• International Journal of Oral Biology
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• v.44 no.4
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• pp.165-172
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• 2019

Berberine has been used clinically for more than a decade to treat various diseases, has been shown to be effective in osteoblast differentiation, and is a potential treatment option for osteoporosis. However, compared with existing osteoporosis drugs, berberine is somewhat less effective. This study aimed to identify a new compound with efficacy superior to that of berberine. The osteogenic activities of various berberine derivatives were evaluated via cell differentiation in C2C12 preosteoblast cell lines. Alkaline phosphatase (ALP) staining assay and structure-activity relationship demonstrated that compound 2b had a potent osteogenic effect. Furthermore, compound 2b dose dependently increased ALP activity and showed no toxicity at the effective concentration, indicating its efficacy. Additionally, compound 2b upregulated BMP2-induced transcriptional activity in a promoter activity assay using ALP, BSP, and OC promoters.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.140.4-140
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• 2001

This paper presents the duplex controller operated as master slave for Self Excited Static Type excitation system and the results of operation for duplex digital excitation system. Software is made up duplex multi-tasking control algorithm which is based on VxWorks(real-time OS), preprocessing algorithm for input-output signal, BSP & Device Driver for interfacing hardware and software, and OIS(Operator Interface Station) program, HMI S/W. Master controller and slave controller intercommunicate dominant data to minimize bump when controller switchover from master to slave occurs. Communication between master controller and slave controller is duplicated and communication between OIS and controller is duplicated. Hardware is made up VMEBUS based controller which is designed with PPC & I/O board ...

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.10
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• pp.922-929
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• 2004

In this paper, we develop control hardware such as an FPGA based general purposed intelligent controller with a DSP board to solve nonlinear system control problems. PID control algorithms are implemented in an FPGA and neural network control algorithms are implemented in a BSP board. An FPGA was programmed with VHDL to achieve high performance and flexibility. The additional hardware such as an encoder counter and a PWM generator can be implemented in a single FPGA device. As a result, the noise and power dissipation problems can be minimized and the cost effectiveness can be achieved. To show the performance of the developed controller, it was tested fur nonlinear systems such as a robot hand and an inverted pendulum.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.1
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• pp.135-158
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• 2018

High-Speed vehicles can be considered as multiple mobile nodes that move together in a large-scale mobile network. High-speed makes the time allowed for a mobile node to complete a handover procedure shorter and more frequently. Hence, several protocols are used to manage the mobility of mobile nodes such as Network Mobility (NEMO). However, there are still some problems such as high handover latency and packet loss. So efficient handover management is needed to meet Quality of Service (QoS) requirements for real-time applications. This paper utilizes the cross-layer seamless handover technique for network mobility presented in cellular networks. It extends this technique to propose QoS-aware NEMO protocol which considers QoS requirements for real-time applications. A novel analytical framework is developed to compare the performance of the proposed protocol with basic NEMO using cost functions for realistic city mobility model. The numerical results show that QoS-aware NEMO protocol improves the performance in terms of handover latency, packet delivery cost, location update cost, and total cost.

• Korean Management Science Review
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• v.13 no.3
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• pp.49-73
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• 1996

Common problems have been observed in the existing Information Requirements Analysis (IRA) methodologies such as BSP(IBM), CSF(Rockart), or ISP(Information Engineering), etc. These methodologies require too much time and human resources for the IRA process, involves high complexity, and their IRA outcomes are frequently biased by the subjective views of the people involved. In this paper, we introduce a new methodology for the enterprise wide information requirements analysis utilizing templates and nine closed-ended questions. Extending the BIAIT(Business Information Analysis and Integration Technique) method, this methodology presents nine question about each firm's order type(7Q's for customer side and 2Q's for supplier side) to derive information processing characteristics of the firms. As the central component of this methodology, data and process templates for the manufacturing industry were established. To validate the methodology, suitability of the data and process templates were examined through six real world business cases.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.04a
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• pp.229-232
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• 2002

본 논문에서는 게임엔진에서 쓰이는 공간 분류기법의 종류인 BSP, 포털, PVS 에 대한 기본 개념과 각각의 장단점을 설명하였다. 그리고 상용게임엔진에서의 공간 분류기법을 비교하고 여러게임엔진에서 어떤 공간 분류기법이 사용되는지를 논술한다.

• Journal of Life Science
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• v.24 no.8
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• pp.851-859
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• 2014

The present study was designed to investigate whether ethanol extracts of Sophora flavescens (GS), Glycyrrhiza uralensis (GC), Dictamnus dasycarpus (BSP), and their mixtures (GGB-1, -2, -3, and -4) inhibit 1-chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD) in a mouse model. DNCB was topically applied on the dorsal surface of Balb/c mice to induce AD-like skin lesions. The pathological phenotypes of AD, such as erythema, ear thickness, edema, scabs, and discharge, were significantly decreased in the GGB (DNCB + GS:GC:BSP = 3:1:1 mixture)-1-treated groups compared with the other treated groups. The weight of the spleen in immune organs was significantly decreased in the GGB-1-treated groups, whereas the weight of the liver in a control group was similar to that of the groups treated with the samples. Furthermore, toluidine blue staining analysis, a method used to specifically identify mast cells, showed that master cell infiltration into the dermis of the GGB-1-treated group was significantly decreased. The immunoglobulin E concentration was lower in the GGB-1-treated group. In addition, the levels of inflammatory cytokines (interferon-${\gamma}$, interleukin-1, 4, 5, 6, and 13, $1{\beta}$, and tumor necrosis factor-${\alpha}$) were also significantly reduced in the GGB-1-treated group. Taken together, these results suggest that a mixture of GS, GC, and BSP in a proportion of 3:1:1 (GGB-1) may contribute to the relief of AD symptoms and may be considered an excellent candidate for an AD therapeutic drug.

• Journal of Periodontal and Implant Science
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• v.35 no.2
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• pp.321-333
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• 2005

1. 목적 in vitro 상에서 법랑기질유도체가 치주인대섬유아세포, 불멸화 조골세포와 백악질 유래세포의 증식과 유전자 발현에 미치는 영향을 알아보고자 하였다. 2. 연구방법 및 재료 <세포증식 연구> 교정을 목적으로 발거한 치아에서 분리, 배양한 치주인대섬유아세포와 백악질유래세포, 그리고 $SaOs_2$ 세포를 이용하였다. 법랑기질유도체가 세포 증식에 미치는 영향을 알아보기 위해, 35 mm Petri dish에 dish 당 $5{\times}10^3$ 개의 세포를 접종하였다. 대조군은 1% 항생제와 10% FBS를 포함한 DMEM 배지를 이용했고, 5mM 초산을 첨가한 군과 첨가하지 않은 두 개의 대조군이 이용되었다. 실험군은 100 ${\mu}g/ml$의 법랑기질유도제를 첨가한 군과 100 ${\mu}g/ml$의 법랑기질유도체와 5 mM의 초산을 첨가한 2개의 실험군이 이용되었다. 각 군은 세 개의 배양접시에 행해졌고, 1, 3, 8일에 세포의 수를 각각 측정하였다. 결과는 repeated measures ANOVA로 통계 처리하였다. <유전자 발현 연구> 각 세포의 형질 특성을 알아보기 위해 RT-PCR을 실시하여 조골세포 분화 표식자와 연관된 Human collagen type I(COL I), human osteopontin(OP), human osteocalcin(OC), human alkaline phosphatase(ALP)와 human bone sialoprotein(BSP)의 mRNA 발현을 실험 1, 3, 8일에 걸쳐, 세 군의 차이를 비교 관찰하였다. 3. 결과 <세포증식 연구> 치주인대세포와 백악질유래세포, 그리고 $SaOs_2$ 세포의 증식은 법랑기질유도체에 의해 영향을 받지 않았다. 대조군과 초산이 포함된 대조군 그리고 법랑기질유도체와 초산이 포함된 실험군에서 유의할 만한 세포 수의 차이가 실험 기간 1, 3, 8일에 걸쳐 나타나지 않았다(p<0.05). <유전자 발현 연구> ALP와 COL I은 세 군의 세포에서 모두 발현되었고, 발현 정도는 EMD에 영향을 받지 않았다. OC은 세 군에서 모두 비교적 약하게 발현되었고, 특히 $SaOs_2$ cell과 백악질유래세포에서 약하게 발현되었다. EMD는 OC의 발현정도를 약하게 하였다. OP은 백악질유래세포에서 1, 3, 8일에 걸쳐 EMD 유무에 관련 없이 발현되지 않았다. 그러나 치주인대세포와 $SaOs_2$ cell에서는 강하게 발현되었다. BSP는 치주인대세포와 $SaOs_2$ cell에서 1, 3, 8일에 걸쳐 비교적 고르게 발현되었다. EMD 배지에서 배양된 백악질유래세포는 8일에는 BSP가 발현되지 않았다. 4 결론 이번 실험 결과에 의하면 법랑기질유도체는 치주인대세포, 불멸화 조골세포와 백악질 유래세포의 증식에 있어 유의성 있는 효과를 나타내지 않았다. 그러나, 유전자 발현에 있어서는, 치주인대세포와 백악질유래세포, 그리고 $SaOs_2$ 세포 모두에서 OC mRNA의 발현을 억제하는 효과를 나타내었다. EMD는 세포의 증식에는 영향을 미치지 않지만, 유전자 발현에 있어 일부 영향을 미치는 것으로 보인다. 법랑기질유도체가 세포의 증식과 유전자 발현에 미치는 영향은 배양된 세포의 형질특성, 배양환경, 배양일수 등에 따라 달라질 수 있다. 그러므로 법랑기질유도체가 in vitro 상에서 세포에 미치는 영향은 보다 정량화된 연구가 필요하다.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.6
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• pp.467-478
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• 2020

Hypervisor virtualize hardware resources to utilize them more effectively. At the same time, hypervisor's characteristics of time and space partitioning improves reliability of flight software by reducing a complexity of the flight software. Korea Aerospace Research Institute chooses one of hypervisors for space, XtratuM, and examine its applicability to the flight software. XtratuM has strong points in performance improvement with high reliability. However, it does not support SMP. Therefore, it has limitation in using it with high performance applications including satellite altitude orbit control systems. This paper proposes RTEMS XM-SMP to support SMP with RTEMS, one of real time operating systems for space. Several components are added as hypercalls, and initialization processes are modified to use several processors with inter processors communication routines. In addition, all components related to processors are updated including context switch and interrupts. The effectiveness of the developed RTEMS XM-SMP is demonstrated with a GR740 board by executing SMP benchmark functions. Performance improvements are reviewed to check the effectiveness of SMP operations.

• Journal of Digital Convergence
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• v.10 no.3
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• pp.227-232
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• 2012

The purpose of this research is to analyzed the Korean adolescents' weight control behaviors by BMI(Body Mass Index) and body shape perception. The data of this study abtained 73,238 adolescents, aged 12-18years from the '2010 6th Korea Youth Risk Behavior web-based Survey. The data were analyzed by frequency, percentile, chi-square test, Binominal Logistic Regression analysis. The results of this research were as following. First, the answer to question about adolescents' body shape perception is high in "normal" and "a little fat", but the result of BMI show that the most of them are in "underweight". Second, the female students tends to perceive themselves obese than male students do. Third, the female student try to lose weight but male student try to gain weight. Also the higher BMI is, the more the student have tendency to try to lose their weight. In conclusion, BSP leds directly weight control behavior, so in order to reduce unnecessary weight loss or improper methods weight control behavior. It is important to educate the students to have a sound perception about body shape.