• Smart Structures and Systems
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• 제13권3호
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• pp.407-418
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• 2014

The purpose of this paper is to present an Integrated Life Cycle Bridge Information Modeling that can be used throughout different phases of the bridge life cycle including: design, construction, and operation and maintenance phases. Bridge Information Modeling (BrIM) has become an effective tool in bridge engineering and construction. It has been used in obtaining accurate shop drawings, cost estimation, and visualization. In this paper, BrIM is used as an integrated tool for bridges life cycle information modeling. In the design phase, BrIM model can be used in obtaining optimum construction methods and performing structural advanced analysis. During construction phase, the model selects the appropriate locations for mobile cranes, monitors the status of precast components, and controls documents. Whereas, it acts as a tool for bridge management system in operation and maintenance phase. The paper provides a detailed description for each use of BrIM model in design, construction, and operation and maintenance phases of bridges. It is proven that BrIM is an effective tool for bridge management systems throughout their life phases.

• Smart Structures and Systems
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• 제26권4호
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• pp.533-544
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• 2020

Effective bridge maintenance reduces bridge operation costs and extends its service life. The possibility of storing bridge life-cycle data in a 3D parametric model of the bridge through Bridge Information Modeling (BrIM) provides new opportunities to enhance current practices of bridge maintenance management. This study develops a Decision Support System (DSS), namely BrDSS, which employs BrIM and an efficient optimization model for bridge maintenance planning. The BrIM model in BrDSS extracts basic data of elements required for the optimization process and visualizes the inspection data and the optimization results to the user to help in decision makings. In the optimization module of the DSS, the specifically formulated Genetic Algorithm (GA) eliminates the chances of producing infeasible solutions for faster convergence. The practicality of the presented DSS was explored by utilizing the DSS in the maintenance planning of a bridge under operation in the southwest of Iran.

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.1885-1889
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• 2012

Among 23 cytochrome P450s, CYP125A4 was proposed as a putative monooxygenase based on the high level of amino acid sequence homology (54% identity and 75% similarity) with the well characterized C27-steroid $Mycobacterium$ $tuberculosis$ CYP125A1. Utilizing MTBCYP125A1 as a template, homology modeling of SPCYP125A4 was conducted by Accelrys Discovery Studio 3.1 software. The modeled SPCYP125A4 structure with lowest energy value was subsequently assessed for its stereochemical quality and side-chain environment. The final model was generated by showing its active site through the molecular dynamics. The docking of steroids showed broad specificity of SPCYP125A4 with different orientation of ligand within active site facing the heme. One poses of C27-steroid with C26 facing the heme with distance of 3.734 ${\AA}$ from the Fe were predominant.

• Journal of Microbiology and Biotechnology
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• 제22권7호
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• pp.917-922
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• 2012

Homology modeling of Streptomyces peucetius CYP147F1 was constructed using three cytochrome P450 structures, CYP107L1, CYPVdh, and CYPeryF, as templates. The lowest energy SPCYP147F1 model was then assessed for stereochemical quality and side-chain environment by Accelrys Discovery Studio 3.1 software. Further activesite optimization of the SPCYP147F1 was performed by molecular dynamics to generate the final SPCYP147F1 model. The substrate limonene was then docked into the model. The model-limonene complex was used to validate the active-site architecture, and functionally important residues within the substrate recognition site were identified by subsequent characterization of the secondary structure. The docking of limonene suggested that SPCYP147F1 would have broad specificity with the ligand based on the two different orientations of limonene within the active site facing to the heme. Limonene with C7 facing the heme with distance of $3.4{\AA}$ from the Fe was predominant.

• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4652-4659
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• 2022

Among the detector materials available at room temperature, thallium bromide (TlBr), which has a relatively high atomic number and density, is widely used for gamma camera imaging. This study aimed to verify the usefulness of TlBr through quantitative evaluation by modeling detectors of various compound types using Monte Carlo simulations. The Geant4 application for tomographic emission was used for simulation, and detectors based on cadmium zinc telluride and cadmium telluride materials were selected as a comparison group. A pixel-matched parallel-hole collimator with proven excellent performance was modeled, and phantoms used for quality control in nuclear medicine were used. The signal-to-noise ratio (SNR), contrast to noise ratio (CNR), sensitivity, and full width at half maximum (FWHM) were used for quantitative analysis to evaluate the image quality. The SNR, CNR, sensitivity, and FWHM for the TlBr detector material were approximately 1.05, 1.04, 1.41, and 1.02 times, respectively, higher than those of the other detector materials. The SNR, CNR and sensitivity increased with increasing detector thickness, but the spatial resolution in terms of FWHM decreased. Thus, we demonstrated the feasibility and possibility of using the TlBr detector material in comparison with commercial detector materials.

• Journal of Microbiology and Biotechnology
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• 제22권8호
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• pp.1059-1065
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• 2012

Biocatalytic transfer of oxygen in isolated cytochrome P450 or whole microbial cells is an elegant and efficient way to achieve selective hydroxylation. Cytochrome P450 CYP105P2 was isolated from Streptomyces peucetius that showed a high degree of amino acid identity with hydroxylases. Previously performed homology modeling, and subsequent docking of the model with flavone, displayed a reasonable docked structure. Therefore, in this study, in a pursuit to hydroxylate the flavone ring, CYP105P2 was co-expressed in a two-vector system with putidaredoxin reductase (camA) and putidaredoxin (camB) from Pseudomonas putida for efficient electron transport. HPLC analysis of the isolated product, together with LC-MS analysis, showed a monohydroxylated flavone, which was further established by subsequent ESI/MS-MS. A successful 10.35% yield was achieved with the whole-cell bioconversion reaction in Escherichia coli. We verified that CYP105P2 is a potential bacterial hydroxylase.

• 대한기계학회논문집B
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• 제23권2호
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• pp.272-280
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• 1999

A cycle analysis was achieved to predict the characteristics by comprehensive modeling and simulation of an air-cooled, double-effect absorption system using a new $H_2O/LiBr+HO(CH_2)_3OH$ solution. The simulation results showed that the new working fluid may provide the crystallization limit 8% higher than the conventional $H_2O/LiBr$ solution. With a crystallization margin of 3wt%(weight%), the optimal solution distribution ratio was found in the range of 36 to 40%. Variation of cooling air Inlet temperature has a sensitive effect on the cooling COP and corrosion problem. The simulation of heat exchangers with UA value revealed that the absorber and the evaporator are relatively important for an air-cooled system compared with the condenser and the low temperature generator. The effect of cooling air flow rate, circulation weak solution flow rate and chilled water inlet temperature were also examined. The new working fluid may provide the COP approximately 5% higher than the conventional $H_2O/LiBr$ solution.

• 한국방재학회 논문집
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• 제6권3호
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• pp.69-76
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• 2006

본 연구에서는 침수위험이 큰 도시하천내에 건설된 도로의 침수로 인한 피해를 미연에 방지하고 적절한 교통통제계획, EAP 등을 수립하기 위한 수문, 수리학적 분석과정을 제시하였다. 연구대상지역으로 우리나라의 대표적 도시하천인 중랑천 유역의 좌우안에 위치한 동부간선도로를 선정하고 비상대처계획 수립을 위한 기초자료를 작성하였다. HEC-HMS에 의하여 유출 해석을 실시하였으며, UNET을 이용하여 주요 지점 및 구간별 침수특성을 분석하였다. 이문철교부근(하구에서 약 9.5 km)과 월릉교부근(하구에서 약 11.5 km)에서 침수위험이 가장 높아 이문철교부근은 10년 빈도시에, 월릉교부근의 좌안도로는 20년 빈도시에 각각 침수가 되는 것으로 나타났다. 누가강우량과 지속시간을 고려한 침수특성 분석결과 강우 지속시간 7시간 이하에서 누가강우량이 250 mm이상일 경우에는 월계1교지점의 위험홍수위(EL.17.84 m)를 초과하는 것으로 분석되었다. 한강의 배수위를 고려하지 않은 경우에는 C2(월계1교-중랑교, 좌안), C1(월계1교-중랑교, 우안), D(중랑교-군자교)구간순으로 침수위험이 높은 것으로 나타났으나 배수위를 고려한 경우에는 D2(중랑교-군자교, 좌안), E(군자교-용비교)구간의 침수위험이 오히려 높은 것으로 분석되었다.

• 한국정밀공학회지
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• 제15권4호
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• pp.83-90
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• 1998

In this paper, we present neural network for control of Left Ventricular Assist Device(LVAD) system with a pneumatically driven mock circulation system. Beat rate(BR), Systole-Diastole Rate(SDR) and flow rate are collected as the main variables of the LVAD system. System modeling is completed using the neural network with input variables(BR, SBR, their derivatives, actual flow) and output variable(actual flow). It is necessary to apply high perfomance control techniques, since the LVAD system represent nonlinear and time-varing characteristics. Fortunately. the neural network can be applied to control of a nonlinear dynamic system by learning capability In this study, we identify the LVAD system with neural network and control the LVAD system by PID controller and neural network feedforward controller. The ability and effectiveness of controlling the LVAD system using the proposed algorithm will be demonstrated by experiment.

• 제어로봇시스템학회논문지
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• 제4권3호
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• pp.315-320
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• 1998

In this paper, we present the PID control method for the controlling flow rate of highly complicated nonlinear Left Ventricular Assist Device(LVAD) with pneumatically driven mock circulatory system. Beat Rate (BR), Systole-Diastole Rate (SDR) and flow rate are used as the main variables of the LVAD system. System modeling is completed using the neural network with input variables (BR, SDR, their derivatives, actual flow) and an output valiable(actual flow). Then, as the basis of this model, we perform the simulation of PID control to predict the performance and tendency of the system and control the flow rate of LVAD system using the PID controller. The ability and effectiveness of identifying and controlling a LVAD system using the proposed algorithm will be demonstrated through computer simulation and experiments.