those from b. japonicum. Our results suggest that Bradyrhizobium sp. (Cassia) CN9135 may be more closely related to B. elkanii than to B. japonicum.

• Journal of Microbiology and Biotechnology
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• v.13 no.4
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• pp.529-536
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• 2003

The growth-inhibitory activity of Cassia tora seed-derived materials against seven intestinal bacteria was examined in vitro, and compared with that of anthraquinone, anthraflavine, anthrarufin, and 1-hydroxyanthraquinone. The active constituent of C. tore seeds was characterized as quinizarin, using various spectroscopic analyses. The growth responses varied depending on the compound, dose, and bacterial strain tested. At 1 mg/disk, quinizarin exhibited a strong inhibition of Clostridium perfringens and moderate inhibition of Staphylococcus aureus without any adverse effects on the growth of Bifidobacterium adolescentis, B. bifidum, B. longum, and Lactobacillus casei. Furthermore, the isolate at 0.1 mg/disk showed moderate and no activity against C. perfringens and S. aureus. The structure-activity relationship revealed that anthrarufin, anthraflavine, and quinizarin moderately inhibited the growth of S. aureus. However. anthraquinone and 1-hydroxyanthraquinone did not inhibit the human intestinal bacteria tested. As for the morphological effect of 1 mg/disk quinizarin, most strains of C. perfringens were damaged and disappeared, indicating that the strong activity of quinizarin was morphologically exhibited against C. perfringens. The inhibitory effect on aflatoxin $B_1$ biotransformation by anthraquinones revealed that anthrarufin ($IC_50,\;11.49\mu\textrm{M}$) anthraflavine ($IC_50,\;26.94\mu\textrm{M}$), and quinizarin ($IC_50,\;4.12\mu\textrm{M}$), were potent inhibitors of aflatoxin ${B_1}-8,9-epoxide$ formation. However, anthraquinone and 1-hydroxyanthraquinone did not inhibit the mouse liver microsomal sample to convert aflatoxin $B_1$ to aflatoxin ${B_1}-8,9-epoxide$. These results indicate that the two hydroxyl groups on A ring of anthraquinones may be essential for inhibiting the formation of aflatoxin ${B_1}-8,9-epoxide$. Accordingly, as naturally occurring inhibitory agents, the C. tora seed-derived materials described could be useful as a preventive agent against diseases caused by harmful intestinal bacteria, such as clostridia, and as an inhibitory agent for the mouse liver microsomal conversion of aflatoxin $B_1$ to aflatoxin ${B_1}-8,9-epoxide$.

• Journal of Species Research
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• v.13 no.3
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• pp.340-351
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• 2024

A new species of the canuellid genus Brianola Monard, 1926 (Copepoda: Harpacticoida) was collected during a meiofauna survey in July 2021 at the intertidal muddy sand of Phuket Island, Thailand. Currently, there are only eight known species of Brianola: B. stebleri, B. exigua, B. curvirostris, B. elegans, B. sydneyensis, B. vangoethemi, B. hamondi, and B. haliensis. Thus, the Brianola rawaiensis sp. nov. from Thailand is the ninth species of the genus. The new species, Brianola rawaiensis is most closely related to B. haliensis by sharing a four-segmented antennule in females and five-segmented antennule in males, eight-segmented antennary exopod and three-segmented antennary endopod, and P1 exp-3 with 5 spines/setae. However, B. rawaiensis sp. nov. is different from B. haliensis by having: 1) P1 exp-1 with 1 outer pinnate spine, 2) P1 exp-2 with inner plumose seta, 3) P2 exp-3 with 3 setae/spines, 4) P2 enp-1 with one inner plumose seta, 5) P4 enp-1 with inner seta. Sexual dimorphism is expressed in the antennule and segmentation of the urosome. Ovigerous female bearing one egg sac with 20 eggs.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.27 no.1
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• pp.21-30
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• 1991

The estimation of the fish biomass density or the size of fish by means of the acoustic equipment is an important part in the quantitative assessment of fisheries resources. The precision of such estimates depend upon the target strength of fish and the accuracy to which the acoustic equipment has been calibrated. This paper examine the accuracy of the digital measurement system which is manufactured by way of trial in order to masure the target strength of fish, and calibrations of that system carry out with an ogive and a ellipsoid made of the aluminum and the epoxy, respectively. Furthermore, measurements of target strength for eight species of fish are made at 25, 50, 100 kHz. The accuracy of the digital measurement system is compared the theory with measurements on ogive and ellipsoid, and the agreement is reasonable. Result of establishments on the target strength to fish length and to fish weight regression obtained from the measurements are available to provide the methods of design for use in interpreting acoustic measurements of fish abundance on the experimented eight species.

• Bulletin of the Korean Chemical Society
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• v.29 no.8
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• pp.1479-1484
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• 2008

Protein tyrosine phosphatase (PTP) 1B is the superfamily of PTPs and a negative regulator of multiple receptor tyrosine kinases (RTKs). Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as a strategy for the treatment of type 2 diabetes and obesity. Recently, it has been reported that amentoflavone, a biflavonoid extracted from Selaginella tamariscina, inhibited PTP1B. In the present study, docking model between amentoflavone and PTP1B was determined using automated docking study. Based on this docking model and the interactions between the known inhibitors and PTP1B, we determined multiple pharmacophore maps which consisted of five features, two hydrogen bonding acceptors, two hydrogen bonding donors, and one lipophilic. Using receptor-oriented pharmacophore-based in silico screening, we searched the biflavonoid database including 40 naturally occurring biflavonoids. From these results, it can be proposed that two biflavonoids, sumaflavone and tetrahydroamentoflavone can be potent allosteric inhibitors, and the linkage at 5',8''-position of two flavones and a hydroxyl group at 4'-position are the critical factors for their allosteric inhibition. This study will be helpful to understand the mechanism of allosteric inhibition of PTP1B by biflavonoids and give insights to develop potent inhibitors of PTP1B.

• Proceedings of the KIEE Conference
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• 2002.07c
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• pp.1518-1520
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• 2002

Purpose of this research compares best transfer speed about applied frequency and voltage using characteristic of $L_1-B_4$ mode and $L_1-B_8$ mode linear ultrasonic motor that use piezoelectric effect. By method of study, analyzed best transfer speed measuring and comparison load status that use actuality telephone card in $L_1-B_4$ mode linear ultrasonic motor and no-load status of $L_1-B_8$ mode linear ultrasonic motor. Experiment result is applied frequency(58.4Hz) in $L_1-B_4$ mode linear ultrasonic motor (load state) and the best transfer speed by 19.8[cm/s] at applied voltage(56V) point. Also, $L_1-B_8$ mode linear ultrasonic motor (no-load state) is best transfer speed by applied frequency(27.9kHz) and 32.96[cm/s] at applied voltage (50V) point.

• Journal of the Korean Chemical Society
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• v.39 no.6
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• pp.440-445
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• 1995

The chemical compositions and stability constants, thermodynamic parameters for the neodymium(Ⅲ) complexes of substituted benzo-1,4,7,10,13-pentaoxacyclopentadecane(B15C5) have been determined by spectrophotometry and conductometry in methanol solution at various temperatures. As substituents, CH3, Br, CHO, NO2, and 3,4-(NO2)2 were used. In methanol solution the ratios of neodymium(Ⅲ) to the ligands in the complexes are 1 : 1. The stability constants were increased in order of B15C5-3,4-(NO2)2 < B15C5-NO2 < B15C5-CHO < B15C5-Br < B15C5 < B15C5-CH3. This observation can be explained in terms of the substituent effect. The order of stability constants was dimethylsulfoxide < acetone < acetonitrile in solution and the magnitudes were found to be inversely proportional to the solvents donicities. These results could be understood in terms of solvent basicity, ligand basicity, solvation of the cation, and entropy changes of complex formation.

• Journal of IKEEE
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• v.28 no.1
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• pp.33-37
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• 2024

In this paper, we report the design and the measurement of a X-band low noise amplifier (LNA) monolithic microwave integrated circuit (MMIC) using a 0.25 ㎛ gate length microstrip GaN-on-SiC high electron mobility transistor (HEMT) technology. The developed X-band GaN-based LNA MMIC achieves small signal gain of 22.75 dB ~ 25.14 dB and noise figure of 1.84 dB ~ 1.94 dB in the desired band of 9 GHz to 10 GHz. Input and output return loss values are -11.36 dB ~ -24.49 dB and -11.11 dB ~ -17.68 dB, respectively. The LNA MMIC can withstand 40 dBm (10 W) input power without performance degradation. The chip dimensions are 3.67 mm × 1.15 mm. The developed GaN-based LNA MMIC is applicable to various X-band applications.

• Toxicological Research
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• v.32 no.2
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• pp.89-93
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• 2016

Human cytochrome P450 enzymes (P450s, CYPs) are major oxidative catalysts that metabolize various xenobiotic and endogenous compounds. Many carcinogens induce cancer only after metabolic activation and P450 enzymes play an important role in this phenomenon. P450 1B1 mediates bioactivation of many procarcinogenic chemicals and carcinogenic estrogen. It catalyzes the oxidation reaction of polycyclic aromatic carbons, heterocyclic and aromatic amines, and the 4-hydroxylation reaction of $17{\beta}$-estradiol. Enhanced expression of P450 1B1 promotes cancer cell proliferation and metastasis. There are at least 25 polymorphic variants of P450 1B1 and some of these have been reported to be associated with eye diseases. In addition, P450 1B1 polymorphisms can greatly affect the metabolic activation of many procarcinogenic compounds. It is necessary to understand the relationship between metabolic activation of such substances and P450 1B1 polymorphisms in order to develop rational strategies for the prevention of its toxic effect on human health.

• Communications of the Korean Mathematical Society
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• v.10 no.2
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• pp.305-315
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• 1995

The class $R_{\gamma-1,p}(A,B,\alpha)$ for $-1 \leq B < A \leq 1,\gamma > (B -1)p+(A_B)(p-\alpha)/1-B$ and $0 \leq \alpha < p$ consisting of p-valently analytic functions in the open unit disc is defined with the help of convolution technique. We study containment property, integral transforms and a sufficient condition for an analytic function to be in $R_{\gamma-1,p}(A,B,\alpha)$.