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Effects of Scoparone on Liver Function (Scoparone의 간 기능에 대한 영향)

  • 최석영;조민경;홍순명;김병삼
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.2
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    • pp.344-349
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    • 1998
  • The purpose of this study was carried out to investigate the effect of scoparone(6, 7-dimethoxyco-umarin) on liver function. Sprague-Dawley rats were treated with scoparone at a dose of 20mg/kg body weight for 5 days. Hepatic bile flow, liver weight, BSP(bromosulfophthalein) biliary excretion, alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities, malondialdehyde production and lactate dehydrogenase(LDH) release were assayed. Among them, ALT and AST activities, malondialdehyde production and LDH release were assayed by using primary hepatocyte cultures at a concentration of 0.1mg/ml. Scoparone treatment had no effect on liver weight and hepatic bile flow. Scoparone treatment not only increased BSP biliary excretion, but also recovered the decreased BSP biliary excretion by CCl4, Also scoparone significantly decreased with the increases of ALT and AST activities, malondialdehyde production and LDH release induced by CCl4. These results suggested that scoparone could protect the liver damage by chemicals via promoting the liver excretory function.

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Effects of Ipriflavone on bone remodeling in the rat calvarial cell (백서 두개관세포에서 Ipriflavone이 골조직 개조에 미치는 영향)

  • Lee, Yong-Seung;Kim, Young-Jun;Lee, Ki-Heon;Hwang, Hyeon-Shik
    • The korean journal of orthodontics
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    • v.35 no.4 s.111
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    • pp.275-285
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    • 2005
  • Ipriflavone (isoprofoxyisoflavone), a synthetic derivative from soy isoflavone diazein, has been shown to inhibit bone resorption and perhaps stimulate bone formation This study was performed to examine the effects of ipriflavone on the proliferation and bone remodeling in rat calvarial cells in vitro The rat calvarial cells were isolated from fetus aged 20 to 21 days and cultured In BGJb media The graded concentration of ipriflavone $(10^{-9}\;10^{-5}M)$ was administered into cultured cells. When the cell proliferation was estimated through the measurement of MTT assay, there was no increase in cellular proliferation of the rat calvarial cell at any ipriflavone concentration. The cellular activity was evaluated through the formation of mineralized nodules stained by alizarin red. The formation of mineralized nodules significantly increased at concentrations of $10^{-8}M,\;10^{-7}M\;and\;10^{-6}M$ ipriflavone. Reverse transcription-polymerase chain reaction analyses (RT-PCR) were done at 7 and 14 days after culture to detect the expression of Bone Sialoprotein (BSP), Type I Collagen (COL I) and Osteocalcin(OCN) As a result, the expressions of BSP and COL I increased on the 7th day of culture and the expression of OCN increased on the 14th day of culture. These results indicate that ipriflavone facilitates the bone remodeling process bvy promoting rat calvarial cell differentiation aid stimulating mineralization through increased expression of extracellular matrix genes. such as BSP. COL I and OCN.

A Study on Conformance Testing Method to Verify the BioAPI Based System Module (BioAPl기반 시스템 모듈을 검증하기 위한 적합성시험 방법 연구)

  • Lee Yoo-Young;Kwon Young-Bin
    • The KIPS Transactions:PartB
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    • v.11B no.7 s.96
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    • pp.759-768
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    • 2004
  • Recently the biometric recognition technology is intensively studied and the standardization of the technology has been highly demanded for its commercialization. Currently many blometric recognition products are being developed based on the BioAPl(Biometric Application Program-ming Interface) specification. However, the reliable testing tools (or scenarios) to evaluate performance and conformance of the products are not shown yet. In this paper, a conformance testing method is presented, which verifies a biometric recognition system to meet the requirements of the BioAPl standard. Two different testing procedures are used in the proposed method. The first procedure evaluates that each functions offered in the BioAPl specification are correctly implemented and that the functions are actually used in the system. Through the Procedure, a BSP(Biometric Service Provider) system is executed on the framework of the BioAPl functions. It requires selection of parameters and prece-dent functions that should be executed first. The second procedure evaluates the abilities of module management, handling operations and ver-ification process by the analysis of the test cases. It tests the correctness of the system operation when a testing scenario is given. The proposed testing method is applied on a fingerprint verification BSP using the sample BSP provided by the BioAPl consortium. The experimental results shows the benefits of the proposed testing method.

Effect of Alcohol Detoxification Beverage that Contained Bulnesia sarmienti on Alcohol-metabolizing Enzymes and Antioxidant Enzyme Activities (Bulnesia sarmienti 를 함유한 숙취해소 음료가 알코올대사 및 항산화 효소활성에 미치는 영향)

  • Lim, Ae-Kyung;Jung, Mee-Jung;Lee, Jae-Wook;Hong, Joo-Heon;Kim, Kil-Soo;Jung, Seok-Bang;Kim, Dae-Ik
    • Food Science and Preservation
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    • v.18 no.3
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    • pp.407-413
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    • 2011
  • This study was carried out to investigate the effect of a beverage that contained Bulnesia sarmienti(BSP, 2.5%) on rats to which alcohol was administered. The treatment of the BSP group reduced the serum alcohol concentration to 52%, compared to 47% in the positive control(PC) group. Similar pattell1s were observed in the enhancement of alcohol dehydrogenase(ADH), acetaldehyde dehydrogenase(ALDH), alkaline phosphate(ALP), alanine aminotransferase(ALT), asparate aminotransferase(AST), total cholesterol(CHOL), ${\gamma}$-glutamyltrasferase(GGT), glucose(GLU), total bilirubin, and total protein(TP) in the serum. Also, in the BSP group, the lipoxidase(LPO), glutathion-S-transferase(GST), XO, catalase(CAT), and superoxide dismutase(SOD) were significantly reduced, compared to the CO and PC groups in the liver. The glutathione(GSH) activity increased in the BSP group, though. These results indicate that Bulnesia sarmienti extract can enhance alcohol metabolization activity.

Analysis of Tuning Unit Characteristic for Track Circuit Maintenance Efficiency (궤도회로의 유지보수 효율화를 위한 동조 유니트 특성 분석)

  • Kim, Yong-Kyu;Baek, Jong-Hyen;Park, Jae-Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.12
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    • pp.3594-3599
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    • 2009
  • The train control system used in Gyeongbu-line is classified in ATC, IXL and CTC. The ATC data related to speed and space control for trains are transmitted from wayside to onboard by way of UM71 AF track circuits and BSP Loop. The information transferred by track circuits is composed of operation data which directly influence to the train operation and the information transferred by BSP Loop is used in the section which requires the additional data transmission about the particular track-side environment such as tunnel, hot box detector or insulated section. In this paper, for the BA type turning unit of the UM71 AF track circuits which is mainly used in the linking section of existing and high-speed lines from the opening of the Gyeongbu line till the present, we not only analyze the characteristics of BA but also compare and analyze baseline values and the measured values. With this analysis, we will be able to propose how to solve the problems about operation and maintenance such as track circuit malfunctions of the relevant sections.

Adaptive Load Balancing Scheme using a Combination of Hierarchical Data Structures and 3D Clustering for Parallel Volume Rendering on GPU Clusters (계층 자료구조의 결합과 3차원 클러스터링을 이용하여 적응적으로 부하 균형된 GPU-클러스터 기반 병렬 볼륨 렌더링)

  • Lee Won-Jong;Park Woo-Chan;Han Tack-Don
    • Journal of KIISE:Computer Systems and Theory
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    • v.33 no.1_2
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    • pp.1-14
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    • 2006
  • Sort-last parallel rendering using a cluster of GPUs has been widely used as an efficient method for visualizing large- scale volume datasets. The performance of this method is constrained by load balancing when data parallelism is included. In previous works static partitioning could lead to self-balance when only task level parallelism is included. In this paper, we present a load balancing scheme that adapts to the characteristic of volume dataset when data parallelism is also employed. We effectively combine the hierarchical data structures (octree and BSP tree) in order to skip empty regions and distribute workload to corresponding rendering nodes. Moreover, we also exploit a 3D clustering method to determine visibility order and save the AGP bandwidths on each rendering node. Experimental results show that our scheme can achieve significant performance gains compared with traditional static load distribution schemes.

The Effect of Over-expression and Inactivation of Nuclear Factor I-C on the Dentin Matrix Gene Expression of MDPC-23 Odontoblasts (Nuclear Factor I-C 과발현과 발현억제가 MDPC-23 상아모세포주의 상아질 기질유전자 발현에 미치는 영향)

  • Bae, Hyun-Sook;Cho, Young-Sik
    • Journal of dental hygiene science
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    • v.9 no.4
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    • pp.427-433
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    • 2009
  • Nuclear factor I-C (NFI-C) null mice demonstrated aberrant odontoblast differentiation and abnormal dentin formation. In order to elucidate the mechanisms responsible for these changes, we evaluated the expression of dentin matrix gene after over-expression and inactivation of NFI-C in MDPC-23 cells by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Collagen type I (Col I), osteocalcin (OC), and dentin sialophosphoprotein (DSPP) expression was decreased after inactivation of NFI-C. However, bone sialoprotein (BSP) expression was dramatically increased after inactivation of NFI-C. ALP and DMP4 expression was not changed after inactivation of NFI-C. The expression of alkaline phoshatase (ALP) and dentin matrix protein 4 (DMP4) was increased after over-expression of NFI-C, while Col I, OC, DSPP, and BSP expression was decreased. These findings suggest that odontoblasts after loss of NFI-C lost the phenotype of odontoblasts and acquired those of osteoblasts.

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Effects of a Breastfeeding Support Program on the Prevalence of Exclusive Breastfeeding and Growth in Late Preterm Infants

  • Jang, Gun Ja;Hong, Yeon Ran
    • Child Health Nursing Research
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    • v.26 no.1
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    • pp.90-97
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    • 2020
  • Purpose: The purpose of this study was to investigate the effects of a breastfeeding support program (BSP) on the prevalence of exclusive breastfeeding and growth in late-preterm infants. Methods: A quasi-experimental study was conducted. The participants were 40 late preterm infants (LPIs), of whom 20 were assigned to the experimental group and 20 to the control group. For the mothers in the experimental group, a BSP was provided prior to the LPIs' discharge and reinforced once a week for 4 weeks. Information on the feeding type was collected by observation and the LPIs' body weight was measured. Results: There were significant differences in feeding type by group and time. Exclusive breastfeeding was 5.18 times more common in the experimental group than in the control group (odds ratio=5.18, 95% confidence interval=1.11~16.70). However, weekly weight gain did not show a significant relationship with group and time (F=0.40, p=.712). Conclusion: The BSP was helpful for increasing the rate of exclusive breastfeeding in LPIs. Furthermore, the LPIs in the experimental group, which had a higher likelihood of being exclusively breastfed, showed an equivalent amount of weight gain as the LPIs in the control group, in which infants were more likely to be formula-fed.

A Study on Inter-operability of NEMO and PMIPv6 for Enhanced IP Mobility Support (향상된 IP 이동성 지원을 위한 NEMO와 PMIPv6의 상호 운용성에 관한 연구)

  • Kim, Seong-Chul;Lee, Ho-Sun;Cho, Yong-Bum;Cho, Sung-Joon
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2008.10a
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    • pp.886-889
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    • 2008
  • There are Proxy Mobile IPv6(PMIPv6) and Network Mobility Basic Support Protocol (NEMO BSP) for more enhanced mobility support. These have a common purpose to support seamless IP mobility at network infrastructure level whenever mobile nodes(MNs) move between foreign networks. But it is different that the NEMO BSP supports an entire network's mobility, while the PMIPv6 supports only a single MN's mobility. In this paper, a new scheme is proposed to guarantee an interoperability of PMIPv6 and NEMO BSP.

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