• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제17권1호
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• pp.23-32
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• 2011

Recently, with the advent of high risk infectious agent such as the Ebola virus, SARS, special research facilities dealing with such dangerous pathogenic are drawing attention gradually. Especially, this kind of facilities can be called BL4(Biosafety Level 4) facility. At the moment, Korean government is going to construct BL4 institute in order to handle efficiently such kind of pathogen. However, there are no proper design guidelines for BL4 facility. This paper proposes circulation system of BL4 facility on the basis of analysis of existing BL4 guidelines of Canada, and Korean BL3 facilities. The outcomes of this study are as follows. At first, functional areas of BL4 facilities have been divided into three categories according to the hazard level ; dangerous area, transitional area, and ordinary area. Secondly, circulation system of BL4 facility has been explored as a form of diagram according to the circulating subjects. These include human, laboratory animals, hazardous pathogen, equipments and cloth. This study has some limitations in that it lacks empirical evidences and concrete SOPs(Standard Operating Procedure). Despite of some weaknesses, it is expected to give some preliminary guidelines for the design of circulation system in BL4 facilities.

• 한국임상수의학회지
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• 제12권1호
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• pp.789-798
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• 1995

우백혈병 바이러스감염 B 세포주(BL2M3 및 BL312)의 배양상층액에 대한 자기세포들의 증식반응을 검토하였다. 그 결과 BL2M3 및 BL312세포의 배양상층액을 자기세포인 BL2M3세포에 첨가했을 때 농도에 비례하여 현저한 증식을 유도하였다. 이것은 배양 4-5일차, 배양상층액의 첨가농도는 50-60%,세포수는 5x$10^4$-5x$10^{5}$ /ml에서 최적의 증식반응을 보였다. 우태아혈청(FBS) 무첨가 BL2M3 및 BL312세포의 배양상층액에 대해서도 BL2M3세포는 동일한 증식반응을 보였다. 한편 BL2M3 및 BL312세포의 배양상층액을 BL312세포에 첨가했을 때는 BL2M3세포의 경우에 비해 현저하지 않았다. 또한 BL2M3 및 BL312세포의 배양상층액은 말초혈액 림프구에 대해서도 pokeweed mitogen(PWM)첨가 유무에 관계없이 증식을 유도하였다. 그러나 PWM자극 말초혈액 단핵세포의 배양상층액은 BL2M3 및 BL312세포에 대해서 전혀 증식을 유도하지 못했다. 이상의 결과로부터 우백혈병 바이러스감염 B세포주 특히 BL2M3세포는 세포자신이 증식인자를 분비하고 그것과 반응하여 증식하는 소위 autocrine growth 양상을 보이는 것으로 판명되었다.

• Journal of Oral Medicine and Pain
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• 제8권1호
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• pp.121-126
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• 1983

This study is conducted with a view to make correct sexual differentiation by the utilization of discriminant functions. For that purpose were randomly sampled out 148 young adults testes, comprising 67 males and 81 females, ranging from 15 through 18 years fo age. Based on the values made available from the measurement of 6 items corresponding to the maxillary cast models, a statistical analysis was made to abstract feasible discriminant functions. The results findings are as follows: 1. The mean value by sex indicates, in all items, higher one in male group than in female group. 2. Through the measurement were defined as singnificant items in sexual differentiation the bucco-lingual dimensions of canine, 1st-molar, 2nd molar, and 1st bimolat width. 3. Derived from the value from measurement items were discriminant functions with the intention of applying them to sexual differentiation, as follows: 1) Y=-25.4112+0.7513BL3+0.3298BL4-0.2854BL5+0.7350BL6-0.3482BL7+0.2893AW (as tested by Method I) 2)Y=-25.0628+0.7737BL3+0.7468BL6-0.3885BL5+0.2951AW(as tested by Method II) BL3 : Bucco-lingual dimension of upper canine BL4 : Bucco-lingual dimension of upper first prmolar BL5 : Bucco-lingual dimension of upper second premolar BL5 : Bucco-lingual dimension of upper first molar BL6 : Bucco-lingual dimension of upper second molar AW : Upper first bimolar width 4. Sexual defferentiation in terms of descriminant functions represented a probility of 74.6%.

• International Journal of Industrial Entomology and Biomaterials
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• 제4권1호
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• pp.23-30
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• 2002

The general and specific combining abilities and hybrid vigour of seven polyvoltine breeds [BL24, BL62, BL6S, BL67, BL68, BL69, and Pure Mysore (PM)] with five bivoltine breeds (NB4D2, CSR2, CSR5, CSR18 and CSR19) were evaluated in a line ${times}$ tester design by analysing six quantitative traits viz., fecundity, yield 110,000 larvae both by number and weight, cocoon weight, shell weight and cocoon shell ratio. ANOVA estimates showed significant effects for all the traits indicating the role of both additive and non- additive gene actions. Estimation of GCA revealed that the breed BL67 exhibited significant positive effects toy all the six traits followed by BL68 for four important economic traits viz., fecundity, cocoon weight, shell weight and cocoon shell ratio. Among testers, CSR5 showed significant GCA effects for five traits whereas CSR2 exhibited for shell weight and shell ratio. Three hybrids viz., BL67${times}$ NB4D2, BL67 ${times}$CSR5 and BL67${times}$ CSR19 excelled in four quantitative traits for SCA. Majority of the hybrids expressed positive hybrid vigour for cocoon yield/10,000 larvae by weight, cocoon weight and shell weight. Four hybrids namely PM ${times}$ NB4D2, BL67 ${times}$NB4D2, BL67${times}$ CSR5 and BL67${times}$ CSR19 manifesting positive hybrid vigour for five economic traits were adjudicated as best Heterotic hybrids and recommended for commercial exploitation to increase the silk yield.

• 한국자연치유학회지
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• 제10권1호
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• pp.26-32
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• 2021

목적: 경혈 지압에서 모든 혈의 가압 방향은 통상적으로 수직 방향이다. 그러나 지실혈(BL52)에서는 수직 방향이 배꼽 부위를 향하는지 몸통의 중심을 향하는지 명확하지 않다. 본 연구에서는 30명의 대상자의 BL52에 대한 지압의 방향에 따른 압통 역치를 측정하여 효과적인 지압 방향을 연구하는 것이었다. 방법: 대상자의 명문혈(GV4)을 중심으로 좌우 지실혈까지의 거리와 GV4와 배꼽까지의 거리를 측정하여 명문혈 좌우 지실혈이 배꼽을 지나는 타원을 이용하여 좌우 지실혈에서 배꼽 방향 및 몸통 중심 방향의 각도를 계산했다. BL52에 두 방향으로 가압하면서 대상자들이 통증을 느끼는 시점의 압력을 통증 역치로 하였다. 압통역치는 대상자의 좌우 BL52에서 3분 간격으로 3번씩 측정하였다. 결과: 대상자들의 좌우 BL52에서 측정된 압통 역치는 몸통 중심부를 향하여 가압할 때 상대적으로 유의하게 감소하였다(p < .05). BL52에서는가압방향이몸통의중심부를향할때압력에대해더예민한것으로나타났다. 결론: 주변보다 외부 자극에 더 예민한 경혈의 지압 요법에서, BL52에서는 몸통의 중심부를 향하도록 지압하는 것이 배꼽 방향으로 지압하는 것보다 효율적이라는 것을 시사한다.

• 대한수의학회지
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• 제47권4호
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• pp.469-473
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• 2007

This study was performed to investigate the effects of urinary acupoint (BL-23, BL-28) by acupuncture (AP) and electroacupuncture (EA) on urinary bladder in dogs. Four healthy male dogs aged within the range of 6~8 months were used in this experiment. For Electrodes implantation on the bladder, dogs were to undergo surgical operation. The purpose of investigating the effect on urinary bladder was to evaluate electromyogram (EMG) changes according to AP or EA at Shen Shu (BL-23), Pang Guang Shu (BL-28) and non-acupoint. AP and EA (2~4 V, 10 Hz) were applied for 20 min to each point. EMG was evaluated when acupuncture began stimulation and as soon as the stimulation by electroacupuncture was gone. By the experiment of investigating the effect of urinary time it was estimated to measure time up to urination from stimulation on effective acupoint, after saline was filled with 70% of whole volumes on urinary bladder. The wave of EMG on resting stage showed simple and regular, whereas that of EMG on urination showed irregularly strong peaks before urination. Acupuncture of BL-28 had an influence on changes of EMG which had irregular peaks on urination. But the changes of EMG after acupuncture of BL-28 and control were regular like resting stage. The changes of EMG after EA at BL-23 and BL-28 showed irregularly a variety of wave forms. The interval through urination from stimulation at BL-28 and control become short as measuring time by EA (p<0.01). According to the results, AP at BL-28 was effective to urinary bladder. EA at BL-23 and BL-28 was effective to urinary bladder. Especially, the interval on stimulating at BL-28 by EA was the shortest in measuring time to urination from stimulation.

• 수산해양기술연구
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• 제20권1호
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• pp.17-22
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• 1984

시각막의 바탕과 줄무늬 색상을 흑색, 청색, 적색, 백색과 황색 중 2가지씩 순열시킨 20가지 경우에 대하여 붕어 Carassius carassius와 금붕어 Carassius auratus의 시각운동반응을 조사한 결과는 다음과 같다. 1. 붕어의 시각운동반응율은 적색-흑색, 청색-황색과 백색-흑색 일 때 80~90%로 높았으며, 황색-백색, 백색-황색, 흑색-청색, 청색-흑색과 적색-백색일 때 25~40%로 낮았다. 2. 금붕어의 시각운동반응율은 백색-황색, 청색-흑색과 백색-적색을 제외하고는 80%이상으로 높았었다. 3. 붕어의 3분 동안의 평균선 회수는 황색-청색, 백색-청색, 황색-흑색과 백색-흑색일 때 7.5~9.5회로 많았으며, 청색-적색, 황색-백색, 흑색-청색, 적색-모든 색과 청색-흑색일 때 1.8~3.9회로 적었다. 4. 금붕어의 3분 동안의 평균선 회수는 황색-청색, 백색-청색과 백색-흑색일 때만 4.1~4.9회이고, 나머지는 1.6~3.5회로 적었다

• 동의생리병리학회지
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• 제17권2호
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• pp.481-485
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• 2003

Experimental studies were done to research the clinical effects of Juglandis Semen aqua-acupuncture and acupuncture(BL13, BL17, BL13ㆍ17 and free points) on the anti-allergic inflammation response. The following results have been obtained ; JSAA was increased in the lymphocyte proliferation in cultured murine thymocytes and splenocytes. The production of IL-1β was decreased in Juglandis Semen aqua-acupuncture and acupuncture(BL13, BL17 and BL13ㆍ17) group. The production of IL-4 was decreased in Juglandis Semen aqua-acupuncture and acupuncture(BL13, BL17 and BL13ㆍ17) group. The production of total IgG was decreased in Juglandis Semen aqua-acupuncture(BL13 and BL13ㆍ17) and acupuncture(BL13, BL17 and BL13ㆍ17) group. According to the above results, Semen aqua-acupuncture and acupuncture(BL13, BL17 and BL13ㆍ17) both enhances the specific immune response in T and B cells and depress the allergic inflammation reaction.

• 한국임상수의학회지
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• 제22권3호
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• pp.202-205
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• 2005

본 연구는 개에서 위수혈(BL-21) 및 중완혈(CV-12)에 대한 지침의 구토억제효과를 규명할 목적으로 수행하였다. 사용 혈위는 BL-21 및 CV-12이었다. 각 군에서 구토 유발을 위하여 $2{\%}$ xylazine(2.2 mg/kg)을 투여하였으며, metoclopramide 수침은 1 mg/kg의 비율로 해당 혈위에 각각 수침하였다 대조군 및 실험군에 있어서 xylazine 투여 20분전에 BL-21 및 CV-12에 자침, metoclopramide 수침 및 뜸 처치를 각각 실시하였다. 대조군 및 실험군에서 구토율 및 구토발현시간을 각각 조사한 결과는 다음과 같았다. BL-21자침군, CV-12 자침군 및 BL-21과 CV-12 병용 자침군의 구토율은 각각 $33.3{\%}\;50.0{\%}$ 및 $33.3{\%}$로서 대조군($66.7{\%}$)보다 낮았다. BL-21 자침군, CV-12 자침군 및 BL-21과 CV-12 병용 자침군에 있어서 구토 발현 시간은 대조군과 유사하였다. BL-21 수침군 및 CV-12 수침군의 구토 억제율은 각각 $100{\%}$ 및 $83.6{\%}$로서 수침군의 대조군($63.6{\%}$)보다 높았다. 구토발현시간은 수침군의 BL-21 수침군은 0분이었으며, CV-12 수침군은 5분으로서 수침군의 대조군과 유사하였다. BL-21 뜸 처치군 및 CV-12뜸 처치군의 구토율은 각각 $33.3{\%}$로서 뜸 처치군의 대조군($66.7{\%}$)보다 낮았다. 구토발현시간은 뜸 처치군의 대조군 $2{\~}4$분, BL-21 뜸 처치군이 $2{\~}4$분 및 CV-12 뜸 처치군이 $2{\~}3$분으로서 큰 차이를 나타내지 않았다. 이상의 결과를 종합해 볼 때, 개에서 $2{\%}$ xylazine 투여로 유발된 구토에 대한 BL-21 및 CV-12의 자침, metoclopramide 수침 및 뜸 처치가 각각 구토 억제에 효과적이었으며, 또한 이들 중 BL-21에 대한 metoclopramide 수침의 구토억제 효과가 가장 우수하였다.

• Journal of Acupuncture Research
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• 제21권3호
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• pp.169-178
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• 2004

Objective : This study was designed to investigate the effects of acupuncture, moxibustion and electro-acupuncture at LI4 and LR3, BL18 and BL25 on serum gastin level in rats. Methods : LI4 and LR3 which belong to Large Intestine Meridian and liver Meridian are acupuncture points frequently used for healing gastrointestinal disease in oriental medicine. BL18 and BL25 which belong to Bladder Meridian are acupuncture points used for healing hepatic disease and intestinal disease in oriental medicine. Serum gastrin level by radioimmnunoassay was measured at 3 days after acupuncture, moxibustion and electro-acupuncture of those acupoints. Results & Conclusion : Moxibustion applied to the BL18 acupoint, BL25 acupoint decreased gastrin level of serum, but moxibustion applied to the BL18+BL25 acupoints did not produced significant effect. Acupuncture applied to the LI4 acupoint, LR4 acupoint did not produced significant effect, but acupuncture applied to the LI4+LR4 acupoints increased gastrin level of serum, Electro-acupuncture applied to the LI4 acupoint, LR4 acupoint increased gastrin level of serum, and electro-acupuncture applied to the LI4+LR4 acupoints also increased gastrin level of serum.