• Journal of Life Science
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• v.28 no.9
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• pp.1042-1047
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• 2018

The red algae Gracilaria vermiculophylla is widespread on seashores worldwide and has been used as food in Asian countries. Previous studies have reported that extracts of Gracilaria red algae have beneficial anti-oxidant and anti-inflammatory effects. The present study examined the anti-senescence effects of Gracilaria vermiculophylla extracts (GV-Ex) in replicatively senescent human bone marrow mesenchymal stem cells (hBM-MSCs). GV-Ex pretreatment improved the cellular viability of hBM-MSCs that had been injured by oxidative stress. These effects of GV-Ex were confirmed by MTT assay and immunoblot analysis using the apoptotic proteins p53 and cleaved caspase-3. The reactive oxygen species (ROS) levels were examined in long-term cultured Passages 17 (P-17) mesenchymal stem cells (MSC) and compared to P-7 MSC. The ROS accumulation was greater in the P-17 than in the P-7. However, these increased ROS levels in the P-17 were decreased significantly after treatment with GV-Ex, and restoration of the levels of the anti-oxidant enzymes SOD1, SOD2, and CAT was also observed under these conditions. In addition, P-17 hBM-MSC treated with GV-Ex had decreased levels of the senescence proteins p53, p21, and p16. The results show that the ability of P-17 hBM-MSC to differentiate into osteocytes and adipocytes was improved by GV-Ex treatment, suggesting that GV-Ex ameliorates the functional decline of senescent stem cells.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.3
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• pp.697-707
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• 2015

This paper covered the design and implementation of the demodulation receiver in the ADS-B 1090ES system, which is one of the CNS/ATM's surveillance systems. This researched demodulation performed at the level required by RTCA DO-268B and EUROCAE ED-129. The single signal process method, which applies a baseline multi-sample technique among multi-amplitude sample demodulations, was suggested to improve the quality of the receiver signal, the dynamic range and so on. The suggested multi-signal level tuning method has enhanced the single-signal process method, reducing the unstable reception ratio by the transmit output level difference and manufacturing receiver hardware. The result was that the receiver suggested by the method had 0~87dBm in dynamic range and -90dBm in MTL. This shows a better performance by -3dBm less than the international standard in ADS-B 1090ES ground receiver equipment. The systems which use a similar modulation method, will be considered to be widely applied.

• Applied Chemistry for Engineering
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• v.10 no.3
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• pp.349-353
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• 1999

A study was carried out to see the effects of phenol on the biological degradation of a wastewater containing 2,4-dichlorophenol and 2,4-dinitrophenol and the biodegradation kinetic coefficients of Eckenfelder's modified model for the activated sludge process. The system containing base mix (BM) which was formulated with essential energy sources and nutrients was run down and washed out when 2,4-dichlorophenol and 2,4-dinitrophenol was introduced into the base mix unit without acclimation to phenol. Whereas for the system acclimated to phenol, the treatment efficiency was 91.9% in terms of $BOD_5$ and treatability for each chemical of phenol, 2,4-dichlorophenol, and 2,4-dinitrophenol was 99.8%, 43.3% and 62.5% based on concentration, respectively. Additional BM was added into the combined unit containing phenol, 2,4-dichlorophenol, 2,4-dinitrophenol so that the better treatment efficiency was achieved for each compound. The biokinetic coefficient of Eckenfelder's modified model without phenol acclimation was not estimated because the system did not reach the steady state. Thc coefficient for the phenol acclimation was 12.44 /day, however it was changed as 46.91 /day in addition of both of phenol acclimation and 47 mg/l of BM. The results presented above could be useful for the process design and further study in the field of biodegradation of benzene derivatives.

• YAKHAK HOEJI
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• v.50 no.3
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• pp.160-165
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• 2006

Germanium is found in a range of minerals and ores and is present in foods including beans, tomato juice, oysters, tuna and garlic. Germanium is a non-metallic element, which can exist in valence states of 2 and 4. Clinical trials and use in private practices for more than a decade have demonstrated organic germanium's efficacy in treating serious disease including cancer, arthritis and senile osteoporosis. But it was rarely reported that inorganic germanium has biological properties. STB-BM contains mineral complex, rare earth elements and a little amount of Inorganic germanium. The experiment was carried out the anti-obesity effect. To investigate anti-obesity effect of STB-BM, we measured the effect of body weight, fat weight (subcutaneous fat, epididymal fat, visceral fat, kidney fat and total fat) and serum biochemical level in rats fed high fat diets. STB-BM 35 mg/kg suppressed the increasing ratio of body weight, epididymal fat weight, visceral fat weight, total fat weight, triglyceride and LDL-cholesterol (p<0.05).

• BMB Reports
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• v.51 no.11
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• pp.545-546
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• 2018

With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient's environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as $TGF-{\beta}$ and elevation of regulatory T cells (Tregs) and T helper-2 cells (Th2 cells), would play important roles, in the neuroprotective effect on motor neuronal cell death mechanisms in ALS. Single cycle of repeated intrathecal injections of BM-MSCs demonstrated a clinical benefit lasting at least 6 months, with safety, in ALS patients. Cytokine profiles of CSF provided evidence that BM-MSCs, have a role in switching from pro-inflammatory to anti-inflammatory conditions. Inverse correlation of $TGF-{\beta}1$ and MCP-1 levels, could be a potential biomarker to responsiveness. Thus, additional cycles of BM-MSC treatment are required, to confirm long-term efficacy and safety.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.3
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• pp.321-325
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• 2002

Karyotype analysis was carried out on blood samples of 30 water buffaloes belonging to different breed groups (i.e. Philippine Carabao (PC), Indian Murrah (IM), Bulgarian Murrah (BM), "$F_1$ 50% IM-50% PC", "$F_1$ 50% BM-50% PC" and "75% IM-25% PC"), using the modified Leucocyte Culture Technique. The modal chromosome numbers of the PC, "$F_1$ 50% IM-50% PC", "$F_1$ 50% BM-50% PC", IM, BM and "75% IM-25% PC" were 2n=48, 49, 49, 50, 50 and 50, respectively. The water buffalo chromosomes are mostly acrocentric (79.67%) and the remainder submetacentric (20.33%). Results of the ordinary least square analysis showed significant breed effects (p<0.01) on other karyotypic characteristics (i.e. relative length, arm ratio and centromeric index). Significant correlation between karyotypic characteristics and some animal performance traits were also found. The significant correlation values imply that karyotypic characteristics can be used as important criteria to select potentially productive young water buffaloes. In the future, more production and reproduction traits from non-institutional herds should be included in the analysis to reveal meaningful correlations with various karyotypic characteristics.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.3C
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• pp.234-240
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• 2002

A power amplifier with AlGaAs/InGaAs/GaAs HBT's has been developed for customer premise equipments of the quasi millimeter-wave frequency-band broadband wireless local loop(BWLL) system. Parameters of the linear and nonlinear equivalent circuits for a common base HBT have been extracted by a fitting method. The amplifier has been designed through the linear and nonlinear circuit simulations and fabricated on a ceramic substrate for a hybrid IC. The amplifier has produced a 25.5-dBm output power with 35% power-added efficiency(PAE) at 24.4 GHz and achieved a 7.5-dB linear power gain at 24.8 GHz. In 24.25 ∼24.75 GHz band, the amplifier has exhibited a saturated output over larger than 22 dBm and PAE higher than 25%.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.2
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• pp.77-85
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• 2015

This paper presents our performance evaluation after the way of minimizing waiting times between channel switching for eMBMS(evolved Multimedia Broadcast/Multicast Services) technique in LTE-Advanced systems. Existing composition of MBMS using IGMP(Internet Group Management Protocol) transfers the data with Multicast from BM-SC(Broadcast Multicast Service Center) to eNB(evolevd Node B) and with Broadcast from eNB to UE(User Equipment). Therefore, in case of channel switching, IGMP Join report should be transferred to BM-SC and then wait user's contents to be retransferred from eNB. To achieve this, Subscriber Channel technique of priorities is used for minimizing waiting times between channel switching as UE broadcasts favorite channels in advance.

• Proceedings of the Korean Society of Computer Information Conference
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• 2008.06a
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• pp.279-284
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• 2008

부가서비스는 공급자가 소비자에게 제공하는 본질적인 재화 또는 서비스에 추가하여 부수적으로 제공되는 서비스라는 사전적 의미를 갖고 있다. 최근에는 IT 기술이 발전함에 따라, 웹을 기반으로 한 다양한 부가서비스가 각 산업에서 등장하였으며, 때로는 기본적인 서비스처럼 여겨지기도 할 만큼 성장하고 있다. 전력산업에서도 이러한 시대적 요구와 경쟁력 강화를 위한 수단으로 부가서비스가 도입되고 있다. 초기에는 주로 이메일 청구서 형태의 단순한 서비스였으나, 현재는 다양한 전력 인프라와 데이터를 이용한 전력부가서비스가 시도되고 있다. 국내에도 전력부가서비스 개념이 도입되어, 초기에는 전력부가서비스의 필요성과 이에 대한 인식이 부족하여 제한적인 분야에서만 개발되어왔다. 그러나 최근들어 공급자는 고객을 위한 부가서비스의 중요성을 인식하게 되고, 수용가 또한 이에 대한 높은 관심을 보임에 따라, 점차 다양한 분야로 확대되는 경향을 보이고 있다. 본 논문에서는 이와 같은 시장의 변화를 고려하여, 국내의 전력산업 환경에 적합한 부가서비스 BM을 개발하되, 성공적인 전력부가서비스로 구축하기 위해 수용가의 선호도와 요구사항을 조사하고 이를 충분히 반영한 전력부가서비스 BM(Business Model) 개발 및 시스템 구축방안에 대하여 소개하고자 한다.

• The Journal of Korean Association of Computer Education
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• v.6 no.4
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• pp.23-30
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• 2003

This paper proposes a passage retrieval system based on Okapi's BM25 for developing an efficient QA system and evaluates performances of the passage retrieval system. The test collection of TREC Q&A track which is composed of about one million documents was indexed and a hundred queries of TREC Q&A track are used as testing queries. The experimental results shows that the proposed passage retrieval system can reach to 100% recall rate by searching in only 1700 sentences while the conventional document retrieval system have to search about 120 thousands sentences which are about 70 times more than the proposed passage retrieval system.